m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG03347)
Name |
Curcumin
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Synonyms |
curcumin; 458-37-7; Diferuloylmethane; Natural yellow 3; Turmeric yellow; Turmeric; Curcuma; Kacha haldi; Gelbwurz; Indian saffron; Curcumin I; Souchet; Halud; Halad; Haidr; Haldar; Merita earth; Yellow Ginger; Terra Merita; Yellow Root; Safran d'Inde; Yo-Kin; Golden seal; Curcuma oil; Orange Root; Oils, curcuma; CI Natural Yellow 3; Curcumine; Hydrastis; Indian turmeric; Yellow puccoon; Turmeric extract; Diferaloylmethane; Kurkumin [Czech]; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione; Tumeric yellow; Turmeric oil
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Status |
Phase 3
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Structure |
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Formula |
C21H20O6
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InChI |
1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
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InChIKey |
VFLDPWHFBUODDF-FCXRPNKRSA-N
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PubChem CID | |||||
TTD Drug ID | |||||
VARIDT Drug ID |
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
DNA [cytosine-5]-methyltransferase 3B (DNMT3B)
RNA demethylase ALKBH5 (ALKBH5)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | DNA [cytosine-5]-methyltransferase 3B (DNMT3B) is a therapeutic target for Curcumin. The RNA demethylase ALKBH5 (ALKBH5) has potential in affecting the response of Curcumin through regulating the expression of DNA [cytosine-5]-methyltransferase 3B (DNMT3B). | [1], [2] | ||
Matrix metalloproteinase-13 (MMP-13)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Curcumin. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Curcumin through regulating the expression of Matrix metalloproteinase-13 (MMP-13). | [3], [4] | ||
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Matrix metalloproteinase-13 (MMP-13) is a therapeutic target for Curcumin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Curcumin through regulating the expression of Matrix metalloproteinase-13 (MMP-13). | [4], [5] | ||
Matrix metalloproteinase-9 (MMP-9)
E3 ubiquitin-protein ligase Hakai (CBLL1)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Curcumin. The E3 ubiquitin-protein ligase Hakai (CBLL1) has potential in affecting the response of Curcumin through regulating the expression of Matrix metalloproteinase-9 (MMP-9). | [6], [7] | ||
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Matrix metalloproteinase-9 (MMP-9) is a therapeutic target for Curcumin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Curcumin through regulating the expression of Matrix metalloproteinase-9 (MMP-9). | [7], [8] | ||
P-glycoprotein 1 (ABCB1)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for Curcumin. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Curcumin through regulating the expression of P-glycoprotein 1 (ABCB1). | [9], [10] | ||
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for Curcumin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Curcumin through regulating the expression of P-glycoprotein 1 (ABCB1). | [10], [11] | ||
Prostaglandin G/H synthase 2 (COX-2)
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Prostaglandin G/H synthase 2 (COX-2) is a therapeutic target for Curcumin. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Curcumin through regulating the expression of Prostaglandin G/H synthase 2 (COX-2). | [5], [12] | ||
References