m6A-centered Drug Response Information

General Information of the Drug (ID: M6APDG03023)
Name
Pentamidine isethionate
Synonyms
Pentamidine (isethionate); Pentamidine diisethionate; Pentamidine isethionate salt; Pentamidine isothionate; Pentaminide isetionate; USAF XR-10; V2P3K60DA2; 1,5-Bis(p-amidinophenoxy)pentane bis(2-hydroxyethanesulfonate salt); 140-64-7; 4,4'-(Pentamethylenedioxy)dibenzamidine bis(2-hydroxyethanesulfonate); 4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate); CCRIS 1660; CHEBI:7977; MFCD00079213; UNII-V2P3K60DA2; PENTAMIDINE ISETHIONATE; Nebupent (as isethionate); Pentacarinat (as isethionate); Pentam 300 (as isethionate); Pentamide; Pentamidin; Pentamidina; Pentamidina [DCIT]; Pentamidine [INN:BAN:DCF]; Pentamidine mesylate; Pentamidinum; Pentamidinum [INN-Latin]; pentamidine; 100-33-4; 4,4'-(Pentamethylenedioxy)dibenzamidine; 4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide; 4,4'-Diamidinodiphenoxypentane; CCRIS 3825; UNII-673LC5J4LQ; p,p'-(Pentamethylenedioxy)dibenzamidine
    Click to Show/Hide
Status
Approved
Structure
3D MOL
2D MOL
Formula
C23H36N4O10S2
InChI
1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;2*3-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6)
InChIKey
YBVNFKZSMZGRAD-UHFFFAOYSA-N
PubChem CID
8813
INTEDE Drug ID
DR1252
Target Gene(s) and Their Upstream m6A Regulator, Together with the Effect of Target Gene(s) in Drug Response
The target genes involved in drug-target interaction (such as drug-metabolizing enzymes, drug transporters and therapeutic targets) and drug-mediated cell death signaling (including modulating DNA damage and repair capacity, escaping from drug-induced apoptosis, autophagy, cellular metabolic reprogramming, oncogenic bypass signaling, cell microenvironment, cell stemness, etc.) could be regulated by m6A regulator(s) and affected their corresponding drug response. You can browse detailed information on drug-related target gene(s) mediated by m6A regulators.
Cytochrome P450 2C8 (CYP2C8)
Fat mass and obesity-associated protein (FTO)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pentamidine isethionate. The Fat mass and obesity-associated protein (FTO) has potential in affecting the response of Pentamidine isethionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 14 (METTL14)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pentamidine isethionate. The Methyltransferase-like 14 (METTL14) has potential in affecting the response of Pentamidine isethionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
Methyltransferase-like 3 (METTL3)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pentamidine isethionate. The Methyltransferase-like 3 (METTL3) has potential in affecting the response of Pentamidine isethionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
YTH domain-containing protein 2 (YTHDC2)
In total 1 mechanisms lead to this potential drug response
 Regulator Info 
Response Summary Cytochrome P450 2C8 (CYP2C8) is a therapeutic target for Pentamidine isethionate. The YTH domain-containing protein 2 (YTHDC2) has potential in affecting the response of Pentamidine isethionate through regulating the expression of Cytochrome P450 2C8 (CYP2C8). [1], [2]
References
Ref 1 Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression. Biochem Pharmacol. 2020 Jan;171:113697. doi: 10.1016/j.bcp.2019.113697. Epub 2019 Nov 7.
Ref 2 Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. doi: 10.1007/s00228-003-0636-9. Epub 2003 Aug 12.