m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0245)
Name
Glioblastoma multiforme
ICD
ICD-11: XH0MB1
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
In total 2 item(s) under this disease
Crosstalk ID: M6ACROT05338
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target Forkhead box protein O3 (FOXO3)
 Target Gene 
Epigenetic Regulator hsa-miR-27a-3p
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship ncRNA → m6A
Crosstalk ID: M6ACROT05968
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target PDH kinase 1 (PDK1)
 Target Gene 
Epigenetic Regulator Long non-coding RNA just proximal to the X-inactive specific transcript (JPX)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship ncRNA → m6A
Drug Temozolomide
 Drug Info 
References
Ref 1 Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102. doi: 10.1124/dmd.31.9.1093.
Ref 2 Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer. Ann Oncol. 2010 Jun;21(6):1302-1307. doi: 10.1093/annonc/mdp524. Epub 2009 Nov 16.
Ref 3 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. doi: 10.1038/s41573-019-0013-8.