m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01020)
Name
Amodiaquine
Synonyms
Amodiachin; Amodiachinum; Amodiaquin; Amodiaquina; Amodiaquina [INN-Spanish]; Amodiaquine USP24; Amodiaquine hydrochloride; Amodiaquine, ring-closed; Amodiaquinum; Amodiaquinum [INN-Latin]; CAM-AQI; Cam-AQ1; Camochin; Camoquin; Camoquin Hcl; Camoquinal; Camoquine; Flavoquine; Miaquin; S. N. 10751; SN 10,751; amodiaquine; 4-[(7-CHLOROQUINOLIN-4-YL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL; 86-42-0; C20H22ClN3O; CHEBI:2674; NSC 13453; Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-; UNII-220236ED28
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Status
Phase 4
Structure
Formula
C20H22ClN3O
InChI
1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)
InChIKey
OVCDSSHSILBFBN-UHFFFAOYSA-N
PubChem CID
2165
INTEDE Drug ID
DR0102
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 1B1 (CYP1B1)
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Amodiaquine. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Amodiaquine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [2], [3]
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amodiaquine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [4], [5]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amodiaquine. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [4], [5]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amodiaquine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [4], [5]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Amodiaquine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Amodiaquine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [4], [5]
References
Ref 1 LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression. Oncogene. 2020 Jul;39(31):5358-5372. doi: 10.1038/s41388-020-1338-9. Epub 2020 Jun 23.
Ref 2 Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407. doi: 10.1124/jpet.300.2.399.
Ref 3 METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F839-F847. doi: 10.1152/ajprenal.00222.2020. Epub 2020 Sep 21.
Ref 4 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 5 Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther. 2007 Aug;82(2):197-203. doi: 10.1038/sj.clpt.6100122. Epub 2007 Mar 14.