General Information of the m6A Regulator (ID: REG00014)
Regulator Name Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
Synonyms
IGF2 mRNA-binding protein 3; IMP-3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3; IMP3; KOC1; VICKZ3
    Click to Show/Hide
Gene Name IGF2BP3
Regulator Type WRITER ERASER READER
Regulator Link Click to View Full Information of This Regulator
Full List of Target Gene(s) of This m6A Regulator and Corresponding Potential Drug Response(s)
Ephrin type-A receptor 2 (EPHA2)
BT5528 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for BT5528. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of BT5528 through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [1], [2]
CAR-T cells targeting EphA2 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for CAR-T cells targeting EphA2. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of CAR-T cells targeting EphA2 through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [1], [3]
DS-8895 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for DS-8895. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of DS-8895 through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [1], [4]
MEDI-547 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for MEDI-547. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of MEDI-547 through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [1], [5]
MEDI-543 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for MEDI-543. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of MEDI-543 through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [1], [6]
AMP-PNP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Ephrin type-A receptor 2 (EPHA2) is a therapeutic target for AMP-PNP. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of AMP-PNP through regulating the expression of Ephrin type-A receptor 2 (EPHA2). [1], [7]
Fascin (FSCN1)
NP-G2-044 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Fascin (FSCN1) is a therapeutic target for NP-G2-044. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of NP-G2-044 through regulating the expression of Fascin (FSCN1). [8], [9]
Glucose transporter type 1 (SLC2A1)
D-glucose [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for D-glucose. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of D-glucose through regulating the expression of Glucose transporter type 1 (SLC2A1). [10], [11]
Quercetin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for Quercetin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Quercetin through regulating the expression of Glucose transporter type 1 (SLC2A1). [10], [12]
2-Deoxyglucose [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for 2-Deoxyglucose. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 2-Deoxyglucose through regulating the expression of Glucose transporter type 1 (SLC2A1). [10], [13]
WZB-117 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for WZB-117. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of WZB-117 through regulating the expression of Glucose transporter type 1 (SLC2A1). [10], [14]
Arsenite [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for Arsenite. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Arsenite through regulating the expression of Glucose transporter type 1 (SLC2A1). [10], [15]
Dehydroascorbic acid [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Glucose transporter type 1 (SLC2A1) is a therapeutic target for Dehydroascorbic acid. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dehydroascorbic acid through regulating the expression of Glucose transporter type 1 (SLC2A1). [10], [16]
Hexokinase-2 (HK2)
VDA-1102 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Hexokinase-2 (HK2) is a therapeutic target for VDA-1102. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of VDA-1102 through regulating the expression of Hexokinase-2 (HK2). [10], [17]
Hypoxia-inducible factor 1 alpha (HIF-1A)
HIF-1alpha [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for HIF-1alpha. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of HIF-1alpha through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [19]
IT-101 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for IT-101. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of IT-101 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [20]
2-Methoxyestradiol [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for 2-Methoxyestradiol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 2-Methoxyestradiol through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [21]
PT2385 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for PT2385. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of PT2385 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [22]
ENMD-1198 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ENMD-1198. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ENMD-1198 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [23]
EZN-2968 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for EZN-2968. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of EZN-2968 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [24]
PX-478 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for PX-478. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of PX-478 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [25]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [26]
ISIS 175510 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 175510. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 175510 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298697 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298697. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298697 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298699 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298699. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298699 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298700 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298700. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298700 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298701 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298701. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298701 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298702 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298702. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298702 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298711 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298711. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298711 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298712 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298712. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298712 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298743 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298743. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298743 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298744 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298744. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298744 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298745 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298745. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298745 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [27]
ISIS 298746 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298746. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ISIS 298746 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [18], [28]
P-glycoprotein 1 (ABCB1)
Abacavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Abacavir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Abacavir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [30]
Acebutolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Acebutolol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Acebutolol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Acrivastine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Acrivastine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Acrivastine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [32]
Actinomycin D [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Actinomycin D. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Actinomycin D through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Afatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Afatinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Afatinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [34]
Ajmaline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ajmaline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ajmaline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [35]
Albendazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Albendazole. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Albendazole through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [36]
Aldosterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Aldosterone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Aldosterone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [37]
Aliskiren fumarate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Aliskiren fumarate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Aliskiren fumarate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [38]
Ambrisentan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ambrisentan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ambrisentan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [39]
Amiodarone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amiodarone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Amiodarone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Amisulpride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amisulpride. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Amisulpride through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Amitriptyline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amitriptyline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Amitriptyline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [41]
Amoxicillin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amoxicillin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Amoxicillin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Amphotericin B [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amphotericin B. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Amphotericin B through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [42]
Amprenavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Amprenavir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Amprenavir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Apixaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Apixaban. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Apixaban through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [43]
Apremilast [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Apremilast. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Apremilast through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Aprepitant [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Aprepitant. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Aprepitant through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Arsenic trioxide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Arsenic trioxide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Arsenic trioxide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [46]
Aspirin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Aspirin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Aspirin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [41]
Atenolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Atenolol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Atenolol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [47]
Atomoxetine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Atomoxetine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Atomoxetine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Axitinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Axitinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Axitinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [48]
Azasetron [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Azasetron. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Azasetron through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Azathioprine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Azathioprine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Azathioprine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [41]
Azithromycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Azithromycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Azithromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [49]
Baloxavir marboxil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Baloxavir marboxil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Baloxavir marboxil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [50]
Baricitinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Baricitinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Baricitinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [51]
Beclomethasone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Beclomethasone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Beclomethasone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [52]
Beclomethasone dipropionate [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Beclomethasone dipropionate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Beclomethasone dipropionate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [52]
Bepridil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bepridil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bepridil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
beta-Acetyldigoxin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for beta-Acetyldigoxin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of beta-Acetyldigoxin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [53]
beta-Carotene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for beta-Carotene. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of beta-Carotene through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [42]
Betamethasone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Betamethasone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Betamethasone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [54]
Betrixaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Betrixaban. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Betrixaban through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [55]
Bicalutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bicalutamide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bicalutamide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [56]
Binimetinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Binimetinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Binimetinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [57]
Biotin [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Biotin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Biotin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [58]
Boceprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Boceprevir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Boceprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [59]
Bosutinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bosutinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bosutinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [60]
Brilinta [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Brilinta. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Brilinta through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Bromocriptine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bromocriptine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bromocriptine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Bupropion [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bupropion. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bupropion through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [62]
Cabergoline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cabergoline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cabergoline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [63]
Canagliflozin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Canagliflozin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Canagliflozin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [64]
Cannabidiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cannabidiol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cannabidiol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Carfilzomib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Carfilzomib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Carfilzomib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [65]
Carvedilol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Carvedilol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Carvedilol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Cefoperazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cefoperazone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cefoperazone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Cefotetan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cefotetan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cefotetan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Ceftriaxone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ceftriaxone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ceftriaxone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Celiprolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Celiprolol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Celiprolol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [66]
Cepharanthine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cepharanthine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cepharanthine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [67]
Ceritinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ceritinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ceritinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [68]
Cerivastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cerivastatin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cerivastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [69]
Cetirizine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cetirizine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cetirizine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [70]
Chlorambucil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Chlorambucil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Chlorambucil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Chloramphenicol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Chloramphenicol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Chloramphenicol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [71]
Chlorpromazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Chlorpromazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Chlorpromazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Ciclesonide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ciclesonide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ciclesonide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [52]
Cimetidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cimetidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cimetidine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Cinchonidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cinchonidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cinchonidine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Cisplatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cisplatin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cisplatin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Citalopram [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Citalopram. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Citalopram through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [72]
Clarithromycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clarithromycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Clarithromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Clobazam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clobazam. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Clobazam through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Clofazimine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clofazimine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Clofazimine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [73]
Clomifene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clomifene. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Clomifene through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [74]
Clomiphene citrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clomiphene citrate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Clomiphene citrate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [74]
Clomipramine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clomipramine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Clomipramine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Clonidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clonidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Clonidine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [41]
Clopidogrel [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clopidogrel. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Clopidogrel through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [75]
Clozapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Clozapine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Clozapine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Colchicine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Colchicine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Colchicine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [76]
Cortisone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cortisone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cortisone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [54]
Cyclosporine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cyclosporine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cyclosporine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [77]
Cytarabine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cytarabine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cytarabine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Dabigatran [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dabigatran. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dabigatran through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [78]
Dabrafenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dabrafenib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dabrafenib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [79]
Daclatasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Daclatasvir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Daclatasvir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [78]
Dactinomycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dactinomycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dactinomycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [80]
Darunavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Darunavir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Darunavir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [81]
Debrisoquine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Debrisoquine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Debrisoquine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [82]
Deflazacort [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Deflazacort. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Deflazacort through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Delavirdine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Delavirdine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Delavirdine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [30]
Desipramine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Desipramine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Desipramine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [83]
Desloratadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Desloratadine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Desloratadine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [84]
Diazepam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Diazepam. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Diazepam through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [85]
Dicloxacillin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dicloxacillin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dicloxacillin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [86]
Diethylstilbestrol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Diethylstilbestrol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Diethylstilbestrol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [74]
Digitoxin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Digitoxin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Digitoxin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [87]
Digoxin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Digoxin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Digoxin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [88]
Dihydroergocristine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dihydroergocristine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dihydroergocristine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [89]
Diltiazem [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Diltiazem. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Diltiazem through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Dipyridamole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dipyridamole. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dipyridamole through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Docetaxel [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Docetaxel. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Docetaxel through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [90]
Dolutegravir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dolutegravir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dolutegravir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Domperidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Domperidone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Domperidone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Doxycycline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Doxycycline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Doxycycline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Ebastine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ebastine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ebastine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Edoxaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Edoxaban. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Edoxaban through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [91]
Efavirenz [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Efavirenz. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Efavirenz through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Eletriptan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Eletriptan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Eletriptan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Eliglustat tartrate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Eliglustat tartrate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Eliglustat tartrate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Emetine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Emetine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Emetine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [80]
Empagliflozin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Empagliflozin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Empagliflozin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Epinastine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Epinastine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Epinastine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [92]
Epirubicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Epirubicin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Epirubicin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Ergotamine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ergotamine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ergotamine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Erythromycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Erythromycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Erythromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [93]
Eslicarbazepine acetate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Eslicarbazepine acetate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Eslicarbazepine acetate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [94]
Estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Estradiol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Estradiol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [74]
Estriol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Estriol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Estriol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [95]
Estrone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Estrone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Estrone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [95]
Estrone sulfate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Estrone sulfate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Estrone sulfate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [69]
Ethinyl estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ethinyl estradiol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ethinyl estradiol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [95]
Etoposide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Etoposide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Etoposide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [96]
Ezetimibe [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ezetimibe. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ezetimibe through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [97]
Famciclovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Famciclovir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Famciclovir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [32]
Felodipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Felodipine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Felodipine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [98]
Fentanyl [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fentanyl. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Fentanyl through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Fesoterodine fumarate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fesoterodine fumarate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Fesoterodine fumarate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [99]
Fexofenadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fexofenadine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Fexofenadine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [100]
Fluoxetine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fluoxetine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Fluoxetine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [101]
Flupentixol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Flupentixol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Flupentixol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Fluphenazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fluphenazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Fluphenazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Fluticasone propionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fluticasone propionate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Fluticasone propionate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [52]
Fluvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fluvastatin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Fluvastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [83]
Fluvoxamine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fluvoxamine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Fluvoxamine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Folic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Folic acid. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Folic acid through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [102]
Fosamprenavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fosamprenavir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Fosamprenavir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Gatifloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Gatifloxacin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Gatifloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [103]
Gilteritinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Gilteritinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Gilteritinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Glutathione [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Glutathione. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Glutathione through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [104]
Gramicidin D [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Gramicidin D. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Gramicidin D through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Grepafloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Grepafloxacin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Grepafloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Guanabenz [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Guanabenz. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Guanabenz through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [83]
Guanfacine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Guanfacine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Guanfacine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [105]
Haloperidol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Haloperidol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Haloperidol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Hydrocortisone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Hydrocortisone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Hydrocortisone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [52]
Hydroxyurea [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Hydroxyurea. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Hydroxyurea through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Ibrutinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ibrutinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ibrutinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [106]
Idarubicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Idarubicin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Idarubicin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [107]
Imatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Imatinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Imatinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [108]
Imipramine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Imipramine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Imipramine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [41]
Indacaterol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Indacaterol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Indacaterol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Indinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Indinavir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Indinavir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [109]
Indomethacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Indomethacin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Indomethacin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [110]
Ingenol-3-angelate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ingenol-3-angelate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ingenol-3-angelate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [111]
Irinotecan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Irinotecan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Irinotecan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [112]
Itraconazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Itraconazole. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Itraconazole through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Ivacaftor [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ivacaftor. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ivacaftor through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [113]
Ivermectin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ivermectin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ivermectin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [114]
Ivosidenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ivosidenib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ivosidenib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [115]
Ixabepilone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ixabepilone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ixabepilone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [116]
Ketoconazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ketoconazole. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ketoconazole through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
L-tryptophan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for L-tryptophan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of L-tryptophan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [117]
Labetalol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Labetalol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Labetalol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Lamotrigine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lamotrigine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Lamotrigine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [118]
Lansoprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lansoprazole. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Lansoprazole through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [83]
Lapatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lapatinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Lapatinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Ledipasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ledipasvir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ledipasvir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Lenalidomide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lenalidomide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Lenalidomide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [119]
Lenvatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lenvatinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Lenvatinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [120]
Levetiracetam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Levetiracetam. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Levetiracetam through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [121]
Levodopa [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Levodopa. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Levodopa through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Levofloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Levofloxacin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Levofloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Levomepromazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Levomepromazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Levomepromazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Levomilnacipran [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Levomilnacipran. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Levomilnacipran through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [122]
Lidocaine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lidocaine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Lidocaine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Linagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Linagliptin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Linagliptin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Loperamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Loperamide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Loperamide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [123]
Lopinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lopinavir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Lopinavir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [124]
Loratadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Loratadine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Loratadine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [84]
Losartan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Losartan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Losartan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [125]
Lovastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lovastatin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Lovastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Lovastatin acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Lovastatin acid. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Lovastatin acid through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Maraviroc [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Maraviroc. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Maraviroc through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Mefloquine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mefloquine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Mefloquine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [126]
Melphalan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Melphalan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Melphalan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [127]
Meperidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Meperidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Meperidine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [128]
Mequitazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mequitazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Mequitazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [32]
Methadone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Methadone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Methadone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [129]
Methotrexate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Methotrexate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Methotrexate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Methylprednisolone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Methylprednisolone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Methylprednisolone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [130]
Methysergide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Methysergide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Methysergide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [32]
Midazolam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Midazolam. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Midazolam through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [83]
Midostaurin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Midostaurin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Midostaurin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Mitomycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mitomycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Mitomycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [131]
Mitoxantrone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mitoxantrone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Mitoxantrone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Morphine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Morphine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Morphine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [132]
Moxidectin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Moxidectin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Moxidectin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [133]
Mycophenolate mofetil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mycophenolate mofetil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Mycophenolate mofetil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [134]
Nadolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nadolol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nadolol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Nalbuphine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nalbuphine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nalbuphine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [32]
Naloxegol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Naloxegol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Naloxegol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Nelfinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nelfinavir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nelfinavir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [135]
Neostigmine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Neostigmine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Neostigmine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Nevirapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nevirapine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nevirapine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Nicardipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nicardipine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nicardipine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [136]
Nifedipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nifedipine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nifedipine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Nilotinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nilotinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nilotinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Nimodipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nimodipine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nimodipine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Nintedanib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nintedanib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nintedanib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [137]
Nisoldipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nisoldipine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nisoldipine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Nitrendipine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nitrendipine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nitrendipine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Nizatidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nizatidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nizatidine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [138]
Norfloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Norfloxacin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Norfloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Olanzapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Olanzapine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Olanzapine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Olmesartan medoxomil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Olmesartan medoxomil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Olmesartan medoxomil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Olopatadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Olopatadine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Olopatadine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Omadacycline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Omadacycline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Omadacycline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [139]
Ombitasvir [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ombitasvir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ombitasvir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Omeprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Omeprazole. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Omeprazole through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [83]
Ondansetron [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ondansetron. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ondansetron through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [126]
Oseltamivir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Oseltamivir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Oseltamivir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [140]
Oxcarbazepine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Oxcarbazepine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Oxcarbazepine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [141]
Palbociclib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Palbociclib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Palbociclib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [142]
Paliperidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Paliperidone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Paliperidone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [143]
Panobinostat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Panobinostat. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Panobinostat through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [144]
Pantoprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pantoprazole. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pantoprazole through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [83]
Paroxetine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Paroxetine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Paroxetine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Pazopanib hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pazopanib hydrochloride. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pazopanib hydrochloride through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [145]
Pemirolast [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pemirolast. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pemirolast through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Pentazocine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pentazocine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pentazocine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Perazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Perazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Perazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Perphenazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Perphenazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Perphenazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Phenobarbital [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Phenobarbital. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Phenobarbital through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [141]
Phenprocoumon [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Phenprocoumon. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Phenprocoumon through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [146]
Phenytoin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Phenytoin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Phenytoin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [141]
Pibrentasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pibrentasvir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pibrentasvir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Pimozide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pimozide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pimozide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Pirarubicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pirarubicin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pirarubicin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Pirenzepine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pirenzepine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pirenzepine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [32]
Pomalidomide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pomalidomide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pomalidomide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [147]
Ponatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ponatinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ponatinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [148]
Posaconazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Posaconazole. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Posaconazole through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Pravastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pravastatin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pravastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Prazosin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Prazosin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Prazosin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [149]
Prednisolone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Prednisolone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Prednisolone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [150]
Prednisone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Prednisone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Prednisone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [54]
Progesterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Progesterone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Progesterone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [85]
Propafenone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Propafenone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Propafenone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Propranolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Propranolol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Propranolol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Protriptyline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Protriptyline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Protriptyline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [32]
Prucalopride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Prucalopride. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Prucalopride through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [151]
Quercetin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Quercetin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Quercetin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [152]
Quetiapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Quetiapine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Quetiapine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [40]
Quinine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Quinine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Quinine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Raloxifene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Raloxifene. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Raloxifene through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [153]
Ramosetron [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ramosetron. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ramosetron through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [154]
Ranitidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ranitidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ranitidine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Ranolazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ranolazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ranolazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [155]
Regorafenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Regorafenib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Regorafenib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [156]
Reserpine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Reserpine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Reserpine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Rifampicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Rifampicin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Rifampicin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Rifaximin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Rifaximin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Rifaximin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [157]
Riociguat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Riociguat. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Riociguat through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [158]
Risperidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Risperidone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Risperidone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [159]
Ritonavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ritonavir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ritonavir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [160]
Rivaroxaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Rivaroxaban. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Rivaroxaban through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [161]
Romidepsin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Romidepsin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Romidepsin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [162]
Rosuvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Rosuvastatin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Rosuvastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [163]
S-licarbazepine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for S-licarbazepine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of S-licarbazepine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [94]
Saphris [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Saphris. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Saphris through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Saquinavir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Saquinavir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Saquinavir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [164]
Saxagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Saxagliptin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Saxagliptin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Sertraline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sertraline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Sertraline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Silodosin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Silodosin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Silodosin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [165]
Simeprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Simeprevir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Simeprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Simvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Simvastatin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Simvastatin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Sitagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sitagliptin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Sitagliptin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Sofosbuvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sofosbuvir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Sofosbuvir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [166]
Sparfloxacin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sparfloxacin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Sparfloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Spiperone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Spiperone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Spiperone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Sumatriptan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sumatriptan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Sumatriptan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [167]
Sunitinib malate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sunitinib malate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Sunitinib malate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [168]
Tacrine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tacrine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tacrine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [169]
Tacrolimus [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tacrolimus. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tacrolimus through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Tadalafil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tadalafil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tadalafil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [170]
Talazoparib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Talazoparib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Talazoparib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [171]
Telaprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Telaprevir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Telaprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [59]
Telithromycin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Telithromycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Telithromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [172]
Temsirolimus [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Temsirolimus. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Temsirolimus through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [173]
Tenofovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tenofovir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tenofovir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Tenofovir disoproxil [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tenofovir disoproxil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tenofovir disoproxil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Tenoxicam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tenoxicam. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tenoxicam through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Testosterone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Testosterone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Testosterone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [83]
Tetracycline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tetracycline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tetracycline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Thiamphenicol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Thiamphenicol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Thiamphenicol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [71]
Thioridazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Thioridazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Thioridazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Timolol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Timolol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Timolol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [66]
Tolvaptan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tolvaptan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tolvaptan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [174]
Topiramate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Topiramate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Topiramate through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [175]
Topotecan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Topotecan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Topotecan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [176]
Toremifene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Toremifene. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Toremifene through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [74]
Tramadol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tramadol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tramadol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [177]
Trifluoperazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Trifluoperazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Trifluoperazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Triflupromazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Triflupromazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Triflupromazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Trimethoprim [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Trimethoprim. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Trimethoprim through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Triprolidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Triprolidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Triprolidine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [178]
Trospium chloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Trospium chloride. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Trospium chloride through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [179]
Vecuronium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vecuronium. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Vecuronium through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [126]
Venetoclax [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Venetoclax. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Venetoclax through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [180]
Verapamil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Verapamil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Verapamil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [181]
vildagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for vildagliptin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of vildagliptin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [182]
Vinblastine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vinblastine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Vinblastine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [183]
Vincristine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vincristine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Vincristine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [184]
Vindesine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vindesine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Vindesine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Vinorelbine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vinorelbine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Vinorelbine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [185]
Zidovudine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Zidovudine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Zidovudine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [30]
Ziprasidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ziprasidone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ziprasidone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Zolmitriptan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Zolmitriptan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Zolmitriptan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
4-Hydroxytamoxifen [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for 4-Hydroxytamoxifen. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 4-Hydroxytamoxifen through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [74]
Asimadoline [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Asimadoline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Asimadoline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Asunaprevir [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Asunaprevir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Asunaprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Belotecan [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Belotecan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Belotecan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
CBT-1 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for CBT-1. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of CBT-1 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [186]
Corticosterone [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Corticosterone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Corticosterone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [74]
Dasabuvir [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dasabuvir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dasabuvir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Morphine-6-glucuronide [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Morphine-6-glucuronide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Morphine-6-glucuronide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Pazufloxacin [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pazufloxacin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pazufloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [187]
Relugolix [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Relugolix. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Relugolix through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Simvastatin acid [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Simvastatin acid. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Simvastatin acid through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [188]
Sitafloxacin [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Sitafloxacin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Sitafloxacin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Tenofovir alafenamide [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tenofovir alafenamide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tenofovir alafenamide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [189]
Vibegron [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Vibegron. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Vibegron through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
(Z)-endoxifen [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for (Z)-endoxifen. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of (Z)-endoxifen through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [190]
ABT-263 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for ABT-263. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ABT-263 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [191]
Bisantrene [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bisantrene. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bisantrene through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Cholesterol [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cholesterol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cholesterol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [192]
CP-122721 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for CP-122721. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of CP-122721 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [193]
Curcumin [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Curcumin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Curcumin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Dihydrotestosterone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dihydrotestosterone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dihydrotestosterone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [194]
Dolastatin 10 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dolastatin 10. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dolastatin 10 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [195]
Fucoxanthin [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Fucoxanthin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Fucoxanthin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [42]
Gallopamil [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Gallopamil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Gallopamil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Gepirone [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Gepirone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Gepirone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Glecaprevir [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Glecaprevir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Glecaprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Norverapamil [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Norverapamil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Norverapamil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [196]
NSC325663 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for NSC325663. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of NSC325663 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [197]
Paritaprevir [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Paritaprevir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Paritaprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Roscovitine [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Roscovitine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Roscovitine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [198]
Staurosporine [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Staurosporine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Staurosporine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
EDP-322 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for EDP-322. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of EDP-322 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [199]
Genz 644282 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Genz 644282. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Genz 644282 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [200]
Naringenin [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Naringenin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Naringenin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [152]
Norbuprenorphine [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Norbuprenorphine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Norbuprenorphine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [201]
Prostaglandin A2 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Prostaglandin A2. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Prostaglandin A2 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [202]
Substance P [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Substance P. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Substance P through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [203]
Talinolol [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Talinolol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Talinolol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [204]
Velpatasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Velpatasvir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Velpatasvir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
Voxilaprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Voxilaprevir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Voxilaprevir through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [44]
W-198 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for W-198. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of W-198 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [205]
YP-005 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for YP-005. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of YP-005 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [206]
Abamectin B1A [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Abamectin B1A. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Abamectin B1A through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [207]
AG1478 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for AG1478. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of AG1478 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [208]
Bouvardin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bouvardin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bouvardin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [197]
Bunitrolol [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bunitrolol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bunitrolol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [209]
Cephaeline [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cephaeline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cephaeline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [197]
Coelenterazine [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Coelenterazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Coelenterazine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [210]
Cycloheximide [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Cycloheximide. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cycloheximide through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [42]
Desmethylsertraline [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Desmethylsertraline. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Desmethylsertraline through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [62]
E-guggulsterone [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for E-guggulsterone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of E-guggulsterone through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [211]
Epothilone A [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Epothilone A. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Epothilone A through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Geneticin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Geneticin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Geneticin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [212]
Metildigoxin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Metildigoxin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Metildigoxin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [61]
Metkephamid [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Metkephamid. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Metkephamid through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [197]
MG-132 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for MG-132. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of MG-132 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [213]
N-desethyl sunitinib [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for N-desethyl sunitinib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of N-desethyl sunitinib through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [214]
Nafoxidine [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nafoxidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nafoxidine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [74]
Nogalamycin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nogalamycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nogalamycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [197]
Nonactin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Nonactin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nonactin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [80]
Okadaic acid [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Okadaic acid. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Okadaic acid through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [197]
Pepstatin A [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pepstatin A. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pepstatin A through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Puromycin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Puromycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Puromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [212]
Selamectin [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Selamectin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Selamectin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [207]
Silvestrol [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Silvestrol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Silvestrol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [215]
SNS-032 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for SNS-032. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of SNS-032 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
4,3'',5''-trimethoxy-[1,1':2',1'']-terphenyl [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for 4,3'',5''-trimethoxy-[1,1':2',1'']-terphenyl. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 4,3'',5''-trimethoxy-[1,1':2',1'']-terphenyl through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [216]
6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for 6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [217]
Azidopine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Azidopine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Azidopine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Bcecf-Am [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Bcecf-Am. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bcecf-Am through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Hoechst 33342 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Hoechst 33342. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Hoechst 33342 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Leupeptin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Leupeptin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Leupeptin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Paraquat [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Paraquat. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Paraquat through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Tiapamil [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tiapamil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tiapamil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
TRISMETHOXYRESVERATROL [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for TRISMETHOXYRESVERATROL. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of TRISMETHOXYRESVERATROL through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [216]
Valinomycin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Valinomycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Valinomycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [136]
XR-9456 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for XR-9456. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of XR-9456 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [217]
XR-9504 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for XR-9504. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of XR-9504 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [217]
XR-9544 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for XR-9544. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of XR-9544 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [218]
XR-9577 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for XR-9577. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of XR-9577 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [217]
[1,1':2',1'']-terphenyl-4,3'',5''-triol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for [1,1':2',1'']-terphenyl-4,3'',5''-triol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of [1,1':2',1'']-terphenyl-4,3'',5''-triol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [216]
ABT-737 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for ABT-737. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ABT-737 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [191]
Alprenolol [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Alprenolol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Alprenolol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [83]
Apafant [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Apafant. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Apafant through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [219]
Astemizole [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Astemizole. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Astemizole through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [45]
Biricodar [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Biricodar. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Biricodar through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [216]
Calphostin C [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Calphostin C. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Calphostin C through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Dexniguldipine [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Dexniguldipine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Dexniguldipine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [197]
Droloxifene [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Droloxifene. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Droloxifene through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
ELACRIDAR [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for ELACRIDAR. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ELACRIDAR through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [220]
Flesinoxan [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Flesinoxan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Flesinoxan through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [221]
Hydroxybupropion [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Hydroxybupropion. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Hydroxybupropion through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [62]
Isoxicam [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Isoxicam. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Isoxicam through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
LY335979 [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for LY335979. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of LY335979 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [222]
Melagatran [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Melagatran. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Melagatran through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Mibefradil [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mibefradil. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Mibefradil through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Mithramycin [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Mithramycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Mithramycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Niguldipine [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Niguldipine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Niguldipine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
ONT-093 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for ONT-093. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ONT-093 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [223]
Pafenolol [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Pafenolol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pafenolol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Rhodamine 123 [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Rhodamine 123. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Rhodamine 123 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [136]
Roxithromycin [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Roxithromycin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Roxithromycin through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [172]
S9788 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for S9788. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of S9788 through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Tariquidar [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tariquidar. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tariquidar through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [224]
Terfenadine [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Terfenadine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Terfenadine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Tolafentrine [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Tolafentrine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Tolafentrine through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [83]
Trans-flupentixol [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Trans-flupentixol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Trans-flupentixol through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Valspodar [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Valspodar. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Valspodar through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [33]
Ximelagatran [Withdrawn]
In total 1 mechanisms lead to this potential drug response
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Ximelagatran. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ximelagatran through regulating the expression of P-glycoprotein 1 (ABCB1). [29], [31]
Programmed cell death 1 ligand 1 (PD-L1)
Atezolizumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Atezolizumab. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Atezolizumab through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [226]
Avelumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Avelumab. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Avelumab through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [227]
Bavencio [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Bavencio. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bavencio through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [228]
Durvalumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Durvalumab. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Durvalumab through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [229]
RG-7446 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for RG-7446. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of RG-7446 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [230]
CS1001 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for CS1001. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of CS1001 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [231]
KN046 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for KN046. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of KN046 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [232]
MEDI4736 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for MEDI4736. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of MEDI4736 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [233]
MPDL-3280A [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for MPDL-3280A. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of MPDL-3280A through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [234]
BGB-A333 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for BGB-A333. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of BGB-A333 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [235]
Bintrafusp alfa [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Bintrafusp alfa. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bintrafusp alfa through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [236]
CX-072 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for CX-072. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of CX-072 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [237]
GS-4224 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for GS-4224. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of GS-4224 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [238]
INCB86550 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for INCB86550. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of INCB86550 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [239]
KN035 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for KN035. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of KN035 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [240]
M7824 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for M7824. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of M7824 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [241]
NM21-1480 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for NM21-1480. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of NM21-1480 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [229]
Pidilizumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Pidilizumab. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Pidilizumab through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [26], [225]
ALPN-202 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for ALPN-202. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ALPN-202 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [242]
Anti-PD-L1 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Anti-PD-L1. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Anti-PD-L1 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [243]
Anti-PD-L1 CSR T cells [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Anti-PD-L1 CSR T cells. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Anti-PD-L1 CSR T cells through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [26], [225]
BMS-986189 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for BMS-986189. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of BMS-986189 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [229]
CA-170 [Phase 1]
In total 2 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for CA-170. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of CA-170 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [241]
Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for CA-170. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of CA-170 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [244]
Cosibelimab [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for Cosibelimab. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Cosibelimab through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [245]
FAZ053 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for FAZ053. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of FAZ053 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [229]
FS118 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for FS118. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of FS118 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [246]
GEN1046 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for GEN1046. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of GEN1046 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [247]
IBI318 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for IBI318. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of IBI318 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [248]
INBRX-105 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for INBRX-105. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of INBRX-105 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [249]
KD033 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for KD033. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of KD033 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [250]
LY3300054 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for LY3300054. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of LY3300054 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [26], [225]
LY3415244 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for LY3415244. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of LY3415244 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [251]
MCLA-145 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for MCLA-145. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of MCLA-145 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [252]
MSB2311 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for MSB2311. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of MSB2311 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [229]
PD-L1 t-haNK [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for PD-L1 t-haNK. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of PD-L1 t-haNK through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [253]
RG6084 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for RG6084. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of RG6084 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [241]
TAK-252 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for TAK-252. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of TAK-252 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [254]
CA-327 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Programmed cell death 1 ligand 1 (PD-L1) is a therapeutic target for CA-327. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of CA-327 through regulating the expression of Programmed cell death 1 ligand 1 (PD-L1). [225], [229]
Proto-oncogene c-Myc (MYC)
AVI-5126 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Proto-oncogene c-Myc (MYC) is a therapeutic target for AVI-5126. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of AVI-5126 through regulating the expression of Proto-oncogene c-Myc (MYC). [255], [256]
Resten-NG [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Proto-oncogene c-Myc (MYC) is a therapeutic target for Resten-NG. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Resten-NG through regulating the expression of Proto-oncogene c-Myc (MYC). [255], [257]
TWS-119 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Proto-oncogene c-Myc (MYC) is a therapeutic target for TWS-119. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of TWS-119 through regulating the expression of Proto-oncogene c-Myc (MYC). [255], [258]
Thymidine kinase 1 (TK1)
DEOXYCYTIDINE [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for DEOXYCYTIDINE. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of DEOXYCYTIDINE through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
Penciclovir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for Penciclovir. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Penciclovir through regulating the expression of Thymidine kinase 1 (TK1). [8], [260]
TK-DLI [Preregistration]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for TK-DLI. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of TK-DLI through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
FV-100 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for FV-100. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of FV-100 through regulating the expression of Thymidine kinase 1 (TK1). [8], [261]
Radiosensitizer gene therapy [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for Radiosensitizer gene therapy. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Radiosensitizer gene therapy through regulating the expression of Thymidine kinase 1 (TK1). [8], [262]
RP101 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for RP101. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of RP101 through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
HQK-1004 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for HQK-1004. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of HQK-1004 through regulating the expression of Thymidine kinase 1 (TK1). [8], [263]
Rilapladib [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for Rilapladib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Rilapladib through regulating the expression of Thymidine kinase 1 (TK1). [8], [264]
Thymidine kinase-expressing adenovirus and ganciclovir suicide gene therapy [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for Thymidine kinase-expressing adenovirus and ganciclovir suicide gene therapy. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Thymidine kinase-expressing adenovirus and ganciclovir suicide gene therapy through regulating the expression of Thymidine kinase 1 (TK1). [8], [265]
(South)-Methanocarba-Thymidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for (South)-Methanocarba-Thymidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of (South)-Methanocarba-Thymidine through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine through regulating the expression of Thymidine kinase 1 (TK1). [8], [266]
1-[2-(2-triphenylmethoxyethoxy)ethyl]thymine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 1-[2-(2-triphenylmethoxyethoxy)ethyl]thymine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 1-[2-(2-triphenylmethoxyethoxy)ethyl]thymine through regulating the expression of Thymidine kinase 1 (TK1). [8], [266]
1-[5-(triphenylmethoxy)pentyl]thymine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 1-[5-(triphenylmethoxy)pentyl]thymine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 1-[5-(triphenylmethoxy)pentyl]thymine through regulating the expression of Thymidine kinase 1 (TK1). [8], [266]
1-[6-(triphenylmethoxy)hexyl]thymine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 1-[6-(triphenylmethoxy)hexyl]thymine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 1-[6-(triphenylmethoxy)hexyl]thymine through regulating the expression of Thymidine kinase 1 (TK1). [8], [266]
1-[7-(triphenylmethoxy)heptyl]thymine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 1-[7-(triphenylmethoxy)heptyl]thymine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 1-[7-(triphenylmethoxy)heptyl]thymine through regulating the expression of Thymidine kinase 1 (TK1). [8], [267]
2'-deoxythymidine triphosphate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 2'-deoxythymidine triphosphate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 2'-deoxythymidine triphosphate through regulating the expression of Thymidine kinase 1 (TK1). [8], [264]
2'-Deoxyuridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 2'-Deoxyuridine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 2'-Deoxyuridine through regulating the expression of Thymidine kinase 1 (TK1). [8], [268]
3'-(1,2,3-Triazol-1-yl)-3'-deoxy-beta-D-thymidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 3'-(1,2,3-Triazol-1-yl)-3'-deoxy-beta-D-thymidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 3'-(1,2,3-Triazol-1-yl)-3'-deoxy-beta-D-thymidine through regulating the expression of Thymidine kinase 1 (TK1). [8], [260]
3-(2-propyn-1-yl)thymidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 3-(2-propyn-1-yl)thymidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 3-(2-propyn-1-yl)thymidine through regulating the expression of Thymidine kinase 1 (TK1). [8], [269]
5-Bromothienyldeoxyuridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 5-Bromothienyldeoxyuridine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 5-Bromothienyldeoxyuridine through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
5-Iodo-2'-Deoxyuridine-5'-Monophosphate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 5-Iodo-2'-Deoxyuridine-5'-Monophosphate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 5-Iodo-2'-Deoxyuridine-5'-Monophosphate through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
5-propyl-2'-deoxyuridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 5-propyl-2'-deoxyuridine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 5-propyl-2'-deoxyuridine through regulating the expression of Thymidine kinase 1 (TK1). [8], [269]
6-(Dihydroxy-Isobutyl)-Thymine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 6-(Dihydroxy-Isobutyl)-Thymine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 6-(Dihydroxy-Isobutyl)-Thymine through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
6-Hydroxypropylthymine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 6-Hydroxypropylthymine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 6-Hydroxypropylthymine through regulating the expression of Thymidine kinase 1 (TK1). [8], [270]
9-(4-Hydroxybutyl)-N2-Phenylguanine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 9-(4-Hydroxybutyl)-N2-Phenylguanine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 9-(4-Hydroxybutyl)-N2-Phenylguanine through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
9-Hydroxypropyladenine, R-Isomer [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 9-Hydroxypropyladenine, R-Isomer. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 9-Hydroxypropyladenine, R-Isomer through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
9-Hydroxypropyladenine, S-Isomer [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for 9-Hydroxypropyladenine, S-Isomer. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of 9-Hydroxypropyladenine, S-Isomer through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
BVDU-MP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for BVDU-MP. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of BVDU-MP through regulating the expression of Thymidine kinase 1 (TK1). [8], [271]
Deoxythymidine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for Deoxythymidine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Deoxythymidine through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
Edoxudine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for Edoxudine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Edoxudine through regulating the expression of Thymidine kinase 1 (TK1). [8], [269]
ITdU [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for ITdU. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ITdU through regulating the expression of Thymidine kinase 1 (TK1). [8], [266]
L-5-(bromovinyl)deoxyuridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for L-5-(bromovinyl)deoxyuridine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of L-5-(bromovinyl)deoxyuridine through regulating the expression of Thymidine kinase 1 (TK1). [8], [272]
L-5-iodo-2'-deoxyuridine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for L-5-iodo-2'-deoxyuridine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of L-5-iodo-2'-deoxyuridine through regulating the expression of Thymidine kinase 1 (TK1). [8], [269]
N2-(3-trifluoromethylphenyl)guanine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for N2-(3-trifluoromethylphenyl)guanine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of N2-(3-trifluoromethylphenyl)guanine through regulating the expression of Thymidine kinase 1 (TK1). [8], [269]
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
Thymidine-5'-Phosphate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for Thymidine-5'-Phosphate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Thymidine-5'-Phosphate through regulating the expression of Thymidine kinase 1 (TK1). [8], [259]
Sitimagene ceradenovec [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for Sitimagene ceradenovec. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Sitimagene ceradenovec through regulating the expression of Thymidine kinase 1 (TK1). [8], [273]
Vascular endothelial growth factor A (VEGFA)
Aflibercept [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for Aflibercept. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Aflibercept through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [274]
Bevacizumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for Bevacizumab. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bevacizumab through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [275]
Brolucizumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for Brolucizumab. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Brolucizumab through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [276]
Ranibizumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for Ranibizumab. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Ranibizumab through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [277]
Faricimab [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for Faricimab. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Faricimab through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [278]
Abicipar pegol [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for Abicipar pegol. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Abicipar pegol through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [279]
MP0250 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for MP0250. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of MP0250 through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [280]
PTC299 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for PTC299. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of PTC299 through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [281]
RG7221 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for RG7221. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of RG7221 through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [282]
RO5520985 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for RO5520985. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of RO5520985 through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [283]
SNN-0029 [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for SNN-0029. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of SNN-0029 through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [26]
ABI-011 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for ABI-011. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ABI-011 through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [284]
MP-0112 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for MP-0112. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of MP-0112 through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [285]
Navicixizumab [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for Navicixizumab. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Navicixizumab through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [26]
SFLT-01 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for SFLT-01. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of SFLT-01 through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [241]
ALN-VEG01 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for ALN-VEG01. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of ALN-VEG01 through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [286]
Bevasiranib [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Vascular endothelial growth factor A (VEGFA) is a therapeutic target for Bevasiranib. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Bevasiranib through regulating the expression of Vascular endothelial growth factor A (VEGFA). [1], [275]
References
Ref 1 m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling. Cell Death Dis. 2022 May 21;13(5):483. doi: 10.1038/s41419-022-04950-2.
Ref 2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1619).
Ref 3 MMAE Delivery Using the Bicycle Toxin Conjugate BT5528. Mol Cancer Ther. 2020 Jul;19(7):1385-1394. doi: 10.1158/1535-7163.MCT-19-1092. Epub 2020 May 12.
Ref 4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1822).
Ref 5 ClinicalTrials.gov (NCT02575261) CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients
Ref 6 Clinical pipeline report, company report or official report of Daiichi Sankyo.
Ref 7 Clinical and biological impact of EphA2 overexpression and angiogenesis in endometrial cancer. Cancer Biol Ther. 2010 Dec 15;10(12):1306-14. doi: 10.4161/cbt.10.12.13582. Epub 2010 Dec 15.
Ref 8 Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018 Mar;20(3):285-295. doi: 10.1038/s41556-018-0045-z. Epub 2018 Feb 23.
Ref 9 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. doi: 10.1042/0264-6021:3510095.
Ref 10 m(6)A-dependent glycolysis enhances colorectal cancer progression. Mol Cancer. 2020 Apr 3;19(1):72. doi: 10.1186/s12943-020-01190-w.
Ref 11 The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):121-38. doi: 10.1016/j.mam.2012.07.001.
Ref 12 Oral Bioavailability and Disposition of Phytochemicals
Ref 13 Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding. J Biol Chem. 1994 Aug 12;269(32):20533-8.
Ref 14 Clinical pipeline report, company report or official report of Roche.
Ref 15 Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. Biochem Biophys Res Commun. 2006 Dec 15;351(2):424-30. doi: 10.1016/j.bbrc.2006.10.054. Epub 2006 Oct 17.
Ref 16 Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem. 1997 Jul 25;272(30):18982-9. doi: 10.1074/jbc.272.30.18982.
Ref 17 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2019).
Ref 18 Knockdown of m6A Reader IGF2BP3 Inhibited Hypoxia-Induced Cell Migration and Angiogenesis by Regulating Hypoxia Inducible Factor-1Alpha in Stomach Cancer. Front Oncol. 2021 Sep 21;11:711207. doi: 10.3389/fonc.2021.711207. eCollection 2021.
Ref 19 Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015). Expert Opin Ther Pat. 2016;26(3):309-22. doi: 10.1517/13543776.2016.1146252. Epub 2016 Feb 16.
Ref 20 A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth. Mol Cancer Ther. 2008 Nov;7(11):3598-608. doi: 10.1158/1535-7163.MCT-08-0510. Epub 2008 Oct 30.
Ref 21 CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer. Breast Cancer Res Treat. 2015 Apr;150(3):559-67. doi: 10.1007/s10549-015-3349-8. Epub 2015 Apr 2.
Ref 22 The biology and chemistry of hyperlipidemia. Bioorg Med Chem. 2007 Jul 15;15(14):4674-99. doi: 10.1016/j.bmc.2007.04.031. Epub 2007 Apr 25.
Ref 23 Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1Alpha), in patients with refractory solid tumors. Cancer Chemother Pharmacol. 2014 Feb;73(2):343-8. doi: 10.1007/s00280-013-2362-z. Epub 2013 Nov 30.
Ref 24 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma. Clin Cancer Res. 2004 Dec 15;10(24):8665-73. doi: 10.1158/1078-0432.CCR-04-1393.
Ref 25 ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties. Mol Cancer Ther. 2010 May;9(5):1408-18. doi: 10.1158/1535-7163.MCT-09-0894. Epub 2010 May 4.
Ref 26 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 27 US patent application no. 7,217,572, Modulation of HIF1.alpha. and HIF2.alpha. expression.
Ref 28 Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6305-10. doi: 10.1016/j.bmcl.2007.09.005. Epub 2007 Sep 7.
Ref 29 Binding of RNA m6A by IGF2BP3 triggers chemoresistance of HCT8 cells via upregulation of ABCB1. Am J Cancer Res. 2021 Apr 15;11(4):1428-1445. eCollection 2021.
Ref 30 The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research. Antiviral Res. 2009 May;82(2):A99-109.
Ref 31 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
Ref 32 Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. doi: 10.1124/jpet.102.039255.
Ref 33 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. doi: 10.1016/j.canlet.2015.10.010. Epub 2015 Oct 20.
Ref 34 Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation. Pharmacol Res. 2017 Jun;120:43-50. doi: 10.1016/j.phrs.2017.01.035. Epub 2017 Mar 10.
Ref 35 ATP-dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by mdr1 P-glycoprotein. FEBS Lett. 1994 Apr 25;343(2):168-72. doi: 10.1016/0014-5793(94)80312-9.
Ref 36 The anthelminthic agent albendazole does not interact with p-glycoprotein. Drug Metab Dispos. 2002 Apr;30(4):365-9. doi: 10.1124/dmd.30.4.365.
Ref 37 MDR1 genotype-dependent regulation of the aldosterone system in humans. Pharmacogenet Genomics. 2007 Feb;17(2):137-44. doi: 10.1097/01.fpc.0000239969.46594.d0.
Ref 38 Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys. Biopharm Drug Dispos. 2015 Jan;36(1):15-33. doi: 10.1002/bdd.1920. Epub 2014 Oct 31.
Ref 39 Potential for pharmacokinetic interactions between ambrisentan and cyclosporine. Clin Pharmacol Ther. 2010 Oct;88(4):513-20. doi: 10.1038/clpt.2010.120. Epub 2010 Sep 1.
Ref 40 Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. doi: 10.1211/0022357043969.
Ref 41 Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. doi: 10.1016/s0378-5173(03)00372-7.
Ref 42 Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87.
Ref 43 Effect of Rifampin on the Pharmacokinetics of Apixaban, an Oral Direct Inhibitor of Factor Xa. Am J Cardiovasc Drugs. 2016 Apr;16(2):119-27. doi: 10.1007/s40256-015-0157-9.
Ref 44 Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition.
Ref 45 Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109.
Ref 46 Arsenic trioxide induces apoptosis equally in T lymphoblastoid leukemia MOLT-4 cells and P-gp-expressing daunorubicin-resistant MOLT-4 cells. Cancer Chemother Pharmacol. 2003 Feb;51(2):119-26. doi: 10.1007/s00280-002-0543-2. Epub 2002 Nov 20.
Ref 47 Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. doi: 10.1016/s0024-3205(01)01494-1.
Ref 48 Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Eur J Clin Pharmacol. 2012 May;68(5):645-55. doi: 10.1007/s00228-011-1171-8. Epub 2011 Dec 15.
Ref 49 Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. World J Gastroenterol. 2017 Nov 21;23(43):7678-7692. doi: 10.3748/wjg.v23.i43.7678.
Ref 50 Baloxavir Marboxil FDA label
Ref 51 Prediction of Transporter-Mediated Drug-Drug Interactions for Baricitinib. Clin Transl Sci. 2017 Nov;10(6):509-519. doi: 10.1111/cts.12486. Epub 2017 Jul 27.
Ref 52 Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302.
Ref 53 P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):337-43.
Ref 54 Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. doi: 10.1023/b:pham.0000003377.39548.f6.
Ref 55 Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism. Vasc Health Risk Manag. 2015 Jun 26;11:343-51. doi: 10.2147/VHRM.S63060. eCollection 2015.
Ref 56 Effects of the ABCG2 and ABCB1 drug transporter polymorphisms on the pharmacokinetics of bicalutamide in humans. Clin Chim Acta. 2015 Jan 1;438:7-11. doi: 10.1016/j.cca.2014.08.006. Epub 2014 Aug 11.
Ref 57 The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors. Int J Cancer. 2018 Jan 15;142(2):381-391. doi: 10.1002/ijc.31052. Epub 2017 Oct 4.
Ref 58 Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. Mol Pharm. 2006 May-Jun;3(3):329-39. doi: 10.1021/mp0500768.
Ref 59 Drug interactions and protease inhibitors used in the treatment of hepatitis C: how to manage?. Eur J Clin Pharmacol. 2014 Jul;70(7):775-89. doi: 10.1007/s00228-014-1679-9. Epub 2014 May 10.
Ref 60 In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib. J Hematol Oncol. 2015 Jul 7;8:81. doi: 10.1186/s13045-015-0179-4.
Ref 61 KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665)
Ref 62 Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein. Biol Pharm Bull. 2008 Feb;31(2):231-4.
Ref 63 Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas. Eur J Endocrinol. 2012 Sep;167(3):327-35. doi: 10.1530/EJE-12-0198. Epub 2012 Jun 6.
Ref 64 In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin. Br J Clin Pharmacol. 2017 May;83(5):1082-1096. doi: 10.1111/bcp.13186. Epub 2016 Dec 20.
Ref 65 Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1. Am J Hematol. 2013 Apr;88(4):265-72. doi: 10.1002/ajh.23387. Epub 2013 Mar 8.
Ref 66 Relationship between urinary sodium excretion and pioglitazone-induced edema. J Diabetes Investig. 2010 Oct 19;1(5):208-11.
Ref 67 Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein. J Pharmacol Exp Ther. 1995 Oct;275(1):73-8.
Ref 68 P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer. EBioMedicine. 2015 Dec 12;3:54-66. doi: 10.1016/j.ebiom.2015.12.009. eCollection 2016 Jan.
Ref 69 Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67.
Ref 70 Stereoselective and multiple carrier-mediated transport of cetirizine across Caco-2 cell monolayers with potential drug interaction. Chirality. 2010 Jul;22(7):684-92. doi: 10.1002/chir.20815.
Ref 71 Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model. J Pharm Sci. 2018 Apr;107(4):1178-1184. doi: 10.1016/j.xphs.2017.11.021. Epub 2017 Dec 5.
Ref 72 ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram. Int J Legal Med. 2013 May;127(3):579-86. doi: 10.1007/s00414-013-0849-0. Epub 2013 Mar 21.
Ref 73 Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy. J Antimicrob Chemother. 2016 Jan;71(1):17-26. doi: 10.1093/jac/dkv316. Epub 2015 Oct 15.
Ref 74 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. doi: 10.1016/0006-2952(94)90099-x.
Ref 75 Impact of P-glycoprotein on clopidogrel absorption. Clin Pharmacol Ther. 2006 Nov;80(5):486-501. doi: 10.1016/j.clpt.2006.07.007.
Ref 76 Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. doi: 10.1016/j.bcp.2009.04.002. Epub 2009 Apr 11.
Ref 77 Contribution of down-regulation of intestinal and hepatic cytochrome P450 3A to increased absorption of cyclosporine A in a rat nephrosis model. J Pharmacol Exp Ther. 2008 Nov;327(2):592-9. doi: 10.1124/jpet.108.142091. Epub 2008 Aug 25.
Ref 78 Influence of ABCB11 and HNF4Alpha genes on daclatasvir plasma concentration: preliminary pharmacogenetic data from the Kineti-C study. J Antimicrob Chemother. 2017 Oct 1;72(10):2846-2849. doi: 10.1093/jac/dkx237.
Ref 79 Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases. J Pharmacol Exp Ther. 2013 Mar;344(3):655-64. doi: 10.1124/jpet.112.201475. Epub 2012 Dec 17.
Ref 80 Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia. 2005 Feb;46(2):224-35.
Ref 81 Impact of drug transporters on cellular resistance towards saquinavir and darunavir. J Antimicrob Chemother. 2010 Nov;65(11):2319-28.
Ref 82 Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. doi: 10.1023/a:1018877803319.
Ref 83 A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26.
Ref 84 P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos. 2003 Mar;31(3):312-8. doi: 10.1124/dmd.31.3.312.
Ref 85 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. doi: 10.1023/a:1013358126640.
Ref 86 Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport?. Pharm Res. 2002 Apr;19(4):457-62. doi: 10.1023/a:1015191511817.
Ref 87 The association of ABCB1 polymorphisms and elevated serum digitoxin concentrations in geriatric patients. Eur J Clin Pharmacol. 2008 Apr;64(4):367-72. doi: 10.1007/s00228-007-0418-x. Epub 2007 Dec 16.
Ref 88 MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain. Biochem Biophys Res Commun. 2010 Jul 16;398(1):7-12. doi: 10.1016/j.bbrc.2010.05.084. Epub 2010 May 25.
Ref 89 Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32.
Ref 90 Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients. Br J Cancer. 2010 Aug 10;103(4):560-6. doi: 10.1038/sj.bjc.6605789. Epub 2010 Jul 13.
Ref 91 Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine. Br J Clin Pharmacol. 2016 Dec;82(6):1591-1600. doi: 10.1111/bcp.13092. Epub 2016 Sep 23.
Ref 92 Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier. Drug Metab Dispos. 2004 May;32(5):519-24.
Ref 93 Enhanced corneal absorption of erythromycin by modulating P-glycoprotein and MRP mediated efflux with corticosteroids. Pharm Res. 2009 May;26(5):1270-82. doi: 10.1007/s11095-008-9741-x. Epub 2008 Oct 29.
Ref 94 In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein. Epilepsia. 2011 Oct;52(10):1894-904.
Ref 95 P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. doi: 10.1023/b:pham.0000033017.52484.81.
Ref 96 Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharm Res. 2003 Aug;20(8):1200-9. doi: 10.1023/a:1025049014674.
Ref 97 Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2010 Jun;87(6):663-7. doi: 10.1038/clpt.2009.266. Epub 2010 Mar 10.
Ref 98 The influence of CYP3A5*3 and BCRPC421A genetic polymorphisms on the pharmacokinetics of felodipine in healthy Chinese volunteers. J Clin Pharm Ther. 2017 Jun;42(3):345-349. doi: 10.1111/jcpt.12505. Epub 2017 Feb 28.
Ref 99 Blood-brain barrier permeation and efflux exclusion of anticholinergics used in the treatment of overactive bladder. Drugs Aging. 2012 Apr 1;29(4):259-73. doi: 10.2165/11597530-000000000-00000.
Ref 100 Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism. Clin Pharmacol Ther. 2005 Aug;78(2):191-201. doi: 10.1016/j.clpt.2005.04.012.
Ref 101 Fluoxetine and reversal of multidrug resistance. Cancer Lett. 2006 Jun 18;237(2):180-7.
Ref 102 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31. doi: 10.1016/j.preghy.2011.12.001. Epub 2012 Jan 4.
Ref 103 Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance. Int J Pharm. 2010 Aug 16;395(1-2):114-21. doi: 10.1016/j.ijpharm.2010.05.027. Epub 2010 May 24.
Ref 104 Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells. BMC Pharmacol Toxicol. 2015 Dec 15;16:37. doi: 10.1186/s40360-015-0038-5.
Ref 105 An in vitro evaluation of guanfacine as a substrate for P-glycoprotein. Neuropsychiatr Dis Treat. 2011;7:501-5.
Ref 106 P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability. Mol Pharm. 2018 Nov 5;15(11):5124-5134. doi: 10.1021/acs.molpharmaceut.8b00702. Epub 2018 Oct 10.
Ref 107 Amonafide L-malate is not a substrate for multidrug resistance proteins in secondary acute myeloid leukemia. Leukemia. 2008 Nov;22(11):2110-5.
Ref 108 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50. doi: 10.1097/FTD.0b013e31820beb02.
Ref 109 HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry. 1998 Mar 17;37(11):3594-601. doi: 10.1021/bi972709x.
Ref 110 Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1. Br J Cancer. 2007 Oct 22;97(8):1077-83. doi: 10.1038/sj.bjc.6604010. Epub 2007 Oct 16.
Ref 111 The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res. 2010 Jun 1;70(11):4509-19.
Ref 112 Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1. Drug Metab Dispos. 2002 Jul;30(7):763-70. doi: 10.1124/dmd.30.7.763.
Ref 113 Investigation of the effects of the CFTR potentiator ivacaftor on human P-glycoprotein (ABCB1). Sci Rep. 2017 Dec 13;7(1):17481. doi: 10.1038/s41598-017-17773-5.
Ref 114 MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin. Eur J Pharmacol. 2003 Jan 24;460(2-3):85-91. doi: 10.1016/s0014-2999(02)02955-2.
Ref 115 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB14568)
Ref 116 Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2011 May;337(2):423-32. doi: 10.1124/jpet.110.175604. Epub 2011 Jan 24.
Ref 117 Pharmacogenetics of antidepressants. Front Pharmacol. 2011 Feb 16;2:6. doi: 10.3389/fphar.2011.00006. eCollection 2011.
Ref 118 Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008 Dec;55(8):1364-75. doi: 10.1016/j.neuropharm.2008.08.032. Epub 2008 Sep 11.
Ref 119 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB00480)
Ref 120 Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer. Sci Rep. 2019 Apr 1;9(1):5404. doi: 10.1038/s41598-019-41820-y.
Ref 121 Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. doi: 10.1016/j.neuropharm.2006.07.038. Epub 2006 Oct 10.
Ref 122 P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood-brain barrier in?vivo. Neuropharmacology. 2016 Apr;103:104-11. doi: 10.1016/j.neuropharm.2015.12.009. Epub 2015 Dec 15.
Ref 123 In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system. Drug Metab Dispos. 2008 Feb;36(2):268-75. doi: 10.1124/dmd.107.017434. Epub 2007 Oct 25.
Ref 124 Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir. Br J Pharmacol. 2010 Jul;160(5):1224-33. doi: 10.1111/j.1476-5381.2010.00759.x.
Ref 125 Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar;129(6):1235-43. doi: 10.1038/sj.bjp.0703150.
Ref 126 Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 2004 Jan;75(1):13-33.
Ref 127 Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. Br J Cancer. 1998;77(2):201-9. doi: 10.1038/bjc.1998.34.
Ref 128 Opioids and efflux transporters. Part 3: P-glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3638-40. doi: 10.1016/j.bmcl.2008.04.046. Epub 2008 Apr 25.
Ref 129 In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites. Pharmacology. 2007;80(4):304-11. doi: 10.1159/000107104. Epub 2007 Aug 9.
Ref 130 Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells. Biol Pharm Bull. 2002 Mar;25(3):393-6. doi: 10.1248/bpb.25.393.
Ref 131 In vivo expansion of MDR1-transduced cells accompanied by a post-transplantation chemotherapy regimen with mitomycin C and methotrexate. J Gene Med. 2010 Jul;12(7):596-603. doi: 10.1002/jgm.1474.
Ref 132 Genetic variability and clinical efficacy of morphine. Acta Anaesthesiol Scand. 2005 Aug;49(7):902-8. doi: 10.1111/j.1399-6576.2005.00772.x.
Ref 133 Moxidectin and the avermectins: Consanguinity but not identity. Int J Parasitol Drugs Drug Resist. 2012 Apr 14;2:134-53. doi: 10.1016/j.ijpddr.2012.04.001. eCollection 2012 Dec.
Ref 134 Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 2008 Oct;30(5):559-64. doi: 10.1097/FTD.0b013e3181838063.
Ref 135 Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study. J Infect Dis. 2005 Dec 1;192(11):1931-42. doi: 10.1086/497610. Epub 2005 Nov 1.
Ref 136 Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605. doi: 10.1042/BJ20060632.
Ref 137 Effects of Ketoconazole and Rifampicin on the Pharmacokinetics of Nintedanib in Healthy Subjects. Eur J Drug Metab Pharmacokinet. 2018 Oct;43(5):533-541. doi: 10.1007/s13318-018-0467-9.
Ref 138 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB00585)
Ref 139 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB12455)
Ref 140 Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system. Antimicrob Agents Chemother. 2009 Nov;53(11):4753-61. doi: 10.1128/AAC.01541-08. Epub 2009 Aug 31.
Ref 141 The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev. 2012 Jul;64(10):930-42.
Ref 142 Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model. J Pharmacol Exp Ther. 2015 Nov;355(2):264-71. doi: 10.1124/jpet.115.228213. Epub 2015 Sep 9.
Ref 143 Invega (paliperidone) extended release tablets FDA Label
Ref 144 Panobinostat for the treatment of multiple myeloma: the evidence to date. J Blood Med. 2015 Oct 8;6:269-76. doi: 10.2147/JBM.S69140. eCollection 2015.
Ref 145 Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer. Xenobiotica. 2013 May;43(5):443-53. doi: 10.3109/00498254.2012.734642. Epub 2012 Nov 16.
Ref 146 Role of P-glycoprotein in the uptake/efflux transport of oral vitamin K antagonists and rivaroxaban through the Caco-2 cell model. Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):259-65. doi: 10.1111/bcpt.12084. Epub 2013 Jun 25.
Ref 147 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB08910)
Ref 148 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB08901)
Ref 149 Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10594-9. doi: 10.1073/pnas.94.20.10594.
Ref 150 The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone. J Endocrinol. 2002 Oct;175(1):251-60. doi: 10.1677/joe.0.1750251.
Ref 151 Resolor, INN-prucalopride
Ref 152 Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med. 2004 Mar 1;36(5):592-604.
Ref 153 Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment. Transl Res. 2012 Oct;160(4):298-308.
Ref 154 Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier. J Pharm Pharmacol. 2002 Aug;54(8):1055-63.
Ref 155 Ranolazine-tacrolimus interaction. Ann Pharmacother. 2010 Nov;44(11):1844-9. doi: 10.1345/aph.1P297. Epub 2010 Sep 28.
Ref 156 Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1). Pharm Res. 2015 Jul;32(7):2205-16. doi: 10.1007/s11095-014-1609-7. Epub 2015 Jan 8.
Ref 157 Advantageous Solubility-Permeability Interplay When Using Amorphous Solid Dispersion (ASD) Formulation for the BCS Class IV P-gp Substrate Rifaximin: Simultaneous Increase of Both the Solubility and the Permeability. AAPS J. 2017 May;19(3):806-813. doi: 10.1208/s12248-017-0052-1. Epub 2017 Feb 15.
Ref 158 Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in?vitro. Pulm Pharmacol Ther. 2014 Aug;28(2):130-7. doi: 10.1016/j.pupt.2014.02.004. Epub 2014 Mar 21.
Ref 159 Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition. Clin Pharmacol Ther. 2005 Jul;78(1):43-51. doi: 10.1016/j.clpt.2005.03.009.
Ref 160 MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells. AIDS. 2005 Oct 14;19(15):1617-25. doi: 10.1097/01.aids.0000183626.74299.77.
Ref 161 Downregulation of ABCB1 gene in patients with total hip or knee arthroplasty influences pharmacokinetics of rivaroxaban: a population pharmacokinetic-pharmacodynamic study. Eur J Clin Pharmacol. 2019 Jun;75(6):817-824. doi: 10.1007/s00228-019-02639-8. Epub 2019 Feb 6.
Ref 162 Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Clin Cancer Res. 2009 Feb 15;15(4):1496-503. doi: 10.1158/1078-0432.CCR-08-1215.
Ref 163 Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. doi: 10.1124/dmd.108.021410. Epub 2008 Jul 10.
Ref 164 Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. doi: 10.1023/b:pham.0000026434.82855.69.
Ref 165 The influence of UGT2B7, UGT1A8, MDR1, ALDH, ADH, CYP3A4 and CYP3A5 genetic polymorphisms on the pharmacokinetics of silodosin in healthy Chinese volunteers. Drug Metab Pharmacokinet. 2013;28(3):239-43. doi: 10.2133/dmpk.dmpk-12-rg-106. Epub 2012 Dec 18.
Ref 166 Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine. Clin Pharmacol Ther. 2018 Dec;104(6):1191-1198. doi: 10.1002/cpt.1072. Epub 2018 Apr 26.
Ref 167 HT29-MTX and Caco-2/TC7 monolayers as predictive models for human intestinal absorption: role of the mucus layer. J Pharm Sci. 2001 Oct;90(10):1608-19. doi: 10.1002/jps.1111.
Ref 168 JNK-AKT-NF-KappaB controls P-glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells. Biochem Pharmacol. 2018 Oct;156:120-134. doi: 10.1016/j.bcp.2018.08.020. Epub 2018 Aug 16.
Ref 169 Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes. J Pharm Pharm Sci. 2014;17(3):427-38. doi: 10.18433/j3801t.
Ref 170 In Vitro P-Glycoprotein-Mediated Transport of Tadalafil: A Comparison with Sildenafil. Biol Pharm Bull. 2017;40(8):1314-1319. doi: 10.1248/bpb.b17-00278.
Ref 171 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB11760)
Ref 172 Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays. Eur J Pharm Sci. 2010 Sep 11;41(1):86-95.
Ref 173 Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer. Cancer Chemother Pharmacol. 2017 Sep;80(3):653-659. doi: 10.1007/s00280-017-3379-5. Epub 2017 Jul 4.
Ref 174 In vitro P-glycoprotein interactions and steady-state pharmacokinetic interactions between tolvaptan and digoxin in healthy subjects. J Clin Pharmacol. 2011 May;51(5):761-9. doi: 10.1177/0091270010376193. Epub 2010 Aug 2.
Ref 175 The antiepileptic drug topiramate is a substrate for human P-glycoprotein but not multidrug resistance proteins. Pharm Res. 2009 Nov;26(11):2464-70.
Ref 176 Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells. Pharm Res. 2008 Nov;25(11):2601-12. doi: 10.1007/s11095-008-9678-0. Epub 2008 Jul 25.
Ref 177 Tramadol hydrochloride: pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug delivery systems. Biomed Pharmacother. 2015 Mar;70:234-8. doi: 10.1016/j.biopha.2015.01.022. Epub 2015 Feb 7.
Ref 178 Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures. Drug Metab Dispos. 2007 Aug;35(8):1341-9.
Ref 179 Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8. doi: 10.1021/mp500532x. Epub 2014 Dec 10.
Ref 180 Venclexta FDA label
Ref 181 Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells. Protein Expr Purif. 2009 Jul;66(1):7-14. doi: 10.1016/j.pep.2009.02.010. Epub 2009 Feb 20.
Ref 182 Pharmacokinetics of dipeptidylpeptidase-4 inhibitors. Diabetes Obes Metab. 2010 Aug;12(8):648-58.
Ref 183 Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan;61(1):76-84. doi: 10.1016/j.phrs.2009.07.002. Epub 2009 Jul 21.
Ref 184 L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18. doi: 10.1016/j.toxlet.2009.11.018. Epub 2009 Nov 26.
Ref 185 Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8.
Ref 186 Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. doi: 10.1038/s41573-020-00108-x. Epub 2021 Jan 19.
Ref 187 Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats. Eur J Pharmacol. 2004 Oct 6;501(1-3):151-9.
Ref 188 Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharm Res. 2004 Sep;21(9):1686-91.
Ref 189 Pharmacokinetics of Tenofovir Alafenamide When Coadministered With Other HIV Antiretrovirals. J Acquir Immune Defic Syndr. 2018 Aug 1;78(4):465-472. doi: 10.1097/QAI.0000000000001699.
Ref 190 P-glycoprotein (ABCB1) transports the primary active tamoxifen metabolites endoxifen and 4-hydroxytamoxifen and restricts their brain penetration. J Pharmacol Exp Ther. 2011 Jun;337(3):710-7.
Ref 191 The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochem Biophys Res Commun. 2011 May 6;408(2):344-9.
Ref 192 Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. Biochem Biophys Res Commun. 2000 Oct 5;276(3):909-16.
Ref 193 P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1252-9.
Ref 194 P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells. Prostate. 2004 Apr 1;59(1):77-90.
Ref 195 Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. doi: 10.1074/jbc.271.6.3163.
Ref 196 Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82.
Ref 197 Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95.
Ref 198 ATP-binding cassette B1 transports seliciclib (R-roscovitine), a cyclin-dependent kinase inhibitor. Drug Metab Dispos. 2010 Nov;38(11):2000-6.
Ref 199 Mechanisms of tetrandrine and 5-bromotetrandrine in reversing multidrug resistance may relate to down-regulation of multidrug resistance associated protein 7 expression. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jun;20(3):558-63.
Ref 200 Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Mol Cancer Ther. 2011 Aug;10(8):1490-9.
Ref 201 Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15.
Ref 202 Unveiling the role of multidrug resistance proteins in hypertension. Hypertension. 2009 Aug;54(2):210-6.
Ref 203 Transport of somatostatin and substance P by human P-glycoprotein. FEBS Lett. 2004 Sep 10;574(1-3):55-61.
Ref 204 Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells. J Pharm Sci. 2007 Oct;96(10):2808-17. doi: 10.1002/jps.20975.
Ref 205 A pharmacodynamic study of the P-glycoprotein antagonist CBT-1? in combination with paclitaxel in solid tumors. Oncologist. 2012;17(4):512. doi: 10.1634/theoncologist.2012-0080. Epub 2012 Mar 13.
Ref 206 Lipid dependence of ABC transporter localization and function. Chem Phys Lipids. 2009 Oct;161(2):57-64.
Ref 207 Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship. Eur J Pharm Sci. 2007 Jan;30(1):84-94.
Ref 208 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
Ref 209 Contribution of P-glycoprotein to bunitrolol efflux across blood-brain barrier. Biopharm Drug Dispos. 1999 Mar;20(2):85-90.
Ref 210 Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1702-7.
Ref 211 Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1. Biochem Biophys Res Commun. 2008 May 2;369(2):363-8.
Ref 212 ATP-binding cassette transporters as pitfalls in selection of transgenic cells. Anal Biochem. 2010 Apr 15;399(2):246-50.
Ref 213 Increased ABCB1 expression in TP-110-resistant RPMI-8226 cells. Biosci Biotechnol Biochem. 2010;74(9):1913-9.
Ref 214 P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib. J Pharmacol Exp Ther. 2012 Apr;341(1):164-73.
Ref 215 Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells. AAPS J. 2011 Sep;13(3):357-64.
Ref 216 Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. doi: 10.1021/jm060253o.
Ref 217 Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. doi: 10.1016/j.bmc.2007.11.057. Epub 2007 Nov 28.
Ref 218 A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer. Invest New Drugs. 2005 Aug;23(4):311-5. doi: 10.1007/s10637-005-1439-x.
Ref 219 Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. Eur J Pharm Sci. 2002 Aug;16(3):119-28.
Ref 220 Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)). Biochem Pharmacol. 2008 Mar 15;75(6):1302-12. doi: 10.1016/j.bcp.2007.12.001. Epub 2007 Dec 14.
Ref 221 Active efflux of the 5-HT(1A) receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier. Eur J Pharm Sci. 2001 Aug;14(1):81-6.
Ref 222 In vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against MDR clinical Neisseria gonorrhoeae isolates and international reference strains. J Antimicrob Chemother. 2015 Jan;70(1):173-7. doi: 10.1093/jac/dku344. Epub 2014 Sep 1.
Ref 223 2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties. J Med Chem. 2008 Dec 11;51(23):7602-13. doi: 10.1021/jm800928j.
Ref 224 A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxorubicin in patients with advanced malignancy. Clin Cancer Res. 2004 May 15;10(10):3265-72. doi: 10.1158/1078-0432.CCR-03-0644.
Ref 225 METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N(6)-methyladenosine modification of PD-L1 mRNA in breast cancer. Mol Cancer. 2022 Feb 23;21(1):60. doi: 10.1186/s12943-021-01447-y.
Ref 226 PD-1 as a potential target in cancer therapy. Cancer Med. 2013 October; 2(5): 662-673.
Ref 227 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Ref 228 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
Ref 229 Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
Ref 230 Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells. Cancer Immunol Res. 2015 Oct;3(10):1148-1157. doi: 10.1158/2326-6066.CIR-15-0059. Epub 2015 May 26.
Ref 231 ClinicalTrials.gov (NCT03403777) Avelumab in Refractory Testicular Germ Cell Cancer.. U.S. National Institutes of Health.
Ref 232 A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018). Expert Opin Ther Pat. 2018 Sep;28(9):665-678. doi: 10.1080/13543776.2018.1512706. Epub 2018 Sep 10.
Ref 233 Targeted immunotherapy for non-small cell lung cancer. World J Clin Oncol. 2014 May 10; 5(2): 39-47.
Ref 234 GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy. Transl Lung Cancer Res. 2020 Oct;9(5):2008-2015. doi: 10.21037/tlcr-20-608.
Ref 235 Clinical pipeline report, company report or official report of Gilead Sciences.
Ref 236 National Cancer Institute Drug Dictionary (drug id 740856).
Ref 237 National Cancer Institute Drug Dictionary (drug name INCB086550).
Ref 238 Clinical pipeline report, company report or official report of Numab Therapeutics.
Ref 239 Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-Beta and PD-L1, in Second-Line Treatment of Patients With NSCLC: Results From an Expansion Cohort of a Phase 1 Trial. J Thorac Oncol. 2020 Jul;15(7):1210-1222. doi: 10.1016/j.jtho.2020.03.003. Epub 2020 Mar 13.
Ref 240 PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine. J Immunother. 2011 Jun;34(5):409-18. doi: 10.1097/CJI.0b013e31821ca6ce.
Ref 241 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 242 Clinical pipeline report, company report or official report of Shattuck Labs.
Ref 243 ClinicalTrials.gov (NCT02937844) Pilot Study of Autologous Chimeric Switch Receptor Modified T Cells in Recurrent Glioblastoma Multiforme
Ref 244 Clinical pipeline report, company report or official report of Genmab.
Ref 245 CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?. Molecules. 2019 Aug 1;24(15):2804. doi: 10.3390/molecules24152804.
Ref 246 ClinicalTrials.gov (NCT04050709) QUILT 3.064: PD-L1 t-haNK In Subjects With Locally Advanced Or Metastatic Solid Cancers. U.S. National Institutes of Health.
Ref 247 Clinical pipeline report, company report or official report of Alpine Immune Sciences.
Ref 248 Clinical pipeline report, company report or official report of Inhibrx.
Ref 249 Clinical pipeline report, company report or official report of BeiGene.
Ref 250 Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers
Ref 251 Clinical pipeline report, company report or official report of Innovent.
Ref 252 Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012 Jun 28;366(26):2455-65. doi: 10.1056/NEJMoa1200694. Epub 2012 Jun 2.
Ref 253 Clinical pipeline report, company report or official report of Kadmon.
Ref 254 Safety and Immunogenicity of LY3415244, a Bispecific Antibody Against TIM-3 and PD-L1, in Patients With Advanced Solid Tumors. Clin Cancer Res. 2021 May 15;27(10):2773-2781. doi: 10.1158/1078-0432.CCR-20-3716. Epub 2021 Jan 13.
Ref 255 The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells. Cancer Discov. 2021 Feb;11(2):480-499. doi: 10.1158/2159-8290.CD-20-0331. Epub 2020 Oct 6.
Ref 256 Local delivery of c-myc neutrally charged antisense oligonucleotides with transport catheter inhibits myointimal hyperplasia and positively affects vascular remodeling in the rabbit balloon injury model. Catheter Cardiovasc Interv. 2001 Oct;54(2):247-56. doi: 10.1002/ccd.1277.
Ref 257 Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154. doi: 10.1155/2011/483154. Epub 2010 Dec 27.
Ref 258 Anti-ageing pipeline starts to mature. Nat Rev Drug Discov. 2018 Sep;17(9):609-612. doi: 10.1038/nrd.2018.134. Epub 2018 Aug 3.
Ref 259 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 260 Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes. J Med Chem. 1982 Jun;25(6):644-9. doi: 10.1021/jm00348a007.
Ref 261 Company report (Takara Bio)
Ref 262 Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase. Mol Pharmacol. 2002 Feb;61(2):249-54. doi: 10.1124/mol.61.2.249.
Ref 263 Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy. Clin Cancer Res. 1997 Nov;3(11):2081-8.
Ref 264 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. doi: 10.1093/nar/gkq1126. Epub 2010 Nov 8.
Ref 265 Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignancies. Curr Opin Oncol. 2001 Sep;13(5):360-7. doi: 10.1097/00001622-200109000-00008.
Ref 266 N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73. doi: 10.1021/jm0610550.
Ref 267 Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward human thymidine kinase type 1. J Med Chem. 2008 Nov 13;51(21):6689-98. doi: 10.1021/jm800530p. Epub 2008 Oct 7.
Ref 268 Sitimagene ceradenovec: a gene-based drug for the treatment of operable high-grade glioma. Future Oncol. 2010 Nov;6(11):1691-710. doi: 10.2217/fon.10.134.
Ref 269 Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. doi: 10.1128/AAC.01284-06. Epub 2007 Apr 16.
Ref 270 Crystal structure of varicella zoster virus thymidine kinase. J Biol Chem. 2003 Jul 4;278(27):24680-7. doi: 10.1074/jbc.M302025200. Epub 2003 Apr 9.
Ref 271 Trichomonas vaginalis thymidine kinase: purification, characterization and search for inhibitors. Biochem J. 1998 Aug 15;334 ( Pt 1)(Pt 1):15-22. doi: 10.1042/bj3340015.
Ref 272 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2010 Apr 8;53(7):2902-12. doi: 10.1021/jm901532h.
Ref 273 Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer. Hum Gene Ther. 2003 Feb 10;14(3):227-41. doi: 10.1089/10430340360535788.
Ref 274 FDA Approved Drug Products from FDA Official Website. 2004. Application Number: (ANDA) 125085.
Ref 275 VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016). Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. doi: 10.1080/13543776.2017.1344215. Epub 2017 Jun 23.
Ref 276 Bevasiranib for the Treatment of Wet, Age-Related Macular Degeneration
Ref 277 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 278 Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina. 2006 Oct;26(8):859-70. doi: 10.1097/01.iae.0000242842.14624.e7.
Ref 279 Clinical pipeline report, company report or official report of Genentech (2009).
Ref 280 Phase I and pharmacokinetic trial of PTC299 in pediatric patients with refractory or recurrent central nervous system tumors: a PBTC study. J Neurooncol. 2015 Jan;121(1):217-24. doi: 10.1007/s11060-014-1665-1. Epub 2014 Nov 19.
Ref 281 Bispecific antibodies and their applications
Ref 282 Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. doi: 10.1038/nrd4478.
Ref 283 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 284 Clinical pipeline report, company report or official report of Neuronova.
Ref 285 sFLT01: a novel fusion protein with antiangiogenic activity. Mol Cancer Ther. 2011 Mar;10(3):404-15. doi: 10.1158/1535-7163.MCT-10-0813. Epub 2011 Jan 20.
Ref 286 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)