m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01244)
Name
Ixazomib
Synonyms
Ixazomib; Ixazomib (MLN2238); Ixazomib (USAN); Ixazomib Impurity; Ixazomib [INN]; Ixazomib [USAN:INN]; Ixazomib(MLN2238); Ixozamib; MLN 2238; MLN-2238; MLN2238; MLN2238(Ixazomib); SCHEMBL3742758; (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid; (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid; 1072833-77-2; 71050168A2; C14H19BCl2N2O4; CHEBI:90942; CHEMBL2141296; CTK4A5116; EX-A547; GTPL8450; KS-00000PQX; UNII-71050168A2
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Status
Approved
Structure
3D MOL
2D MOL
Formula
C14H19BCl2N2O4
InChI
1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1
InChIKey
MXAYKZJJDUDWDS-LBPRGKRZSA-N
PubChem CID
25183872
INTEDE Drug ID
DR0901
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ixazomib. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Ixazomib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ixazomib. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Ixazomib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ixazomib. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Ixazomib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Ixazomib. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Ixazomib through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
References
Ref 1 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 2 Ninlaro- European Medicines Agency - European Union