m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG03087)
Name
Paraoxon
Synonyms
Chinorta; Chinorto; Diethyl 4-nitrophenyl phosphate; Diethyl p-nitrophenyl phosphate; Diethyl paraoxon; Diethyl-p-nitrophenyl phosphate; Diethylparaoxon; Ester 25; Ethyl paraoxan; Ethyl paraoxon; Eticol; Fosfakol; Mintaco; Mintacol; Miotisal; Miotisal A; Oxyparathion; PARAOXON; Paraoxon-ethyl; Paraoxone; Paroxan; Pestox 101; Phosphachole; Phosphacol; Phosphakol; Soluglacit; Soluglaucit; p-Nitrophenyl diethyl phosphate; 311-45-5; E 600 (pesticide); Phosphoric acid diethyl 4-nitrophenyl ester; Phosphoric acid, diethyl 4-nitrophenyl ester
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Status
Investigative
Structure
Formula
C10H14NO6P
InChI
1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
InChIKey
WYMSBXTXOHUIGT-UHFFFAOYSA-N
PubChem CID
9395
INTEDE Drug ID
DR1241
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Paraoxon. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Paraoxon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Paraoxon. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Paraoxon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Paraoxon. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Paraoxon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Paraoxon. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Paraoxon through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
References
Ref 1 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 2 Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32. doi: 10.1016/j.tox.2006.04.024. Epub 2006 Apr 26.