m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG02535)
| Name |
Hydrocortisone
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| Synonyms |
11-beta-Hydrocortisone; 11-beta-Hydroxycortisone; 11beta,17,21-Trihydroxyprogesterone; 11beta-Hydrocortisone; 11beta-Hydroxycortisone; 17-Hydroxycorticosterone; 17alpha-Hydroxycorticosterone; ACETASOL HC; ACETIC ACID W/ HYDROCORTISONE; Acticort; Acticort (TN); Aeroseb HC; Aeroseb-HC; Ala-Cort; Ala-Scalp; Alacort; Algicirtis; Alphaderm; Amberin; Anflam; Anti-inflammatory hormone; Anucort; Anucort-HC; Anusol HC (TN); AnusolHC; Aquacort; Aquanil HC; Balneol-hc; Barseb HC; Basan-Corti; Beta-hc; COR-OTICIN; CaldeCORT Spray; Cetacort; Chronocort; Clear aid; Cleiton; Cobadex; Colocort; Colocort (TN); Component of Lubricort; Component of Neo-Cort-Dome; Component of Otalgine; Corhydron; Cort-Dome; Cortanal; Cortef; Cortef (TN); Cortenema; Cortesal; Corticreme; Cortifair; Cortifan; Cortiment; Cortisol; Cortisol alcohol; Cortisol, Hydrocortisone; Cortisolonum; Cortisporin; Cortisporin Otico; Cortispray; Cortolotion; Cortonema; Cortoxide; Cortril; Cremesone; Cremicort-H; Cutisol; Cyclodextrin-encapsulated hydrocortisone; Delacort; Derm-Aid; Dermacort; Dermaspray; Dermil; Dermocortal; Dermolate; Dihydrocostisone; Dioderm; Dome-cort; Domolene-HC; Drotic; DuoCort; Ef corlin; Efcorbin; Efcortelan; Efcortelin; Eldecort; Eldercort; Epicort; Epicortisol; Epiderm H; Esiderm H; Evacort; Ficortril; Fiocortril; Flexicort; Foille Insetti; Genacort; Genacort (lotion); Glycort; Gyno-Cortisone; H 4001; H-Cort; HC #1; HC #4; HC (HYDROCORTISONE); HYDROCORTISONE AND ACETIC ACID; HYDROCORTISONE IN ABSORBASE; Heb Cort; Heb-Cort; Hi-cor; Hidalone; Hidro-Colisona; Hidrocortisona [INN-Spanish]; Hycort; Hycortol; Hycortole; Hydracort; Hydrasson; Hydro-Adreson; Hydro-Colisona; Hydro-RX; Hydrocortal; Hydrocorticosterone; Hydrocortisone (JP15/USP/INN); Hydrocortisone [INN:BAN:JAN]; Hydrocortisone alcohol; Hydrocortisone base; Hydrocortisone free alcohol; Hydrocortisone solution; Hydrocortisone-Water Soluble; Hydrocortisonum [INN-Latin]; Hydrocortisyl; Hydrocortone; Hydroskin; Hydroxycortisone; Hytisone; Hytone; Hytone (TN); Hytone lotion; Idrocortisone; Idrocortisone [DCIT]; Incortin-H; Incortin-hydrogen; Kendall's compound F; Komed HC; Kyypakkaus; Lacticare HC; Lacticare-HC; Lactisona; Lubricort; Maintasone; Medicort; Meusicort; Mildison; Milliderm; Neo-Cortef; Neosporin-H Ear; Nogenic HC; Nutracort; Nystaform-HC; ORLEX HC; Optef; Otocort; Otosone-F; Pediotic Suspension; Penecort; Permicort; Polcort H; Preparation H Hydrocortisone Cream; Prepcort; Prevex HC; Proctocort; Proctozone HC; Protocort; Rectasol-HC; Rectoid; Reichstein's substance M; Remederm HC; Sanatison; Scalp-Cort; Scalpicin Capilar; Schericur; Scheroson F; Sigmacort; Signef; Stie-cort; Stiefcorcil; Synacort; Systral Hydrocort; Tarcortin; Texacort; Texacort lotion 25; Timocort; Transderma H; Traumaide; Uniderm; VoSol HC; Vytone; Zenoxone; [3H]cortisol
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| Status |
Approved
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| Structure |
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| Formula |
C21H30O5
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| InChI |
1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
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| InChIKey |
JYGXADMDTFJGBT-VWUMJDOOSA-N
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| PubChem CID | |||||
| VARIDT Drug ID | |||||
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
P-glycoprotein 1 (ABCB1)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for Hydrocortisone. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Hydrocortisone through regulating the expression of P-glycoprotein 1 (ABCB1). | [1], [2] | ||
Methyltransferase-like 3 (METTL3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for Hydrocortisone. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Hydrocortisone through regulating the expression of P-glycoprotein 1 (ABCB1). | [2], [3] | ||
References