General Information of the Drug (ID: M6APDG02629)
Name
Verapamil hydrochloride
Synonyms
Vasopten; Verabeta; Veracor; Verahexal; Veraloc; Veramil; Verapamil Ebewe; Verapamil HCl; Verapamil hydrochloride; Verapin; Verasal; Verasifar; Veratensin; Verdilac; Veroptinstada; Vetrimil; Vortac; Veramex; Verapamil [USAN:INN:BAN]; Verapamilo; Verapamilo [INN-Spanish]; Verapamilum; Verapamilum [INN-Latin]; Verelan; Verelan PM; Verpamil; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile; 52-53-9; Berkatens; CCRIS 6749; CP-16533-1; Calan; Calcan; Cardiagutt; Covera-HS; D-365; Dignover; Dilacoran; Falicard; Finoptin; Geangin; Iproveratril; Isoptimo; Isoptin; Isoptine; Isotopin; Izoptin; Lekoptin; Novo-Veramil; Quasar; Securon; Tarka; Univer; VERAPAMIL; Vasolan; (+/-)-VERAPAMIL HYDROCHLORIDE; 152-11-4; Anpec; Calaptin; Calcan hydrochloride; Cardiabeltin; Cardioprotect; Caveril; Civicor; Coraver; Corpamil; Durasoptin; Elthon; Flamon; Harteze; Hexasoptin; Hormitol; Ikacor; Ikapress; Inselon; Isoptino; Jenapamil; Lodixal; Magotiron; Manidon; Ormil; Praecicor; Rapam; Robatelan; Univex; Vasomil
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Status
Approved
Structure
3D MOL
Formula
C27H39ClN2O4
InChI
1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChIKey
DOQPXTMNIUCOSY-UHFFFAOYSA-N
PubChem CID
62969
INTEDE Drug ID
DR1681
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Verapamil hydrochloride. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Verapamil hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Verapamil hydrochloride. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Verapamil hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Verapamil hydrochloride. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Verapamil hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Verapamil hydrochloride. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Verapamil hydrochloride through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
References
Ref 1 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 2 Differential expression and function of CYP2C isoforms in human intestine and liver. Pharmacogenetics. 2003 Sep;13(9):565-75. doi: 10.1097/00008571-200309000-00005.