m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02185)
Name
Diclofenac sodium
Synonyms
Delimon; Delphimix; Dichronic; Diclofenac (Sodium); Diclofenac sodium; Diclofenac sodium salt; Diclophenac sodium; Dyloject; EINECS 239-346-4; Feloran; GP 45840; Kriplex; Neriodin; Olfen; Orthophen; Ortofen; Prophenatin; Sodium (o-(2,6-dichloroanilino)phenyl)acetate; Sodium diclofenac; Tsudohmin; UNII-QTG126297Q; Urigon; Valetan; Voltaren ophthalmic; Voltarene; Vonafec; Vurdon; Diclofenac; Diclofenac acid; Diclofenac resinate; Diclofenaco; Diclofenaco [INN-Spanish]; Diclofenacum; Diclofenacum [INN-Latin]; Diclophenac; Novapirina; Pennsaid; ProSorb-D; UNII-144O8QL0L1; Voltaren; Voltarol; Dichlofenac; 15307-86-5; 2-((2,6-Dichlorophenyl)amino)benzeneacetic acid; 2-(2,6-Dichloroanilino)phenylacetic Acid; 2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid; 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid; Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-; CHEBI:47381; Cataflam; 15307-79-6; Allvoran; Anthraxiton; Assaren; Ba 47210; Batafil; Blesin; C14H10Cl2NNaO2; CCRIS 1909
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Status
Approved
Structure
3D MOL
2D MOL
Formula
C14H10Cl2NNaO2
InChI
1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
InChIKey
KPHWPUGNDIVLNH-UHFFFAOYSA-M
PubChem CID
5018304
INTEDE Drug ID
DR0488
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diclofenac sodium. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Diclofenac sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diclofenac sodium. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Diclofenac sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diclofenac sodium. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Diclofenac sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Diclofenac sodium. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Diclofenac sodium through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
References
Ref 1 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 2 Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry. 2004 Dec 14;43(49):15379-92. doi: 10.1021/bi0489309.