m6A-centered Drug Response Information
General Information of the Drug (ID: M6APDG01943)
| Name |
Nifedipine
|
||||
|---|---|---|---|---|---|
| Synonyms |
AWD Pharma Brand of Nifedipine; Adalat; Adalat (TN); Adalat 10; Adalat 20; Adalat 5; Adalat CC; Adalat CR; Adalat Crono; Adalat FT; Adalat GITS; Adalat GITS 30; Adalat LA; Adalat LP; Adalat Oros; Adalat PA; Adalat Retard; Adalat XL; Adalate; Adalate LP; Adapine; Adapress; Adcock Ingram Brand of Nifedipine; Adipine XL; Afeditab; Afeditab CR; Afeditab CR (TN); Alat; Aldipin; Alfadal; Alonix; Alonix S; Alpha-Nifedipine Retard;Apo-Nifed; Angipec; Anifed; Anpine; Aprical; Aprical long; Bay-1040; Bay-a-1040; Bay1040; Bayer Brand of Nifedipine; Bonacid; Calcibloc; Calcigard; Calcilat; Camont; Cardifen; Cardilat; Cardionorm; Chronadalate; Chronadalate LP; Citilat; Coracten; Coracten XL; Coral; Cordafen; Cordaflex; Cordalat; Cordicant; Cordilan; Cordipin; Cordipine; Corinfar; Corotrend; Corynphar; Depin; Dignokonstant; Dilafed; Dipinkor; Duranifin; Ecodipi; Ecodipin; Ecodipin E; Emaberin; Fedcor; Fedcor Retard; Fenamon; Fenamon SR; Fenigidin; Fenihidin; Fenihidine; Fortipine LA; Glopir; Hadipin; Hexadilat; Infedipin; Introcar; KB-1712P; KRKA Brand of Nifedipine; Kordafen; Korinfar; Macorel; Megalat; Monohydrochloride, Nifedipine; Myogard; N 7634; N1fedilat; Nedipin; Nicardia; Nifangin; Nifar; Nifdemin; Nifebene; Nifecard; Nifecor; Nifedepat; Nifediac; Nifedical; Nifedical (TN); Nifedical XL; Nifedicor; Nifedin; Nifedine; Nifedipine (JP15/USP/INN); Nifedipine Bayer Brand; Nifedipine GTIS; Nifedipine KRKA Brand; Nifedipine Monohydrochloride; Nifedipine Orion Brand; Nifedipine Pfizer Brand; Nifedipine Retard; Nifedipine [USAN:BAN:INN:JAN]; Nifedipine-GTIS; Nifedipino; Nifedipino [INN-Spanish]; Nifedipinum; Nifedipinum [INN-Latin]; Nifedipres; Nifedirex LP; Nifelan; Nifelat; Nifelat Q; Nifelate; Nifensar XL; Nificard; Nifidine; Nifipen; Niphedipine; Orion Brand of Nifedipine; Orix; Oxcord; Pfizer Brand of Nifedipine; Pidilat; Procardia; Procardia (TN); Procardia XL; Sepamit; Slofedipine XL; Tensipine MR; Tibricol; Vascard; Zenusin
Click to Show/Hide
|
||||
| Status |
Approved
|
||||
| Structure |
 |
||||
| Formula |
C17H18N2O6
|
||||
| InChI |
1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
|
||||
| InChIKey |
HYIMSNHJOBLJNT-UHFFFAOYSA-N
|
||||
| PubChem CID | |||||
| VARIDT Drug ID | |||||
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
P-glycoprotein 1 (ABCB1)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for Nifedipine. The Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) has potential in affecting the response of Nifedipine through regulating the expression of P-glycoprotein 1 (ABCB1). | [1], [2] | ||
Methyltransferase-like 3 (METTL3)
| In total 1 mechanisms lead to this potential drug response | ||||
| Response Summary | P-glycoprotein 1 (ABCB1) is a therapeutic target for Nifedipine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Nifedipine through regulating the expression of P-glycoprotein 1 (ABCB1). | [2], [3] | ||
References