m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG02156)
Name
Propofol
Synonyms
Propofolum; Propofolum [Latin]; Propovan; Rapinovet; Recofol; propofol; 2,6-Bis(1-methylethyl)phenol; 2,6-DIISOPROPYLPHENOL; 2,6-Diisopropyl phenol; 2,6-bis(propan-2-yl)phenol; 2,6-di(propan-2-yl)phenol; 2078-54-8; C12H18O; CCRIS 9000; Ampofol; Diisopropylphenol; Diprifusor; Diprivan; Diprivan 10; Diprivan Injectable emulsion; Diprofol; Disoprivan; Disoprofol; Fresofol; Ivofol; Phenol, 2,6-bis(1-methylethyl)-; Phenol, 2,6-diisopropyl-; Propofol-Lipuro; EINECS 218-206-6; HSDB 7123; ICI 35868; ICI-35868; NSC 5105; Pofol; UNII-YI7VU623SF
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Status
Approved
Structure
Formula
C12H18O
InChI
1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
InChIKey
OLBCVFGFOZPWHH-UHFFFAOYSA-N
PubChem CID
4943
INTEDE Drug ID
DR1365
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Propofol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Propofol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Propofol. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Propofol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Propofol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Propofol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Propofol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Propofol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
References
Ref 1 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 2 Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95. doi: 10.1093/bja/80.6.788.