m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03358
 [1], [2]
Histone modification H3K27ac HDAC2 ALKBH5 Direct Inhibition m6A modification FOXO3 FOXO3 ALKBH5 Demethylation : m6A sites
m6A Modification:
m6A Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
m6A Target Forkhead box protein O3 (FOXO3)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Histone deacetylase 2 (HDAC2) ERASER View Details
Regulated Target Histone H3 lysine 27 acetylation (H3K27ac) View Details
Downstream Gene ALKBH5 View Details
Crosstalk Relationship Histone modification  →  m6A Inhibition
Crosstalk Mechanism histone modification directly impacts m6A modification through modulating the level of m6A regulator
Crosstalk Summary Mechanically, HDAC2-reduced Histone H3 lysine 27 acetylation (H3K27ac) inhibits ALKBH5 transcription in CRC, whereas ectopic ALKBH5 expression decreases tumorigenesis of CRC cells and protects mice from colitis-associated tumor development.METTL14/ALKBH5/IGF2BPs combine to modulate JMJD8 stability in an m6A-dependent manner, which increases glycolysis and accelerates the development of CRC by enhancing the enzymatic activity of PKM2. ALKBH5 plays an antitumor role in colorectal cancer by modulating the Forkhead box protein O3 (FOXO3)/miR-21/SPRY2 axis, which not only suggests a regulatory effect between ALKBH5 and FOXO3, but also provides a new therapeutic direction for colorectal cancer.
Responsed Disease Colorectal cancer ICD-11: 2B91
 Disease Info 
Pathway Response FoxO signaling pathway hsa04068
In-vitro Model
 HCT 116 Colon carcinoma Homo sapiens CVCL_0291
Caco-2 Colon adenocarcinoma Homo sapiens CVCL_0025
SW480 Colon adenocarcinoma Homo sapiens CVCL_0546
SW620 Colon adenocarcinoma Homo sapiens CVCL_0547
FHC Normal Homo sapiens CVCL_3688
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Histone deacetylase 2 (HDAC2) 113 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name CHR-3996 Phase 1/2 [3]
Synonyms
CCT-075453; CHR-2504; HDAC inhibitors, Chroma Therapeutics; Histone deacetylase inhibitors, Chroma
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4 nM
External Link
CID: 49857317
TTD: D06TKI
DrugBank: DB15419
 Compound Name PMID29671355-Compound-74 Patented [4]
MOA Inhibitor
Activity IC50 = 119 nM
External Link
CID: 72946782
TTD: D0N2FN
 Compound Name PMID29671355-Compound-59 Patented [4]
MOA Inhibitor
Activity IC50 = 10 nM
External Link
CID: 130319551
TTD: D0C9NX
 Compound Name PMID29671355-Compound-55 Patented [4]
MOA Inhibitor
Activity IC50 < 1000 nM
External Link
CID: 60198673
TTD: D0OU0J
 Compound Name PMID29671355-Compound-11 Patented [4]
MOA Inhibitor
Activity IC50 = 24 nM
External Link
CID: 118005782
TTD: D0EH2K
 Compound Name PMID29671355-Compound-9 Patented [4]
MOA Inhibitor
Activity IC50 = 128 nM
External Link
CID: 57381425
TTD: D0Q1QY
 Compound Name PMID29671355-Compound-8 Patented [4]
MOA Inhibitor
Activity IC50 = 123000 nM
External Link
TTD: D0LN1T
 Compound Name PMID29671355-Compound-61 Patented [4]
MOA Inhibitor
Activity IC50 = 45.9 nM
External Link
TTD: D0JB4S
 Compound Name PMID29671355-Compound-23 Patented [4]
MOA Inhibitor
Activity IC50 = 7450 nM
External Link
CID: 118884610
TTD: D00HXJ
 Compound Name PMID29671355-Compound-44 Patented [4]
MOA Inhibitor
Activity IC50 < 150 nM
External Link
CID: 72710871
TTD: D0N2DK
 Compound Name PMID29671355-Compound-56 Patented [4]
MOA Inhibitor
Activity IC50 = 54.4 nM
External Link
CID: 56965342
TTD: D0CH8Q
 Compound Name PMID29671355-Compound-67 Patented [4]
MOA Inhibitor
Activity IC50 > 50000 nM
External Link
CID: 60201048
TTD: D0M0RE
 Compound Name PMID29671355-Compound-31 Patented [4]
MOA Inhibitor
Activity IC50 = 2 nM
External Link
CID: 90479372
TTD: D0DI9S
DrugBank: DB14979
 Compound Name PMID29671355-Compound-21 Patented [4]
MOA Inhibitor
Activity IC50 = 4880 nM
External Link
CID: 86295624
TTD: D0LP1K
 Compound Name PMID29671355-Compound-62 Patented [4]
MOA Inhibitor
Activity IC50 = 100 to 500 nM
External Link
TTD: D07WAT
 Compound Name PMID29671355-Compound-43 Patented [4]
MOA Inhibitor
Activity IC50 = 124 nM
External Link
CID: 118515590
TTD: D0BP8I
 Compound Name PMID29671355-Compound-25 Patented [4]
MOA Inhibitor
Activity IC50 = 5400 nM
External Link
CID: 126569528
TTD: D0RA0D
 Compound Name N8-hydroxy-2-methoxy-N1-phenyloctanediamide Investigative [5]
Synonyms
CHEMBL251010; SCHEMBL8158442
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
CID: 25065930
TTD: D01AVS
 Compound Name N-(4'-acetyl-4-aminobiphenyl-3-yl)benzamide Investigative [6]
Synonyms
CHEMBL1099078; BDBM50317997
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3800 nM
External Link
CID: 46887380
TTD: D01TSM
 Compound Name N-Hydroxy-E-3-(4'-chlorobiphenyl-4-yl)-acrylamide Investigative [7]
Synonyms
CHEMBL557066; SCHEMBL3292989; SCHEMBL3292983; BDBM50293365
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1860 nM
External Link
CID: 15986508
TTD: D02TQA
 Compound Name N7-hydroxy-2-methoxy-N1-phenylheptanediamide Investigative [5]
Synonyms
CHEMBL251206; SCHEMBL8143763
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
CID: 25065710
TTD: D03TNE
 Compound Name N7-hydroxy-N1-phenyl-2-propoxyheptanediamide Investigative [5]
Synonyms
CHEMBL251406; SCHEMBL8144856
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
CID: 25065713
TTD: D03TQD
 Compound Name N-(4-amino-4'-vinylbiphenyl-3-yl)benzamide Investigative [6]
Synonyms
CHEMBL1096397; BDBM50318002
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 800 nM
External Link
CID: 46887334
TTD: D05RWU
 Compound Name N-(4-amino-3'-methoxybiphenyl-3-yl)benzamide Investigative [6]
Synonyms
CHEMBL1097747; BDBM50317991
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1300 nM
External Link
CID: 46887438
TTD: D06IWR
 Compound Name KAR-1880 Investigative [8]
Synonyms
Anti-inflammatory OS-HDI; OS-HDI-2; HDAC 2 inhibitors (topical, dermatitis/psoriasis), Karus
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D06YYY
 Compound Name N-(2-amino-5-(pyridin-4-yl)phenyl)benzamide Investigative [6]
Synonyms
CHEMBL1095096
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3900 nM
External Link
CID: 46887378
TTD: D07BMT
 Compound Name N-(4-amino-3'-methylbiphenyl-3-yl)benzamide Investigative [6]
Synonyms
CHEMBL1094108; BDBM50317995
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3100 nM
External Link
CID: 46887381
TTD: D07WSB
 Compound Name N-(3'-acetyl-4-aminobiphenyl-3-yl)benzamide Investigative [6]
Synonyms
CHEMBL1097746; BDBM50317992
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 13000 nM
External Link
CID: 46887437
TTD: D08USK
 Compound Name N-(4-amino-4'-fluorobiphenyl-3-yl)benzamide Investigative [6]
Synonyms
CHEMBL1098337; SCHEMBL15398027; BDBM50317988
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1400 nM
External Link
CID: 46830345
TTD: D08YLO
 Compound Name N8,2-dihydroxy-N1-phenyloctanediamide Investigative [5]
Synonyms
CHEMBL251009; SCHEMBL8144564
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
CID: 25065929
TTD: D09SVH
 Compound Name N-(2-amino-5-(furan-3-yl)phenyl)benzamide Investigative [6]
Synonyms
CHEMBL1095095; Benzamide, N-[2-amino-5-(3-furanyl)phenyl]-; BDBM50318000
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 39 nM
External Link
CID: 46830327
TTD: D0A4KW
 Compound Name N-Hydroxy-E-3-(biphenyl-4-yl)-acrylamide Investigative [7]
Synonyms
CHEMBL556532; SCHEMBL3292226; SCHEMBL3290139
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 820 nM
External Link
CID: 42632368
TTD: D0AK8Q
 Compound Name 2-(allyloxy)-N8-hydroxy-N1-phenyloctanediamide Investigative [5]
Synonyms
CHEMBL402719; SCHEMBL8150833
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
CID: 25065931
TTD: D0D2US
 Compound Name 2-(benzyloxy)-N7-hydroxy-N1-phenylheptanediamide Investigative [5]
Synonyms
CHEMBL402718; SCHEMBL8152458
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
CID: 25065925
TTD: D0FI2F
 Compound Name N-(4-amino-4'-bromobiphenyl-3-yl)benzamide Investigative [6]
Synonyms
CHEMBL1097748; BDBM50317990
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 600 nM
External Link
CID: 46887439
TTD: D0H4SC
 Compound Name N-(2-amino-5-(furan-2-yl)phenyl)benzamide Investigative [6]
Synonyms
CHEMBL1097651
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 43 nM
External Link
CID: 46830328
TTD: D0I2KC
 Compound Name 5-(Biphenyl-4-yl)-pentanoic acid N-hydroxyamide Investigative [7]
Synonyms
CHEMBL541239; SCHEMBL7045815
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 720 nM
External Link
CID: 22915475
TTD: D0K3MR
 Compound Name N-(4-aminobiphenyl-3-yl)benzamide Investigative [6]
Synonyms
CHEMBL271741; 3max; SCHEMBL16380794; BDBM50232053; N-(4-amino-biphenyl-3-yl)-benzamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 27 nM
External Link
CID: 44454143
TTD: D0MD7H
 Compound Name N-(2-amino-5-(benzofuran-2-yl)phenyl)benzamide Investigative [6]
Synonyms
CHEMBL1097063
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 10000 nM
External Link
CID: 46887475
TTD: D0Q4LX
 Compound Name N-(2-aminophenyl)benzamide Investigative [6]
Synonyms
2'-AMINOBENZANILIDE; 721-47-1; CHEMBL405072; AC1LFSYX; AC1Q5NOK; ACMC-1AE0C; Oprea1_478192; MLS000084661; SCHEMBL407834; N-(2-amino-phenyl)-benzamide; AC1Q514U; Benzamide, N-(2-aminophenyl)-; CTK2H2825; DTXSID60353948; RFDVMOUXHKTCDO-UHFFFAOYSA-N; MolPort-001-783-352; ZINC225957; HMS2355D18; STL497474; BDBM50232046; AKOS000133162; MCULE-5545982713; NE17312; SMR000019009; TC-170926; KB-298435; ST51030142; EN300-31745; SR-01000389415; AE-641/00785046
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3100 nM
External Link
CID: 759408
TTD: D0U8FC
 Compound Name N-(4-amino-4'-methoxybiphenyl-3-yl)benzamide Investigative [6]
Synonyms
CHEMBL1095412; BDBM50317998
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 140 nM
External Link
CID: 46887379
TTD: D0W2PX
 Compound Name N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide Investigative [7]
Synonyms
CHEMBL538710; SCHEMBL3292721; SCHEMBL3292715; BDBM50293355
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 330 nM
External Link
CID: 15986510
TTD: D0W9BH
 Compound Name N-(2-amino-5-(thiazol-2-yl)phenyl)benzamide Investigative [6]
Synonyms
CHEMBL1097278
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 390 nM
External Link
CID: 46887333
TTD: D0Y4SD
 Compound Name N-(2-aminophenyl)quinoxaline-6-carboxamide Investigative [9]
Synonyms
benzamide-type inhibitor, 20; CHEMBL236060; BDBM19424
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2000 nM
External Link
CID: 23648267
TTD: D01FYB
 Compound Name 7-Biphenyl-4-yl-heptanoic acid hydroxyamide Investigative [10]
Synonyms
CHEMBL125098; BDBM50222335; 7-(4-Biphenylyl)heptanehydroximic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44349481
TTD: D01RJY
 Compound Name 8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid Investigative [11]
Synonyms
CHEMBL115049; 436150-72-0; SCHEMBL7368556; CTK1D2674; DTXSID40658342; BDBM50221807; 8-[([1,1'-Biphenyl]-4-yl)oxy]-2-oxooctanoic acid; Octanoic acid, 8-([1,1'-biphenyl]-4-yloxy)-2-oxo-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44341224
TTD: D03XXI
 Compound Name 1,1,1-Trifluoro-8-phenoxy-octan-2-one Investigative [12]
Synonyms
CHEMBL114796; BDBM50217940
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44342886
TTD: D04ETX
 Compound Name 7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide Investigative [11]
Synonyms
CHEMBL114184; SCHEMBL3383144
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 22915465
TTD: D04LLD
 Compound Name 7-Phenoxy-heptanoic acid hydroxyamide Investigative [10]
Synonyms
CHEMBL124322; N-hydroxy-7-phenoxyheptanamide; 7-Phenoxyheptanehydroximic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25798548
TTD: D05ZGM
 Compound Name 1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one Investigative [12]
Synonyms
CHEMBL117916; SCHEMBL7366611; BDBM50217945
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44342905
TTD: D06BKA
 Compound Name N-(4-hydroxybiphenyl-3-yl)benzamide Investigative [13]
Synonyms
CHEMBL269935; SCHEMBL5724398; BDBM50232005
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 200 nM
External Link
CID: 44454650
TTD: D0E0TA
 Compound Name 8-Phenyl-octanoic acid hydroxyamide Investigative [10]
Synonyms
CHEMBL123624; N-Hydroxy-8-phenyloctanamide; SCHEMBL5807174
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 14098189
TTD: D0H9DS
 Compound Name 8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one Investigative [12]
Synonyms
CHEMBL116023; SCHEMBL7368359; BDBM50218558
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44343094
TTD: D0NL6C
 Compound Name N-(2-aminophenyl)nicotinamide Investigative [13]
Synonyms
N-(2-Amino-phenyl)-nicotinamide; 436089-31-5; N-(2-aminophenyl)pyridine-3-carboxamide; CHEMBL236678; AC1LMN6K; SCHEMBL18086514; CTK4I7538; DTXSID50360661; CHEBI:125506; ZINC873967; BDBM50220259; 3463AE; AKOS000129725; RTR-042156; MCULE-7933541910; N-(2-aminophenyl)-3-pyridylcarboxamide; ZB014940; ACM436089315; ST086607; ASN 01337807; KB-298440; TR-042156; BC4148434; SR-01000329900; SR-01000329900-1; BRD-K20880473-001-04-6
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 6980 nM
External Link
CID: 1133083
TTD: D04UVL
 Compound Name santacruzamate A Investigative [14]
Synonyms
CAY10683
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.112 nM
External Link
CID: 72946782
TTD: D09RKA
 Compound Name N-(4-aminobiphenyl-3-yl)nicotinamide Investigative [13]
Synonyms
CHEMBL255805; BDBM50232035
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 900 nM
External Link
CID: 44454415
TTD: D0M9LJ
 Compound Name N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide Investigative [13]
Synonyms
CHEMBL256440; SCHEMBL1066609
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 390 nM
External Link
CID: 44454416
TTD: D0Q2GM
 Compound Name N-(2-aminophenyl)-4-methoxybenzamide Investigative [9]
Synonyms
AC1LFX2W; Cambridge id 5129152; Oprea1_722128; benzamide-type inhibitor, 22; CHEMBL236061; SCHEMBL5226034; BDBM19426; CTK7A1998; MolPort-001-019-504; BDYVCYUXCNZYRW-UHFFFAOYSA-N; ZINC281656; STK156256; AKOS000130378; MCULE-9183453747; N-(2-Amino-phenyl)4-methoxy-benzamide; N-(2-amino-phenyl)-4-methoxy-benzamide; NCGC00240897-01; N1-(4-methoxybenzoyl)-1,2-benzenediamine; N1-(4-methoxy-benzoyl)-1,2-benzenediamine; ST50908739; N-(2-aminophenyl)(4-methoxyphenyl)carboxamide; SR-01000196394
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 900 nM
External Link
CID: 785232
TTD: D0YO6M
 Compound Name 4-Phenylbutyrohydroxamic acid Investigative [15]
Synonyms
N-Hydroxy-4-phenylbutanamide; 32153-46-1; NSC131300; UNII-QX182FOM5S; QX182FOM5S; 4-phenylbutanehydroxamic acid; CHEMBL55895; Benzenebutanamide, N-hydroxy-; NSC 131300; AC1Q7DIW; AC1L5RDX; Phenylbutyrylhydroxamic Acid; AC1Q5QD1; N-Hydroxy-4-phenyl-butyramide; 4-Phenylbutyryl hydroxamic acid; SCHEMBL1350853; CTK4G8310; DTXSID60185943; MolPort-011-492-164; UPHXPXYRKPCXHK-UHFFFAOYSA-N; ZINC4962622; STL301752; BDBM50015142; AKOS009266186; MCULE-9765156954; NSC-131300; NE28489; BCB03_000829; EN300-68596
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 430 nM
External Link
CID: 279980
TTD: D02NWS
 Compound Name 8-Oxo-8-phenyl-octanoic acid hydroxyamide Investigative [16]
Synonyms
CHEMBL95959; SCHEMBL3383197; N-hydroxy-8-oxo-8-phenyloctanamide
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11075845
TTD: D0S0WK
 Compound Name Octanedioic acid bis-hydroxyamide Investigative [17]
Synonyms
Suberohydroxamic acid
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 29 nM
External Link
CID: 5173
TTD: D07YZZ
 Compound Name ST-2986 Investigative [18]
Synonyms
CHEMBL471041; SCHEMBL3444455; BDBM50278219
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 11000 nM
External Link
CID: 44138031
TTD: D0N9AK
 Compound Name 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide Investigative [12]
Synonyms
9,9,9-Trifluoro-8-Oxo-N-Phenylnonanamide; CHEMBL113537; 2gh6; SCHEMBL2702892; KRCXZGYVOZSCSF-UHFFFAOYSA-N; BDBM50121062; DB07553
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1400 nM
External Link
CID: 9882812
TTD: D00KFF
DrugBank: DB07553
 Compound Name 7-Mercapto-heptanoic acid phenylamide Investigative [19]
Synonyms
Thiol-SAHA (t-SAHA); CHEMBL325676; SCHEMBL14821761; BDBM152692
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1300 nM
External Link
CID: 11379392
TTD: D00SEE
 Compound Name 6-benzenesulfinylhexanoic acid hydroxamide Investigative [20]
Synonyms
6-(benzenesulfinyl)hexanoic acid hydroxyamide; 875737-03-4
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11694528
TTD: D00ZSD
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-succinamide Investigative [21]
Synonyms
CHEMBL193959
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44401339
TTD: D01MFV
 Compound Name 7-Mercapto-heptanoic acid biphenyl-4-ylamide Investigative [19]
Synonyms
CHEMBL112311
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11220728
TTD: D01XWZ
 Compound Name N-Hydroxy-4-phenylacetylamino-benzamide Investigative [22]
Synonyms
CHEMBL356824; 656261-23-3; SCHEMBL675578; CTK1J6158; DTXSID40458440; ZINC13533297; AKOS030583151; Benzeneacetamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11196500
TTD: D01XXN
 Compound Name 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide Investigative [19]
Synonyms
CHEMBL344920; 651767-99-6; SCHEMBL3736839; CTK1J8444; DTXSID50432973; HWYLREOMBVUGJQ-UHFFFAOYSA-N; BDBM50222416; ZINC13587789; AKOS030603042; N-Phenyl-6-(bromoacetylamino)hexanamide; Hexanamide, 6-[(bromoacetyl)amino]-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9927379
TTD: D02MQM
 Compound Name N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide Investigative [23]
Synonyms
CHEMBL143674; SCHEMBL673760
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MOA Inhibitor
External Link
CID: 11323577
TTD: D02UTC
 Compound Name 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [24]
Synonyms
CHEMBL126355; BDBM50222394
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350626
TTD: D02WZK
 Compound Name Octanedioic acid hydroxyamide pyridin-4-ylamide Investigative [25]
Synonyms
SCHEMBL8082656; CHEMBL165162; ZINC13472304
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10967421
TTD: D04GGW
 Compound Name N-(6-Mercapto-hexyl)-benzamide Investigative [19]
Synonyms
CHEMBL112364; BDBM50223650
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11447748
TTD: D04HSS
 Compound Name 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [25]
Synonyms
CHEMBL167455
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11086699
TTD: D04NSP
 Compound Name N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide Investigative [22]
Synonyms
SCHEMBL675474
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11231829
TTD: D04ZDI
 Compound Name 6-benzenesulfonylhexanoic acid hydroxamide Investigative [20]
Synonyms
CHEMBL203207
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11572583
TTD: D05AHZ
 Compound Name 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one Investigative [12]
Synonyms
SCHEMBL7373122; CHEMBL116578
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44342872
TTD: D05FEJ
 Compound Name Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester Investigative [19]
Synonyms
CHEMBL111806; SCHEMBL14812153
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11254470
TTD: D05GVY
 Compound Name 4-Butyrylamino-N-hydroxy-benzamide Investigative [23]
Synonyms
CHEMBL142254; 656261-22-2; Benzamide, N-hydroxy-4-[(1-oxobutyl)amino]-; SCHEMBL675234; CTK1J6159; DTXSID90461262
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11287488
TTD: D05LLX
 Compound Name 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [24]
Synonyms
CHEMBL127328
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350703
TTD: D05VFP
 Compound Name 7-Mercapto-heptanoic acid biphenyl-3-ylamide Investigative [19]
Synonyms
CHEMBL320323
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11449823
TTD: D05XAN
 Compound Name 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione Investigative [26]
MOA Inhibitor
External Link
CID: 3082127
TTD: D06IQB
 Compound Name N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide Investigative [22]
Synonyms
SCHEMBL676079
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11347053
TTD: D06VBN
 Compound Name 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide Investigative [19]
Synonyms
CHEMBL324126
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11277483
TTD: D06XNP
 Compound Name 7-Mercapto-heptanoic acid pyridin-3-ylamide Investigative [19]
Synonyms
CHEMBL332246; Heptanamide, 7-mercapto-N-3-pyridinyl-; BDBM50223653
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11345433
TTD: D07FJU
 Compound Name 6-Phenoxy-hexane-1-thiol Investigative [19]
Synonyms
CHEMBL109796; 6-phenoxyhexane-1-thiol; 1-Hexanethiol, 6-phenoxy-; SCHEMBL5679745; MolPort-020-180-823; BDBM50223652; AKOS018584222; MCULE-9521857089
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11298778
TTD: D09YBN
 Compound Name 4-Benzoylamino-N-hydroxy-benzamide Investigative [22]
Synonyms
SCHEMBL673678; CHEMBL191227
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11817702
TTD: D09ZNU
 Compound Name 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [16]
Synonyms
CHEMBL143734; NSC718168; AC1L8L82; SCHEMBL13039735; ZINC5579677; BDBM50082664; NSC-718168; NCI60_040737; 6-(4-Chlorobenzoylamino)hexanehydroxamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 403373
TTD: D0A5LS
 Compound Name 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one Investigative [12]
Synonyms
CHEMBL112148; SCHEMBL7364383; BDBM50218532
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44341053
TTD: D0AX7B
 Compound Name 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [24]
Synonyms
CHEMBL127351; SCHEMBL7365180; HWZHDGRMABBYOV-UHFFFAOYSA-N; BDBM50222367; 7-((1,1'-biphenyl)-3-yloxy)-1-(1 ,3-oxazol-2-yl)-1-heptanone
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350718
TTD: D0B2ZJ
 Compound Name 6-Mercapto-hexanoic acid phenylamide Investigative [19]
Synonyms
CHEMBL109654; Hexanamide, 6-mercapto-N-phenyl-; SCHEMBL14254925; BDBM50027600
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2220 nM
External Link
CID: 11436024
TTD: D0B3ZM
 Compound Name Cyclostellettamine derivative Investigative [27]
Synonyms
CHEMBL88332
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 23327627
TTD: D0C0VP
 Compound Name N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide Investigative [16]
Synonyms
CHEMBL139999; SCHEMBL1232700; BDBM50082661; ZINC13472309
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9943996
TTD: D0C2KD
 Compound Name 5-Mercapto-pentanoic acid phenylamide Investigative [19]
Synonyms
N-Phenyl-5-mercaptovaleramide; CHEMBL114344; Pentanamide, 5-mercapto-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11608171
TTD: D0D2KE
 Compound Name Octanedioic acid hydroxyamide pyridin-2-ylamide Investigative [25]
Synonyms
SCHEMBL8090513; CHEMBL164872; ZINC13472303
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11747496
TTD: D0E8KR
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide Investigative [21]
Synonyms
CHEMBL193979
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44401305
TTD: D0F0KS
 Compound Name 2-(methylsulfonylthio)ethyl 2-propylpentanoate Investigative [26]
Synonyms
CHEMBL271677; SCHEMBL4156413
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24759251
TTD: D0H1FZ
 Compound Name (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one Investigative [24]
Synonyms
CHEMBL126465; SCHEMBL7368197; SCHEMBL7368201
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350655
TTD: D0KE3I
 Compound Name N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide Investigative [22]
Synonyms
SCHEMBL676080
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11312563
TTD: D0QO0L
 Compound Name N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide Investigative [28]
Synonyms
N-hydroxy-4-(3-phenylpropanamido)benzamide
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0R4BS
 Compound Name N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide Investigative [22]
Synonyms
SCHEMBL7311087
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11472431
TTD: D0R5VG
 Compound Name 8-Oxo-8-phenyl-octanoic acid Investigative [25]
Synonyms
8-Oxo-8-phenyloctanoic acid; 7-Benzoylheptanoic acid; 24314-23-6; Benzeneoctanoic acid, h-oxo-; 7-BENZOYL HEPTANOIC ACID; AC1L6TSB; SCHEMBL3381106; 8-keto-8-phenyl-caprylic acid; CHEMBL162423; 8-Oxo-8-phenyloctanoic acid #; CTK4F3363; DTXSID40305602; UMCSRRHQLAVYRS-UHFFFAOYSA-N; ZINC2168376; 7009f; NSC171230; AKOS016022495; NSC-171230; MCULE-7202530747; ACM24314236; ST50825837
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 298878
TTD: D0RU1X
 Compound Name N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide Investigative [22]
Synonyms
CHEMBL143336; 656261-24-4; SCHEMBL674421; CTK1J6157; DTXSID30433908; ZINC13533300; AKOS030583673; n-hydroxy-4-(4-phenylbutyryl-amino)benzamide; Benzenebutanamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9994848
TTD: D0S7WQ
 Compound Name 6-phenylsulfanylhexanoic acid hydroxamide Investigative [20]
Synonyms
Hexanamide, N-hydroxy-6-(phenylthio)-; CHEMBL203028; SCHEMBL7317658
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11637291
TTD: D0S9JF
 Compound Name ST-2987 Investigative [18]
Synonyms
CHEMBL471042; SCHEMBL3444989; SCHEMBL3444984; BDBM50278220
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2670 nM
External Link
CID: 44138032
TTD: D0T0SK
 Compound Name 7-Mercapto-heptanoic acid quinolin-3-ylamide Investigative [19]
Synonyms
CHEMBL112234
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10379373
TTD: D0T4IY
 Compound Name 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide Investigative [29]
Synonyms
CHEMBL84288
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11528707
TTD: D0V2ZO
 Compound Name 8-Mercapto-octanoic acid phenylamide Investigative [19]
Synonyms
8-mercapto-N-phenyloctanamide; CHEMBL326433; ZINC13609343
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 754 nM
External Link
CID: 11149404
TTD: D0XZ9Q
 Compound Name N-(6-Hydroxycarbamoyl-hexyl)-benzamide Investigative [25]
Synonyms
CHEMBL57107; 174664-71-2; SCHEMBL573254; CTK0A7470; DTXSID00433435; BDBM50220823; ZINC13490043; 7-(Benzoylamino)heptanehydroxamic acid; AKOS030580013; Benzamide, N-[7-(hydroxyamino)-7-oxoheptyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9965141
TTD: D0YY9M
 Compound Name 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one Investigative [12]
Synonyms
CHEMBL326529; SCHEMBL7365237; BDBM50217957
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44342825
TTD: D0Z3BM
 Compound Name 7-Mercapto-heptanoic acid benzothiazol-2-ylamide Investigative [19]
Synonyms
CHEMBL178779
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11346934
TTD: D0Z5KX
 Compound Name N-Hydroxy-4-(pentanoylamino-methyl)-benzamide Investigative [23]
Synonyms
CHEMBL143102
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44361923
TTD: D0Z7YS
 Compound Name PSAMMAPLIN A Investigative [16]
Synonyms
110659-91-1; Bisprasin; NSC614495; AC1O46WI; SCHEMBL364511; ZINC150352860; NSC-614495; B723735K022; J-002461; Benzenepropanamide, N,N'-(dithiodi-2,1-ethanediyl)bis(3-bromo-4-hydroxy-alpha-(hydroxyimino)-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 6400741
TTD: D0N0TS
2B91: Colorectal cancer 25 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Retifanlimab Approved [30]
Synonyms
INCMGA0012; Retifanlimab
    Click to Show/Hide
External Link
TTD: D0PG5O
 Compound Name Aflibercept Approved [31]
Synonyms
Ziv-Aflibercept; Zaltrap (TN); VEGF Trap; VEGF Trap-Eye
    Click to Show/Hide
External Link
TTD: D0C9ET
 Compound Name Regorafenib Approved [32]
Synonyms
755037-03-7; BAY 73-4506; Regorafenibum; Stivarga; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY73-4506; Regorafenib (BAY 73-4506); UNII-24T2A1DOYB; 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide; BAY-73-4506; 24T2A1DOYB; CHEMBL1946170; CHEBI:68647; Stivarga (TN); BAY73-4506 hydrochloride; Regorafenib [USAN:INN]
    Click to Show/Hide
External Link
CID: 11167602
TTD: D09GDD
DrugBank: DB08896
 Compound Name Bevacizumab Approved [33]
Synonyms
Bevacizumab (ophthalmic slow-release tissue tablet)
    Click to Show/Hide
External Link
TTD: D04KBL
 Compound Name SYM-004 Phase 3 [33]
Synonyms
Chimeric IgG1 antibody 1024 (cancer), Symphogen; Chimeric IgG1 antibody 992 (cancer), Symphogen; Chimeric IgG1 antibodies992 + 1024 (cancer), Symphogen
    Click to Show/Hide
External Link
TTD: D0CR8H
 Compound Name Bevacizumab + Erlotinib Phase 3 [34]
External Link
TTD: D09BKY
 Compound Name CPI-613 Phase 3 [33]
Synonyms
95809-78-2; 6,8-bis(benzylthio)octanoic acid; CPI 613; MLS006010202; SCHEMBL1062218; 6,8-Bis(benzylsulfanyl)octanoic acid; Octanoic acid, 6,8-bis((phenylmethyl)thio)-; Octanoic acid, 6,8-bis[(phenylMethyl)thio]-; 6,8-Bis[(phenylmethyl)thio]octanoic acid; CPI613; CHEMBL3186849; QCR-193; AOB1058; MolPort-023-219-128; HMS3656L06; C22H28O2S2; BCP04663; EX-A2043; s2776; AKOS025142095; BCP9000552; DB12109; RL06062; CS-0961; NCGC00344764-01; SMR004701300; AS-16613; BC261916; AK174899; HY-15453; BCP0726000030; KB-293127; AB0035874
    Click to Show/Hide
External Link
CID: 24770514
TTD: D07NVI
DrugBank: DB12109
 Compound Name Bevacizumab Approved [31]
External Link
TTD: D0FX3U
 Compound Name AlloStim Phase 2/3 [35]
Synonyms
AlloStim (TN)
    Click to Show/Hide
External Link
TTD: D0B3CC
 Compound Name Sibrotuzumab Phase 2 [36]
External Link
TTD: DVX3H0
 Compound Name CV301 Phase 2 [37]
External Link
TTD: D9LT5G
 Compound Name Efatutazone Phase 2 [38]
Synonyms
Inolitazone; 223132-37-4; 5-[[4-[[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy]phenyl]methyl]-2,4-Thiazolidinedione; Efatutazone [INN]; RS5444; CS-7017; SCHEMBL3246054; CHEMBL3545280; JCYNMRJCUYVDBC-UHFFFAOYSA-N; Efatutazone;CS-7017;RS5444; BCP07478; AKOS030526729; DB11894; CS-0778; KB-77905; DA-07988; HY-14792; QC-10456; 4CA-1384; FT-0737589; 5-[4-[6-(4-amino-3 ,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione
    Click to Show/Hide
External Link
CID: 9832447
TTD: D0Y8NZ
DrugBank: DB11894
 Compound Name LOR-2040 Phase 2 [39]
External Link
TTD: D0I7NG
 Compound Name RG7221 Phase 2 [40]
External Link
TTD: D06FTM
 Compound Name PEG-SN38 Phase 2 [41]
Synonyms
EZN-2208
    Click to Show/Hide
External Link
CID: 59443782
TTD: D05UFP
 Compound Name MEGF0444A Phase 2 [42]
External Link
TTD: D01LES
 Compound Name Encapsulated cell therapy Phase 1/2 [43]
External Link
TTD: D0XY8C
 Compound Name AB928 Phase 1/2 [44]
External Link
CID: 135242184
TTD: D04UBI
 Compound Name MGD007 Phase 1 [40]
External Link
TTD: D00PEN
 Compound Name BNC-101 Phase 1 [45]
External Link
TTD: DD6AZ5
 Compound Name Navicixizumab Phase 1 [33]
External Link
TTD: D00IVN
 Compound Name RG7160 Discontinued in Phase 2 [46]
External Link
TTD: D0E2CQ
 Compound Name Nimesulide Terminated [47]
Synonyms
51803-78-2; N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide; Mesulid; Flogovital; Sulidene; Nimed; R-805; 4-NITRO-2-PHENOXYMETHANESULFONANILIDE; Nisulid; Nimesulidum [INN-Latin]; Nimesulida [INN-Spanish]; R 805; UNII-V4TKW1454M; 4-Nitro-2-phenoxy-methanesulfonanilide; 4'-Nitro-2'-phenoxymethanesulfonanilide; Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)-; EINECS 257-431-4; 4'-Nitro-2'-phenoxymethansulfonanilid; BRN 2421175; CHEMBL56367; MLS000069680; V4TKW1454M; Methanesulfonanilide, 4'-nitro-2'-phenoxy-; CHEBI:44445; Dulanermin
    Click to Show/Hide
External Link
CID: 4495
TTD: D0C0JT
DrugBank: DB04743
 Compound Name Saracatinib Phase 2 [48]
External Link
CID: 10302451
TTD: D05YTN
DrugBank: DB11805
 Compound Name G3139 + Irinotecan Investigative [49]
External Link
CID: 91865905
TTD: D05IAN
References
Ref 1 Therapeutic m(6)A Eraser ALKBH5 mRNA-Loaded Exosome-Liposome Hybrid Nanoparticles Inhibit Progression of Colorectal Cancer in Preclinical Tumor Models. ACS Nano. 2023 Jun 27;17(12):11838-11854. doi: 10.1021/acsnano.3c03050. Epub 2023 Jun 13.
Ref 2 m(6)A demethylase ALKBH5 inhibits cell proliferation and the metastasis of colorectal cancer by regulating the FOXO3/miR-21/SPRY2 axis. Am J Transl Res. 2021 Oct 15;13(10):11209-11222. eCollection 2021.
Ref 3 A phase I pharmacokinetic and pharmacodynamic study of CHR-3996, an oral class I selective histone deacetylase inhibitor in refractory solid tumors. Clin Cancer Res. 2012 May 1;18(9):2687-94. doi: 10.1158/1078-0432.CCR-11-3165.
Ref 4 HDAC inhibitors: a 2013-2017 patent survey. Expert Opin Ther Pat. 2018 Apr 19:1-17. doi: 10.1080/13543776.2018.1459568. Online ahead of print.
Ref 5 Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. doi: 10.1016/j.bmcl.2007.09.014. Epub 2007 Sep 8.
Ref 6 Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. doi: 10.1016/j.bmcl.2010.03.091. Epub 2010 Mar 30.
Ref 7 Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Eur J Med Chem. 2009 May;44(5):1900-12. doi: 10.1016/j.ejmech.2008.11.005. Epub 2008 Nov 19.
Ref 8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2616).
Ref 9 Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50(23):5543-6. doi: 10.1021/jm701079h. Epub 2007 Oct 17.
Ref 10 A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20. doi: 10.1016/j.bmcl.2003.07.012.
Ref 11 Alpha-keto amides as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3331-5. doi: 10.1016/s0960-894x(03)00685-1.
Ref 12 Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. doi: 10.1016/s0960-894x(02)00754-0.
Ref 13 SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. doi: 10.1016/j.bmcl.2008.10.052. Epub 2008 Oct 14.
Ref 14 Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33. doi: 10.1021/np400198r. Epub 2013 Oct 28.
Ref 15 Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. doi: 10.1038/nchembio.313. Epub 2010 Feb 7.
Ref 16 Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. doi: 10.1021/jm0303094.
Ref 17 Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. J Med Chem. 2002 Jul 18;45(15):3296-309. doi: 10.1021/jm0208119.
Ref 18 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. doi: 10.1016/j.bmcl.2009.02.029. Epub 2009 Feb 12.
Ref 19 Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48(4):1019-32. doi: 10.1021/jm049207j.
Ref 20 Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. doi: 10.1021/jm051010j.
Ref 21 Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. doi: 10.1016/j.bmcl.2005.02.075.
Ref 22 Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. doi: 10.1021/jm0503749.
Ref 23 Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. doi: 10.1021/jm0303655.
Ref 24 Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. doi: 10.1016/j.bmcl.2003.09.007.
Ref 25 Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. doi: 10.1021/jm015568c.
Ref 26 New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. doi: 10.1016/j.bmcl.2008.02.007. Epub 2008 Feb 8.
Ref 27 Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. doi: 10.1016/j.bmcl.2004.02.062.
Ref 28 Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors. Eur J Med Chem. 2009 Nov;44(11):4470-6. doi: 10.1016/j.ejmech.2009.06.010. Epub 2009 Jun 17.
Ref 29 Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. doi: 10.1016/j.bmcl.2004.03.012.
Ref 30 Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
Ref 31 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 32 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5891).
Ref 33 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 34 ClinicalTrials.gov (NCT00130728) A Study to Evaluate the Efficacy of Bevacizumab in Combination With Tarceva for Advanced Non-Small Cell Lung Cancer
Ref 35 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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