m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01315)
Name
Citalopram
Synonyms
1,3-Dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile; 1,3-dihydro[3,4]benzofuran-5-carbonitrile; 1-(3-(Dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile; AE-641/00603021; Akarin; Akarin (TN); Celapram; Celapram (TN); Celexa; Celexa (TN); Celius; Celius (TN); Ciazil; Ciazil (TN); Cilift; Cilift (TN); Cipram; Cipram (TN); Cipramil (TN); Ciprapine; Ciprapine (TN); Citabax; Citabax (TN); Citadur; Citadur (TN); Citalec; Citalec (TN); Citalopram (USP/INN); Citalopram [Celexa]; Citalopram [INN:BAN]; Citalopramum; Citalopramum [INN-Latin]; Citaxin (TN); Citol (TN); Citopam; Citopam (TN); Citox (TN); Citrol (TN); Cytalopram; Dalsan; Dalsan (TN); Humorup; Lu 10-171; Lu-10-171; Nitalapram; Oropram; Pramcit; Recital; Recital (TN); Seropram; Seropram (TN); Talam; Talam (TN); Talohexal; Temperax; Vodelax; Zentius; Zentius (TN); Zetalo; Zetalo (TN); [3H]Citalopram
    Click to Show/Hide
Status
Approved
Structure
Formula
C20H21FN2O
InChI
1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3
InChIKey
WSEQXVZVJXJVFP-UHFFFAOYSA-N
PubChem CID
2771
VARIDT Drug ID
DR00319
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
P-glycoprotein 1 (ABCB1)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Citalopram. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Citalopram through regulating the expression of P-glycoprotein 1 (ABCB1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary P-glycoprotein 1 (ABCB1) is a therapeutic target for Citalopram. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Citalopram through regulating the expression of P-glycoprotein 1 (ABCB1). [2], [3]
References
Ref 1 Binding of RNA m6A by IGF2BP3 triggers chemoresistance of HCT8 cells via upregulation of ABCB1. Am J Cancer Res. 2021 Apr 15;11(4):1428-1445. eCollection 2021.
Ref 2 ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram. Int J Legal Med. 2013 May;127(3):579-86. doi: 10.1007/s00414-013-0849-0. Epub 2013 Mar 21.
Ref 3 METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner. Exp Mol Med. 2021 Jan;53(1):91-102. doi: 10.1038/s12276-020-00510-w. Epub 2021 Jan 8.