General Information of the m6A Regulator (ID: REG00023)
Regulator Name YTH domain-containing protein 2 (YTHDC2)
Synonyms
3'-5' RNA helicase YTHDC2; hYTHDC2
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Gene Name YTHDC2
Regulator Type WRITER ERASER READER
Regulator Link Click to View Full Information of This Regulator
Full List of Target Gene(s) of This m6A Regulator and Corresponding Potential Drug Response(s)
Apoptosis mediating surface antigen FAS (FAS)
VB-111 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for VB-111. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of VB-111 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [1], [2]
APG-101 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APG-101. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of APG-101 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [1], [3]
DE-098 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for DE-098. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of DE-098 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [1], [4]
APO-010 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APO-010. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of APO-010 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [1], [5]
2-aminophenoxazine-3-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for 2-aminophenoxazine-3-one. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 2-aminophenoxazine-3-one through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [1], [6]
APG-103 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APG-103. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of APG-103 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [1], [7]
F61F12 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for F61F12. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of F61F12 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [1], [8]
ISIS 17020 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for ISIS 17020. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 17020 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). [1], [9]
Cystine/glutamate transporter (SLC7A11)
L-glutamic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cystine/glutamate transporter (SLC7A11) is a therapeutic target for L-glutamic acid. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of L-glutamic acid through regulating the expression of Cystine/glutamate transporter (SLC7A11). [10], [11]
SXC-2023 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cystine/glutamate transporter (SLC7A11) is a therapeutic target for SXC-2023. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of SXC-2023 through regulating the expression of Cystine/glutamate transporter (SLC7A11). [10], [12]
Cytochrome P450 2C8 (CYP2C8)
Almotriptan malate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Almotriptan malate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Almotriptan malate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [14]
Aminophenazone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Aminophenazone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Aminophenazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [15]
Amiodarone hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amiodarone hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Amiodarone hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [16]
Amitriptyline hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amitriptyline hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Amitriptyline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [17]
Amodiaquine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amodiaquine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [18]
Anastrozole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Anastrozole. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Anastrozole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [19]
Apalutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Apalutamide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Apalutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [20]
Apixaban [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Apixaban. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Apixaban through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [21]
Atorvastatin calcium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Atorvastatin calcium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Atorvastatin calcium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Azelastine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Azelastine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Azelastine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [23]
Benzyl alcohol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Benzyl alcohol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Benzyl alcohol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [24]
Beraprost [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Beraprost. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Beraprost through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [25]
Brigatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Brigatinib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Brigatinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [26]
Bromfenac [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Bromfenac. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Bromfenac through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [27]
Buprenorphine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Buprenorphine hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Buprenorphine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [28]
Cabazitaxel [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cabazitaxel. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cabazitaxel through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [29]
Caffeine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Caffeine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [30]
Capsaicin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Capsaicin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Capsaicin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [31]
Carbamazepine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Carbamazepine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Carbamazepine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [32]
Cefaloridine [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cefaloridine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cefaloridine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [33]
Celecoxib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Celecoxib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Celecoxib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [34]
Cerivastatin sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cerivastatin sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cerivastatin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Cisapride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cisapride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cisapride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [35]
Clozapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Clozapine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Clozapine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [36]
Cyclophosphamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cyclophosphamide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cyclophosphamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [37]
Dabrafenib mesylate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dabrafenib mesylate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Dabrafenib mesylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Dapsone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dapsone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Dapsone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [38]
Desloratadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Desloratadine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Desloratadine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [39]
Dexibuprofen [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dexibuprofen. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Dexibuprofen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [40]
Diazepam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diazepam. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Diazepam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [41]
Diclofenac sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diclofenac sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Diclofenac sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [42]
Diethylstilbestrol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diethylstilbestrol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Diethylstilbestrol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [43]
Diltiazem hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diltiazem hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Diltiazem hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [44]
Eltrombopag olamine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Eltrombopag olamine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Eltrombopag olamine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [45]
Enasidenib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Enasidenib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Enasidenib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [46]
Enzalutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Enzalutamide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Enzalutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Estradiol acetate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol acetate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Estradiol acetate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Estradiol cypionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol cypionate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Estradiol cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [47]
Estradiol valerate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol valerate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Estradiol valerate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [47]
Eszopiclone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Eszopiclone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Eszopiclone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [48]
Ethinyl estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ethinyl estradiol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ethinyl estradiol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [49]
Fluvastatin sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Fluvastatin sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Fluvastatin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [50]
Glasdegib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Glasdegib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Glasdegib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [51]
Halofantrine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Halofantrine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Halofantrine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [52]
Ibuprofen [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ibuprofen. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ibuprofen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [40]
Ifosfamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ifosfamide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ifosfamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [37]
Imatinib mesylate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Imatinib mesylate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Imatinib mesylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Irbesartan [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Irbesartan. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Irbesartan through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [49]
Istradefylline [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Istradefylline. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Istradefylline through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [53]
Ixazomib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ixazomib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ixazomib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [54]
Ketobemidone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ketobemidone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ketobemidone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [55]
Ketorolac [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ketorolac. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ketorolac through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [56]
Lansoprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lansoprazole. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lansoprazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [57]
Lapatinib ditosylate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lapatinib ditosylate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lapatinib ditosylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [58]
Levomilnacipran [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Levomilnacipran. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Levomilnacipran through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [59]
Lidocaine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lidocaine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lidocaine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [60]
Loperamide hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Loperamide hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Loperamide hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [61]
Loratadine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Loratadine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Loratadine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Lorlatinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lorlatinib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lorlatinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [62]
Losartan potassium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Losartan potassium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Losartan potassium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [63]
Lovastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lovastatin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lovastatin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [64]
Mefenamic acid [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mefenamic acid. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mefenamic acid through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Meloxicam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Meloxicam. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Meloxicam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [65]
Mephenytoin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mephenytoin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mephenytoin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [66]
Mestranol [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mestranol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mestranol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [67]
Methadone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Methadone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Methadone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [68]
Mirtazapine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mirtazapine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mirtazapine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [60]
Montelukast sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Montelukast sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Montelukast sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [69]
Morphine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Morphine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Morphine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [70]
Mycophenolate mofetil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mycophenolate mofetil. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mycophenolate mofetil through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [71]
Naloxone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Naloxone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Naloxone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [28]
Naproxen [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Naproxen. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Naproxen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [72]
Nicardipine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nicardipine hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Nicardipine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [60]
Nicotine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nicotine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Nicotine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [73]
Nilotinib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nilotinib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Nilotinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Ombitasvir [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ombitasvir. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ombitasvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [74]
Omeprazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Omeprazole. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Omeprazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [75]
Pazopanib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pazopanib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Pazopanib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [76]
Pentamidine isethionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pentamidine isethionate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Pentamidine isethionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [77]
Perphenazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Perphenazine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Perphenazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [78]
Phenobarbital [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenobarbital. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Phenobarbital through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [79]
Phenprocoumon [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenprocoumon. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Phenprocoumon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [80]
Phenytoin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenytoin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Phenytoin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [60]
Pioglitazone hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pioglitazone hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Pioglitazone hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [81]
Piroxicam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Piroxicam. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Piroxicam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [82]
Pitavastatin calcium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pitavastatin calcium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Pitavastatin calcium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [83]
Propofol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Propofol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Propofol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [84]
Quinidine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Quinidine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Quinidine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Quinine sulfate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Quinine sulfate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Quinine sulfate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Repaglinide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Repaglinide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Repaglinide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [85]
Riociguat [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Riociguat. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Riociguat through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [86]
Rofecoxib [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rofecoxib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Rofecoxib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Rosiglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rosiglitazone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Rosiglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [87]
Selegiline hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selegiline hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Selegiline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [88]
Selexipag [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selexipag. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Selexipag through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [89]
Simvastatin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Simvastatin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Simvastatin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [90]
Sitagliptin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sitagliptin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sitagliptin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [91]
Sulfadiazine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfadiazine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sulfadiazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [92]
Sulfamethoxazole [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfamethoxazole. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sulfamethoxazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [93]
Sulfinpyrazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfinpyrazone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sulfinpyrazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [60]
Tazarotene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tazarotene. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Tazarotene through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [94]
Tegafur [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tegafur. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Tegafur through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [95]
Temazepam [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Temazepam. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Temazepam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [96]
Terbinafine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Terbinafine hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Terbinafine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [48]
Testosterone cypionate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone cypionate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Testosterone cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Testosterone enanthate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone enanthate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Testosterone enanthate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Testosterone undecanoate [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone undecanoate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Testosterone undecanoate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
Thalidomide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Thalidomide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Thalidomide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [97]
Tolbutamide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tolbutamide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Tolbutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [98]
Torasemide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Torasemide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Torasemide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [99]
Treprostinil [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Treprostinil. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Treprostinil through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [100]
Trifarotene [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trifarotene. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Trifarotene through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [101]
Trimethadione [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trimethadione. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Trimethadione through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [102]
Trimethoprim [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trimethoprim. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Trimethoprim through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [103]
Troglitazone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Troglitazone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Troglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [104]
Velpatasvir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Velpatasvir. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Velpatasvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [105]
Verapamil hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Verapamil hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Verapamil hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [106]
Vortioxetine hydrobromide [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Vortioxetine hydrobromide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Vortioxetine hydrobromide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [107]
Voxilaprevir [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Voxilaprevir. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Voxilaprevir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [105]
Warfarin sodium [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Warfarin sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Warfarin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [72]
Zafirlukast [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zafirlukast. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Zafirlukast through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [103]
Zidovudine [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zidovudine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Zidovudine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [60]
Zopiclone [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zopiclone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Zopiclone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [108]
BMS-298585 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for BMS-298585. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BMS-298585 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [109]
BNP-1350 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for BNP-1350. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BNP-1350 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [110]
CKD-501 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for CKD-501. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CKD-501 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [111]
CYT-387 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for CYT-387. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CYT-387 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [112]
Dasabuvir [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dasabuvir. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Dasabuvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [113]
Domperidone [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Domperidone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Domperidone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [114]
DRF-2593 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for DRF-2593. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of DRF-2593 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [111]
EMD-128130 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for EMD-128130. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of EMD-128130 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [115]
Estradiol [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Estradiol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [22]
LAS-17177 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LAS-17177. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of LAS-17177 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [116]
LAU-7b [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LAU-7b. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of LAU-7b through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [117]
LY-2484595 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LY-2484595. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of LY-2484595 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [118]
NSC-122758 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for NSC-122758. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of NSC-122758 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [119]
QLT-091001 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for QLT-091001. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of QLT-091001 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [119]
Rivoglitazone [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rivoglitazone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Rivoglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [120]
AZD-2014 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AZD-2014. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AZD-2014 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [121]
GSK-1278863 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for GSK-1278863. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of GSK-1278863 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [122]
TAK-652 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for TAK-652. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of TAK-652 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [123]
AG-1549 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AG-1549. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AG-1549 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [124]
AZD-9496 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AZD-9496. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AZD-9496 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [125]
H3B-6545 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for H3B-6545. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of H3B-6545 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [126]
M-813 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for M-813. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of M-813 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [127]
MK-0822 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for MK-0822. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of MK-0822 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [128]
Antipyrine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Antipyrine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Antipyrine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [48]
Cyamemazine [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cyamemazine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cyamemazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [129]
Paraoxon [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Paraoxon. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Paraoxon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [130]
ABT-001 [Discontinued]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ABT-001. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ABT-001 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [131]
ADD-3878 [Discontinued]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ADD-3878. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ADD-3878 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [111]
Aleglitazar [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Aleglitazar. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Aleglitazar through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [132]
ML-3000 [Discontinued]
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ML-3000. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ML-3000 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [13], [48]
Hypoxia-inducible factor 1 alpha (HIF-1A)
HIF-1alpha [Phase 4]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for HIF-1alpha. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of HIF-1alpha through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [134]
IT-101 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for IT-101. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of IT-101 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [135]
2-Methoxyestradiol [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for 2-Methoxyestradiol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 2-Methoxyestradiol through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [136]
PT2385 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for PT2385. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of PT2385 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [137]
ENMD-1198 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ENMD-1198. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ENMD-1198 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [138]
EZN-2968 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for EZN-2968. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of EZN-2968 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [139]
PX-478 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for PX-478. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of PX-478 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [140]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [141]
ISIS 175510 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 175510. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 175510 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298697 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298697. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298697 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298699 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298699. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298699 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298700 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298700. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298700 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298701 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298701. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298701 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298702 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298702. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298702 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298711 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298711. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298711 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298712 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298712. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298712 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298743 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298743. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298743 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298744 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298744. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298744 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298745 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298745. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298745 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [142]
ISIS 298746 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298746. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298746 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). [133], [143]
Insulin-like growth factor I receptor (IGF1R)
Mecasermin [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Mecasermin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mecasermin through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [145]
Somatomedin-1 [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Somatomedin-1. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Somatomedin-1 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [141], [144]
Teprotumumab [Approved]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Teprotumumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Teprotumumab through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [146]
Rinfabate [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Rinfabate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Rinfabate through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [147]
AMG 479 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AMG 479. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AMG 479 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [148]
AXL-1717 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AXL-1717. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AXL-1717 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [149]
Cixutumumab [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Cixutumumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cixutumumab through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [150]
MM-141 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for MM-141. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of MM-141 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [151]
R1507 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for R1507. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of R1507 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [152]
TT-100 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for TT-100. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of TT-100 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [153]
VPI-2690B [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for VPI-2690B. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of VPI-2690B through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [154]
AEW-541 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AEW-541. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AEW-541 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [155]
BIIB 022 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for BIIB 022. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BIIB 022 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [156]
Cyclolignan picropodophyllin [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Cyclolignan picropodophyllin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cyclolignan picropodophyllin through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [157]
FPI-1434 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for FPI-1434. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of FPI-1434 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [158]
HF-0299 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for HF-0299. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of HF-0299 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [159]
RG-7010 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for RG-7010. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of RG-7010 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [160]
ATL-1101 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for ATL-1101. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ATL-1101 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [161]
BMS-695735 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for BMS-695735. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BMS-695735 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [162]
4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for 4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [163]
4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for 4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [164]
AG 1024 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AG 1024. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AG 1024 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [165]
Alpha-D-Mannose [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Alpha-D-Mannose. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Alpha-D-Mannose through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [166]
AMP-PNP [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AMP-PNP. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AMP-PNP through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [166]
AZD3463 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AZD3463. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AZD3463 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [167]
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for BMS 536924. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BMS 536924 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [163]
Fucose [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Fucose. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Fucose through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [168]
GSK-1838705A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for GSK-1838705A. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of GSK-1838705A through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [169]
GSK1511931 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for GSK1511931. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of GSK1511931 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [170]
JB-1 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for JB-1. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of JB-1 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [171]
NVP-ADW742 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for NVP-ADW742. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of NVP-ADW742 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [168]
PQ401 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for PQ401. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of PQ401 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [172]
AVE-1642 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AVE-1642. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AVE-1642 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [173]
Figitumumab [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Figitumumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Figitumumab through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [174]
KW-2450 [Discontinued in Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for KW-2450. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of KW-2450 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). [144], [175]
Interleukin-6 (IL6)
Siltuximab [Approved]
In total 2 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for Siltuximab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Siltuximab through regulating the expression of Interleukin-6 (IL6). [176], [177]
Interleukin-6 (IL6) is a therapeutic target for Siltuximab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Siltuximab through regulating the expression of Interleukin-6 (IL6). [176], [180]
Olokizumab [Phase 3]
In total 2 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for Olokizumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Olokizumab through regulating the expression of Interleukin-6 (IL6). [176], [178]
Interleukin-6 (IL6) is a therapeutic target for Olokizumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Olokizumab through regulating the expression of Interleukin-6 (IL6). [176], [179]
Sirukumab [Phase 3]
In total 2 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for Sirukumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sirukumab through regulating the expression of Interleukin-6 (IL6). [176], [181]
Interleukin-6 (IL6) is a therapeutic target for Sirukumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sirukumab through regulating the expression of Interleukin-6 (IL6). [176], [184]
ALD-518 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for ALD-518. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ALD-518 through regulating the expression of Interleukin-6 (IL6). [176], [178]
CDP-6038 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for CDP-6038. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CDP-6038 through regulating the expression of Interleukin-6 (IL6). [174], [176]
Clazakizumab [Phase 2]
In total 2 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for Clazakizumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Clazakizumab through regulating the expression of Interleukin-6 (IL6). [176], [178]
Interleukin-6 (IL6) is a therapeutic target for Clazakizumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Clazakizumab through regulating the expression of Interleukin-6 (IL6). [176], [182]
PF-04236921 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for PF-04236921. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of PF-04236921 through regulating the expression of Interleukin-6 (IL6). [176], [183]
YSIL6 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for YSIL6. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of YSIL6 through regulating the expression of Interleukin-6 (IL6). [174], [176]
C326 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for C326. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of C326 through regulating the expression of Interleukin-6 (IL6). [176], [185]
Gerilimzumab [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for Gerilimzumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Gerilimzumab through regulating the expression of Interleukin-6 (IL6). [176], [186]
MEDI5117 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for MEDI5117. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of MEDI5117 through regulating the expression of Interleukin-6 (IL6). [176], [187]
OP-R003 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Interleukin-6 (IL6) is a therapeutic target for OP-R003. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of OP-R003 through regulating the expression of Interleukin-6 (IL6). [176], [178]
Nuclear factor erythroid 2-related factor 2 (Nrf2)
ABT-RTA-408 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for ABT-RTA-408. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ABT-RTA-408 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [188], [189]
CXA10 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for CXA10. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CXA10 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [188], [190]
Omaveloxolone [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for Omaveloxolone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Omaveloxolone through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [188], [191]
OT-551 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for OT-551. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of OT-551 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [188], [192]
OT551 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for OT551. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of OT551 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [188], [193]
SFX-01 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for SFX-01. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of SFX-01 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [188], [194]
HPP971 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for HPP971. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of HPP971 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [188], [195]
CAT4001 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for CAT4001. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CAT4001 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [188], [196]
M102 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for M102. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of M102 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [188], [197]
TFM735 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for TFM735. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of TFM735 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). [188], [191]
RAC-alpha serine/threonine-protein kinase (AKT1)
AZD5363 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for AZD5363. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AZD5363 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [141], [144]
Enzastaurin [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Enzastaurin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Enzastaurin through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [198]
GDC-0068 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for GDC-0068. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of GDC-0068 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [141], [144]
ARQ 092 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for ARQ 092. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ARQ 092 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [199]
CI-1033 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for CI-1033. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CI-1033 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [141], [144]
CMX-2043 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for CMX-2043. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CMX-2043 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [157]
GSK2110183 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for GSK2110183. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of GSK2110183 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [200]
PTX-200 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for PTX-200. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of PTX-200 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [141], [144]
RX-0201 [Phase 2]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for RX-0201. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of RX-0201 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [201]
Triciribine prodrug [Phase 1/2]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Triciribine prodrug. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Triciribine prodrug through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [202]
ARQ 751 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for ARQ 751. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ARQ 751 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [201]
BMS-754807 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for BMS-754807. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BMS-754807 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [203]
M2698 [Phase 1]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for M2698. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of M2698 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [141], [144]
(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [204]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [205]
4,5,6-trihydroxy-3-methylphthalide [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for 4,5,6-trihydroxy-3-methylphthalide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 4,5,6-trihydroxy-3-methylphthalide through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [204]
A-443654 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for A-443654. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of A-443654 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [204]
A-674563 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for A-674563. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of A-674563 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [206]
Akt inhibitor VIII [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Akt inhibitor VIII. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Akt inhibitor VIII through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [166]
ALM-301 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for ALM-301. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ALM-301 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [170]
Bisindolylmaleimide-I [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Bisindolylmaleimide-I. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Bisindolylmaleimide-I through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [207]
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for BMS 536924. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BMS 536924 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [204]
BX-517 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for BX-517. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BX-517 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [208]
CI-1040 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for CI-1040. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CI-1040 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [201]
Inositol 1,3,4,5-Tetrakisphosphate [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Inositol 1,3,4,5-Tetrakisphosphate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Inositol 1,3,4,5-Tetrakisphosphate through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [209]
KN-62 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for KN-62. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of KN-62 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [207]
Lactoquinomycin [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Lactoquinomycin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lactoquinomycin through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [210]
LD-101 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for LD-101. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of LD-101 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [201]
MYRIOCIN [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for MYRIOCIN. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of MYRIOCIN through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [211]
NU-1001-41 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for NU-1001-41. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of NU-1001-41 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [201]
RO-316233 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for RO-316233. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of RO-316233 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [204]
Ro31-8220 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Ro31-8220. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ro31-8220 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [212]
SB-747651A [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for SB-747651A. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of SB-747651A through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [213]
STAUROSPORINONE [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for STAUROSPORINONE. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of STAUROSPORINONE through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [211]
VLI-27 [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for VLI-27. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of VLI-27 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [144], [201]
Squalestatin 1 [Terminated]
In total 1 mechanisms lead to this potential drug response
Response Summary RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Squalestatin 1. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Squalestatin 1 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). [141], [144]
Transforming growth factor beta 2 (TGFB2)
AP12009 [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Transforming growth factor beta 2 (TGFB2) is a therapeutic target for AP12009. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AP12009 through regulating the expression of Transforming growth factor beta 2 (TGFB2). [8], [214]
Belagenpumatucel-L [Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Transforming growth factor beta 2 (TGFB2) is a therapeutic target for Belagenpumatucel-L. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Belagenpumatucel-L through regulating the expression of Transforming growth factor beta 2 (TGFB2). [214], [215]
OT-101 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response
Response Summary Transforming growth factor beta 2 (TGFB2) is a therapeutic target for OT-101. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of OT-101 through regulating the expression of Transforming growth factor beta 2 (TGFB2). [214], [216]
Lerdelimumab [Investigative]
In total 1 mechanisms lead to this potential drug response
Response Summary Transforming growth factor beta 2 (TGFB2) is a therapeutic target for Lerdelimumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lerdelimumab through regulating the expression of Transforming growth factor beta 2 (TGFB2). [214], [217]
Ranagengliotucel-T [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response
Response Summary Transforming growth factor beta 2 (TGFB2) is a therapeutic target for Ranagengliotucel-T. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ranagengliotucel-T through regulating the expression of Transforming growth factor beta 2 (TGFB2). [214], [218]
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