m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01294)
Name
Selegiline hydrochloride
Synonyms
Selegiline Hcl; Selegiline hydrochloride; Selegilina; Selegilina [INN-Spanish]; Selegilinum; Selegilinum [INN-Latin]; Selegyline; UNII-2K1V7GP655; Zalapar; l-E 250; selegiline; selgene; (-)-Deprenil; (-)-selegiline; (R)-(-)-N,alpha-Dimethyl-N-2-propinylphenethylamine; (R)-(-)-N-Methyl-N-(1-phenyl-2-propyl)-2-propinylamin; 14611-51-9; 2K1V7GP655; Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, (R)-; CHEBI:9086; CHEMBL972; Carbex; Deprenyl; Emsam; Jumex; L-Deprenalin; N-methyl-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-amine; UNII-6W731X367Q; l-Deprenyl hydrochloride; (-)-Deprenil hydrochloride; (-)-Deprenyl hydrochloride; (-)-E-250 hydrochloride; (-)-Phenylisopropylmethylpropynylamine; (R)-(-)-Deprenyl hydrochloride; (R)-N-Methyl-N-(1-phenylpropan-2-yl)prop-2-yn-1-amine hydrochloride; 14611-52-0; 6W731X367Q; Eldepryl hydrochloride; FPF1100; HSDB 7183; Jumex hydrochloride; R-(-)-Deprenyl (hydrochloride)
    Click to Show/Hide
Status
Approved
Structure
3D MOL
2D MOL
Formula
C13H18ClN
InChI
1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1
InChIKey
IYETZZCWLLUHIJ-UTONKHPSSA-N
PubChem CID
26758
INTEDE Drug ID
DR1467
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selegiline hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Selegiline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selegiline hydrochloride. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Selegiline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selegiline hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Selegiline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Selegiline hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Selegiline hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
References
Ref 1 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 2 Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102. doi: 10.1124/dmd.31.9.1093.