m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00673)

Target Name	SVIL antisense RNA 1 (SVIL-AS1)
Synonyms	RP11-534G20.3 Click to Show/Hide
Gene Name	SVIL-AS1
Chromosomal Location	10p11.23
Gene ID	102724316
HGNC ID	HGNC:51219

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

SVIL-AS1 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RIP-seq result supporting the interaction between SVIL-AS1 and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 9.54E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	The reduction in cell proliferation induced by SVIL antisense RNA 1 (SVIL-AS1) overexpression could be rescued by E2F1 overexpression or METTL3 knockdown. In conclusion, METTL3-induced SVIL-AS1 in LUAD, which connects m6A and lncRNA in lung cancer carcinogenesis.
Target Regulation	Up regulation
Responsed Disease	Lung cancer		ICD-11: 2C25	Disease Info
In-vitro Model	NCI-H1650	Minimally invasive lung adenocarcinoma	Homo sapiens	CVCL_1483
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
In-vivo Model	A549 cells (1 × 10⁶ cells) were intraperitoneally injected into the abdomen of nude mice. Tumor length and width were measured and recorded every 4 days after inoculation. Tumor volume was calculated as 1/2 × length × width2. The tumor weight was weighed and recorded 20 days after inoculation.

Lung cancer [ICD-11: 2C25]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	The reduction in cell proliferation induced by SVIL antisense RNA 1 (SVIL-AS1) overexpression could be rescued by E2F1 overexpression or METTL3 knockdown. In conclusion, METTL3-induced SVIL-AS1 in LUAD, which connects m6A and lncRNA in lung cancer carcinogenesis.
Responsed Disease	Lung cancer [ICD-11: 2C25]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
In-vitro Model	NCI-H1650	Minimally invasive lung adenocarcinoma	Homo sapiens	CVCL_1483
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens	CVCL_0023
In-vivo Model	A549 cells (1 × 10⁶ cells) were intraperitoneally injected into the abdomen of nude mice. Tumor length and width were measured and recorded every 4 days after inoculation. Tumor volume was calculated as 1/2 × length × width2. The tumor weight was weighed and recorded 20 days after inoculation.

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 4 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02152		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info
Drug	Metformin	Drug Info
Crosstalk ID: M6ACROT02165		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info
Drug	Metformin	Drug Info
Crosstalk ID: M6ACROT02178		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info
Drug	Osimertinib	Drug Info
Crosstalk ID: M6ACROT02191		Crosstalk Info
Epigenetic Regulator	DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	DNA modification → m6A
Disease	Lung cancer	Disease Info
Drug	Osimertinib	Drug Info

Histone modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03388		Crosstalk Info
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Lung cancer	Disease Info
Drug	Gefitinib	Drug Info
Crosstalk ID: M6ACROT03401		Crosstalk Info
Regulated Target	Histone H3 lysine 4 monomethylation (H3K4me1)
Crosstalk relationship	Histone modification → m6A
Disease	Lung cancer	Disease Info
Drug	Gefitinib	Drug Info

Non-coding RNA

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05617		Crosstalk Info
Epigenetic Regulator	SVIL antisense RNA 1 (SVIL-AS1)
Regulated Target	Transcription factor E2F1 (E2F1)
Crosstalk relationship	m6A → ncRNA
Disease	Lung cancer	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00673)

SVIL antisense RNA 1 (SVIL-AS1)

Adenosine-to-Inosine editing (A-to-I)

In total 6 m6A sequence/site(s) in this target gene
mod ID: A2ISITE004049		Click to Show/Hide the Full List
mod site	chr10:29459194-29459195:+		[2]
Sequence	TCATAGCTCTCTGCAGCCTTAAACTCCTGGACTCAAGCAGT
Transcript ID List	ENST00000446807.5; ENST00000414457.5; ENST00000455774.1; ENST00000423223.5; ENST00000445521.5; ENST00000413405.5
External Link	RMBase: RNA-editing_site_15253
mod ID: A2ISITE004050		Click to Show/Hide the Full List
mod site	chr10:29459993-29459994:+		[2]
Sequence	CTACCTACTTGGGGTGGCTGAGGTGGTAGGGTCGTTTGAGC
Transcript ID List	ENST00000413405.5; ENST00000455774.1; ENST00000446807.5; ENST00000423223.5; ENST00000414457.5; rmsk_3271266; ENST00000445521.5
External Link	RMBase: RNA-editing_site_15255
mod ID: A2ISITE004051		Click to Show/Hide the Full List
mod site	chr10:29460000-29460001:+		[2]
Sequence	CTTGGGGTGGCTGAGGTGGTAGGGTCGTTTGAGCCCAGGGG
Transcript ID List	rmsk_3271266; ENST00000414457.5; ENST00000455774.1; ENST00000413405.5; ENST00000423223.5; ENST00000445521.5; ENST00000446807.5
External Link	RMBase: RNA-editing_site_15256
mod ID: A2ISITE004052		Click to Show/Hide the Full List
mod site	chr10:29460024-29460025:+		[2]
Sequence	TCGTTTGAGCCCAGGGGTTCAAGGTTTGTGTGAGCCATGAT
Transcript ID List	ENST00000446807.5; ENST00000423223.5; ENST00000445521.5; rmsk_3271266; ENST00000414457.5; ENST00000455774.1; ENST00000413405.5
External Link	RMBase: RNA-editing_site_15257
mod ID: A2ISITE004053		Click to Show/Hide the Full List
mod site	chr10:29460040-29460041:+		[2]
Sequence	GTTCAAGGTTTGTGTGAGCCATGATTGAGTCACCACACTGC
Transcript ID List	ENST00000414457.5; ENST00000455774.1; ENST00000446807.5; ENST00000445521.5; ENST00000423223.5; ENST00000413405.5; rmsk_3271266
External Link	RMBase: RNA-editing_site_15258
mod ID: A2ISITE004054		Click to Show/Hide the Full List
mod site	chr10:29460054-29460055:+		[2]
Sequence	TGAGCCATGATTGAGTCACCACACTGCAGCCTGGGTGACAA
Transcript ID List	ENST00000414457.5; ENST00000413405.5; ENST00000423223.5; ENST00000455774.1; ENST00000445521.5; ENST00000446807.5; rmsk_3271266
External Link	RMBase: RNA-editing_site_15259

N6-methyladenosine (m6A)

In total 35 m6A sequence/site(s) in this target gene
mod ID: M6ASITE095984		Click to Show/Hide the Full List
mod site	chr10:29410254-29410255:+		[3]
Sequence	TATTAGTCGTCTGTGAAAGAACAGCTGGATCTTGTGAAGTG
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; GSC-11; HEK293A-TOA; iSLK; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000438202.5; ENST00000445521.5; ENST00000446807.5; ENST00000609413.5; ENST00000623175.3; ENST00000455774.1; ENST00000423223.5; ENST00000414457.5; ENST00000413405.5; ENST00000430295.5; ENST00000608994.5; ENST00000646086.1; ENST00000427063.6
External Link	RMBase: m6A_site_96567
mod ID: M6ASITE095985		Click to Show/Hide the Full List
mod site	chr10:29415395-29415396:+		[4]
Sequence	GATGATACCTTTGATCCAGAACTTGCAGCAACAATAGGTGA
Motif Score	3.373380952
Cell/Tissue List	A549
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000413405.5; ENST00000455774.1; ENST00000445521.5; ENST00000430295.5; ENST00000414457.5; ENST00000423223.5; ENST00000446807.5; ENST00000438202.5; ENST00000623175.3; ENST00000646086.1; ENST00000609413.5; ENST00000608994.5; ENST00000427063.6
External Link	RMBase: m6A_site_96568
mod ID: M6ASITE095986		Click to Show/Hide the Full List
mod site	chr10:29418207-29418208:+		[4]
Sequence	CACTTTACATCACTTTCCAGACAACTGGAATTTGAGACAAT
Motif Score	2.897386905
Cell/Tissue List	A549
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000446807.5; ENST00000608994.5; ENST00000430295.5; ENST00000623175.3; ENST00000455774.1; ENST00000445521.5; ENST00000413405.5; ENST00000423223.5; ENST00000414457.5; ENST00000438202.5; ENST00000609413.5; ENST00000427063.6
External Link	RMBase: m6A_site_96569
mod ID: M6ASITE095987		Click to Show/Hide the Full List
mod site	chr10:29418223-29418224:+		[4]
Sequence	CCAGACAACTGGAATTTGAGACAATGTCTGTGACAGCAGTC
Motif Score	2.897386905
Cell/Tissue List	A549
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000609413.5; ENST00000413405.5; ENST00000623175.3; ENST00000427063.6; ENST00000455774.1; ENST00000445521.5; ENST00000438202.5; ENST00000414457.5; ENST00000446807.5; ENST00000608994.5; ENST00000430295.5; ENST00000423223.5
External Link	RMBase: m6A_site_96570
mod ID: M6ASITE095988		Click to Show/Hide the Full List
mod site	chr10:29420510-29420511:+		[3]
Sequence	ACAATGCAGGAATCACATGAACCTGTCCATCCACAGATAAA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000609413.5; ENST00000445521.5; ENST00000423223.5; ENST00000427063.6; rmsk_3271187; ENST00000446807.5; ENST00000430295.5; ENST00000623175.3; ENST00000438202.5; ENST00000413405.5; ENST00000608994.5; ENST00000455774.1; ENST00000414457.5
External Link	RMBase: m6A_site_96571
mod ID: M6ASITE095989		Click to Show/Hide the Full List
mod site	chr10:29420542-29420543:+		[3]
Sequence	ACAGATAAAGTGGTAAAGAAACTGCCGTATTAGATACATGA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; A549; fibroblasts
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000455774.1; ENST00000414457.5; ENST00000609413.5; ENST00000427063.6; rmsk_3271187; ENST00000438202.5; ENST00000423223.5; ENST00000445521.5; ENST00000446807.5; ENST00000413405.5; ENST00000430295.5; ENST00000623175.3
External Link	RMBase: m6A_site_96572
mod ID: M6ASITE095990		Click to Show/Hide the Full List
mod site	chr10:29420595-29420596:+		[3]
Sequence	CAGCCATAAAGCTTCGGGAAACCCTGTCATCCGCAACCACG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; hNPCs; fibroblasts; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000446807.5; ENST00000423223.5; ENST00000427063.6; ENST00000438202.5; ENST00000623175.3; rmsk_3271187; ENST00000609413.5; ENST00000445521.5; ENST00000413405.5; ENST00000430295.5; ENST00000414457.5; ENST00000455774.1
External Link	RMBase: m6A_site_96573
mod ID: M6ASITE095991		Click to Show/Hide the Full List
mod site	chr10:29420623-29420624:+		[3]
Sequence	ATCCGCAACCACGTGGAGAAACCTGTCCATCCACAGATGAA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; U2OS; hNPCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000455774.1; ENST00000438202.5; rmsk_3271187; ENST00000427063.6; ENST00000446807.5; ENST00000609413.5; ENST00000430295.5; ENST00000445521.5; ENST00000413405.5; ENST00000414457.5; ENST00000423223.5; ENST00000623175.3
External Link	RMBase: m6A_site_96574
mod ID: M6ASITE095992		Click to Show/Hide the Full List
mod site	chr10:29420735-29420736:+		[3]
Sequence	GTTTGGAGCAACACAGATGAACCTGTCCATCCACAAATGAA
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000455774.1; ENST00000623175.3; ENST00000446807.5; ENST00000430295.5; ENST00000427063.6; ENST00000609413.5; ENST00000413405.5; ENST00000423223.5; rmsk_3271188; ENST00000445521.5; ENST00000414457.5; ENST00000438202.5
External Link	RMBase: m6A_site_96575
mod ID: M6ASITE095993		Click to Show/Hide the Full List
mod site	chr10:29420757-29420758:+		[3]
Sequence	CTGTCCATCCACAAATGAAGACATCAAGAAACTCTAGTATG
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000446807.5; ENST00000430295.5; rmsk_3271189; ENST00000414457.5; ENST00000413405.5; ENST00000455774.1; ENST00000438202.5; ENST00000423223.5; ENST00000427063.6; ENST00000445521.5
External Link	RMBase: m6A_site_96576
mod ID: M6ASITE095994		Click to Show/Hide the Full List
mod site	chr10:29420767-29420768:+		[3]
Sequence	ACAAATGAAGACATCAAGAAACTCTAGTATGTACACAAGGC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000423223.5; rmsk_3271189; ENST00000430295.5; ENST00000414457.5; ENST00000446807.5; ENST00000413405.5; ENST00000455774.1; ENST00000438202.5; ENST00000445521.5; ENST00000427063.6
External Link	RMBase: m6A_site_96577
mod ID: M6ASITE095995		Click to Show/Hide the Full List
mod site	chr10:29420791-29420792:+		[3]
Sequence	TAGTATGTACACAAGGCAAAACACTTCAGCTATCAAAATCA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; Huh7; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000413405.5; rmsk_3271189; ENST00000455774.1; ENST00000438202.5; ENST00000414457.5; ENST00000445521.5; ENST00000430295.5; ENST00000423223.5; ENST00000446807.5; ENST00000427063.6
External Link	RMBase: m6A_site_96578
mod ID: M6ASITE095996		Click to Show/Hide the Full List
mod site	chr10:29420984-29420985:+		[3]
Sequence	GCTGACCCAGCAATAACTGAACAGCTGATATGTACCTCACA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hESCs; fibroblasts; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000445521.5; ENST00000430295.5; ENST00000423223.5; ENST00000438202.5; ENST00000446807.5; ENST00000413405.5; ENST00000427063.6; ENST00000455774.1; ENST00000414457.5
External Link	RMBase: m6A_site_96579
mod ID: M6ASITE095997		Click to Show/Hide the Full List
mod site	chr10:29421119-29421120:+		[3]
Sequence	TTAATCCCAGTGAGCTCCAAACAAGTTTTAGGAGGCTCCCC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000413405.5; ENST00000446807.5; ENST00000430295.5; ENST00000438202.5; ENST00000423223.5; ENST00000414457.5; ENST00000427063.6; ENST00000455774.1; ENST00000445521.5
External Link	RMBase: m6A_site_96580
mod ID: M6ASITE095998		Click to Show/Hide the Full List
mod site	chr10:29421143-29421144:+		[3]
Sequence	GTTTTAGGAGGCTCCCCAAAACCAGTGAAGACTTTAACTAA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000445521.5; ENST00000414457.5; ENST00000446807.5; ENST00000438202.5; ENST00000430295.5; ENST00000455774.1; ENST00000423223.5; ENST00000427063.6; ENST00000413405.5
External Link	RMBase: m6A_site_96581
mod ID: M6ASITE095999		Click to Show/Hide the Full List
mod site	chr10:29421153-29421154:+		[3]
Sequence	GCTCCCCAAAACCAGTGAAGACTTTAACTAAAAGTAGAATT
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; fibroblasts; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000438202.5; ENST00000423223.5; ENST00000445521.5; ENST00000427063.6; ENST00000430295.5; ENST00000413405.5; ENST00000446807.5; ENST00000414457.5; ENST00000455774.1
External Link	RMBase: m6A_site_96582
mod ID: M6ASITE096000		Click to Show/Hide the Full List
mod site	chr10:29421188-29421189:+		[3]
Sequence	AGAATTTCAAAGTATTAGAAACCAAACCCCAAAATTAAATG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000430295.5; ENST00000455774.1; ENST00000438202.5; ENST00000413405.5; ENST00000445521.5; ENST00000446807.5; ENST00000423223.5; ENST00000427063.6; ENST00000414457.5
External Link	RMBase: m6A_site_96583
mod ID: M6ASITE096001		Click to Show/Hide the Full List
mod site	chr10:29421193-29421194:+		[3]
Sequence	TTCAAAGTATTAGAAACCAAACCCCAAAATTAAATGTGAAG
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; A549; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000446807.5; ENST00000414457.5; ENST00000413405.5; ENST00000430295.5; ENST00000423223.5; ENST00000438202.5; ENST00000445521.5; ENST00000455774.1; ENST00000427063.6
External Link	RMBase: m6A_site_96584
mod ID: M6ASITE096002		Click to Show/Hide the Full List
mod site	chr10:29421248-29421249:+		[3]
Sequence	TGAGCTGGCCCATCTGGTGGACACAGGATTTGCGTTATCGA
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; A549; hESC-HEK293T; GM12878; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000446807.5; ENST00000455774.1; ENST00000445521.5; ENST00000423223.5; ENST00000430295.5; ENST00000427063.6; ENST00000438202.5; ENST00000413405.5; ENST00000414457.5
External Link	RMBase: m6A_site_96585
mod ID: M6ASITE096003		Click to Show/Hide the Full List
mod site	chr10:29421352-29421353:+		[3]
Sequence	TACCAAATACAGCAGAGCAAACCCGGCTTTGAGGCAAGGGC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; A549; U2OS; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000455774.1; ENST00000413405.5; ENST00000445521.5; ENST00000438202.5; ENST00000423223.5; ENST00000414457.5; ENST00000427063.6; ENST00000430295.5; ENST00000446807.5
External Link	RMBase: m6A_site_96586
mod ID: M6ASITE096004		Click to Show/Hide the Full List
mod site	chr10:29421460-29421461:+		[5]
Sequence	TTCTCCTGGCCTCCTTGTAAACCCAAACCGCCAGGTACCTC
Motif Score	2.185083333
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000446807.5; ENST00000438202.5; ENST00000455774.1; ENST00000413405.5; ENST00000427063.6; ENST00000445521.5; ENST00000414457.5; ENST00000430295.5; ENST00000423223.5
External Link	RMBase: m6A_site_96587
mod ID: M6ASITE096005		Click to Show/Hide the Full List
mod site	chr10:29421466-29421467:+		[5]
Sequence	TGGCCTCCTTGTAAACCCAAACCGCCAGGTACCTCAATTTT
Motif Score	2.185083333
Cell/Tissue List	iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000430295.5; ENST00000446807.5; ENST00000445521.5; ENST00000438202.5; ENST00000427063.6; ENST00000414457.5; ENST00000455774.1; ENST00000413405.5; ENST00000423223.5
External Link	RMBase: m6A_site_96588
mod ID: M6ASITE096006		Click to Show/Hide the Full List
mod site	chr10:29422028-29422029:+		[3]
Sequence	GCCCTACACCAAAGTGGGAGACATTCAGAATCGAGGCGAAA
Motif Score	2.897386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; fibroblasts; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000427063.6; ENST00000438202.5; ENST00000413405.5; ENST00000445521.5; ENST00000446807.5; ENST00000455774.1; ENST00000430295.5; ENST00000423223.5; ENST00000414457.5
External Link	RMBase: m6A_site_96597
mod ID: M6ASITE096007		Click to Show/Hide the Full List
mod site	chr10:29422125-29422126:+		[3]
Sequence	GCCCTGTGTGAATGTGGAAGACCAGCAGATTGGAGGTGGAA
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; TIME; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000427063.6; ENST00000413405.5; ENST00000438202.5; ENST00000445521.5; ENST00000446807.5; ENST00000455774.1; ENST00000414457.5; ENST00000430295.5; ENST00000423223.5
External Link	RMBase: m6A_site_96598
mod ID: M6ASITE096008		Click to Show/Hide the Full List
mod site	chr10:29424094-29424095:+		[6]
Sequence	AACTATAACATGACTTAAGAACTTTTATGCATGGACTTTGT
Motif Score	3.373380952
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000445521.5; ENST00000455774.1; ENST00000438202.5; ENST00000423223.5; ENST00000414457.5; ENST00000413405.5; ENST00000430295.5; ENST00000446807.5
External Link	RMBase: m6A_site_96599
mod ID: M6ASITE096009		Click to Show/Hide the Full List
mod site	chr10:29458332-29458333:+		[3]
Sequence	CCTCGTCATGTCTAGTGCAAACTGGAAACATTGGGAGAAGC
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000445521.5; ENST00000423223.5; ENST00000438202.5; ENST00000455774.1; ENST00000430295.5; ENST00000414457.5; ENST00000446807.5; ENST00000413405.5
External Link	RMBase: m6A_site_96609
mod ID: M6ASITE096010		Click to Show/Hide the Full List
mod site	chr10:29458339-29458340:+		[3]
Sequence	ATGTCTAGTGCAAACTGGAAACATTGGGAGAAGCGCCCCGC
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000445521.5; ENST00000413405.5; ENST00000423223.5; ENST00000455774.1; ENST00000438202.5; ENST00000414457.5; ENST00000446807.5; ENST00000430295.5
External Link	RMBase: m6A_site_96610
mod ID: M6ASITE096011		Click to Show/Hide the Full List
mod site	chr10:29458424-29458425:+		[3]
Sequence	ATCCCCACCCCACCGGAAGAACCGCTTACCTCGAAGTCTTC
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000455774.1; ENST00000445521.5; ENST00000446807.5; ENST00000414457.5; ENST00000423223.5; ENST00000413405.5; ENST00000438202.5
External Link	RMBase: m6A_site_96611
mod ID: M6ASITE096012		Click to Show/Hide the Full List
mod site	chr10:29458661-29458662:+		[7]
Sequence	GTTTTATTAAGTGCTTACAGACACACAGCCCTGTGCCACCT
Motif Score	2.897386905
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000413405.5; ENST00000438202.5; ENST00000446807.5; ENST00000414457.5; ENST00000423223.5; ENST00000455774.1; ENST00000445521.5
External Link	RMBase: m6A_site_96615
mod ID: M6ASITE096013		Click to Show/Hide the Full List
mod site	chr10:29458773-29458774:+		[5]
Sequence	AAAGCCCTGCAGTTGTCTGGACTTTTAATTTTTAAAATTTT
Motif Score	4.065041667
Cell/Tissue List	MSC; TIME
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000414457.5; ENST00000455774.1; ENST00000445521.5; ENST00000423223.5; ENST00000413405.5; ENST00000438202.5; ENST00000446807.5
External Link	RMBase: m6A_site_96616
mod ID: M6ASITE096014		Click to Show/Hide the Full List
mod site	chr10:29483278-29483279:+		[8]
Sequence	CAGATTGCAGGGTGAGGGGGACAAACCTGGGCCAGGAGCCA
Motif Score	3.643047619
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000413405.5; ENST00000414457.5; ENST00000446807.5
External Link	RMBase: m6A_site_96638
mod ID: M6ASITE096015		Click to Show/Hide the Full List
mod site	chr10:29487188-29487189:+		[3]
Sequence	CTTTTCTATGACGTTTGCAAACTCTCCTACCCACAGGAAGC
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000413405.5
External Link	RMBase: m6A_site_96653
mod ID: M6ASITE096016		Click to Show/Hide the Full List
mod site	chr10:29487303-29487304:+		[3]
Sequence	TGCACATGTCTTCTTCCTGAACACGAGGCAGACAGTCACCG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000413405.5
External Link	RMBase: m6A_site_96658
mod ID: M6ASITE096017		Click to Show/Hide the Full List
mod site	chr10:29487314-29487315:+		[3]
Sequence	TCTTCCTGAACACGAGGCAGACAGTCACCGTCTTTCCAGAC
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000413405.5
External Link	RMBase: m6A_site_96659
mod ID: M6ASITE096018		Click to Show/Hide the Full List
mod site	chr10:29487333-29487334:+		[3]
Sequence	GACAGTCACCGTCTTTCCAGACAGAACGGGGATAGGACGCA
Motif Score	2.897386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000413405.5
External Link	RMBase: m6A_site_96660

Ref 1	N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1. Bioengineered. 2022 Feb;13(2):3093-3107. doi: 10.1080/21655979.2022.2025697.
Ref 2	Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol. 2004 Aug;22(8):1001-5. doi: 10.1038/nbt996. Epub 2004 Jul 18.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 5	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 6	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 7	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 8	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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