m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG01126)
Name
Benzyl alcohol
Synonyms
Bentalol; Benzal alcohol; Benzenecarbinol; Benzoyl alcohol; Benzyl alcohol (natural); Benzylicum; Alcool benzilico [DCIT]; Alcool benzylique; BENZYL-ALCOHOL; Euxyl K 100; Hydroxytoluene; Itch-X; Methanol, phenyl-; Phenolcarbinol; Phenyl Methanol; Phenyl-Methanol; Phenylcarbinolum; Phenylmethyl alcohol; alpha-Toluenol; alpha-hydroxytoluene; benzenemethanol; benzyl alcohol; benzylalcohol; benzylic alcohol; hydroxymethylbenzene; phenylcarbinol; phenylmethanol; (Hydroxymethyl)benzene; .alpha.-Toluenol; 100-51-6; Caswell No. 081F
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Status
Approved
Structure
Formula
C7H8O
InChI
1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
InChIKey
WVDDGKGOMKODPV-UHFFFAOYSA-N
PubChem CID
244
INTEDE Drug ID
DR0200
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Benzyl alcohol. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Benzyl alcohol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Benzyl alcohol. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Benzyl alcohol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Benzyl alcohol. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Benzyl alcohol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Benzyl alcohol. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Benzyl alcohol through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
References
Ref 1 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 2 Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65. doi: 10.1080/004982597240253.