m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00260)

Target Name	Forkhead box protein O3 (FOXO3)
Synonyms	AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1; FKHRL1; FOXO3A Click to Show/Hide
Gene Name	FOXO3
Chromosomal Location	6q21
Function	Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3. Click to Show/Hide
Gene ID	2309
Uniprot ID	FOXO3_HUMAN
HGNC ID	HGNC:3821
KEGG ID	hsa:2309

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

FOXO3 can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

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YTH domain-containing family protein 1 (YTHDF1) [READER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by YTHDF1*
Cell Line	AGS cell line	Homo sapiens
Treatment: shYTHDF1 AGS Control: shNC AGS		GSE166972
Regulation		logFC: 1.07E+00 p-value: 3.17E-02
More Results	Click to View More RNA-seq Results
*Representative RIP-seq result supporting the interaction between FOXO3 and the regulator*
Cell Line	Hela	Homo sapiens
Regulation	logFC: 2.44E+00	GSE63591

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene			[1]
Response Summary	METTL3 can sensitise hepatocellular carcinoma cells to sorafenib through stabilising Forkhead box protein O3 (FOXO3) in an m6A-dependent manner and translated by YTHDF1, thereby inhibiting the transcription of autophagy-related genes, including ATG3, ATG5, ATG7, ATG12, and ATG16L1.
Target Regulation	Up regulation
Responsed Disease	Hepatocellular carcinoma	ICD-11: 2C12.02	Disease Info
Responsed Drug	Sorafenib	Approved	Drug Info
Pathway Response	FoxO signaling pathway		hsa04068
Cell Process	Cell autophagy

Methyltransferase-like 14 (METTL14) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL14*
Cell Line	MDA-MB-231	Homo sapiens
Treatment: siMETTL14 MDA-MB-231 cells Control: MDA-MB-231 cells		GSE81164
Regulation		logFC: -1.48E+00 p-value: 5.68E-29
More Results	Click to View More RNA-seq Results

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[2]
Response Summary	Global RNA m6A methylation and METTL14 expression were significantly increased in placental tissues obtained from patients with preeclampsia. Forkhead box protein O3 (FOXO3) inhibition effectively prevented the impairment of trophoblast proliferation and invasion, and diminished the induction of trophoblast autophagy and apoptosis in METTL14-overexpressing HTR-8/SVneo cells.
Target Regulation	Up regulation
Responsed Disease	Pre-eclampsia		ICD-11: JA24	Disease Info
Cell Process	Cell autophagy
In-vitro Model	HTR-8/SVneo	Normal	Homo sapiens	CVCL_7162
In-vitro Model	HTR-8	Normal	Homo sapiens	CVCL_D728

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by METTL3*
Cell Line	mouse embryonic stem cells	Mus musculus
Treatment: METTL3-/- ESCs Control: Wild type ESCs		GSE145309
Regulation		logFC: 8.00E-01 p-value: 1.28E-68
More Results	Click to View More RNA-seq Results

In total 2 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[3]
Response Summary	METTL3 and Forkhead box protein O3 (FOXO3) levels are tightly correlated in hepatocellular carcinoma patients. In mouse xenograft models, METTL3 depletion significantly enhances sorafenib resistance of HCC by abolishing the identified METTL3-mediated FOXO3 mRNA stabilization, and overexpression of FOXO3 restores m6 A-dependent sorafenib sensitivity.
Target Regulation	Down regulation
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Responsed Drug	Sorafenib		Approved	Drug Info
Pathway Response	FoxO signaling pathway			hsa04068
Cell Process	Cell Transport
	Cell catabolism
	Cell autophagy
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
	Hepa 1-6	Hepatocellular carcinoma of the mouse	Mus musculus	CVCL_0327
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HUVEC-C	Normal	Homo sapiens	CVCL_2959
	WRL 68	Endocervical adenocarcinoma	Homo sapiens	CVCL_0581
In-vivo Model	For the drug-resistant subcutaneous tumor models, drug administration was adopted when the tumors reached about 50 mm³ in size, at which point mice were randomized for treatment with DMSO(intraperitoneally) or sorafenib (50 mg/kg/every 2 days, intraperitoneally). For the patient-derived tumor xenograft model, drug administration began 4 weeks after tumors reached about 100 mm³ in size with sorafenib (50 mg/kg/every 3 days, intraperitoneally) or siCtrl/siMETTL3 intratumor injection.
Experiment 2 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3 can sensitise hepatocellular carcinoma cells to sorafenib through stabilising Forkhead box protein O3 (FOXO3) in an m6A-dependent manner and translated by YTHDF1, thereby inhibiting the transcription of autophagy-related genes, including ATG3, ATG5, ATG7, ATG12, and ATG16L1.
Target Regulation	Up regulation
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Responsed Drug	Sorafenib		Approved	Drug Info
Pathway Response	FoxO signaling pathway			hsa04068
Cell Process	Cell autophagy

RNA demethylase ALKBH5 (ALKBH5) [ERASER]

Regulator Info

*Representative RNA-seq result indicating the expression of this target gene regulated by ALKBH5*
Cell Line	143B cell line	Homo sapiens
Treatment: siALKBH5 transfected 143B cells Control: siControl 143B cells		GSE154528
Regulation		logFC: -1.05E+00 p-value: 3.53E-06
More Results	Click to View More RNA-seq Results

In total 2 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[4]
Response Summary	ALKBH5 plays an antitumor role in colorectal cancer by modulating the Forkhead box protein O3 (FOXO3)/miR-21/SPRY2 axis, which not only suggests a regulatory effect between ALKBH5 and FOXO3, but also provides a new therapeutic direction for colorectal cancer.
Target Regulation	Down regulation
Responsed Disease	Colorectal cancer		ICD-11: 2B91	Disease Info
Pathway Response	FoxO signaling pathway			hsa04068
In-vitro Model	Caco-2	Colon adenocarcinoma	Homo sapiens	CVCL_0025
	FHC	Normal	Homo sapiens	CVCL_3688
	HCT 116	Colon carcinoma	Homo sapiens	CVCL_0291
	SW480	Colon adenocarcinoma	Homo sapiens	CVCL_0546
	SW620	Colon adenocarcinoma	Homo sapiens	CVCL_0547
Experiment 2 Reporting the m6A Methylation Regulator of This Target Gene				[5]
Response Summary	ALKBH5 was upregulated in the cardiomyocytes of diabetic cardiomyopathy mice and posttranscriptionally activated Forkhead box protein O3 (FOXO3) by m6A demethylation in an m6A-YTHDF2-dependent manner.This work reveals the key function of the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway in DCM and provides insight into the critical roles of m6A methylation in DCM.
Target Regulation	Up regulation
Responsed Disease	Diabetic cardiomyopathy		ICD-11: BC43.7	Disease Info
Pathway Response	Hippo signaling pathway			hsa04390
Pathway Response	FoxO signaling pathway			hsa04068
Cell Process	Cell apoptosis
In-vitro Model	Neonatal rat ventricular cardiomyocytes (Primary myocyte cells)
In-vivo Model	The model mice were intraperitoneally injected with streptozotocin (STZ; Sigma-Aldrich Corp., USA). The dose of STZ was 50 mg/kg for 5 days. 7 days after the last injection, blood glucose concentrations were recorded. Mouse models of diabetes were considered established when fasting blood glucose concentrations reached >11.1 mmol/L, and body weight was measured.

YTH domain-containing family protein 3 (YTHDF3) [READER]

Regulator Info

*Representative RIP-seq result supporting the interaction between FOXO3 and the regulator*
Cell Line	Hela	Homo sapiens
Regulation	logFC: 2.93E+00	GSE86214

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene			[6]
Response Summary	YTHDF3 as a negative regulator of antiviral immunity through the translational promotion of Forkhead box protein O3 (FOXO3) mRNA under homeostatic conditions, adding insight into the networks of RNA-binding protein-RNA interactions in homeostatically maintaining host antiviral immune function and preventing inflammatory response.
Target Regulation	Up regulation
Responsed Disease	Inflammatory response	ICD-11: MG46	Disease Info
Pathway Response	FoxO signaling pathway		hsa04068
In-vivo Model	YTHDF3^-/- mice were generated using the CRISPR-Cas9 system.

Colorectal cancer [ICD-11: 2B91]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[4]
Response Summary	ALKBH5 plays an antitumor role in colorectal cancer by modulating the Forkhead box protein O3 (FOXO3)/miR-21/SPRY2 axis, which not only suggests a regulatory effect between ALKBH5 and FOXO3, but also provides a new therapeutic direction for colorectal cancer.
Responsed Disease	Colorectal cancer [ICD-11: 2B91]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)		ERASER	Regulator Info
Target Regulation	Down regulation
Pathway Response	FoxO signaling pathway			hsa04068
In-vitro Model	Caco-2	Colon adenocarcinoma	Homo sapiens	CVCL_0025
	FHC	Normal	Homo sapiens	CVCL_3688
	HCT 116	Colon carcinoma	Homo sapiens	CVCL_0291
	SW480	Colon adenocarcinoma	Homo sapiens	CVCL_0546
	SW620	Colon adenocarcinoma	Homo sapiens	CVCL_0547

Liver cancer [ICD-11: 2C12]

Disease Info

In total 3 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[3]
Response Summary	METTL3 and Forkhead box protein O3 (FOXO3) levels are tightly correlated in hepatocellular carcinoma patients. In mouse xenograft models, METTL3 depletion significantly enhances sorafenib resistance of HCC by abolishing the identified METTL3-mediated FOXO3 mRNA stabilization, and overexpression of FOXO3 restores m6 A-dependent sorafenib sensitivity.
Responsed Disease	Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
Responsed Drug	Sorafenib		Approved	Drug Info
Pathway Response	FoxO signaling pathway			hsa04068
Cell Process	Cell Transport
	Cell catabolism
	Cell autophagy
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
	Hepa 1-6	Hepatocellular carcinoma of the mouse	Mus musculus	CVCL_0327
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HUVEC-C	Normal	Homo sapiens	CVCL_2959
	WRL 68	Endocervical adenocarcinoma	Homo sapiens	CVCL_0581
In-vivo Model	For the drug-resistant subcutaneous tumor models, drug administration was adopted when the tumors reached about 50 mm³ in size, at which point mice were randomized for treatment with DMSO(intraperitoneally) or sorafenib (50 mg/kg/every 2 days, intraperitoneally). For the patient-derived tumor xenograft model, drug administration began 4 weeks after tumors reached about 100 mm³ in size with sorafenib (50 mg/kg/every 3 days, intraperitoneally) or siCtrl/siMETTL3 intratumor injection.
Experiment 2 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 can sensitise hepatocellular carcinoma cells to sorafenib through stabilising Forkhead box protein O3 (FOXO3) in an m6A-dependent manner and translated by YTHDF1, thereby inhibiting the transcription of autophagy-related genes, including ATG3, ATG5, ATG7, ATG12, and ATG16L1.
Responsed Disease	Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Responsed Drug	Sorafenib		Approved	Drug Info
Pathway Response	FoxO signaling pathway			hsa04068
Cell Process	Cell autophagy
Experiment 3 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 can sensitise hepatocellular carcinoma cells to sorafenib through stabilising Forkhead box protein O3 (FOXO3) in an m6A-dependent manner and translated by YTHDF1, thereby inhibiting the transcription of autophagy-related genes, including ATG3, ATG5, ATG7, ATG12, and ATG16L1.
Responsed Disease	Hepatocellular carcinoma [ICD-11: 2C12.02]
Target Regulator	YTH domain-containing family protein 1 (YTHDF1)		READER	Regulator Info
Target Regulation	Up regulation
Responsed Drug	Sorafenib		Approved	Drug Info
Pathway Response	FoxO signaling pathway			hsa04068
Cell Process	Cell autophagy

Ovarian dysfunction [ICD-11: 5A80]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response		[]
Response Summary	Altered m6 A modification was involved in up-regulated expression of Forkhead box protein O3 (FOXO3) mRNA in the luteinized granulosa cells from non-obese polycystic ovary syndrome patients following controlled ovarian hyperstimulation.
Responsed Disease	Ovarian dysfunction [ICD-11: 5A80]
Pathway Response	FoxO signaling pathway	hsa04068
In-vitro Model	()

Cardiomyopathy [ICD-11: BC43]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response			[5]
Response Summary	ALKBH5 was upregulated in the cardiomyocytes of diabetic cardiomyopathy mice and posttranscriptionally activated Forkhead box protein O3 (FOXO3) by m6A demethylation in an m6A-YTHDF2-dependent manner.This work reveals the key function of the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway in DCM and provides insight into the critical roles of m6A methylation in DCM.
Responsed Disease	Diabetic cardiomyopathy [ICD-11: BC43.7]
Target Regulator	RNA demethylase ALKBH5 (ALKBH5)	ERASER	Regulator Info
Target Regulation	Up regulation
Pathway Response	Hippo signaling pathway		hsa04390
	FoxO signaling pathway		hsa04068
Cell Process	Cell apoptosis
In-vitro Model	Neonatal rat ventricular cardiomyocytes (Primary myocyte cells)
In-vivo Model	The model mice were intraperitoneally injected with streptozotocin (STZ; Sigma-Aldrich Corp., USA). The dose of STZ was 50 mg/kg for 5 days. 7 days after the last injection, blood glucose concentrations were recorded. Mouse models of diabetes were considered established when fasting blood glucose concentrations reached >11.1 mmol/L, and body weight was measured.

Pre-eclampsia [ICD-11: JA24]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[2]
Response Summary	Global RNA m6A methylation and METTL14 expression were significantly increased in placental tissues obtained from patients with preeclampsia. Forkhead box protein O3 (FOXO3) inhibition effectively prevented the impairment of trophoblast proliferation and invasion, and diminished the induction of trophoblast autophagy and apoptosis in METTL14-overexpressing HTR-8/SVneo cells.
Responsed Disease	Pre-eclampsia [ICD-11: JA24]
Target Regulator	Methyltransferase-like 14 (METTL14)		WRITER	Regulator Info
Target Regulation	Up regulation
Cell Process	Cell autophagy
In-vitro Model	HTR-8/SVneo	Normal	Homo sapiens	CVCL_7162
In-vitro Model	HTR-8	Normal	Homo sapiens	CVCL_D728

Inflammatory response [ICD-11: MG46]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response			[6]
Response Summary	YTHDF3 as a negative regulator of antiviral immunity through the translational promotion of Forkhead box protein O3 (FOXO3) mRNA under homeostatic conditions, adding insight into the networks of RNA-binding protein-RNA interactions in homeostatically maintaining host antiviral immune function and preventing inflammatory response.
Responsed Disease	Inflammatory response [ICD-11: MG46]
Target Regulator	YTH domain-containing family protein 3 (YTHDF3)	READER	Regulator Info
Target Regulation	Up regulation
Pathway Response	FoxO signaling pathway		hsa04068
In-vivo Model	YTHDF3^-/- mice were generated using the CRISPR-Cas9 system.

Sorafenib [Approved]

Drug Info

In total 3 item(s) under this drug
Experiment 1 Reporting the m6A-centered Drug Response				[3]
Response Summary	METTL3 and Forkhead box protein O3 (FOXO3) levels are tightly correlated in hepatocellular carcinoma patients. In mouse xenograft models, METTL3 depletion significantly enhances sorafenib resistance of HCC by abolishing the identified METTL3-mediated FOXO3 mRNA stabilization, and overexpression of FOXO3 restores m6 A-dependent sorafenib sensitivity.
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Down regulation
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Pathway Response	FoxO signaling pathway			hsa04068
Cell Process	Cell Transport
	Cell catabolism
	Cell autophagy
In-vitro Model	HEK293T	Normal	Homo sapiens	CVCL_0063
	Hepa 1-6	Hepatocellular carcinoma of the mouse	Mus musculus	CVCL_0327
	Hep-G2	Hepatoblastoma	Homo sapiens	CVCL_0027
	HUVEC-C	Normal	Homo sapiens	CVCL_2959
	WRL 68	Endocervical adenocarcinoma	Homo sapiens	CVCL_0581
In-vivo Model	For the drug-resistant subcutaneous tumor models, drug administration was adopted when the tumors reached about 50 mm³ in size, at which point mice were randomized for treatment with DMSO(intraperitoneally) or sorafenib (50 mg/kg/every 2 days, intraperitoneally). For the patient-derived tumor xenograft model, drug administration began 4 weeks after tumors reached about 100 mm³ in size with sorafenib (50 mg/kg/every 3 days, intraperitoneally) or siCtrl/siMETTL3 intratumor injection.
Experiment 2 Reporting the m6A-centered Drug Response				[1]
Response Summary	METTL3 can sensitise hepatocellular carcinoma cells to sorafenib through stabilising Forkhead box protein O3 (FOXO3) in an m6A-dependent manner and translated by YTHDF1, thereby inhibiting the transcription of autophagy-related genes, including ATG3, ATG5, ATG7, ATG12, and ATG16L1.
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Pathway Response	FoxO signaling pathway			hsa04068
Cell Process	Cell autophagy
Experiment 3 Reporting the m6A-centered Drug Response				[1]
Response Summary	METTL3 can sensitise hepatocellular carcinoma cells to sorafenib through stabilising Forkhead box protein O3 (FOXO3) in an m6A-dependent manner and translated by YTHDF1, thereby inhibiting the transcription of autophagy-related genes, including ATG3, ATG5, ATG7, ATG12, and ATG16L1.
Target Regulator	YTH domain-containing family protein 1 (YTHDF1)		READER	Regulator Info
Target Regulation	Up regulation
Responsed Disease	Hepatocellular carcinoma		ICD-11: 2C12.02	Disease Info
Pathway Response	FoxO signaling pathway			hsa04068
Cell Process	Cell autophagy

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

RNA modification

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00520		Crosstalk Info
Epigenetic Regulator	Double-stranded RNA-specific editase 1 (ADARB1)
Regulated Target	MicroRNA 221 (MIR221)
Crosstalk relationship	A-to-I → m6A
Crosstalk ID: M6ACROT00555		Crosstalk Info
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)
Regulated Target	Growth arrest specific 5 (GAS5)
Crosstalk relationship	m5C → m6A

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00521		Crosstalk Info
Epigenetic Regulator	Double-stranded RNA-specific editase 1 (ADARB1)
Regulated Target	MicroRNA 221 (MIR221)
Crosstalk relationship	A-to-I → m6A
Crosstalk ID: M6ACROT00556		Crosstalk Info
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)
Regulated Target	Growth arrest specific 5 (GAS5)
Crosstalk relationship	m5C → m6A

m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00522		Crosstalk Info
Epigenetic Regulator	Double-stranded RNA-specific editase 1 (ADARB1)
Regulated Target	MicroRNA 221 (MIR221)
Crosstalk relationship	A-to-I → m6A
Crosstalk ID: M6ACROT00557		Crosstalk Info
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)
Regulated Target	Growth arrest specific 5 (GAS5)
Crosstalk relationship	m5C → m6A

Histone modification

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03238		Crosstalk Info
Epigenetic Regulator	CREB-binding protein (CREBBP)
Crosstalk relationship	m6A → Histone modification
Disease	Intervertebral disc degeneration	Disease Info

m6A Regulator: RNA demethylase ALKBH5 (ALKBH5)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03358		Crosstalk Info
Epigenetic Regulator	Histone deacetylase 2 (HDAC2)
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Colorectal cancer	Disease Info
Crosstalk ID: M6ACROT03454		Crosstalk Info
Epigenetic Regulator	Histone deacetylase 1 (HDAC1)
Regulated Target	Histone H3 lysine 27 acetylation (H3K27ac)
Crosstalk relationship	Histone modification → m6A
Disease	Colorectal cancer	Disease Info

Non-coding RNA

m6A Regulator: Fat mass and obesity-associated protein (FTO)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05338		Crosstalk Info
Epigenetic Regulator	hsa-miR-27a-3p
Regulated Target	FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship	ncRNA → m6A
Disease	Glioblastoma multiforme	Disease Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00260)

Forkhead box protein O3 (FOXO3)

Adenosine-to-Inosine editing (A-to-I)

In total 18 m6A sequence/site(s) in this target gene
mod ID: A2ISITE001598		Click to Show/Hide the Full List
mod site	chr6:108577694-108577695:+		[13]
Sequence	GGATTGAGTGCCTCTATTTTAGAGACATTAGATTTTGGCTG
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118284
mod ID: A2ISITE001599		Click to Show/Hide the Full List
mod site	chr6:108584756-108584757:+		[13]
Sequence	ATGTTTATTTAAAATGGTTTAGATTTTCATTTGGCTAAAAT
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: RNA-editing_site_118285
mod ID: A2ISITE001600		Click to Show/Hide the Full List
mod site	chr6:108584779-108584780:+		[13]
Sequence	TTTTCATTTGGCTAAAATCTAGGAGGTTGTAGACTAATAGA
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118286
mod ID: A2ISITE001601		Click to Show/Hide the Full List
mod site	chr6:108584797-108584798:+		[13]
Sequence	CTAGGAGGTTGTAGACTAATAGAATAACAATAATGATAGCC
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118287
mod ID: A2ISITE001602		Click to Show/Hide the Full List
mod site	chr6:108584825-108584826:+		[13]
Sequence	AATAATGATAGCCTTTCCTAAGGAGCTCTGAATAGCCTCAG
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118288
mod ID: A2ISITE001603		Click to Show/Hide the Full List
mod site	chr6:108585711-108585712:+		[13]
Sequence	ATTAGAGTGCTTCAGAGGCTACTTAGGGTGCCTTAGGAAAA
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118289
mod ID: A2ISITE001604		Click to Show/Hide the Full List
mod site	chr6:108585725-108585726:+		[13]
Sequence	GAGGCTACTTAGGGTGCCTTAGGAAAAGGTATCGTTATTAT
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: RNA-editing_site_118290
mod ID: A2ISITE001605		Click to Show/Hide the Full List
mod site	chr6:108585770-108585771:+		[13]
Sequence	CCATTAGTCTGTAACCTTCTAGATTTTAGCTGAATGAAACT
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118291
mod ID: A2ISITE001606		Click to Show/Hide the Full List
mod site	chr6:108585777-108585778:+		[13]
Sequence	TCTGTAACCTTCTAGATTTTAGCTGAATGAAACTCTAAACC
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118292
mod ID: A2ISITE001607		Click to Show/Hide the Full List
mod site	chr6:108585802-108585803:+		[14]
Sequence	AATGAAACTCTAAACCACTTAAAACACACTGGGCTCAGTAG
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118293
mod ID: A2ISITE001608		Click to Show/Hide the Full List
mod site	chr6:108599576-108599577:+		[14]
Sequence	GTGGTCTTTTCCATTATGGTAAGCCATAGAGGCTTTCCCGG
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118294
mod ID: A2ISITE001609		Click to Show/Hide the Full List
mod site	chr6:108599979-108599980:+		[13]
Sequence	GGAAGGTCCTCTATGTGAGAAGATCTGAGGGGTAAGCAGGT
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: RNA-editing_site_118295
mod ID: A2ISITE001610		Click to Show/Hide the Full List
mod site	chr6:108599993-108599994:+		[14]
Sequence	GTGAGAAGATCTGAGGGGTAAGCAGGTTTTAATGGACTAAG
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: RNA-editing_site_118296
mod ID: A2ISITE001611		Click to Show/Hide the Full List
mod site	chr6:108600032-108600033:+		[14]
Sequence	AGATTTTTTTTATATGTATAAGGAGGGTGGGAGGAGGATTT
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: RNA-editing_site_118297
mod ID: A2ISITE001612		Click to Show/Hide the Full List
mod site	chr6:108600035-108600036:+		[14]
Sequence	TTTTTTTTATATGTATAAGGAGGGTGGGAGGAGGATTTTAG
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: RNA-editing_site_118298
mod ID: A2ISITE001613		Click to Show/Hide the Full List
mod site	chr6:108600085-108600086:+		[13]
Sequence	TCCATTGGCCTGCAGTTAGAAGTCGAACACTGAACTTGGGA
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118299
mod ID: A2ISITE001614		Click to Show/Hide the Full List
mod site	chr6:108600098-108600099:+		[14]
Sequence	AGTTAGAAGTCGAACACTGAACTTGGGAAAGCTTCTGTGGC
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: RNA-editing_site_118300
mod ID: A2ISITE001615		Click to Show/Hide the Full List
mod site	chr6:108678751-108678752:+		[14]
Sequence	AAAAATCAAATTCCTAAGCCAGGTGCATTGGCGTGCCTGTA
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1; rmsk_2036791
External Link	RMBase: RNA-editing_site_118301

N6-methyladenosine (m6A)

In total 125 m6A sequence/site(s) in this target gene
mod ID: M6ASITE076507		Click to Show/Hide the Full List
mod site	chr6:108560989-108560990:+		[15]
Sequence	TGGGAGGCGGGCGCGGCAGGACTGGGAGGTGGCGGCAGCGG
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; H1A; H1B; GSC-11; HEK293T; HEK293A-TOA; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729613
mod ID: M6ASITE076508		Click to Show/Hide the Full List
mod site	chr6:108561016-108561017:+		[15]
Sequence	GGTGGCGGCAGCGGGCGAGGACTCGCCGAGGACGGGGCTCC
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; H1A; H1B; HEK293T; HEK293A-TOA; MSC; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729614
mod ID: M6ASITE076509		Click to Show/Hide the Full List
mod site	chr6:108561263-108561264:+		[15]
Sequence	TCCGCTCGAAGTGGAGCTGGACCCGGAGTTCGAGCCCCAGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; GSC-11; HEK293A-TOA; MSC; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729615
mod ID: M6ASITE076510		Click to Show/Hide the Full List
mod site	chr6:108561494-108561495:+		[15]
Sequence	CTCCGGGCTGCTCCTTGAGGACTCGGCCCGGGTGCTGGCAC
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; A549; HEK293T; HepG2; H1299; Jurkat; GSC-11; HEK293A-TOA; MSC; iSLK; TIME; TREX; HEC-1-A; GSCs; NB4; MM6; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729616
mod ID: M6ASITE076511		Click to Show/Hide the Full List
mod site	chr6:108561527-108561528:+		[15]
Sequence	GCTGGCACCCGGAGGGCAAGACCCCGGGTCTGGGCCAGCCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HEK293T; HepG2; A549; H1299; Jurkat; GSC-11; HEK293A-TOA; MSC; iSLK; TIME; TREX; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729617
mod ID: M6ASITE076512		Click to Show/Hide the Full List
mod site	chr6:108561683-108561684:+		[15]
Sequence	GCGGCGGAACGCCTGGGGAAACCTGTCCTACGCGGACCTGA
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; GSC-11; HEK293T; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729618
mod ID: M6ASITE076513		Click to Show/Hide the Full List
mod site	chr6:108561698-108561699:+		[15]
Sequence	GGGAAACCTGTCCTACGCGGACCTGATCACCCGCGCCATCG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; GSC-11; HEK293T; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729619
mod ID: M6ASITE076514		Click to Show/Hide the Full List
mod site	chr6:108561731-108561732:+		[15]
Sequence	CGCCATCGAGAGCTCCCCGGACAAACGGCTCACTCTGTCCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; hESC-HEK293T; peripheral-blood; GSC-11; iSLK; MSC; TIME; endometrial; NB4
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729620
mod ID: M6ASITE076515		Click to Show/Hide the Full List
mod site	chr6:108656351-108656352:+		[15]
Sequence	GCTGGTGTCTGGGTGAGTGGACAGTCTCCACAAGGTAAACA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; peripheral-blood; HEK293T; iSLK; MSC; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000540898.1; ENST00000406360.2
External Link	RMBase: m6A_site_729624
mod ID: M6ASITE076516		Click to Show/Hide the Full List
mod site	chr6:108656369-108656370:+		[15]
Sequence	GGACAGTCTCCACAAGGTAAACATGGTTTGGAAGGGCTGAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; peripheral-blood; HEK293T; MSC; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1
External Link	RMBase: m6A_site_729625
mod ID: M6ASITE076517		Click to Show/Hide the Full List
mod site	chr6:108663467-108663468:+		[16]
Sequence	CCTGCAGAACTCCATCCGGCACAACCTGTCACTGCATAGTC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729626
mod ID: M6ASITE076518		Click to Show/Hide the Full List
mod site	chr6:108663514-108663515:+		[15]
Sequence	TGCGGGTCCAGAATGAGGGAACTGGCAAGAGCTCTTGGTGG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729627
mod ID: M6ASITE076519		Click to Show/Hide the Full List
mod site	chr6:108663596-108663597:+		[15]
Sequence	GCGGCGGGCTGTCTCCATGGACAATAGCAACAAGTATACCA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HEK293T; hESC-HEK293T; HEK293A-TOA; iSLK; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000540898.1; ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729628
mod ID: M6ASITE076520		Click to Show/Hide the Full List
mod site	chr6:108663605-108663606:+		[16]
Sequence	TGTCTCCATGGACAATAGCAACAAGTATACCAAGAGCCGTG
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000540898.1; ENST00000343882.10
External Link	RMBase: m6A_site_729629
mod ID: M6ASITE076521		Click to Show/Hide the Full List
mod site	chr6:108663658-108663659:+		[15]
Sequence	AGAAGAAGGCAGCCCTGCAGACAGCCCCCGAATCAGCTGAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; CD34; HEK293T; A549; MM6; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000540898.1; ENST00000406360.2
External Link	RMBase: m6A_site_729630
mod ID: M6ASITE076522		Click to Show/Hide the Full List
mod site	chr6:108663755-108663756:+		[15]
Sequence	TGAGCTGGATGCGTGGACGGACTTCCGTTCACGCACCAATT
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HEK293T; HEK293A-TOA; MSC; iSLK; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000540898.1; ENST00000406360.2
External Link	RMBase: m6A_site_729631
mod ID: M6ASITE076523		Click to Show/Hide the Full List
mod site	chr6:108663875-108663876:+		[17]
Sequence	GCCTCTCTCGCCCATGCTCTACAGCAGCTCAGCCAGCCTGT
Motif Score	2.078666667
Cell/Tissue List	HEK293
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1
External Link	RMBase: m6A_site_729632
mod ID: M6ASITE076524		Click to Show/Hide the Full List
mod site	chr6:108663927-108663928:+		[15]
Sequence	AGCAAGCCGTGCACGGTGGAACTGCCACGGCTGACTGATAT
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; H1A; hESCs; fibroblasts; A549; GM12878; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000540898.1; ENST00000406360.2
External Link	RMBase: m6A_site_729633
mod ID: M6ASITE076525		Click to Show/Hide the Full List
mod site	chr6:108663986-108663987:+		[15]
Sequence	GAATGATGGGCTGACTGAAAACCTCATGGACGACCTGCTGG
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; H1A; hESCs; fibroblasts; GM12878; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729634
mod ID: M6ASITE076526		Click to Show/Hide the Full List
mod site	chr6:108664010-108664011:+		[16]
Sequence	CATGGACGACCTGCTGGATAACATCACGCTCCCGCCATCCC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000540898.1; ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729635
mod ID: M6ASITE076527		Click to Show/Hide the Full List
mod site	chr6:108664050-108664051:+		[15]
Sequence	CAGCCATCGCCCACTGGGGGACTCATGCAGCGGAGCTCTAG
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; H1A; hESCs; fibroblasts; GM12878; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000540898.1; ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729636
mod ID: M6ASITE076528		Click to Show/Hide the Full List
mod site	chr6:108664140-108664141:+		[15]
Sequence	TTTAACAGCACGGTGTTCGGACCTTCATCTCTGAACTCCCT
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; GM12878; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729637
mod ID: M6ASITE076529		Click to Show/Hide the Full List
mod site	chr6:108664154-108664155:+		[15]
Sequence	GTTCGGACCTTCATCTCTGAACTCCCTACGCCAGTCTCCCA
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HEK293T; GM12878; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729638
mod ID: M6ASITE076530		Click to Show/Hide the Full List
mod site	chr6:108664180-108664181:+		[15]
Sequence	TACGCCAGTCTCCCATGCAGACCATCCAAGAGAACAAGCCA
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HEK293T; Huh7; HEK293A-TOA; iSLK; TIME; MSC
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729639
mod ID: M6ASITE076531		Click to Show/Hide the Full List
mod site	chr6:108664193-108664194:+		[15]
Sequence	CATGCAGACCATCCAAGAGAACAAGCCAGCTACCTTCTCTT
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HEK293T; hESC-HEK293T; Huh7; HEK293A-TOA; iSLK; TIME; MSC
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000540898.1; ENST00000406360.2
External Link	RMBase: m6A_site_729640
mod ID: M6ASITE076532		Click to Show/Hide the Full List
mod site	chr6:108664237-108664238:+		[15]
Sequence	TGTCACACTATGGTAACCAGACACTCCAGGACCTGCTCACT
Motif Score	2.897386905
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729641
mod ID: M6ASITE076533		Click to Show/Hide the Full List
mod site	chr6:108664247-108664248:+		[15]
Sequence	TGGTAACCAGACACTCCAGGACCTGCTCACTTCGGACTCAC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1
External Link	RMBase: m6A_site_729642
mod ID: M6ASITE076534		Click to Show/Hide the Full List
mod site	chr6:108664262-108664263:+		[15]
Sequence	CCAGGACCTGCTCACTTCGGACTCACTTAGCCACAGCGATG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729643
mod ID: M6ASITE076535		Click to Show/Hide the Full List
mod site	chr6:108664301-108664302:+		[15]
Sequence	TGTCATGATGACACAGTCGGACCCCTTGATGTCTCAGGCCA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000540898.1; ENST00000406360.2
External Link	RMBase: m6A_site_729644
mod ID: M6ASITE076536		Click to Show/Hide the Full List
mod site	chr6:108664427-108664428:+		[15]
Sequence	GGGAAGTTTGGTCAATCAGAACTTGCTCCACCACCAGCACC
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729645
mod ID: M6ASITE076537		Click to Show/Hide the Full List
mod site	chr6:108664450-108664451:+		[15]
Sequence	TGCTCCACCACCAGCACCAAACCCAGGGCGCTCTTGGTGGC
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729646
mod ID: M6ASITE076538		Click to Show/Hide the Full List
mod site	chr6:108664499-108664500:+		[16]
Sequence	CTTGTCGAATTCTGTCAGCAACATGGGCTTGAGTGAGTCCA
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729647
mod ID: M6ASITE076539		Click to Show/Hide the Full List
mod site	chr6:108664539-108664540:+		[15]
Sequence	AGCAGCCTTGGGTCAGCCAAACACCAGCAGCAGTCTCCTGT
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729648
mod ID: M6ASITE076540		Click to Show/Hide the Full List
mod site	chr6:108664576-108664577:+
Sequence	CTGTCAGCCAGTCTATGCAAACCCTCTCGGACTCTCTCTCA
Motif Score	2.185083333
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729649
mod ID: M6ASITE076541		Click to Show/Hide the Full List
mod site	chr6:108664586-108664587:+
Sequence	GTCTATGCAAACCCTCTCGGACTCTCTCTCAGGCTCCTCCT
Motif Score	4.065041667
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729650
mod ID: M6ASITE076542		Click to Show/Hide the Full List
mod site	chr6:108664625-108664626:+		[18]
Sequence	CTTGTACTCAACTAGTGCAAACCTGCCCGTCATGGGCCATG
Motif Score	2.185083333
Cell/Tissue List	HEK293T; A549
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000406360.2; ENST00000540898.1; ENST00000343882.10
External Link	RMBase: m6A_site_729651
mod ID: M6ASITE076543		Click to Show/Hide the Full List
mod site	chr6:108664667-108664668:+		[15]
Sequence	GAAGTTCCCCAGCGACTTGGACCTGGACATGTTCAATGGGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; A549
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000406360.2; ENST00000343882.10; rmsk_2036780
External Link	RMBase: m6A_site_729652
mod ID: M6ASITE076544		Click to Show/Hide the Full List
mod site	chr6:108664673-108664674:+		[15]
Sequence	CCCCAGCGACTTGGACCTGGACATGTTCAATGGGAGCTTGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HEK293T; hESC-HEK293T; A549
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	rmsk_2036780; ENST00000406360.2; ENST00000540898.1; ENST00000343882.10
External Link	RMBase: m6A_site_729653
mod ID: M6ASITE076545		Click to Show/Hide the Full List
mod site	chr6:108664700-108664701:+		[16]
Sequence	CAATGGGAGCTTGGAATGTGACATGGAGTCCATTATCCGTA
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	rmsk_2036780; ENST00000540898.1; ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729654
mod ID: M6ASITE076546		Click to Show/Hide the Full List
mod site	chr6:108664725-108664726:+		[15]
Sequence	GAGTCCATTATCCGTAGTGAACTCATGGATGCTGATGGGTT
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1
External Link	RMBase: m6A_site_729655
mod ID: M6ASITE076547		Click to Show/Hide the Full List
mod site	chr6:108664805-108664806:+		[15]
Sequence	TGTTGGTTTGAACGTGGGGAACTTCACTGGTGCTAAGCAGG
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000540898.1; ENST00000343882.10
External Link	RMBase: m6A_site_729656
mod ID: M6ASITE076548		Click to Show/Hide the Full List
mod site	chr6:108679834-108679835:+		[15]
Sequence	CTCCTCCTTTAGACCCTCAAACTGACACAAGACCTACAGAG
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000540898.1; ENST00000406360.2
External Link	RMBase: m6A_site_729657
mod ID: M6ASITE076549		Click to Show/Hide the Full List
mod site	chr6:108679845-108679846:+		[15]
Sequence	GACCCTCAAACTGACACAAGACCTACAGAGAAAACCCTTTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729658
mod ID: M6ASITE076550		Click to Show/Hide the Full List
mod site	chr6:108679858-108679859:+		[15]
Sequence	ACACAAGACCTACAGAGAAAACCCTTTGCCAAATCTGCTCT
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000540898.1; ENST00000406360.2
External Link	RMBase: m6A_site_729659
mod ID: M6ASITE076551		Click to Show/Hide the Full List
mod site	chr6:108679889-108679890:+		[15]
Sequence	AATCTGCTCTCAGCAAGTGGACAGTGATACCGTTTACAGCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; Jurkat; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729660
mod ID: M6ASITE076552		Click to Show/Hide the Full List
mod site	chr6:108679912-108679913:+		[16]
Sequence	GTGATACCGTTTACAGCTTAACACCTTTGTGAATCCCACGC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1
External Link	RMBase: m6A_site_729661
mod ID: M6ASITE076553		Click to Show/Hide the Full List
mod site	chr6:108679954-108679955:+		[15]
Sequence	ATTTTCCTAACCCAGCAGAGACTGTTAATGGCCCCTTACCC
Motif Score	3.319380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1B; hNPCs; hESCs; fibroblasts; GM12878; H1299; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729662
mod ID: M6ASITE076554		Click to Show/Hide the Full List
mod site	chr6:108679998-108679999:+		[15]
Sequence	GTGAAGCACTTACCCTTGGAACAGAACTCTAAAAAGTATGC
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729663
mod ID: M6ASITE076555		Click to Show/Hide the Full List
mod site	chr6:108680003-108680004:+		[15]
Sequence	GCACTTACCCTTGGAACAGAACTCTAAAAAGTATGCAAAAT
Motif Score	3.373380952
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1
External Link	RMBase: m6A_site_729664
mod ID: M6ASITE076556		Click to Show/Hide the Full List
mod site	chr6:108680063-108680064:+		[15]
Sequence	GAGCCGCCTGCCAGTGGAGGACAGCACCCCTCAGCACCACC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1
External Link	RMBase: m6A_site_729665
mod ID: M6ASITE076557		Click to Show/Hide the Full List
mod site	chr6:108680100-108680101:+		[16]
Sequence	CACCCACCCTCATTCAGAGCACACCGTGAGCCCCCGTCGGC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729666
mod ID: M6ASITE076558		Click to Show/Hide the Full List
mod site	chr6:108680211-108680212:+		[16]
Sequence	TTTGACTTTCTGAGTTTTTCACATGCATTAACTTGCGGTAT
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000540898.1; ENST00000343882.10
External Link	RMBase: m6A_site_729667
mod ID: M6ASITE076559		Click to Show/Hide the Full List
mod site	chr6:108680277-108680278:+		[15]
Sequence	TTCCCCTAGCAAATTTAAAAACAGAAAGAAAATGTTGTACC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HEK293T; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729668
mod ID: M6ASITE076560		Click to Show/Hide the Full List
mod site	chr6:108680323-108680324:+		[16]
Sequence	CCATTCCGGGTTCGAGCATCACAAGCTTTTGAGCGCATGGA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000540898.1; ENST00000406360.2
External Link	RMBase: m6A_site_729669
mod ID: M6ASITE076561		Click to Show/Hide the Full List
mod site	chr6:108680344-108680345:+		[15]
Sequence	CAAGCTTTTGAGCGCATGGAACTCCATAAACTAACAAATTA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1
External Link	RMBase: m6A_site_729670
mod ID: M6ASITE076562		Click to Show/Hide the Full List
mod site	chr6:108680353-108680354:+		[15]
Sequence	GAGCGCATGGAACTCCATAAACTAACAAATTACATAAACTA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729671
mod ID: M6ASITE076563		Click to Show/Hide the Full List
mod site	chr6:108680370-108680371:+		[15]
Sequence	TAAACTAACAAATTACATAAACTAAAGGGGGATTTTCTTTC
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000540898.1; ENST00000343882.10
External Link	RMBase: m6A_site_729672
mod ID: M6ASITE076564		Click to Show/Hide the Full List
mod site	chr6:108680427-108680428:+		[15]
Sequence	AAAATTATCCTTTTCTAAAAACTGAACAATGGCACAATTGT
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000540898.1; ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729673
mod ID: M6ASITE076565		Click to Show/Hide the Full List
mod site	chr6:108680432-108680433:+		[15]
Sequence	TATCCTTTTCTAAAAACTGAACAATGGCACAATTGTTTGCT
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34; HEK293T; hESC-HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729674
mod ID: M6ASITE076566		Click to Show/Hide the Full List
mod site	chr6:108680470-108680471:+		[15]
Sequence	GCTATGTGCACCCGTCCAGGACAGAACCGTGCATAGGCAAA
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1
External Link	RMBase: m6A_site_729675
mod ID: M6ASITE076567		Click to Show/Hide the Full List
mod site	chr6:108680475-108680476:+		[15]
Sequence	GTGCACCCGTCCAGGACAGAACCGTGCATAGGCAAAAGGAG
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HEK293T; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; ENST00000540898.1
External Link	RMBase: m6A_site_729676
mod ID: M6ASITE076568		Click to Show/Hide the Full List
mod site	chr6:108680557-108680558:+		[19]
Sequence	CAGGGTGATCTGTGGACGGGACCCCAGCACCAAGTCTACGG
Motif Score	3.622404762
Cell/Tissue List	CD34; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729677
mod ID: M6ASITE076569		Click to Show/Hide the Full List
mod site	chr6:108680631-108680632:+		[15]
Sequence	AGTGTCCTCAGCTAATGTGAACAGTGTTGGTCTGCTGGTTA
Motif Score	2.951386905
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; ENST00000540898.1
External Link	RMBase: m6A_site_729678
mod ID: M6ASITE076570		Click to Show/Hide the Full List
mod site	chr6:108680655-108680656:+		[15]
Sequence	TGTTGGTCTGCTGGTTAGAAACTAGAATATTGATATTTTCA
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000540898.1; ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729679
mod ID: M6ASITE076571		Click to Show/Hide the Full List
mod site	chr6:108680764-108680765:+		[15]
Sequence	GAAAAGGAAAAAAAAAAAAAACAAAAAAGTCCTGTTTTGCT
Motif Score	2.20572619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000406360.2; rmsk_2036794; ENST00000343882.10
External Link	RMBase: m6A_site_729680
mod ID: M6ASITE076572		Click to Show/Hide the Full List
mod site	chr6:108680792-108680793:+		[15]
Sequence	GTCCTGTTTTGCTTTGCAGAACAAATGAACTTACAGGTGAG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729681
mod ID: M6ASITE076573		Click to Show/Hide the Full List
mod site	chr6:108680800-108680801:+		[15]
Sequence	TTGCTTTGCAGAACAAATGAACTTACAGGTGAGCATTAAGC
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729682
mod ID: M6ASITE076574		Click to Show/Hide the Full List
mod site	chr6:108680850-108680851:+		[15]
Sequence	GAAATGTGCGAAGAGTAAAAACCCAAGTCAATGCTGAGGCA
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729683
mod ID: M6ASITE076575		Click to Show/Hide the Full List
mod site	chr6:108680897-108680898:+		[16]
Sequence	ACTTCACTGTTTTCCTAAATACACATCCTTGATTATTTTCA
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729684
mod ID: M6ASITE076576		Click to Show/Hide the Full List
mod site	chr6:108680972-108680973:+		[16]
Sequence	TGAGTGAGAGGCAATAGCATACAAACTGATTTTTTAAATAT
Motif Score	2.110482143
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729685
mod ID: M6ASITE076577		Click to Show/Hide the Full List
mod site	chr6:108680976-108680977:+		[15]
Sequence	TGAGAGGCAATAGCATACAAACTGATTTTTTAAATATAAGC
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729686
mod ID: M6ASITE076578		Click to Show/Hide the Full List
mod site	chr6:108681032-108681033:+		[16]
Sequence	ACAAGTGACTCAATGGAAGTACAAAATAGGGCAGTTTTAAC
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729687
mod ID: M6ASITE076579		Click to Show/Hide the Full List
mod site	chr6:108681184-108681185:+		[15]
Sequence	TGGTAGACGGAATAGTTGGGACCACCTTTGGTACATAAGAA
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729688
mod ID: M6ASITE076580		Click to Show/Hide the Full List
mod site	chr6:108681196-108681197:+		[16]
Sequence	TAGTTGGGACCACCTTTGGTACATAAGAAATTGGTATAACG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729689
mod ID: M6ASITE076581		Click to Show/Hide the Full List
mod site	chr6:108681231-108681232:+		[17]
Sequence	ATAACGATGCTCTGATTAGCACAGTATATGCATACTTCTCC
Motif Score	2.830589286
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729690
mod ID: M6ASITE076582		Click to Show/Hide the Full List
mod site	chr6:108681328-108681329:+		[20]
Sequence	ATAAATATATTTTATCATGTACAGTACAAAAATGGAACCTT
Motif Score	2.856142857
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729691
mod ID: M6ASITE076583		Click to Show/Hide the Full List
mod site	chr6:108681584-108681585:+		[16]
Sequence	GAGTTCCATTTGGTATTGTCACACGTCTCCTGCCTCGCTTG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729692
mod ID: M6ASITE076584		Click to Show/Hide the Full List
mod site	chr6:108681700-108681701:+		[16]
Sequence	TGGTTATAGTAGACTGTAGCACATTGCCTTTTCTAAACTGC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729693
mod ID: M6ASITE076585		Click to Show/Hide the Full List
mod site	chr6:108682056-108682057:+		[19]
Sequence	CCAGCATTAGGGTCCTGAGAACTTCTGAGTTCAGAGAAACA
Motif Score	3.373380952
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729694
mod ID: M6ASITE076586		Click to Show/Hide the Full List
mod site	chr6:108682074-108682075:+		[19]
Sequence	GAACTTCTGAGTTCAGAGAAACATGCAAAGTGACTAACAAA
Motif Score	2.20572619
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729695
mod ID: M6ASITE076587		Click to Show/Hide the Full List
mod site	chr6:108682123-108682124:+		[19]
Sequence	TTACCTTTGCAGTTTTACAGACCCTGGGAGCTGCTTTGGGA
Motif Score	2.876744048
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729696
mod ID: M6ASITE076588		Click to Show/Hide the Full List
mod site	chr6:108682200-108682201:+		[19]
Sequence	AAATGTTGAATTCTTTTCAGACATGGTATCTCATTTATTCT
Motif Score	2.897386905
Cell/Tissue List	CD34; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729697
mod ID: M6ASITE076589		Click to Show/Hide the Full List
mod site	chr6:108682275-108682276:+		[19]
Sequence	GTCTTACAGAATGTCCTAGAACCAGATTATCATTTAATCTG
Motif Score	2.930744048
Cell/Tissue List	CD34; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729698
mod ID: M6ASITE076590		Click to Show/Hide the Full List
mod site	chr6:108682298-108682299:+		[19]
Sequence	AGATTATCATTTAATCTGAAACAGCTGAGGAAGGGACAGAG
Motif Score	2.20572619
Cell/Tissue List	CD34; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729699
mod ID: M6ASITE076592		Click to Show/Hide the Full List
mod site	chr6:108682313-108682314:+		[19]
Sequence	CTGAAACAGCTGAGGAAGGGACAGAGAAGGTACAAGGGCAA
Motif Score	3.643047619
Cell/Tissue List	CD34; MT4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729700
mod ID: M6ASITE076593		Click to Show/Hide the Full List
mod site	chr6:108682345-108682346:+		[19]
Sequence	CAAGGGCAAGGCAGCACAAAACAGATCAGGAGAATGAAGAG
Motif Score	2.20572619
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729701
mod ID: M6ASITE076594		Click to Show/Hide the Full List
mod site	chr6:108682419-108682420:+		[19]
Sequence	TTCTTTTTCAAGTAACTAAAACAGCATCTACATGTAGAGTG
Motif Score	2.20572619
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729702
mod ID: M6ASITE076595		Click to Show/Hide the Full List
mod site	chr6:108682455-108682456:+		[19]
Sequence	GAGTGTTGTGGAGAGCTGAGACCAGGGTAAAGTCAAGTGCA
Motif Score	2.876744048
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729703
mod ID: M6ASITE076596		Click to Show/Hide the Full List
mod site	chr6:108682492-108682493:+		[19]
Sequence	TGCAGCATCAGTACTGCGAGACCCACCAGCCCCTGGAGAGG
Motif Score	2.876744048
Cell/Tissue List	CD34
Seq Type List	m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729704
mod ID: M6ASITE076597		Click to Show/Hide the Full List
mod site	chr6:108682813-108682814:+		[15]
Sequence	ATGTTTGATTTATGATGAGAACTATCCGAGGCCACCCTTGG
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729705
mod ID: M6ASITE076598		Click to Show/Hide the Full List
mod site	chr6:108682905-108682906:+		[15]
Sequence	AAGAGTACCTAATGTTGAAAACATGACATGCGCTCTTGGGA
Motif Score	2.20572619
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729706
mod ID: M6ASITE076599		Click to Show/Hide the Full List
mod site	chr6:108682910-108682911:+		[16]
Sequence	TACCTAATGTTGAAAACATGACATGCGCTCTTGGGATCTGC
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729707
mod ID: M6ASITE076600		Click to Show/Hide the Full List
mod site	chr6:108682952-108682953:+		[15]
Sequence	GTTCTCTCCAGGGCTCCAGAACCTGATACCTGTTACCAAAG
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729708
mod ID: M6ASITE076601		Click to Show/Hide the Full List
mod site	chr6:108682991-108682992:+		[16]
Sequence	AGCTAGGAAAGAGCTTTATCACAAGCCTTCACTGTCCTGGC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729709
mod ID: M6ASITE076602		Click to Show/Hide the Full List
mod site	chr6:108683108-108683109:+		[16]
Sequence	TCTGCAATATGATTGCTGAAACACATTTTAAAAATTCAGAA
Motif Score	2.20572619
Cell/Tissue List	HEK293T; hESC-HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; MAZTER-seq; m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729710
mod ID: M6ASITE076603		Click to Show/Hide the Full List
mod site	chr6:108683174-108683175:+		[16]
Sequence	ATCAGTCACACATGTGTAGTACAAGGCGGACTTTGTGTTTG
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729711
mod ID: M6ASITE076604		Click to Show/Hide the Full List
mod site	chr6:108683183-108683184:+		[21]
Sequence	ACATGTGTAGTACAAGGCGGACTTTGTGTTTGTTTTTGGTG
Motif Score	4.065041667
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729712
mod ID: M6ASITE076605		Click to Show/Hide the Full List
mod site	chr6:108683250-108683251:+		[15]
Sequence	TTCCCCACCCTGAGGAGAGGACACCATGGCTTACTACTCAG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HEK293T; hESC-HEK293T; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729713
mod ID: M6ASITE076606		Click to Show/Hide the Full List
mod site	chr6:108683272-108683273:+		[15]
Sequence	ACCATGGCTTACTACTCAGGACAAGTATGCCCCGCTCAGGG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HEK293T; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729714
mod ID: M6ASITE076607		Click to Show/Hide the Full List
mod site	chr6:108683315-108683316:+		[15]
Sequence	TGATTTCAGGTGGCTTCCAAACTTGTACGCAGTTTAAAGAT
Motif Score	2.627720238
Cell/Tissue List	HeLa; CD34; HEK293T; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729715
mod ID: M6ASITE076608		Click to Show/Hide the Full List
mod site	chr6:108683321-108683322:+		[20]
Sequence	CAGGTGGCTTCCAAACTTGTACGCAGTTTAAAGATGGTGGG
Motif Score	2.830077381
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729716
mod ID: M6ASITE076609		Click to Show/Hide the Full List
mod site	chr6:108683343-108683344:+		[15]
Sequence	GCAGTTTAAAGATGGTGGGGACAGACTTTGCCTCTACCTAG
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HEK293T; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729717
mod ID: M6ASITE076610		Click to Show/Hide the Full List
mod site	chr6:108683367-108683368:+		[15]
Sequence	ACTTTGCCTCTACCTAGTGAACCCCACTTAAAGAATAAGGA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HEK293T; fibroblasts; A549; Huh7; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729718
mod ID: M6ASITE076611		Click to Show/Hide the Full List
mod site	chr6:108683461-108683462:+		[15]
Sequence	CCTCCATGTTGGTGCCAAGGACTTGCGAGGGGAAATAAAAA
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HEK293T; A549; hNPCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729719
mod ID: M6ASITE076612		Click to Show/Hide the Full List
mod site	chr6:108683500-108683501:+		[16]
Sequence	AATGTTATCCAGCCTGACCAACATGGAGAAACCCCGTCTCC
Motif Score	2.173910714
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; rmsk_2036796
External Link	RMBase: m6A_site_729720
mod ID: M6ASITE076613		Click to Show/Hide the Full List
mod site	chr6:108683510-108683511:+		[15]
Sequence	AGCCTGACCAACATGGAGAAACCCCGTCTCCATTAAAAATA
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HEK293T; A549; hNPCs; fibroblasts; Huh7; HEK293A-TOA; iSLK; MSC; TIME
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	rmsk_2036796; ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729721
mod ID: M6ASITE076614		Click to Show/Hide the Full List
mod site	chr6:108683606-108683607:+		[15]
Sequence	GAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTCGCA
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HEK293T; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10; rmsk_2036796
External Link	RMBase: m6A_site_729722
mod ID: M6ASITE076615		Click to Show/Hide the Full List
mod site	chr6:108683676-108683677:+		[15]
Sequence	GCCTGGGTAACAAGAGTGAAACTCCGTGTCAAAAAAAAAAA
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T; Huh7; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2; rmsk_2036796
External Link	RMBase: m6A_site_729723
mod ID: M6ASITE076616		Click to Show/Hide the Full List
mod site	chr6:108683734-108683735:+		[22]
Sequence	TCTCTGAAAGCAAAAAGGAAACCCTAACAGCTCTGAACTCT
Motif Score	2.185083333
Cell/Tissue List	HEK293T; Huh7; HEK293A-TOA; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729724
mod ID: M6ASITE076617		Click to Show/Hide the Full List
mod site	chr6:108683740-108683741:+		[20]
Sequence	AAAGCAAAAAGGAAACCCTAACAGCTCTGAACTCTGGTTTT
Motif Score	2.168095238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729725
mod ID: M6ASITE076618		Click to Show/Hide the Full List
mod site	chr6:108683750-108683751:+		[22]
Sequence	GGAAACCCTAACAGCTCTGAACTCTGGTTTTATTTTTCTTG
Motif Score	3.373380952
Cell/Tissue List	HEK293T; Huh7; HEK293A-TOA; iSLK
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729726
mod ID: M6ASITE076619		Click to Show/Hide the Full List
mod site	chr6:108683785-108683786:+		[22]
Sequence	TTCTTGCTGTATTTGGGTGAACATTGTATGATTAGGCATAA
Motif Score	2.951386905
Cell/Tissue List	HEK293T; Huh7; iSLK
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729727
mod ID: M6ASITE076620		Click to Show/Hide the Full List
mod site	chr6:108683884-108683885:+		[23]
Sequence	AAAGCTAGCCTCTCTCAGAGACCGGGGAGGCAGAGTACTAC
Motif Score	2.876744048
Cell/Tissue List	HEK293T; Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729728
mod ID: M6ASITE076621		Click to Show/Hide the Full List
mod site	chr6:108684005-108684006:+		[16]
Sequence	ATCTAAATCTTAAGTGGGTAACATTTTATGCAGTTTAAATG
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729729
mod ID: M6ASITE076622		Click to Show/Hide the Full List
mod site	chr6:108684105-108684106:+		[16]
Sequence	TGGTCATGAGGCCTCTTGCCACACTCCAGAAATACGTGTGC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729730
mod ID: M6ASITE076623		Click to Show/Hide the Full List
mod site	chr6:108684219-108684220:+		[16]
Sequence	TCTTGTATACTTGTCCTAGCACATTATGTACATGGGAAATG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729731
mod ID: M6ASITE076624		Click to Show/Hide the Full List
mod site	chr6:108684243-108684244:+		[16]
Sequence	TATGTACATGGGAAATGTAAACAAATGTGAAGGAGGACCAG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729732
mod ID: M6ASITE076625		Click to Show/Hide the Full List
mod site	chr6:108684310-108684311:+		[16]
Sequence	GTATTGTGCATTTTGGCTTCACATGTTTAACTTTTTTTAAG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729733
mod ID: M6ASITE076626		Click to Show/Hide the Full List
mod site	chr6:108684429-108684430:+		[21]
Sequence	CATATCCCATATAATCTAGAACTAAATATGGTGTGTGGCCA
Motif Score	3.373380952
Cell/Tissue List	HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729734
mod ID: M6ASITE076627		Click to Show/Hide the Full List
mod site	chr6:108684457-108684458:+		[21]
Sequence	TGGTGTGTGGCCATATTTAAACACCTGAGAGTCAAGCAGTT
Motif Score	2.20572619
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729735
mod ID: M6ASITE076628		Click to Show/Hide the Full List
mod site	chr6:108684481-108684482:+		[22]
Sequence	CTGAGAGTCAAGCAGTTGAGACTTTGATTTGAAGCACCTCA
Motif Score	3.319380952
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729736
mod ID: M6ASITE076629		Click to Show/Hide the Full List
mod site	chr6:108684519-108684520:+		[22]
Sequence	TCATCCTTCTTTCAATGCGAACACTATCATATGGCATTCTT
Motif Score	2.951386905
Cell/Tissue List	HEK293T; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000343882.10; ENST00000406360.2
External Link	RMBase: m6A_site_729737
mod ID: M6ASITE076630		Click to Show/Hide the Full List
mod site	chr6:108684605-108684606:+
Sequence	CGCCTTTCTTAAGGATCAAAACCAGTTTGATTTGGGAATCT
Motif Score	2.185083333
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729738
mod ID: M6ASITE076631		Click to Show/Hide the Full List
mod site	chr6:108684661-108684662:+		[20]
Sequence	AAATAGAGATGCAGTACTTAACTTTCCTTGGTGTTTGTAGA
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729739
mod ID: M6ASITE076632		Click to Show/Hide the Full List
mod site	chr6:108684761-108684762:+		[16]
Sequence	ATGTAAATAAAGCATCAGTGACACTCTATCTTACTCCAAGA
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000406360.2; ENST00000343882.10
External Link	RMBase: m6A_site_729740

Ref 1	RNA N6-methyladenosine: a new player in autophagy-mediated anti-cancer drug resistance. Br J Cancer. 2021 May;124(10):1621-1622. doi: 10.1038/s41416-021-01314-z. Epub 2021 Mar 15.
Ref 2	Upregulation of METTL14 contributes to trophoblast dysfunction by elevating FOXO3a expression in an m(6)A-dependent manner. Placenta. 2022 Jun 24;124:18-27. doi: 10.1016/j.placenta.2022.05.008. Epub 2022 May 14.
Ref 3	RNA m(6) A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy. EMBO J. 2020 Jun 17;39(12):e103181. doi: 10.15252/embj.2019103181. Epub 2020 May 5.
Ref 4	m(6)A demethylase ALKBH5 inhibits cell proliferation and the metastasis of colorectal cancer by regulating the FOXO3/miR-21/SPRY2 axis. Am J Transl Res. 2021 Oct 15;13(10):11209-11222. eCollection 2021.
Ref 5	CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy. Eur J Pharmacol. 2022 May 5;922:174915. doi: 10.1016/j.ejphar.2022.174915. Epub 2022 Mar 24.
Ref 6	RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):976-981. doi: 10.1073/pnas.1812536116. Epub 2018 Dec 27.
Ref 7	Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3.
Ref 8	Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer. Ann Oncol. 2010 Jun;21(6):1302-1307. doi: 10.1093/annonc/mdp524. Epub 2009 Nov 16.
Ref 9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71).
Ref 10	Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?. J Autoimmun. 2020 Jul;111:102452. doi: 10.1016/j.jaut.2020.102452. Epub 2020 Apr 10.
Ref 11	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020380)
Ref 12	A human fatty acid synthase inhibitor binds Beta-ketoacyl reductase in the keto-substrate site. Nat Chem Biol. 2014 Sep;10(9):774-9. doi: 10.1038/nchembio.1603. Epub 2014 Aug 3.
Ref 13	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 14	Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. doi: 10.1101/gr.124107.111. Epub 2011 Sep 29.
Ref 15	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 16	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 17	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 18	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 19	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 20	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 21	The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003.
Ref 22	Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635-46. doi: 10.1016/j.cell.2012.05.003. Epub 2012 May 17.
Ref 23	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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