m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00992)
Name
Albendazole
Synonyms
((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle; ((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle [French]; (5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester; (5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester; 5-(Propylthio)-2-carbomethoxyaminobenzimidazole; Albendazol; Albendazol [INN-Spanish]; Albendazole (JAN/USP/INN); Albendazole Armstrong Brand; Albendazole Diba Brand; Albendazole Fustery Brand; Albendazole Hormona Brand; Albendazole Liferpal Brand; Albendazole Monohydrochloride; Albendazole Noe-Socopharm Brand; Albendazole Pfizer Brand; Albendazole Sanicoopa Brand; Albendazole Valdecasas Brand; Albendazole [USAN:INN:BAN:JAN]; Albendazolum; Albendazolum [INN-Latin]; Albendoral; Albenza; Albenza (TN); Albenza, Eskazole, Zentel, Andazol, Albendazole; Armstrong Brand of Albendazole; Bendapar; Bilutac; CARBAMIC ACID, (5-(PROPYLTHIO)-1H-BENZIMIDAZOL-2-YL)-, METHYL ESTER; Carbamic acid, [5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester; Diba Brand of Albendazole; Digezanol; Disthelm; Disthelm, Mediamix V; Endoplus; Eskazole; Eskazole (TN); Fustery Brand of Albendazole; Gascop; Hormona Brand of Albendazole; Liferpal Brand of Albendazole; Lurdex; Mediamix V Disthelm; Methyl 5-(propyl-thio)-2-benzimidazolecarbamate; Methyl 5-(propylthio)-2-benzimidazolecarbamate; Methyl N-[6-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate; Methyl [(2Z)-5-(propylsulfanyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]carbamate; Methyl [5-(Propylthio)benzimidazol-2-yl]carbamate; Methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate; Methyl [5-(propylthio)-1H-benzimidazol-2-yl]carbamate; Methyl [6-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate; Methyl-5-[propylthio]-2-benzimidazole carbamate; MethylN-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate; Metiazol; Monohydrochloride, Albendazole; Noe Socopharm Brand of Albendazole; Noe-Socopharm Brand of Albendazole; O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate; Pfizer Brand of Albendazole; Proftril; SK&F 62979; SK&F-62979; SK&F62979; SKF 62979; SKF-62979; SKF62979; Sanicoopa Brand of Albendazole; Smith Kline & French Brand of Albendazole; SmithKline Beecham Brand of Albendazole; V Disthelm, Mediamix; Valbazen; Valdecasas Brand of Albendazole; Zental; Zentel; Zentel (TN); [5-(Propylthio)benzimidazol-2-yl]carbamic Acid Methyl Ester; [5-(Propythio)-1H-benzimidazol-2-yl]carbamic acid methyl ester
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Status
Approved
Structure
Formula
C12H15N3O2S
InChI
1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
InChIKey
HXHWSAZORRCQMX-UHFFFAOYSA-N
PubChem CID
2082
VARIDT Drug ID
DR01323
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
P-glycoprotein 1 (ABCB1)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Albendazole. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Albendazole through regulating the expression of P-glycoprotein 1 (ABCB1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Albendazole. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Albendazole through regulating the expression of P-glycoprotein 1 (ABCB1). [2], [3]
References
Ref 1 Binding of RNA m6A by IGF2BP3 triggers chemoresistance of HCT8 cells via upregulation of ABCB1. Am J Cancer Res. 2021 Apr 15;11(4):1428-1445. eCollection 2021.
Ref 2 The anthelminthic agent albendazole does not interact with p-glycoprotein. Drug Metab Dispos. 2002 Apr;30(4):365-9. doi: 10.1124/dmd.30.4.365.
Ref 3 METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner. Exp Mol Med. 2021 Jan;53(1):91-102. doi: 10.1038/s12276-020-00510-w. Epub 2021 Jan 8.