m6A-centered Drug Response Information

General Information of the Drug (ID: M6ADRUG0007)
Name
Metformin
Synonyms
657-24-9; 1,1-Dimethylbiguanide; N,N-dimethylimidodicarbonimidic diamide; Metiguanide; Dimethylbiguanide; Glucophage; Haurymelin; Gliguanid; Fluamine; Glumetza; Flumamine; Melbin; Diabex; N,N-Dimethylbiguanide; Metformina; Metforminum; Metformine; Islotin; Glifage; Siofor; N1,N1-Dimethylbiguanide; DMGG; NNDG; Dimethyldiguanide; N,N-Dimethyldiguanide; Metformina [DCIT]; Imidodicarbonimidic diamide, N,N-dimethyl-; Metformina [Spanish]; Metforminum [INN-Latin]; Metformine [INN-French]; Metformin [USAN:INN:BAN]; 1,1-Dimethyl; Diabetosan; Dimethylbiguanidine; Dimethylguanylguanidine; Glycon; Diabex (TN); Diaformin (TN); Dianben (TN); Fortamet (TN); Gen-Metformin; Glucophage (TN); Glumetza (TN); LA-6023; Nu-Metformin; Obimet (TN); Riomet (TN); Metformin (USAN/INN); 1,1-Dimethyl biguanide; 3-(diaminomethylidene)-1,1-dimethylguanidine; [14C]metformin
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Status Approved [1]
Structure
Formula
C4H11N5
InChI
InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
InChIKey
XZWYZXLIPXDOLR-UHFFFAOYSA-N
PubChem CID
4091
TTD Drug ID
D0D7LA
DrugBank ID
DB00331
Full List of m6A Targets Related to This Drug
microRNA let-7b (MIRLET7B)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Drug Response by This Target Gene [3]
Response Summary The participation of Metformin decreased the bindings of DNMT3a/b to the METTL3 promoter with the help of the readers of NKAP and HNRNPA2B1.the mediation of m6A formation on pri-Let-7b processing increased the mature microRNA let-7b (MIRLET7B), whose key role is to suppress the Notch signaling and to re-captivate the Osimertinib treatment.The findings open up future drug development, targeting this pathway for lung cancer patients.
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Target Regulator NF-kappa-B-activating protein (NKAP) READER
 Regulator Info 
Pathway Response Notch signaling pathway hsa04330
In-vitro Model NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
HCC827 Lung adenocarcinoma Homo sapiens CVCL_2063
H1975OR (Osimertinib resistant H1975 cells)
HCC827OR (Osimertinib resistant HCC827 cells)
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
In total 35 item(s) under this drug
Crosstalk ID: M6ACROT02027
 Crosstalk Info 
m6A Regulator YTH domain-containing protein 2 (YTHDC2)
 Regulator Info 
m6A Target Circ_YTHDC2
 Target Gene 
Epigenetic Regulator Methylcytosine dioxygenase TET2 (TET2)
Regulated Target Myocardin (MYOCD)
Crosstalk relationship m6A → DNA modification
Disease Hematological disorders
 Disease Info 
Crosstalk ID: M6ACROT02028
 Crosstalk Info 
m6A Regulator YTH domain-containing protein 2 (YTHDC2)
 Regulator Info 
m6A Target Circ_YTHDC2
 Target Gene 
Epigenetic Regulator Methylcytosine dioxygenase TET2 (TET2)
Regulated Target Serum response factor (SRF)
Crosstalk relationship m6A → DNA modification
Disease Hematological disorders
 Disease Info 
Crosstalk ID: M6ACROT02029
 Crosstalk Info 
m6A Regulator YTH domain-containing protein 2 (YTHDC2)
 Regulator Info 
m6A Target Circ_YTHDC2
 Target Gene 
Epigenetic Regulator Methylcytosine dioxygenase TET2 (TET2)
Regulated Target Krueppel-like factor 4 (KLF4)
Crosstalk relationship m6A → DNA modification
Disease Hematological disorders
 Disease Info 
Crosstalk ID: M6ACROT02058
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02059
 Crosstalk Info 
m6A Regulator NF-kappa-B-activating protein (NKAP)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02060
 Crosstalk Info 
m6A Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02061
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02062
 Crosstalk Info 
m6A Regulator NF-kappa-B-activating protein (NKAP)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02063
 Crosstalk Info 
m6A Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02141
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target PI3-kinase subunit alpha (PI3k/PIK3CA)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02142
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target hsa-miR-143-3p
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02143
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Transcription factor JunB (JUNB)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02145
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Histone-lysine N-methyltransferase EZH2 (EZH2)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02146
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Hepatocyte growth factor receptor (c-Met/MET)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02147
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Zinc finger and BTB domain-containing protein 4 (ZBTB4)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02148
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Mutated in multiple advanced cancers 1 (PTEN)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02149
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target PI3-kinase subunit alpha (PI3k/PIK3CA)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02150
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target RAC-alpha serine/threonine-protein kinase (AKT1)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02151
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Serine/threonine-protein kinase mTOR (MTOR)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02152
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target SVIL antisense RNA 1 (SVIL-AS1)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02153
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target SH3 domain-binding protein 5 (SH3BP5)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02154
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target PI3-kinase subunit alpha (PI3k/PIK3CA)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02155
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target hsa-miR-143-3p
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02156
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Transcription factor JunB (JUNB)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02158
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Histone-lysine N-methyltransferase EZH2 (EZH2)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02159
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Hepatocyte growth factor receptor (c-Met/MET)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02160
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Zinc finger and BTB domain-containing protein 4 (ZBTB4)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02161
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Mutated in multiple advanced cancers 1 (PTEN)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02162
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target PI3-kinase subunit alpha (PI3k/PIK3CA)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02163
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target RAC-alpha serine/threonine-protein kinase (AKT1)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02164
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Serine/threonine-protein kinase mTOR (MTOR)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02165
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target SVIL antisense RNA 1 (SVIL-AS1)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02166
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target SH3 domain-binding protein 5 (SH3BP5)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT05550
 Crosstalk Info 
m6A Regulator NF-kappa-B-activating protein (NKAP)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator MicroRNA let-7b (MIRLET7B)
Crosstalk relationship m6A → ncRNA
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT05551
 Crosstalk Info 
m6A Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator MicroRNA let-7b (MIRLET7B)
Crosstalk relationship m6A → ncRNA
Disease Lung cancer
 Disease Info 
References
Ref 1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 2 Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies. Drug Metab Dispos. 2000 Jul;28(7):789-800.
Ref 3 Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner. Front Oncol. 2022 Jan 6;11:731561. doi: 10.3389/fonc.2021.731561. eCollection 2021.