m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG02414)
| Name |
Terfenadine
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| Synonyms |
1-(4-tert-Butylphenyl)-4-(4-(alpha-hydroxybenzhydryl)piperidino)-butan-1-ol; 1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol; 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol; 1-(p-tert-Butylphenyl)-4-(4'-(alpha-hydroxydiphenylmethyl)-1'-piperidyl)butanol; 1-[4-(1,1-dimethylethyl)phenyl]-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butan-1-ol; Aldaban; Aliud Brand of Terfenadine; Allerplus; Alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol; Alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenyl-methyl)-1-piperidine butanol; Alpha-(4-[1,1-Dimethylethyl]phenyl)-4-[hydroxydiphenylmethyl]-1-piperidinebutanol; Alpha-(p-tert-Butylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Balkis Saft Spezial; Bial Brand of Terfenadine; Cantabria Brand of Terfenadine; Ct Arzneimittel Brand of Terfenadine; Ct-Arzneimittel Brand of Terfenadine; Cyater; Dolorgiet Brand of Terfenadine; Heumann Brand of Terfenadine; Hisfedin; Hoechst Brand of Terfenadine; MDL 9918; MDL-9918; Merck dura Brand of Terfenadine; Mundipharma Brand of Terfenadine; RMI 9918; RMI-9918; RMI9918; Rapidal; Ratiopharm Brand of Terfenadine; Seldane; Seldane (TN); Sigma Tau Brand of Terfenadine; Sigma-Tau Brand of Terfenadine; Stadapharm Brand of Terfenadine; T 9652; Teldane; Teldane (TN); Teldanex; Terdin; Terfedura; Terfemundin; Terfen; Terfenadin AL; Terfenadin Heumann; Terfenadin Stada; Terfenadin von ct; Terfenadin-ratiopharm; Terfenadina; Terfenadina [INN-Spanish]; Terfenadine (JAN/USAN/INN); Terfenadine [USAN:BAN:INN:JAN]; Terfenadinum; Terfenadinum [INN-Latin]; Terfenidine; Terfex; Ternadin; Triludan; Triludan (TN); Wolff Brand of Terfenadine
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| Status |
Withdrawn
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| Structure |
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| Formula |
C32H41NO2
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| InChI |
1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3
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| InChIKey |
GUGOEEXESWIERI-UHFFFAOYSA-N
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| PubChem CID | |||||
| VARIDT Drug ID | |||||
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
P-glycoprotein 1 (ABCB1)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for Terfenadine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Terfenadine through regulating the expression of P-glycoprotein 1 (ABCB1). | [1], [2] | ||
Methyltransferase-like 3 (METTL3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for Terfenadine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Terfenadine through regulating the expression of P-glycoprotein 1 (ABCB1). | [2], [3] | ||
References