m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG00660)
Name
N2-(3-trifluoromethylphenyl)guanine
Status
Investigative
Structure
Formula
C12H8F3N5O
InChI
1S/C12H8F3N5O/c13-12(14,15)6-2-1-3-7(4-6)18-11-19-9-8(10(21)20-11)16-5-17-9/h1-5H,(H3,16,17,18,19,20,21)
InChIKey
IOWPKEYIXBBDOQ-UHFFFAOYSA-N
PubChem CID
135435057
TTD Drug ID
D0YJ5W
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Thymidine kinase 1 (TK1)
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for N2-(3-trifluoromethylphenyl)guanine. The Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) has potential in affecting the response of N2-(3-trifluoromethylphenyl)guanine through regulating the expression of Thymidine kinase 1 (TK1). [1], [2]
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for N2-(3-trifluoromethylphenyl)guanine. The Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) has potential in affecting the response of N2-(3-trifluoromethylphenyl)guanine through regulating the expression of Thymidine kinase 1 (TK1). [1], [2]
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for N2-(3-trifluoromethylphenyl)guanine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of N2-(3-trifluoromethylphenyl)guanine through regulating the expression of Thymidine kinase 1 (TK1). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Thymidine kinase 1 (TK1) is a therapeutic target for N2-(3-trifluoromethylphenyl)guanine. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of N2-(3-trifluoromethylphenyl)guanine through regulating the expression of Thymidine kinase 1 (TK1). [1], [2]
References
Ref 1 Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018 Mar;20(3):285-295. doi: 10.1038/s41556-018-0045-z. Epub 2018 Feb 23.
Ref 2 Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. doi: 10.1128/AAC.01284-06. Epub 2007 Apr 16.