m6A Target Gene Information
General Information of the m6A Target Gene (ID: M6ATAR00053)
| Target Name | Circ_YTHDC2 | ||||
|---|---|---|---|---|---|
| Gene Name | Circ_YTHDC2 | ||||
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
Circ_YTHDC2
can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
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YTH domain-containing protein 2 (YTHDC2) [READER]
| In total 1 item(s) under this regulator | ||||
| Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene | [1] | |||
| Response Summary | YTHDC2/Circ_YTHDC2/TET2 pathway is an important target of metformin in preventing the progression of VSMCs dysfunction under high glucose. | |||
| Target Regulation | Up regulation | |||
| Responsed Disease | Hematological disorders | ICD-11: 3C0Z | ||
| In-vitro Model | A7r5 | Normal | Rattus norvegicus | CVCL_0137 |
Hematological disorders [ICD-11: 3C0Z]
| In total 1 item(s) under this disease | ||||
| Experiment 1 Reporting the m6A-centered Disease Response | [1] | |||
| Response Summary | YTHDC2/Circ_YTHDC2/TET2 pathway is an important target of metformin in preventing the progression of VSMCs dysfunction under high glucose. | |||
| Responsed Disease | Hematological disorders [ICD-11: 3C0Z] | |||
| Target Regulator | YTH domain-containing protein 2 (YTHDC2) | READER | ||
| Target Regulation | Up regulation | |||
| In-vitro Model | A7r5 | Normal | Rattus norvegicus | CVCL_0137 |
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
DNA modification
m6A Regulator: YTH domain-containing protein 2 (YTHDC2)
| In total 4 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT02027 | ||
| Epigenetic Regulator | Methylcytosine dioxygenase TET2 (TET2) | |
| Regulated Target | Myocardin (MYOCD) | |
| Crosstalk relationship | m6A → DNA modification | |
| Disease | Hematological disorders | |
| Drug | Metformin | |
| Crosstalk ID: M6ACROT02028 | ||
| Epigenetic Regulator | Methylcytosine dioxygenase TET2 (TET2) | |
| Regulated Target | Serum response factor (SRF) | |
| Crosstalk relationship | m6A → DNA modification | |
| Disease | Hematological disorders | |
| Drug | Metformin | |
| Crosstalk ID: M6ACROT02029 | ||
| Epigenetic Regulator | Methylcytosine dioxygenase TET2 (TET2) | |
| Regulated Target | Krueppel-like factor 4 (KLF4) | |
| Crosstalk relationship | m6A → DNA modification | |
| Disease | Hematological disorders | |
| Drug | Metformin | |
| Crosstalk ID: M6ACROT02097 | ||
| Epigenetic Regulator | Methylcytosine dioxygenase TET2 (TET2) | |
| Crosstalk relationship | m6A → DNA modification | |
| Disease | Hematological disorders | |
Non-coding RNA
m6A Regulator: YTH domain-containing protein 2 (YTHDC2)
| In total 1 item(s) under this m6A regulator | ||
| Crosstalk ID: M6ACROT05527 | ||
| Epigenetic Regulator | Circ_YTHDC2 | |
| Regulated Target | Tet methylcytosine dioxygenase 2 (TET2) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Hematological disorders | |