m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05968
 [1]
Non-coding RNA JPX FTO  lncRNA       miRNA   circRNA Direct Enhancement m6A modification PDK1 PDK1 FTO Demethylation : m6A sites
m6A Modification:
m6A Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
m6A Target PDH kinase 1 (PDK1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Long non-coding RNA just proximal to the X-inactive specific transcript (JPX) LncRNA View Details
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO) View Details
Crosstalk Relationship ncRNA  →  m6A Enhancement
Crosstalk Mechanism ncRNAs directly impacts m6A modification through recruiting m6A regulator
Crosstalk Summary JPX interacted with N6-methyladenosine (m6A) demethylase FTO and enhanced FTO-mediated PDH kinase 1 (PDK1) mRNA demethylation. JPX exerted its GBM-promotion effects through the FTO/PDK1 axis. These findings reveal the key role of JPX in promoting GBM aerobic glycolysis and temozolomide (TMZ) chemoresistance in an m6A-dependent manner.
Responsed Disease Glioblastoma multiforme ICD-11: XH0MB1
 Disease Info 
Responsed Drug Temozolomide
 Drug Info 
Pathway Response Glycolysis / Gluconeogenesis hsa00010
Cell Process Glycolysis
Cell apoptosis
Cell proliferation
In-vitro Model
 U251 (Fibroblasts or fibroblast like cells)
LN-229 Glioblastoma Homo sapiens CVCL_0393
U87 (A primary glioblastoma cell line)
SHG-44 Astrocytoma Homo sapiens CVCL_6728
LN-18 Glioblastoma Homo sapiens CVCL_0392
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
PDH kinase 1 (PDK1) 99 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Dichloroacetate Phase 4 [2]
Synonyms
2,2-dichloroacetate; Dichloracetate; Dichloroacetate ion; 13425-80-4; Dichloroacetic acid ion(1-); DCA; BRN 3903873; 2q8h; ACETIC ACID, DICHLORO-, ION(1-); 2,2-bis(chloranyl)ethanoate; GTPL4518; CHEBI:28240; DTXSID40158610; STL483470; NCGC00241105-01; 68626-EP2292227A2; 68626-EP2292628A2; 68626-EP2298776A1; 68626-EP2308861A1; 68626-EP2374454A1; A839686; Q27077050
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25975
TTD: D7I9JH
 Compound Name Heteroaryl-carboxamide derivative 4 Patented [3]
Synonyms
PMID25684022-Compound-WO2012058176 27(6)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D00LMA
 Compound Name Pyrazole derivative 61 Patented [3]
Synonyms
PMID25684022-Compound-US20090111799
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2000 nM
External Link
TTD: D00MLJ
 Compound Name PMID25684022-Compound-WO2011137219 37(4-6) Patented [3]
MOA Inhibitor
Activity IC50 = 110 nM
External Link
TTD: D00SVK
 Compound Name Heteroaryl-carboxamide derivative 3 Patented [3]
Synonyms
PMID25684022-Compound-WO2012058176 26(5)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D00ZXR
 Compound Name Pyrimidine derivative 3 Patented [3]
Synonyms
PMID25684022-Compound-WO2011076327
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 120 nM
External Link
TTD: D02MMG
 Compound Name Heterocyclic derivative 15 Patented [3]
Synonyms
PMID25684022-Compound-WO2012044157 4(58)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D02USE
 Compound Name Thieno[3,2-c]pyridine-7-carboxamide derivative 2 Patented [3]
Synonyms
PMID25684022-Compound-WO2006106326c2
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 160 nM
External Link
TTD: D03GFZ
 Compound Name Heteroaryl-carboxamide derivative 9 Patented [3]
Synonyms
PMID25684022-Compound-WO2012058176 32(20)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D03WFI
 Compound Name Thiazole carboxamide derivative 24 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 18(27)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D04BBA
 Compound Name Heterocyclic derivative 12 Patented [3]
Synonyms
PMID25684022-Compound-WO2012044157 1(1.5)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D04BBT
 Compound Name PMID25684022-Compound-US20120277229 41(1.3) Patented [3]
MOA Inhibitor
Activity IC50 = 280 nM
External Link
TTD: D04EDM
 Compound Name Heterocyclic derivative 17 Patented [3]
Synonyms
PMID25684022-Compound-WO2012044157 6(360)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D04MHV
 Compound Name Thiazole carboxamide derivative 27 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 21(40)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D04QRX
 Compound Name PMID25684022-Compound-WO2008079988 Patented [3]
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D04UHW
 Compound Name Pyridinone carboxamide derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2010007116
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 1000 nM
External Link
TTD: D05GMT
 Compound Name Heterocyclic derivative 4 Patented [3]
Synonyms
PMID25684022-Compound-US20120208819 1(1.5)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D05OTD
 Compound Name Thieno[3,2-c]pyridine-7-carboxamide derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2006106326c1
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 350 nM
External Link
TTD: D06BSG
 Compound Name Thiazole carboxamide derivative 9 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 18(27)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D06LCB
 Compound Name PMID25684022-Compound-WO2009153313 Patented [3]
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D06LLS
 Compound Name PMID25684022-Compound-US20120277229 40(1.2) Patented [3]
MOA Inhibitor
Activity IC50 = 160 nM
External Link
TTD: D06LSZ
 Compound Name Thiazole carboxamide derivative 12 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 21(40)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D06PTW
 Compound Name PMID25684022-Compound-WO2004087707 Patented [3]
MOA Inhibitor
Activity IC50 = 320 to 32000 nM
External Link
TTD: D06RGW
 Compound Name Benzimidazole and imidazopyridine derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2011006567
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.1 to 10 nM
External Link
TTD: D06WAN
 Compound Name Thiazole carboxamide derivative 14 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 24(45)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D06WXJ
 Compound Name PMID25684022-Compound-US20130053382 38(5-7) Patented [3]
MOA Inhibitor
Activity IC50 = 85 nM
External Link
TTD: D07FMW
 Compound Name Heterocyclic derivative 9 Patented [3]
Synonyms
PMID25684022-Compound-US20120208819 6(360)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D07HOA
 Compound Name Heterocyclic derivative 10 Patented [3]
Synonyms
PMID25684022-Compound-US20120208819 7(402)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D07IQE
 Compound Name Thiazole carboxamide derivative 11 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 20(38)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D07MSB
 Compound Name PMID25684022-Compound-US20130053382 36(3-5) Patented [3]
MOA Inhibitor
Activity IC50 = 170 nM
External Link
TTD: D07XBA
 Compound Name PMID25684022-Compound-US20120277229 45(1.5) Patented [3]
MOA Inhibitor
Activity IC50 = 780 nM
External Link
TTD: D07ZKE
 Compound Name Thiazole carboxamide derivative 29 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 24(45)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D07ZMG
 Compound Name PMID25684022-Compound-WO2008005457 Patented [3]
MOA Inhibitor
Activity IC50 < 500 nM
External Link
TTD: D08EGT
 Compound Name Heteroaryl-carboxamide derivative 2 Patented [3]
Synonyms
PMID25684022-Compound-WO2012058176 25(3)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D08SNT
 Compound Name Thiazole carboxamide derivative 7 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 16(16)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D08YPQ
 Compound Name Heterocyclic derivative 11 Patented [3]
Synonyms
PMID25684022-Compound-US20120208819 8(443)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D09BNP
 Compound Name PMID25684022-Compound-US20120277229 39(1.1) Patented [3]
MOA Inhibitor
Activity IC50 = 140 nM
External Link
TTD: D09FQP
 Compound Name Heterocyclic derivative 8 Patented [3]
Synonyms
PMID25684022-Compound-US20120208819 5(355)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D0AM2D
 Compound Name Thiazole carboxamide derivative 20 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 14(14)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0B2GM
 Compound Name PMID25684022-Compound-WO2011137219 36(3-5) Patented [3]
MOA Inhibitor
Activity IC50 = 170 nM
External Link
TTD: D0B8OB
 Compound Name PMID25684022-Compound-WO2010127754 Patented [3]
MOA Inhibitor
Activity IC50 = 0.5 to 1000 nM
External Link
TTD: D0C6VX
 Compound Name Indazole derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2003064397
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 10 to 140 nM
External Link
TTD: D0CK8H
 Compound Name Heterocyclic-carboxamide derivative 2 Patented [3]
Synonyms
PMID25684022-Compound-WO2011044157
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 1000 nM
External Link
TTD: D0CQ1M
 Compound Name Heterocyclic derivative 6 Patented [3]
Synonyms
PMID25684022-Compound-US20120208819 3(7.6)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D0D0ML
 Compound Name Imidazo quinoline derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2008054238
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 34 to 330 nM
External Link
TTD: D0D5YE
 Compound Name Thiazole carboxamide derivative 16 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 10(4)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0D8PF
 Compound Name PMID25684022-Compound-WO2012135799 42(1.4) Patented [3]
MOA Inhibitor
Activity IC50 = 300 nM
External Link
TTD: D0DC2P
 Compound Name Bis-indolylmaleimide derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2005041953
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 750 to 14000 nM
External Link
TTD: D0DM2G
 Compound Name Thiazole carboxamide derivative 23 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 17(23)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0DO6K
 Compound Name Heterocyclic derivative 14 Patented [3]
Synonyms
PMID25684022-Compound-WO2012044157 3(7.6)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D0EH9Z
 Compound Name Thiazole carboxamide derivative 18 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 12(12)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0FJ4A
 Compound Name Heterocyclic derivative 18 Patented [3]
Synonyms
PMID25684022-Compound-WO2012044157 7(402)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D0FW3M
 Compound Name Thiazole carboxamide derivative 17 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 11(5)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0GE6F
 Compound Name Heteroaryl-carboxamide derivative 6 Patented [3]
Synonyms
PMID25684022-Compound-WO2012058176 29(8)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D0GH9W
 Compound Name Thiazole carboxamide derivative 19 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 13(13)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0GY8G
 Compound Name Thiazole carboxamide derivative 4 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 13(13)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0H6AF
 Compound Name Heteroaryl-carboxamide derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2012058176 24(47)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D0H7SO
 Compound Name Heterocyclic derivative 13 Patented [3]
Synonyms
PMID25684022-Compound-WO2012044157 2(2.4)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D0HI8X
 Compound Name Thiazole carboxamide derivative 2 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 11(5)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0HP8K
 Compound Name Pyrazolopyridines and imidazopyridine derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2010017047
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 30000 nM
External Link
TTD: D0I1YQ
 Compound Name Dibenzo [c,f]-[2,7]naphthyridine derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-US20070135429
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 60 to 7500 nM
External Link
TTD: D0I5KI
 Compound Name PMID25684022-Compound-WO2011137219 38(5-7) Patented [3]
MOA Inhibitor
Activity IC50 = 85 nM
External Link
TTD: D0IO2X
 Compound Name Benzonaphthyridine derivative 2 Patented [3]
Synonyms
PMID25684022-Compound-WO2008109613
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 8 nM
External Link
TTD: D0IR8B
 Compound Name Heterocyclic derivative 5 Patented [3]
Synonyms
PMID25684022-Compound-US20120208819 2(2.4)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D0J9DI
 Compound Name Thiazole carboxamide derivative 25 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 19(36)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 50 nM
External Link
TTD: D0JR0F
 Compound Name Thiazole carboxamide derivative 10 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 19(36)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 50 nM
External Link
TTD: D0K8XT
 Compound Name Thiazole carboxamide derivative 22 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 16(16)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0KN7T
 Compound Name Heteroaryl-carboxamide derivative 5 Patented [3]
Synonyms
PMID25684022-Compound-WO2012058176 28(7)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D0MG4D
 Compound Name PMID25684022-Compound-WO2008107444 Patented [3]
MOA Inhibitor
Activity IC50 <= 1000 nM
External Link
TTD: D0MI3E
 Compound Name Heteroaryl-carboxamide derivative 7 Patented [3]
Synonyms
PMID25684022-Compound-WO2012058176 30(12)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D0MW7L
 Compound Name PMID25684022-Compound-WO2011137219 35(1-11) Patented [3]
MOA Inhibitor
Activity IC50 = 33 nM
External Link
TTD: D0P0WF
 Compound Name Pyrimidinone derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2010007114
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 1000 nM
External Link
TTD: D0P1VT
 Compound Name Thiazole carboxamide derivative 21 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 15(15)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0P6PT
 Compound Name Thiazole carboxamide derivative 8 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 17(23)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0PD2I
 Compound Name 1,2-dihydroindazolo[4,3-bc][1,5]benzoxazepine derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2010120854
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 7.6 nM
External Link
TTD: D0PJ7M
 Compound Name Thiazole carboxamide derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 10(4)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0Q6RC
 Compound Name Thiazole carboxamide derivative 15 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 9(2)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 nM
External Link
TTD: D0Q8JK
 Compound Name Thiazole carboxamide derivative 28 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 23(41)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0QV1E
 Compound Name PMID25684022-Compound-WO2012135799 43(1.5) Patented [3]
MOA Inhibitor
Activity IC50 = 780 nM
External Link
TTD: D0R0SJ
 Compound Name Thiazole carboxamide derivative 3 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 12(12)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0R3VG
 Compound Name PMID25684022-Compound-US20120277229 44(1.4) Patented [3]
MOA Inhibitor
Activity IC50 = 300 nM
External Link
TTD: D0RE3R
 Compound Name Heterocyclic derivative 16 Patented [3]
Synonyms
PMID25684022-Compound-WO2012044157 5(355)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D0RH6G
 Compound Name PMID25684022-Compound-WO2006015124 Patented [3]
MOA Inhibitor
Activity IC50 = 1000 to 5000 nM
External Link
TTD: D0RP4U
 Compound Name Heterocyclic-carboxamide derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2010065384
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 30000 nM
External Link
TTD: D0RY6M
 Compound Name PMID25684022-Compound-US20130053382 35(1-11) Patented [3]
MOA Inhibitor
Activity IC50 = 33 nM
External Link
TTD: D0SB4A
 Compound Name Heteroaryl-carboxamide derivative 10 Patented [3]
Synonyms
PMID25684022-Compound-WO2012058176 33(21)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D0TB2H
 Compound Name Benzonaphthyridine derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2008109599
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 8 nM
External Link
TTD: D0U3IS
 Compound Name Thiazole carboxamide derivative 5 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 14(14)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0U5HB
 Compound Name Thiazole carboxamide derivative 26 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 20(38)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0U7LW
 Compound Name Heterocyclic derivative 7 Patented [3]
Synonyms
PMID25684022-Compound-US20120208819 4(58)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D0W3JC
 Compound Name Heteroaryl-carboxamide derivative 8 Patented [3]
Synonyms
PMID25684022-Compound-WO2012058176 31(13)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 <= 50 nM
External Link
TTD: D0WT9J
 Compound Name Heterocyclic derivative 19 Patented [3]
Synonyms
PMID25684022-Compound-WO2012044157 8(443)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 to 5000 nM
External Link
TTD: D0WX4H
 Compound Name PMID25684022-Compound-US20130053382 37(4-6) Patented [3]
MOA Inhibitor
Activity IC50 = 110 nM
External Link
TTD: D0Y0RG
 Compound Name PMID25684022-Compound-EP20041486488 Patented [3]
MOA Inhibitor
Activity IC50 = 20000 nM
External Link
TTD: D0YD1Q
 Compound Name Thiazole carboxamide derivative 30 Patented [3]
Synonyms
PMID25684022-Compound-WO2012036974 9(2)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 100 nM
External Link
TTD: D0Z3HW
 Compound Name Thiazole carboxamide derivative 6 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 15(15)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0Z5HL
 Compound Name Indolinone derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-US200607105563
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 520 nM
External Link
CID: 11161844
TTD: D0ZE5U
 Compound Name Thiazole carboxamide derivative 13 Patented [3]
Synonyms
PMID25684022-Compound-US20130165450 23(41)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 250 nM
External Link
TTD: D0ZG0K
 Compound Name Pyrido[4,3-d]pyrimidin-5(6H)-one derivative 1 Patented [3]
Synonyms
PMID25684022-Compound-WO2010019637
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3 to 10000 nM
External Link
TTD: D0ZV9P
References
Ref 1 Long noncoding RNA just proximal to X-inactive specific transcript facilitates aerobic glycolysis and temozolomide chemoresistance by promoting stability of PDK1 mRNA in an m6A-dependent manner in glioblastoma multiforme cells. Cancer Sci. 2021 Nov;112(11):4543-4552. doi: 10.1111/cas.15072. Epub 2021 Aug 30.
Ref 2 Comparison of Antitumor Effects of Combined and Separate Treatment with NO Synthase Inhibitor T1023 and PDK1 Inhibitor Dichloroacetate. Bull Exp Biol Med. 2019 Nov;168(1):92-94. doi: 10.1007/s10517-019-04655-1. Epub 2019 Nov 25.
Ref 3 PDK1 disruptors and modulators: a patent review. Expert Opin Ther Pat. 2015 May;25(5):513-37. doi: 10.1517/13543776.2015.1014801. Epub 2015 Feb 15.