m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01248)
Name
Caffeine
Synonyms
Cafeina; Caffedrine; Caffein; Caffeine, synthetic; Caffine; Cafipel; Coffein; Coffeine; Coffeinum; Caffeine citrate; DHCplus; Dexitac; Durvitan; Eldiatric C; Guaranine; Hycomine; Koffein; Mateina; Methyltheobromide; Methyltheobromine; Nix Nap; No-Doz; Nodaca; Organex; Phensal; Quick-Pep; Refresh'n; Stim; Thein; Theine; Theophylline, 7-methyl; Tirend; Vivarin; Wigraine; caffeine; Caffeina citrate; Caffeine citrate (1:1); Caffeine citrated; Caffeine, Citrated; Citrated caffein; Citric acid, compd. with caffeine (1:1); DSSTox_CID_26938; DSSTox_GSID_46938; DSSTox_RID_82023; NCGC00015208-09; U26EO4675Q; UNII-U26EO4675Q; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, mixt. with 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione; 1,2,3-Propanetricarboxylic acid,2-hydroxy-,compounds,mixt. with 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6- dione; 69-22-7; C8H10N4O2.C6H8O7; CAS-69-22-7; 1,3,7-Trimethyl-2,6-dioxopurine; 1,3,7-Trimethylxanthine; 1958/8/2; 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione; 7-Methyltheophylline; Alert-pep; Anhydrous caffeine; Cafamil; Cafecon
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Status
Approved
Structure
Formula
C8H10N4O2
InChI
1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
InChIKey
RYYVLZVUVIJVGH-UHFFFAOYSA-N
PubChem CID
2519
INTEDE Drug ID
DR0257
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 1B1 (CYP1B1)
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Caffeine. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 1B1 (CYP1B1) is a therapeutic target for Caffeine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 1B1 (CYP1B1). [2], [3]
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Caffeine. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [4], [5]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Caffeine. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [4], [5]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Caffeine. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [4], [5]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Caffeine. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Caffeine through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [4], [5]
References
Ref 1 LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression. Oncogene. 2020 Jul;39(31):5358-5372. doi: 10.1038/s41388-020-1338-9. Epub 2020 Jun 23.
Ref 2 Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. Drug Metab Dispos. 1997 May;25(5):617-22.
Ref 3 METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F839-F847. doi: 10.1152/ajprenal.00222.2020. Epub 2020 Sep 21.
Ref 4 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 5 PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95. doi: 10.1097/FPC.0b013e3283505d5e.