m6A Regulator and Potential Drug Response
General Information of the m6A Regulator (ID: REG00023)
Regulator Name | YTH domain-containing protein 2 (YTHDC2) | ||||
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Synonyms |
3'-5' RNA helicase YTHDC2; hYTHDC2
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Gene Name | YTHDC2 | ||||
Regulator Type | WRITER ERASER READER | ||||
Regulator Link | Click to View Full Information of This Regulator |
Full List of Target Gene(s) of This m6A Regulator and Corresponding Potential Drug Response(s)
Apoptosis mediating surface antigen FAS (FAS)
VB-111 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for VB-111. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of VB-111 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). | [1], [2] | ||
APG-101 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APG-101. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of APG-101 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). | [1], [3] | ||
DE-098 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for DE-098. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of DE-098 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). | [1], [4] | ||
APO-010 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APO-010. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of APO-010 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). | [1], [5] | ||
2-aminophenoxazine-3-one [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for 2-aminophenoxazine-3-one. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 2-aminophenoxazine-3-one through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). | [1], [6] | ||
APG-103 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for APG-103. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of APG-103 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). | [1], [7] | ||
F61F12 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for F61F12. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of F61F12 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). | [1], [8] | ||
ISIS 17020 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Apoptosis mediating surface antigen FAS (FAS) is a therapeutic target for ISIS 17020. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 17020 through regulating the expression of Apoptosis mediating surface antigen FAS (FAS). | [1], [9] | ||
Cystine/glutamate transporter (SLC7A11)
L-glutamic acid [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cystine/glutamate transporter (SLC7A11) is a therapeutic target for L-glutamic acid. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of L-glutamic acid through regulating the expression of Cystine/glutamate transporter (SLC7A11). | [10], [11] | ||
SXC-2023 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cystine/glutamate transporter (SLC7A11) is a therapeutic target for SXC-2023. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of SXC-2023 through regulating the expression of Cystine/glutamate transporter (SLC7A11). | [10], [12] | ||
Cytochrome P450 2C8 (CYP2C8)
Almotriptan malate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Almotriptan malate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Almotriptan malate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [14] | ||
Aminophenazone [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Aminophenazone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Aminophenazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [15] | ||
Amiodarone hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amiodarone hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Amiodarone hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [16] | ||
Amitriptyline hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amitriptyline hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Amitriptyline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [17] | ||
Amodiaquine [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amodiaquine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [18] | ||
Anastrozole [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Anastrozole. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Anastrozole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [19] | ||
Apalutamide [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Apalutamide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Apalutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [20] | ||
Apixaban [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Apixaban. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Apixaban through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [21] | ||
Atorvastatin calcium [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Atorvastatin calcium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Atorvastatin calcium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Azelastine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Azelastine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Azelastine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [23] | ||
Benzyl alcohol [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Benzyl alcohol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Benzyl alcohol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [24] | ||
Beraprost [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Beraprost. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Beraprost through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [25] | ||
Brigatinib [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Brigatinib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Brigatinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [26] | ||
Bromfenac [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Bromfenac. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Bromfenac through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [27] | ||
Buprenorphine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Buprenorphine hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Buprenorphine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [28] | ||
Cabazitaxel [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cabazitaxel. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cabazitaxel through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [29] | ||
Caffeine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Caffeine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [30] | ||
Capsaicin [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Capsaicin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Capsaicin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [31] | ||
Carbamazepine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Carbamazepine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Carbamazepine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [32] | ||
Cefaloridine [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cefaloridine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cefaloridine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [33] | ||
Celecoxib [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Celecoxib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Celecoxib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [34] | ||
Cerivastatin sodium [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cerivastatin sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cerivastatin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Cisapride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cisapride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cisapride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [35] | ||
Clozapine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Clozapine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Clozapine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [36] | ||
Cyclophosphamide [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cyclophosphamide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cyclophosphamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [37] | ||
Dabrafenib mesylate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dabrafenib mesylate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Dabrafenib mesylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Dapsone [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dapsone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Dapsone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [38] | ||
Desloratadine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Desloratadine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Desloratadine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [39] | ||
Dexibuprofen [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dexibuprofen. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Dexibuprofen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [40] | ||
Diazepam [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diazepam. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Diazepam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [41] | ||
Diclofenac sodium [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diclofenac sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Diclofenac sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [42] | ||
Diethylstilbestrol [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diethylstilbestrol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Diethylstilbestrol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [43] | ||
Diltiazem hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diltiazem hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Diltiazem hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [44] | ||
Eltrombopag olamine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Eltrombopag olamine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Eltrombopag olamine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [45] | ||
Enasidenib [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Enasidenib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Enasidenib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [46] | ||
Enzalutamide [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Enzalutamide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Enzalutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Estradiol acetate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol acetate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Estradiol acetate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Estradiol cypionate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol cypionate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Estradiol cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [47] | ||
Estradiol valerate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol valerate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Estradiol valerate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [47] | ||
Eszopiclone [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Eszopiclone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Eszopiclone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [48] | ||
Ethinyl estradiol [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ethinyl estradiol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ethinyl estradiol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [49] | ||
Fluvastatin sodium [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Fluvastatin sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Fluvastatin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [50] | ||
Glasdegib [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Glasdegib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Glasdegib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [51] | ||
Halofantrine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Halofantrine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Halofantrine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [52] | ||
Ibuprofen [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ibuprofen. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ibuprofen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [40] | ||
Ifosfamide [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ifosfamide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ifosfamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [37] | ||
Imatinib mesylate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Imatinib mesylate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Imatinib mesylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Irbesartan [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Irbesartan. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Irbesartan through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [49] | ||
Istradefylline [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Istradefylline. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Istradefylline through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [53] | ||
Ixazomib [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ixazomib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ixazomib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [54] | ||
Ketobemidone [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ketobemidone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ketobemidone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [55] | ||
Ketorolac [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ketorolac. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ketorolac through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [56] | ||
Lansoprazole [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lansoprazole. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lansoprazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [57] | ||
Lapatinib ditosylate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lapatinib ditosylate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lapatinib ditosylate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [58] | ||
Levomilnacipran [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Levomilnacipran. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Levomilnacipran through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [59] | ||
Lidocaine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lidocaine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lidocaine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [60] | ||
Loperamide hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Loperamide hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Loperamide hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [61] | ||
Loratadine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Loratadine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Loratadine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Lorlatinib [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lorlatinib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lorlatinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [62] | ||
Losartan potassium [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Losartan potassium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Losartan potassium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [63] | ||
Lovastatin [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Lovastatin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lovastatin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [64] | ||
Mefenamic acid [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mefenamic acid. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mefenamic acid through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Meloxicam [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Meloxicam. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Meloxicam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [65] | ||
Mephenytoin [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mephenytoin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mephenytoin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [66] | ||
Mestranol [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mestranol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mestranol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [67] | ||
Methadone [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Methadone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Methadone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [68] | ||
Mirtazapine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mirtazapine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mirtazapine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [60] | ||
Montelukast sodium [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Montelukast sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Montelukast sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [69] | ||
Morphine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Morphine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Morphine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [70] | ||
Mycophenolate mofetil [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Mycophenolate mofetil. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mycophenolate mofetil through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [71] | ||
Naloxone [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Naloxone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Naloxone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [28] | ||
Naproxen [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Naproxen. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Naproxen through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [72] | ||
Nicardipine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nicardipine hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Nicardipine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [60] | ||
Nicotine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nicotine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Nicotine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [73] | ||
Nilotinib [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Nilotinib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Nilotinib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Ombitasvir [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ombitasvir. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ombitasvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [74] | ||
Omeprazole [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Omeprazole. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Omeprazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [75] | ||
Pazopanib [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pazopanib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Pazopanib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [76] | ||
Pentamidine isethionate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pentamidine isethionate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Pentamidine isethionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [77] | ||
Perphenazine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Perphenazine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Perphenazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [78] | ||
Phenobarbital [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenobarbital. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Phenobarbital through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [79] | ||
Phenprocoumon [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenprocoumon. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Phenprocoumon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [80] | ||
Phenytoin [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Phenytoin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Phenytoin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [60] | ||
Pioglitazone hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pioglitazone hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Pioglitazone hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [81] | ||
Piroxicam [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Piroxicam. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Piroxicam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [82] | ||
Pitavastatin calcium [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pitavastatin calcium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Pitavastatin calcium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [83] | ||
Propofol [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Propofol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Propofol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [84] | ||
Quinidine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Quinidine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Quinidine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Quinine sulfate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Quinine sulfate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Quinine sulfate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Repaglinide [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Repaglinide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Repaglinide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [85] | ||
Riociguat [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Riociguat. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Riociguat through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [86] | ||
Rofecoxib [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rofecoxib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Rofecoxib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Rosiglitazone [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rosiglitazone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Rosiglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [87] | ||
Selegiline hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selegiline hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Selegiline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [88] | ||
Selexipag [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selexipag. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Selexipag through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [89] | ||
Simvastatin [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Simvastatin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Simvastatin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [90] | ||
Sitagliptin [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sitagliptin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sitagliptin through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [91] | ||
Sulfadiazine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfadiazine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sulfadiazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [92] | ||
Sulfamethoxazole [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfamethoxazole. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sulfamethoxazole through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [93] | ||
Sulfinpyrazone [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Sulfinpyrazone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sulfinpyrazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [60] | ||
Tazarotene [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tazarotene. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Tazarotene through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [94] | ||
Tegafur [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tegafur. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Tegafur through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [95] | ||
Temazepam [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Temazepam. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Temazepam through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [96] | ||
Terbinafine hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Terbinafine hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Terbinafine hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [48] | ||
Testosterone cypionate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone cypionate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Testosterone cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Testosterone enanthate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone enanthate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Testosterone enanthate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Testosterone undecanoate [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Testosterone undecanoate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Testosterone undecanoate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
Thalidomide [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Thalidomide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Thalidomide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [97] | ||
Tolbutamide [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Tolbutamide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Tolbutamide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [98] | ||
Torasemide [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Torasemide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Torasemide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [99] | ||
Treprostinil [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Treprostinil. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Treprostinil through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [100] | ||
Trifarotene [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trifarotene. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Trifarotene through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [101] | ||
Trimethadione [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trimethadione. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Trimethadione through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [102] | ||
Trimethoprim [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Trimethoprim. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Trimethoprim through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [103] | ||
Troglitazone [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Troglitazone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Troglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [104] | ||
Velpatasvir [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Velpatasvir. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Velpatasvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [105] | ||
Verapamil hydrochloride [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Verapamil hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Verapamil hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [106] | ||
Vortioxetine hydrobromide [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Vortioxetine hydrobromide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Vortioxetine hydrobromide through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [107] | ||
Voxilaprevir [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Voxilaprevir. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Voxilaprevir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [105] | ||
Warfarin sodium [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Warfarin sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Warfarin sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [72] | ||
Zafirlukast [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zafirlukast. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Zafirlukast through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [103] | ||
Zidovudine [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zidovudine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Zidovudine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [60] | ||
Zopiclone [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Zopiclone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Zopiclone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [108] | ||
BMS-298585 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for BMS-298585. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BMS-298585 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [109] | ||
BNP-1350 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for BNP-1350. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BNP-1350 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [110] | ||
CKD-501 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for CKD-501. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CKD-501 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [111] | ||
CYT-387 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for CYT-387. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CYT-387 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [112] | ||
Dasabuvir [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Dasabuvir. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Dasabuvir through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [113] | ||
Domperidone [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Domperidone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Domperidone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [114] | ||
DRF-2593 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for DRF-2593. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of DRF-2593 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [111] | ||
EMD-128130 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for EMD-128130. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of EMD-128130 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [115] | ||
Estradiol [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Estradiol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [22] | ||
LAS-17177 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LAS-17177. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of LAS-17177 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [116] | ||
LAU-7b [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LAU-7b. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of LAU-7b through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [117] | ||
LY-2484595 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for LY-2484595. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of LY-2484595 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [118] | ||
NSC-122758 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for NSC-122758. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of NSC-122758 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [119] | ||
QLT-091001 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for QLT-091001. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of QLT-091001 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [119] | ||
Rivoglitazone [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Rivoglitazone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Rivoglitazone through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [120] | ||
AZD-2014 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AZD-2014. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AZD-2014 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [121] | ||
GSK-1278863 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for GSK-1278863. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of GSK-1278863 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [122] | ||
TAK-652 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for TAK-652. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of TAK-652 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [123] | ||
AG-1549 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AG-1549. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AG-1549 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [124] | ||
AZD-9496 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for AZD-9496. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AZD-9496 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [125] | ||
H3B-6545 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for H3B-6545. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of H3B-6545 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [126] | ||
M-813 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for M-813. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of M-813 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [127] | ||
MK-0822 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for MK-0822. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of MK-0822 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [128] | ||
Antipyrine [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Antipyrine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Antipyrine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [48] | ||
Cyamemazine [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Cyamemazine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cyamemazine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [129] | ||
Paraoxon [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Paraoxon. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Paraoxon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [130] | ||
ABT-001 [Discontinued]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ABT-001. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ABT-001 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [131] | ||
ADD-3878 [Discontinued]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ADD-3878. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ADD-3878 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [111] | ||
Aleglitazar [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Aleglitazar. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Aleglitazar through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [132] | ||
ML-3000 [Discontinued]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for ML-3000. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ML-3000 through regulating the expression of Cytochrome P450 2C8 (CYP2C8). | [13], [48] | ||
Hypoxia-inducible factor 1 alpha (HIF-1A)
HIF-1alpha [Phase 4]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for HIF-1alpha. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of HIF-1alpha through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [134] | ||
IT-101 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for IT-101. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of IT-101 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [135] | ||
2-Methoxyestradiol [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for 2-Methoxyestradiol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 2-Methoxyestradiol through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [136] | ||
PT2385 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for PT2385. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of PT2385 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [137] | ||
ENMD-1198 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ENMD-1198. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ENMD-1198 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [138] | ||
EZN-2968 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for EZN-2968. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of EZN-2968 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [139] | ||
PX-478 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for PX-478. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of PX-478 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [140] | ||
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [141] | ||
ISIS 175510 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 175510. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 175510 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298697 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298697. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298697 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298699 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298699. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298699 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298700 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298700. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298700 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298701 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298701. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298701 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298702 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298702. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298702 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298711 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298711. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298711 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298712 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298712. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298712 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298743 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298743. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298743 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298744 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298744. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298744 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298745 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298745. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298745 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [142] | ||
ISIS 298746 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Hypoxia-inducible factor 1 alpha (HIF-1A) is a therapeutic target for ISIS 298746. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ISIS 298746 through regulating the expression of Hypoxia-inducible factor 1 alpha (HIF-1A). | [133], [143] | ||
Insulin-like growth factor I receptor (IGF1R)
Mecasermin [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Mecasermin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Mecasermin through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [145] | ||
Somatomedin-1 [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Somatomedin-1. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Somatomedin-1 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [141], [144] | ||
Teprotumumab [Approved]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Teprotumumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Teprotumumab through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [146] | ||
Rinfabate [Phase 2/3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Rinfabate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Rinfabate through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [147] | ||
AMG 479 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AMG 479. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AMG 479 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [148] | ||
AXL-1717 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AXL-1717. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AXL-1717 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [149] | ||
Cixutumumab [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Cixutumumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cixutumumab through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [150] | ||
MM-141 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for MM-141. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of MM-141 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [151] | ||
R1507 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for R1507. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of R1507 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [152] | ||
TT-100 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for TT-100. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of TT-100 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [153] | ||
VPI-2690B [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for VPI-2690B. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of VPI-2690B through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [154] | ||
AEW-541 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AEW-541. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AEW-541 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [155] | ||
BIIB 022 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for BIIB 022. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BIIB 022 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [156] | ||
Cyclolignan picropodophyllin [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Cyclolignan picropodophyllin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Cyclolignan picropodophyllin through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [157] | ||
FPI-1434 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for FPI-1434. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of FPI-1434 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [158] | ||
HF-0299 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for HF-0299. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of HF-0299 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [159] | ||
RG-7010 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for RG-7010. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of RG-7010 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [160] | ||
ATL-1101 [Preclinical]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for ATL-1101. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ATL-1101 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [161] | ||
BMS-695735 [Preclinical]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for BMS-695735. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BMS-695735 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [162] | ||
4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for 4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [163] | ||
4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for 4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [164] | ||
AG 1024 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AG 1024. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AG 1024 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [165] | ||
Alpha-D-Mannose [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Alpha-D-Mannose. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Alpha-D-Mannose through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [166] | ||
AMP-PNP [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AMP-PNP. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AMP-PNP through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [166] | ||
AZD3463 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AZD3463. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AZD3463 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [167] | ||
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for BMS 536924. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BMS 536924 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [163] | ||
Fucose [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Fucose. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Fucose through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [168] | ||
GSK-1838705A [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for GSK-1838705A. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of GSK-1838705A through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [169] | ||
GSK1511931 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for GSK1511931. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of GSK1511931 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [170] | ||
JB-1 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for JB-1. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of JB-1 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [171] | ||
NVP-ADW742 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for NVP-ADW742. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of NVP-ADW742 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [168] | ||
PQ401 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for PQ401. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of PQ401 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [172] | ||
AVE-1642 [Discontinued in Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for AVE-1642. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AVE-1642 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [173] | ||
Figitumumab [Discontinued in Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for Figitumumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Figitumumab through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [174] | ||
KW-2450 [Discontinued in Phase 1/2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Insulin-like growth factor I receptor (IGF1R) is a therapeutic target for KW-2450. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of KW-2450 through regulating the expression of Insulin-like growth factor I receptor (IGF1R). | [144], [175] | ||
Interleukin-6 (IL6)
Siltuximab [Approved]
In total 2 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for Siltuximab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Siltuximab through regulating the expression of Interleukin-6 (IL6). | [176], [177] | ||
Interleukin-6 (IL6) is a therapeutic target for Siltuximab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Siltuximab through regulating the expression of Interleukin-6 (IL6). | [176], [180] | |||
Olokizumab [Phase 3]
In total 2 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for Olokizumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Olokizumab through regulating the expression of Interleukin-6 (IL6). | [176], [178] | ||
Interleukin-6 (IL6) is a therapeutic target for Olokizumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Olokizumab through regulating the expression of Interleukin-6 (IL6). | [176], [179] | |||
Sirukumab [Phase 3]
In total 2 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for Sirukumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sirukumab through regulating the expression of Interleukin-6 (IL6). | [176], [181] | ||
Interleukin-6 (IL6) is a therapeutic target for Sirukumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Sirukumab through regulating the expression of Interleukin-6 (IL6). | [176], [184] | |||
ALD-518 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for ALD-518. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ALD-518 through regulating the expression of Interleukin-6 (IL6). | [176], [178] | ||
CDP-6038 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for CDP-6038. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CDP-6038 through regulating the expression of Interleukin-6 (IL6). | [174], [176] | ||
Clazakizumab [Phase 2]
In total 2 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for Clazakizumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Clazakizumab through regulating the expression of Interleukin-6 (IL6). | [176], [178] | ||
Interleukin-6 (IL6) is a therapeutic target for Clazakizumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Clazakizumab through regulating the expression of Interleukin-6 (IL6). | [176], [182] | |||
PF-04236921 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for PF-04236921. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of PF-04236921 through regulating the expression of Interleukin-6 (IL6). | [176], [183] | ||
YSIL6 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for YSIL6. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of YSIL6 through regulating the expression of Interleukin-6 (IL6). | [174], [176] | ||
C326 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for C326. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of C326 through regulating the expression of Interleukin-6 (IL6). | [176], [185] | ||
Gerilimzumab [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for Gerilimzumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Gerilimzumab through regulating the expression of Interleukin-6 (IL6). | [176], [186] | ||
MEDI5117 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for MEDI5117. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of MEDI5117 through regulating the expression of Interleukin-6 (IL6). | [176], [187] | ||
OP-R003 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Interleukin-6 (IL6) is a therapeutic target for OP-R003. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of OP-R003 through regulating the expression of Interleukin-6 (IL6). | [176], [178] | ||
Nuclear factor erythroid 2-related factor 2 (Nrf2)
ABT-RTA-408 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for ABT-RTA-408. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ABT-RTA-408 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). | [188], [189] | ||
CXA10 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for CXA10. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CXA10 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). | [188], [190] | ||
Omaveloxolone [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for Omaveloxolone. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Omaveloxolone through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). | [188], [191] | ||
OT-551 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for OT-551. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of OT-551 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). | [188], [192] | ||
OT551 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for OT551. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of OT551 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). | [188], [193] | ||
SFX-01 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for SFX-01. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of SFX-01 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). | [188], [194] | ||
HPP971 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for HPP971. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of HPP971 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). | [188], [195] | ||
CAT4001 [Preclinical]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for CAT4001. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CAT4001 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). | [188], [196] | ||
M102 [Preclinical]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for M102. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of M102 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). | [188], [197] | ||
TFM735 [Preclinical]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for TFM735. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of TFM735 through regulating the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2). | [188], [191] | ||
RAC-alpha serine/threonine-protein kinase (AKT1)
AZD5363 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for AZD5363. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AZD5363 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [141], [144] | ||
Enzastaurin [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Enzastaurin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Enzastaurin through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [198] | ||
GDC-0068 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for GDC-0068. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of GDC-0068 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [141], [144] | ||
ARQ 092 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for ARQ 092. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ARQ 092 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [199] | ||
CI-1033 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for CI-1033. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CI-1033 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [141], [144] | ||
CMX-2043 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for CMX-2043. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CMX-2043 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [157] | ||
GSK2110183 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for GSK2110183. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of GSK2110183 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [200] | ||
PTX-200 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for PTX-200. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of PTX-200 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [141], [144] | ||
RX-0201 [Phase 2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for RX-0201. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of RX-0201 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [201] | ||
Triciribine prodrug [Phase 1/2]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Triciribine prodrug. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Triciribine prodrug through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [202] | ||
ARQ 751 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for ARQ 751. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ARQ 751 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [201] | ||
BMS-754807 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for BMS-754807. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BMS-754807 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [203] | ||
M2698 [Phase 1]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for M2698. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of M2698 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [141], [144] | ||
(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [204] | ||
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [205] | ||
4,5,6-trihydroxy-3-methylphthalide [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for 4,5,6-trihydroxy-3-methylphthalide. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of 4,5,6-trihydroxy-3-methylphthalide through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [204] | ||
A-443654 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for A-443654. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of A-443654 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [204] | ||
A-674563 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for A-674563. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of A-674563 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [206] | ||
Akt inhibitor VIII [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Akt inhibitor VIII. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Akt inhibitor VIII through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [166] | ||
ALM-301 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for ALM-301. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of ALM-301 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [170] | ||
Bisindolylmaleimide-I [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Bisindolylmaleimide-I. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Bisindolylmaleimide-I through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [207] | ||
BMS 536924 [Preclinical]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for BMS 536924. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BMS 536924 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [204] | ||
BX-517 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for BX-517. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of BX-517 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [208] | ||
CI-1040 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for CI-1040. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of CI-1040 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [201] | ||
Inositol 1,3,4,5-Tetrakisphosphate [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Inositol 1,3,4,5-Tetrakisphosphate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Inositol 1,3,4,5-Tetrakisphosphate through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [209] | ||
KN-62 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for KN-62. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of KN-62 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [207] | ||
Lactoquinomycin [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Lactoquinomycin. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lactoquinomycin through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [210] | ||
LD-101 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for LD-101. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of LD-101 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [201] | ||
MYRIOCIN [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for MYRIOCIN. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of MYRIOCIN through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [211] | ||
NU-1001-41 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for NU-1001-41. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of NU-1001-41 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [201] | ||
RO-316233 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for RO-316233. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of RO-316233 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [204] | ||
Ro31-8220 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Ro31-8220. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ro31-8220 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [212] | ||
SB-747651A [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for SB-747651A. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of SB-747651A through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [213] | ||
STAUROSPORINONE [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for STAUROSPORINONE. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of STAUROSPORINONE through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [211] | ||
VLI-27 [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for VLI-27. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of VLI-27 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [144], [201] | ||
Squalestatin 1 [Terminated]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | RAC-alpha serine/threonine-protein kinase (AKT1) is a therapeutic target for Squalestatin 1. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Squalestatin 1 through regulating the expression of RAC-alpha serine/threonine-protein kinase (AKT1). | [141], [144] | ||
Transforming growth factor beta 2 (TGFB2)
AP12009 [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Transforming growth factor beta 2 (TGFB2) is a therapeutic target for AP12009. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of AP12009 through regulating the expression of Transforming growth factor beta 2 (TGFB2). | [8], [214] | ||
Belagenpumatucel-L [Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Transforming growth factor beta 2 (TGFB2) is a therapeutic target for Belagenpumatucel-L. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Belagenpumatucel-L through regulating the expression of Transforming growth factor beta 2 (TGFB2). | [214], [215] | ||
OT-101 [Phase 2/3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Transforming growth factor beta 2 (TGFB2) is a therapeutic target for OT-101. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of OT-101 through regulating the expression of Transforming growth factor beta 2 (TGFB2). | [214], [216] | ||
Lerdelimumab [Investigative]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Transforming growth factor beta 2 (TGFB2) is a therapeutic target for Lerdelimumab. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Lerdelimumab through regulating the expression of Transforming growth factor beta 2 (TGFB2). | [214], [217] | ||
Ranagengliotucel-T [Discontinued in Phase 3]
In total 1 mechanisms lead to this potential drug response | ||||
Response Summary | Transforming growth factor beta 2 (TGFB2) is a therapeutic target for Ranagengliotucel-T. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ranagengliotucel-T through regulating the expression of Transforming growth factor beta 2 (TGFB2). | [214], [218] | ||
References