m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG02630)
| Name |
L-tryptophan
|
||||
|---|---|---|---|---|---|
| Synonyms |
(-)-Tryptophan; (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid; (L)-TRYPTOPHAN; (S)-(-)-2-Amino-3-(3-indolyl)propionic Acid; (S)-(-)-Tryptopha n; (S)-(-)-Tryptophan; (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid; (S)-2-Amino-3-(3-indolyl)propionic acid; (S)-Tryptophan; (S)-a-Amino-1H-indole-3-propanoic acid; (S)-a-Amino-b-indolepropionic acid; (S)-a-Aminoindole-3-propionic acid; (S)-alpha-Amino-1H-indole-3-propanoic acid; (S)-alpha-Amino-beta-indolepropionic acid; (S)-alpha-Aminoindole-3-propionic acid; (S)-alpha-amino-beta-(3-indolyl)-propionic acid; 1-beta-3-Indolylalanine; 151A3008-4CFE-40C9-AC0B-467EF0CB50EA; 1H-Indole-3-alanine; 1H-Indole-3-alanine (VAN); 1beta-3-Indolylalanine; 2-Amino-3-(lH-indol-3-yl)-propanoic acid; 2-Amino-3-indolylpropanoic acid; 2-amino-3-indol-3-ylpropionic acid; 3-Indol-3-ylalanine; Alanine, 3-indol-3-yl; Alpha'-Amino-3-indolepropionic acid; Alpha-Amino-beta-(3-indolyl)-propionic acid; Alpha-amino-beta-(3-indolyl)-pr opionic acid; Alti-Tryptophan; Ardeytropin; EH 121; H-Trp-oh; Indole-3-alanine; Kalma; L-(-)-Tryptophan; L-(-)-Tryptophane; L-TRYPTOPHAN SIGMA GRADE; L-Trp; L-Tryptofan; L-Tryptophan (9CI); L-Tryptophan (JP15); L-Tryptophane; L-Ttp; L-a-Aminoindole-3-propionic acid; L-alpha-Aminoindole-3-propionic acid; L-alpha-amino-3-indolepropionic acid; L-b-3-Indolylalanine; L-beta-3-Indolylalanine; LTR; Lyphan; MT1; Optimax; Pacitron; Propionic acid, 2-amino-3-indol-3-yl; S(-)-1-alpha-Aminoindole-3-propionic acid; Sedanoct; T 0254; TRP NH3+ COOH; TRP-01; Triptofano; Triptofano [Spanish]; Trofan; Trp; Tryptacin; Tryptan; Tryptophan; Tryptophan (H-3); Tryptophan (USP/INN); Tryptophan (VAN); Tryptophan [USAN:INN]; Tryptophan, L-(8CI); Tryptophane; Tryptophane [French]; Tryptophanum; Tryptophanum [Latin]
Click to Show/Hide
|
||||
| Status |
Approved
|
||||
| Structure |
 |
||||
| Formula |
C11H12N2O2
|
||||
| InChI |
1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1
|
||||
| InChIKey |
QIVBCDIJIAJPQS-VIFPVBQESA-N
|
||||
| PubChem CID | |||||
| VARIDT Drug ID | |||||
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
P-glycoprotein 1 (ABCB1)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for L-tryptophan. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of L-tryptophan through regulating the expression of P-glycoprotein 1 (ABCB1). | [1], [2] | ||
Methyltransferase-like 3 (METTL3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for L-tryptophan. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of L-tryptophan through regulating the expression of P-glycoprotein 1 (ABCB1). | [2], [3] | ||
References