m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02284)
Name
Trospium chloride
Synonyms
trospium chloride; Sanctura; Trospium (chloride); Spasmex; Spasmo-lyt; UNII-1E6682427E; Trospium chloride (Sanctura); Relaspium; Santura; Keptan; Azoniaspiro Compound XVII; Spasmo 3; IP631; AS Xvii; 1E6682427E; DSSTox_CID_3724; DSSTox_RID_77166; DSSTox_GSID_23724; Trospii chloridum [INN-Latin]; Uraplex; Cloruro de trospio [INN-Spanish]; Chlorure de trospium [INN-French]; EINECS 233-875-4; Trospium Cl; Trospii chloridum; Sanctura XR; Cloruro de trospio
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Status
Approved
Structure
3D MOL
2D MOL
Formula
C25H30ClNO3
InChI
1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23?;
InChIKey
RVCSYOQWLPPAOA-DHWZJIOFSA-M
PubChem CID
5284631
VARIDT Drug ID
DR01284
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
P-glycoprotein 1 (ABCB1)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Trospium chloride. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Trospium chloride through regulating the expression of P-glycoprotein 1 (ABCB1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Trospium chloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Trospium chloride through regulating the expression of P-glycoprotein 1 (ABCB1). [2], [3]
References
Ref 1 Binding of RNA m6A by IGF2BP3 triggers chemoresistance of HCT8 cells via upregulation of ABCB1. Am J Cancer Res. 2021 Apr 15;11(4):1428-1445. eCollection 2021.
Ref 2 Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8. doi: 10.1021/mp500532x. Epub 2014 Dec 10.
Ref 3 METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner. Exp Mol Med. 2021 Jan;53(1):91-102. doi: 10.1038/s12276-020-00510-w. Epub 2021 Jan 8.