m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG01926)
| Name |
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate
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| Synonyms |
p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate; CHEMBL1236157; T5A; 3tmk; 1mrn; 4TMK; AC1L9KL2; BDBM50366828; DB03280; adenosine 5'-(hexahydrogen pentaphosphate), P"" 5'-ester with thymidine; 103137-88-8; [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [hydroxy-[hydroxy-[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxyphosphoryl]oxyphosphoryl] hydrogen phosphate
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| Status |
Investigative
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| Structure |
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3D MOL
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| Formula |
C20H30N7O23P5
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| InChI |
1S/C20H30N7O23P5/c1-8-3-26(20(32)25-18(8)31)12-2-9(28)10(45-12)4-43-51(33,34)47-53(37,38)49-55(41,42)50-54(39,40)48-52(35,36)44-5-11-14(29)15(30)19(46-11)27-7-24-13-16(21)22-6-23-17(13)27/h3,6-7,9-12,14-15,19,28-30H,2,4-5H2,1H3,(H,33,34)(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H2,21,22,23)(H,25,31,32)/t9-,10+,11+,12+,14+,15+,19+/m0/s1
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| InChIKey |
JCFDSPQTEMXXLO-SLFMBYJQSA-N
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| PubChem CID | |||||
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Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Thymidine kinase 1 (TK1)
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Thymidine kinase 1 (TK1) is a therapeutic target for P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate. The Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) has potential in affecting the response of P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate through regulating the expression of Thymidine kinase 1 (TK1). | [1], [2] | ||
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Thymidine kinase 1 (TK1) is a therapeutic target for P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate. The Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) has potential in affecting the response of P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate through regulating the expression of Thymidine kinase 1 (TK1). | [1], [2] | ||
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Thymidine kinase 1 (TK1) is a therapeutic target for P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate through regulating the expression of Thymidine kinase 1 (TK1). | [1], [2] | ||
Methyltransferase-like 14 (METTL14)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | Thymidine kinase 1 (TK1) is a therapeutic target for P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate through regulating the expression of Thymidine kinase 1 (TK1). | [1], [2] | ||