m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG01010)
Name |
Amiodarone
|
||||
---|---|---|---|---|---|
Synonyms |
(2-Butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diidophenyl)methanone; (2-butyl-1-benzofuran-3-yl)(4-{[2-(diethylamino)ethyl]oxy}-3,5-diiodophenyl)methanone; (2-butyl-1-benzofuran-3-yl)-[4-(2-diethylaminoethyloxy)-3,5-diiodophenyl]methanone; (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone; (2-butylbenzofuran-3-yl)-[4-(2-diethylaminoethoxy)-3,5-diiodo-phenyl]-methanone; (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine; 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-(3,5-diiodo-4-(beta-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-(4'-beta-N-diethylaminoethoxy-3',5'-diiodobenzoyl)benzofuran; 2-Butyl-3-[3,5-diiodo-4-(2-di; 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone; 2-Butyl-3-benzofuranyl p-((2-diethylamino)ethoxy)-m,m-diiodophenyl ketone; 2-Butyl-3-benzofuranyl p-[(2-diethylamino)ethoxy]-m,m-diiodophenyl ketone; 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran; ASTA Medica Brand of Amiodarone Hydrochloride; Alphapharm Brand of Amiodarone Hydrochloride; Amidorone; Aminodarone; Amio-Aqueous IV; Amiobeta; Amiodarex; Amiodarona; Amiodarona [INN-Spanish]; Amiodarone (USAN/INN); Amiodarone Base; Amiodarone [USAN:BAN:INN]; Amiodarons; Amiodaronum; Amiodaronum [INN-Latin]; Amiohexal; Amjodaronum; Ancar; Aratac (TN); Aratac;Arycor; Armstrong Brand of Amiodarone Hydrochloride; Arycor (TN); Atlansil (TN); Berenguer Infale Brand of Amiodarone Hydrochloride; Betapharm Brand of Amiodarone Hydrochloride; Braxan; Corbionax; Cordarex; Cordarone; Cordarone (TN); Cordarone Intravenous; Ethylaminoethoxy)benzoyl]benzofuran; G Gam Brand of Amiodarone Hydrochloride; Hexal Brand of Amiodarone Hydrochloride; Ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl; Ketone, 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl (7CI,8CI); Kordaron; L 3428; L-3428; L3428; Labaz; Leurquin Brand of Amiodarone Hydrochloride; Ortacrone; Pacerone; Pacerone (TN); Pharma Investi Brand of Amiodarone Hydrochloride; Pms-Amiodarone; Rytmarone; SKF 33134-A; SKF 33134A; Sanofi Winthrop Brand of Amiodarone Hydrochloride; Sedacoron; Sedacorone; Tachydaron; Wyeth Brand of Amiodarone Hydrochloride
Click to Show/Hide
|
||||
Status |
Approved
|
||||
Structure |
|
||||
Formula |
C25H29I2NO3
|
||||
InChI |
1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3
|
||||
InChIKey |
IYIKLHRQXLHMJQ-UHFFFAOYSA-N
|
||||
PubChem CID | |||||
VARIDT Drug ID |
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
P-glycoprotein 1 (ABCB1)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for Amiodarone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Amiodarone through regulating the expression of P-glycoprotein 1 (ABCB1). | [1], [2] | ||
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for Amiodarone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amiodarone through regulating the expression of P-glycoprotein 1 (ABCB1). | [2], [3] | ||
References