m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG03088)
Name
Estradiol cypionate
Synonyms
Estradiol cypionate; Depofemin; Depoestradiol; Depo-Estradiol; 313-06-4; Estrapo; Estradep; Depoestra; Estro-Depo; Dep-Estro; Femogen CYP; depGynogen; Depoestradiol cypionate; beta-Estradiol 17-cypionate; Estradiol 17-cypionate; Estradiol cyclopentylpropionate; Pertradiol; Estradiol (cypionate); E. Ionate P.A.; Neoginon Depositum; Estradiol 17-cyclopentylpropionate; Depo-estradiol cyclopentylpropionate; ECP (VAN); Estradiol 17beta-cypionate; NSC 3354; UNII-7E1DV054LO; Cyclopentanepropionic acid, 17-ester with estradiol
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Status
Approved
Structure
Formula
C26H36O3
InChI
1S/C26H36O3/c1-26-15-14-21-20-10-8-19(27)16-18(20)7-9-22(21)23(26)11-12-24(26)29-25(28)13-6-17-4-2-3-5-17/h8,10,16-17,21-24,27H,2-7,9,11-15H2,1H3/t21-,22-,23+,24+,26+/m1/s1
InChIKey
UOACKFBJUYNSLK-XRKIENNPSA-N
PubChem CID
9403
INTEDE Drug ID
DR0638
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol cypionate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Estradiol cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol cypionate. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Estradiol cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol cypionate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Estradiol cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Estradiol cypionate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Estradiol cypionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
References
Ref 1 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 2 Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin. 2001 Feb;22(2):148-54.