m6A-centered Drug Response Information

General Information of the Drug (ID: M6ADRUG0090)
Name
Osimertinib
Synonyms
Osimertinib
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Status Approved [1]
Structure
Formula
C28H33N7O2
InChI
InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)
InChIKey
DUYJMQONPNNFPI-UHFFFAOYSA-N
PubChem CID
71496458
TTD Drug ID
D0O8GK
DrugBank ID
DB09330
Full List of m6A Targets Related to This Drug
microRNA let-7b (MIRLET7B)
 Target Info 
In total 1 item(s) under this target gene
Experiment 1 Reporting the m6A-centered Drug Response by This Target Gene [2]
Response Summary The participation of Metformin decreased the bindings of DNMT3a/b to the METTL3 promoter with the help of the readers of NKAP and HNRNPA2B1.the mediation of m6A formation on pri-Let-7b processing increased the mature microRNA let-7b (MIRLET7B), whose key role is to suppress the Notch signaling and to re-captivate the Osimertinib treatment.The findings open up future drug development, targeting this pathway for lung cancer patients.
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Pathway Response Notch signaling pathway hsa04330
In-vitro Model NCI-H1975 Lung adenocarcinoma Homo sapiens CVCL_1511
HCC827 Lung adenocarcinoma Homo sapiens CVCL_2063
H1975OR (Osimertinib resistant H1975 cells)
HCC827OR (Osimertinib resistant HCC827 cells)
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
In total 33 item(s) under this drug
Crosstalk ID: M6ACROT02064
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02065
 Crosstalk Info 
m6A Regulator NF-kappa-B-activating protein (NKAP)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02066
 Crosstalk Info 
m6A Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02067
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02068
 Crosstalk Info 
m6A Regulator NF-kappa-B-activating protein (NKAP)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02069
 Crosstalk Info 
m6A Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02167
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target PI3-kinase subunit alpha (PI3k/PIK3CA)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02168
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target hsa-miR-143-3p
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02169
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Transcription factor JunB (JUNB)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02171
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Histone-lysine N-methyltransferase EZH2 (EZH2)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02172
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Hepatocyte growth factor receptor (c-Met/MET)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02173
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Zinc finger and BTB domain-containing protein 4 (ZBTB4)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02174
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Mutated in multiple advanced cancers 1 (PTEN)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02175
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target PI3-kinase subunit alpha (PI3k/PIK3CA)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02176
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target RAC-alpha serine/threonine-protein kinase (AKT1)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02177
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Serine/threonine-protein kinase mTOR (MTOR)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02178
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target SVIL antisense RNA 1 (SVIL-AS1)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02179
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target SH3 domain-binding protein 5 (SH3BP5)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02180
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target PI3-kinase subunit alpha (PI3k/PIK3CA)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02181
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target hsa-miR-143-3p
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02182
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Transcription factor JunB (JUNB)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02184
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Histone-lysine N-methyltransferase EZH2 (EZH2)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02185
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Hepatocyte growth factor receptor (c-Met/MET)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02186
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Zinc finger and BTB domain-containing protein 4 (ZBTB4)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02187
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Mutated in multiple advanced cancers 1 (PTEN)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02188
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target PI3-kinase subunit alpha (PI3k/PIK3CA)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02189
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target RAC-alpha serine/threonine-protein kinase (AKT1)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02190
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Serine/threonine-protein kinase mTOR (MTOR)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02191
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target SVIL antisense RNA 1 (SVIL-AS1)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT02192
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target SH3 domain-binding protein 5 (SH3BP5)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Regulated Target Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship DNA modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT03380
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Regulated Target Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship Histone modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT03393
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Regulated Target Histone H3 lysine 4 monomethylation (H3K4me1)
Crosstalk relationship Histone modification → m6A
Disease Lung cancer
 Disease Info 
Crosstalk ID: M6ACROT05549
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target microRNA let-7b (MIRLET7B)
 Target Gene 
Epigenetic Regulator MicroRNA let-7b (MIRLET7B)
Crosstalk relationship m6A → ncRNA
Disease Lung cancer
 Disease Info 
References
Ref 1 mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 Sep;561(7724):556-560. doi: 10.1038/s41586-018-0538-8. Epub 2018 Sep 19.
Ref 2 Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner. Front Oncol. 2022 Jan 6;11:731561. doi: 10.3389/fonc.2021.731561. eCollection 2021.