m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00302)
Target Name Transcription factor JunB (JUNB)
Synonyms
Transcription factor AP-1 subunit JunB
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Gene Name JUNB
Chromosomal Location 19p13.13
Family bZIP family; Jun subfamily
Function
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity).
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Gene ID 3726
Uniprot ID
JUNB_HUMAN
HGNC ID
HGNC:6205
Ensembl Gene ID
ENSG00000171223
KEGG ID
hsa:3726
Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)
JUNB can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).
Browse Regulator
Browse Disease
Methyltransferase-like 3 (METTL3) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by METTL3
Cell Line ARPE-19 cell line Homo sapiens
Treatment: shMETTL3 ARPE-19 cells
Control: shControl ARPE-19 cells
 GSE202017
Regulation
logFC: -8.92E-01
p-value: 4.99E-05
More Results Click to View More RNA-seq Results
Representative RIP-seq result supporting the interaction between JUNB and the regulator
Cell Line MDA-MB-231 Homo sapiens
Regulation logFC: 2.95E+00 GSE60213
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [1]
Response Summary m6A methyltransferase METTL3 is indispensable for TGF-beta-induced EMT of lung cancer cells through the regulation of Transcription factor JunB (JUNB).
Target Regulation Up regulation
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Pathway Response Cytokine-cytokine receptor interaction hsa04060
Cell Process Epithelial-mesenchymal transition
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
LC-2/ad Lung adenocarcinoma Homo sapiens CVCL_1373
Wilms tumor 1-associating protein (WTAP) [WRITER]
 Regulator Info 
Representative RNA-seq result indicating the expression of this target gene regulated by WTAP
Cell Line mouse embryonic stem cells Mus musculus
Treatment: WTAP-/- ESCs
Control: Wild type ESCs
 GSE145309
Regulation
logFC: -8.45E-01
p-value: 6.62E-13
More Results Click to View More RNA-seq Results
In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene [2]
Response Summary MeRIP-Seq of mRNAs of MCF7 with or without treated by TGF-beta showed that mRNA with upregulated m6A modification level after TGF-beta treatment were enriched in TGF-beta signaling pathway. Phosphorylated level of SMAD2 or SMAD3 induced by TGF-beta was impaired when WTAP was silenced. The m6A modification and mRNA level of Transcription factor JunB (JUNB), which is known as a cell cycle inhibitor, both were increased after induction of TGF-beta and decreased after knockdown of WTAP. Phosphorylated level of SMAD2 or SMAD3 induced by TGF-beta was impaired when WTAP was silenced.
Target Regulation Up regulation
Pathway Response TGF-beta signaling pathway hsa04350
Cell cycle hsa04110
Cell Process Arrest cell cycle at G1 phase
Cell apoptosis
In-vitro Model MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
MDA-MB-231 Breast adenocarcinoma Homo sapiens CVCL_0062
Lung cancer [ICD-11: 2C25]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response [1]
Response Summary m6A methyltransferase METTL3 is indispensable for TGF-beta-induced EMT of lung cancer cells through the regulation of Transcription factor JunB (JUNB).
Responsed Disease Lung cancer [ICD-11: 2C25]
Target Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
Target Regulation Up regulation
Pathway Response Cytokine-cytokine receptor interaction hsa04060
Cell Process Epithelial-mesenchymal transition
In-vitro Model A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
LC-2/ad Lung adenocarcinoma Homo sapiens CVCL_1373
References
Ref 1 The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB. Biochem Biophys Res Commun. 2020 Mar 26;524(1):150-155. doi: 10.1016/j.bbrc.2020.01.042. Epub 2020 Jan 22.
Ref 2 The crosstalk between RNA m(6)A epitranscriptome and TGFBeta signaling pathway contributes to the arrest of cell cycle. Gene. 2020 May 15;738:144483. doi: 10.1016/j.gene.2020.144483. Epub 2020 Feb 15.