m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00556
|
[1], [2], [3], [4] | |||
.png)
.png)
 : modification sites
Indirect
Enhancement
m6A modification
FOXO3
FOXO3
METTL3
Methylation
 : m6A sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Forkhead box protein O3 (FOXO3) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> 5-methylcytidine (m5C) | ||||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | READER | View Details | ||
| Regulated Target | Growth arrest specific 5 (GAS5) | View Details | |||
| Crosstalk Relationship | m5C → m6A | Enhancement | |||
| Crosstalk Mechanism | RNA modification indirectly impacts m6A modification through downstream signaling pathways | ||||
| Crosstalk Summary | YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with Forkhead box protein O3 (FOXO3), which was regulated by METTL3-mediated m6A modification. | ||||
In-vitro Model |
Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | |
| HGC-27 | Gastric carcinoma | Homo sapiens | CVCL_1279 | ||
References