m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02138)
Name
Perazine
Synonyms
PERAZINE; Pernazine; Taxilan; Psytomin; N-(3-(4-Methyl-1-piperazinyl)propyl)phenothiazine; P 725; 10-(3-(4-Methyl-1-piperazinyl)propyl)-10H-phenothiazine; N-Methyl-piperazinyl-N'-propyl-phenothiazin; UNII-8915147A2B; EINECS 201-578-9; Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-; 10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-; NSC638694; N-Methyl-piperazinyl-N'-propyl-phenothiazin [German]; N-Methyl-piperazinylpropyl-phenothiazine; NCGC00159492-02; 10H-Phenothiazine
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Status
Approved
Structure
Formula
C20H25N3S
InChI
1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3
InChIKey
WEYVCQFUGFRXOM-UHFFFAOYSA-N
PubChem CID
4744
VARIDT Drug ID
DR01265
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
P-glycoprotein 1 (ABCB1)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Perazine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Perazine through regulating the expression of P-glycoprotein 1 (ABCB1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Perazine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Perazine through regulating the expression of P-glycoprotein 1 (ABCB1). [2], [3]
References
Ref 1 Binding of RNA m6A by IGF2BP3 triggers chemoresistance of HCT8 cells via upregulation of ABCB1. Am J Cancer Res. 2021 Apr 15;11(4):1428-1445. eCollection 2021.
Ref 2 Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. doi: 10.1211/0022357043969.
Ref 3 METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner. Exp Mol Med. 2021 Jan;53(1):91-102. doi: 10.1038/s12276-020-00510-w. Epub 2021 Jan 8.