Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00183)

Target Name	RNA demethylase ALKBH5 (ALKBH5)
Synonyms	EC 1.14.11.53; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 Click to Show/Hide
Gene Name	ALKBH5
Sequence	MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAAAAAAEPYPVSGAKRKYQEDSDPERSDYEEQQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILRKTRLDAPRLETKSLSSSVLPPSYASDRLSGNNRDPALKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPTHRRRGSFSSENYWRKSYESSEDCSEAAGSPARKVKMRRH Click to Show/Hide
Family	AlkB family
Function	Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Click to Show/Hide
Gene ID	54890
HGNC ID	HGNC:25996
Ensembl Gene ID	ENSG00000091542
KEGG ID	hsa:54890
Chromosomal Location	17p11.2

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00183)

RNA demethylase ALKBH5 (ALKBH5)

N4-acetylcytidine (ac4C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: AC4SITE000219		Click to Show/Hide the Full List
mod site	chr17:18208820-18208821:+
Sequence	GTTCAGTCTTCTGCTCGCCCCTTTCCCTCACTGATGTCTGC
Cell/Tissue List	DLD1
Seq Type List	acRIP-seq
Transcript ID List	ENST00000399138.5; ENST00000490106.1; ENST00000541285.1
External Link	RMBase: ac4C_site_770

Adenosine-to-Inosine editing (A-to-I)

In total 3 m6A sequence/site(s) in this target gene
mod ID: A2ISITE007777		Click to Show/Hide the Full List
mod site	chr17:18199959-18199960:+		[1]
Sequence	TACAAGAATTAGCTGGGCATAGTGGCAGGTGTCTGTGATCC
Transcript ID List	ENST00000399138.5; rmsk_4650896; ENST00000541285.1
External Link	RMBase: RNA-editing_site_55542
mod ID: A2ISITE007778		Click to Show/Hide the Full List
mod site	chr17:18203611-18203612:+		[1]
Sequence	TGGGTCCAGACCTTACTGCTAGAACTGAGCCTCCTGAATCC
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: RNA-editing_site_55543
mod ID: A2ISITE007779		Click to Show/Hide the Full List
mod site	chr17:18205554-18205555:+		[1]
Sequence	TTCCTACCCACGTTCAGAGTAACTCTTGCCTGTCAGGCTTG
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: RNA-editing_site_55544

5-methylcytidine (m5C)

In total 1 m6A sequence/site(s) in this target gene
mod ID: M5CSITE001008		Click to Show/Hide the Full List
mod site	chr17:18184134-18184135:+		[2]
Sequence	CCCACTCACGCATGGGGGTTCGGCGCTAAGGACCCCCCTCC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m5C_site_18197

N6-methyladenosine (m6A)

In total 54 m6A sequence/site(s) in this target gene
mod ID: M6ASITE030845		Click to Show/Hide the Full List
mod site	chr17:18183177-18183178:+		[3]
Sequence	CGTTCCTATCTGGGTTCAGAACTGGGGCCGGGTGCTGCAGG
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000541285.1
External Link	RMBase: m6A_site_351320
mod ID: M6ASITE030846		Click to Show/Hide the Full List
mod site	chr17:18184089-18184090:+		[3]
Sequence	AGGCCCTACCCCACGCCCGGACCCTCGACGCCCCCCGCCGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; H1A; LCLs; MT4; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; TREX; iSLK; MSC; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351321
mod ID: M6ASITE030847		Click to Show/Hide the Full List
mod site	chr17:18184096-18184097:+		[4]
Sequence	ACCCCACGCCCGGACCCTCGACGCCCCCCGCCGGGTCCCCC
Motif Score	2.839505952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351322
mod ID: M6ASITE030848		Click to Show/Hide the Full List
mod site	chr17:18184145-18184146:+		[3]
Sequence	ATGGGGGTTCGGCGCTAAGGACCCCCCTCCCTCCGGGGGCC
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; LCLs; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; TREX; iSLK; MSC; endometrial; HEC-1-A; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351323
mod ID: M6ASITE030849		Click to Show/Hide the Full List
mod site	chr17:18184218-18184219:+		[3]
Sequence	TGCCCCGCCCGCCCCGGAGGACCCTAGAGCAGCGTCGTGGG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1B; H1A; GM12878; LCLs; MT4; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351324
mod ID: M6ASITE030850		Click to Show/Hide the Full List
mod site	chr17:18184262-18184263:+		[5]
Sequence	CATGGCGGCCGCCAGCGGCTACACGGACCTGCGTGAGAAGC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351325
mod ID: M6ASITE030851		Click to Show/Hide the Full List
mod site	chr17:18184268-18184269:+		[3]
Sequence	GGCCGCCAGCGGCTACACGGACCTGCGTGAGAAGCTCAAGT
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HEK293T; A549; HepG2; U2OS; H1A; H1B; GM12878; LCLs; MT4; H1299; MM6; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TREX; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351326
mod ID: M6ASITE030852		Click to Show/Hide the Full List
mod site	chr17:18184304-18184305:+		[3]
Sequence	CAAGTCCATGACGTCCCGGGACAACTATAAGGCGGGCAGCC
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HEK293T; A549; hESC-HEK293T; HepG2; U2OS; H1A; H1B; GM12878; LCLs; MT4; H1299; MM6; Jurkat; peripheral-blood; HEK293A-TOA; MSC; TREX; iSLK
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351327
mod ID: M6ASITE030853		Click to Show/Hide the Full List
mod site	chr17:18184389-18184390:+		[3]
Sequence	GCAGCCGCCGCTGCCGCCGAACCTTACCCTGTGTCCGGGGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351328
mod ID: M6ASITE030854		Click to Show/Hide the Full List
mod site	chr17:18184394-18184395:+		[4]
Sequence	CGCCGCTGCCGCCGAACCTTACCCTGTGTCCGGGGCCAAGC
Motif Score	2.052208333
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351329
mod ID: M6ASITE030855		Click to Show/Hide the Full List
mod site	chr17:18184430-18184431:+		[3]
Sequence	CAAGCGCAAGTATCAGGAGGACTCGGACCCCGAGCGCAGCG
Motif Score	4.065041667
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351331
mod ID: M6ASITE030856		Click to Show/Hide the Full List
mod site	chr17:18184436-18184437:+		[3]
Sequence	CAAGTATCAGGAGGACTCGGACCCCGAGCGCAGCGACTATG
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; GM12878; LCLs; MT4; H1299; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351332
mod ID: M6ASITE030857		Click to Show/Hide the Full List
mod site	chr17:18184565-18184566:+		[4]
Sequence	CAAGATCGAGGCCCGCATTGACGAGGTGGTGTCCCGCGCTG
Motif Score	2.833690476
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351333
mod ID: M6ASITE030858		Click to Show/Hide the Full List
mod site	chr17:18184616-18184617:+		[3]
Sequence	GTACAACGAGCACACGGTGGACCGGGCCCCACTGCGCAACA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; H1A; H1B; LCLs; MT4; H1299; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TREX; iSLK; endometrial; HEC-1-A; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351335
mod ID: M6ASITE030859		Click to Show/Hide the Full List
mod site	chr17:18184658-18184659:+		[5]
Sequence	GTACTTCTTCGGCGAAGGCTACACTTACGGCGCCCAGCTGC
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351336
mod ID: M6ASITE030860		Click to Show/Hide the Full List
mod site	chr17:18184660-18184661:+		[4]
Sequence	ACTTCTTCGGCGAAGGCTACACTTACGGCGCCCAGCTGCAG
Motif Score	2.506922619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351337
mod ID: M6ASITE030861		Click to Show/Hide the Full List
mod site	chr17:18184805-18184806:+		[6]
Sequence	CATCCCCGAGGGCTTCGTCAACAGCGCCGTCATCAACGACT
Motif Score	2.173910714
Cell/Tissue List	kidney
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351338
mod ID: M6ASITE030862		Click to Show/Hide the Full List
mod site	chr17:18184859-18184860:+		[3]
Sequence	CTGCATCGTGTCTCACGTGGACCCCATCCACATCTTCGAGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; A549; peripheral-blood; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351339
mod ID: M6ASITE030863		Click to Show/Hide the Full List
mod site	chr17:18184868-18184869:+		[5]
Sequence	GTCTCACGTGGACCCCATCCACATCTTCGAGCGCCCCATCG
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351340
mod ID: M6ASITE030864		Click to Show/Hide the Full List
mod site	chr17:18184965-18184966:+		[3]
Sequence	AAGCCTATTCGGGTGTCGGAACCAGTGCTTTCCCTGCCGGT
Motif Score	2.930744048
Cell/Tissue List	HeLa; HepG2; peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351341
mod ID: M6ASITE030865		Click to Show/Hide the Full List
mod site	chr17:18194998-18194999:+		[3]
Sequence	TCACTGCATACGGCCTCAGGACATCAAGGAGCGCCGAGCAG
Motif Score	3.643047619
Cell/Tissue List	HeLa; Huh7; peripheral-blood
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351342
mod ID: M6ASITE030866		Click to Show/Hide the Full List
mod site	chr17:18206587-18206588:+		[3]
Sequence	CTGTCATTGGGAGTTTCCAGACAGAAGTGTTCCCATTCCTT
Motif Score	2.897386905
Cell/Tissue List	HeLa; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5; ENST00000490106.1
External Link	RMBase: m6A_site_351343
mod ID: M6ASITE030867		Click to Show/Hide the Full List
mod site	chr17:18206622-18206623:+		[3]
Sequence	TTCCTTACTCCTAAAGGTGGACTTGAGGAGGGTCTTTGAAA
Motif Score	4.065041667
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5; ENST00000490106.1
External Link	RMBase: m6A_site_351344
mod ID: M6ASITE030868		Click to Show/Hide the Full List
mod site	chr17:18206652-18206653:+		[3]
Sequence	GGTCTTTGAAAGTCAGCTAGACCAATCTCTAGTTGAACCTC
Motif Score	2.876744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1; ENST00000490106.1
External Link	RMBase: m6A_site_351345
mod ID: M6ASITE030869		Click to Show/Hide the Full List
mod site	chr17:18206668-18206669:+		[3]
Sequence	CTAGACCAATCTCTAGTTGAACCTCAAGGAGAGTGAGGTAC
Motif Score	2.930744048
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000490106.1; ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351346
mod ID: M6ASITE030870		Click to Show/Hide the Full List
mod site	chr17:18206698-18206699:+		[3]
Sequence	GAGTGAGGTACAGAGCAGAGACTGCTGGCTTCCAGGTCTAG
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000399138.5; ENST00000490106.1; ENST00000541285.1
External Link	RMBase: m6A_site_351347
mod ID: M6ASITE030871		Click to Show/Hide the Full List
mod site	chr17:18206815-18206816:+		[3]
Sequence	ATGCATGTTTCCTTTGCAGGACAAGATTAGATGCACCCCGG
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000490106.1; ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351348
mod ID: M6ASITE030872		Click to Show/Hide the Full List
mod site	chr17:18206842-18206843:+		[3]
Sequence	TAGATGCACCCCGGTTGGAAACAAAGTCCCTGAGCAGCTCC
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HEK293T; hESC-HEK293T
Seq Type List	m6A-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000490106.1; ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351349
mod ID: M6ASITE030873		Click to Show/Hide the Full List
mod site	chr17:18206903-18206904:+		[3]
Sequence	TTCAGATCGCCTGTCAGGAAACAACAGGGACCCTGCTCTGA
Motif Score	2.20572619
Cell/Tissue List	HeLa; CD34; HepG2; hESC-HEK293T; endometrial
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000490106.1; ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351350
mod ID: M6ASITE030874		Click to Show/Hide the Full List
mod site	chr17:18206912-18206913:+		[3]
Sequence	CCTGTCAGGAAACAACAGGGACCCTGCTCTGAAACCCAAGC
Motif Score	3.622404762
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000541285.1; ENST00000490106.1; ENST00000399138.5
External Link	RMBase: m6A_site_351351
mod ID: M6ASITE030875		Click to Show/Hide the Full List
mod site	chr17:18206925-18206926:+		[3]
Sequence	AACAGGGACCCTGCTCTGAAACCCAAGCGGTCCCACCGCAA
Motif Score	2.185083333
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; peripheral-blood; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000399138.5; ENST00000541285.1; ENST00000490106.1
External Link	RMBase: m6A_site_351352
mod ID: M6ASITE030876		Click to Show/Hide the Full List
mod site	chr17:18206951-18206952:+		[3]
Sequence	GCGGTCCCACCGCAAGGCAGACCCTGATGCTGCCCACAGGT
Motif Score	2.876744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; peripheral-blood; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000399138.5; ENST00000490106.1; ENST00000541285.1
External Link	RMBase: m6A_site_351353
mod ID: M6ASITE030877		Click to Show/Hide the Full List
mod site	chr17:18208238-18208239:+		[3]
Sequence	GCCACGGATCCTGGAGATGGACAAGGAAGAGAACCGGCGCT
Motif Score	3.643047619
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; Jurkat; peripheral-blood; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5; ENST00000490106.1
External Link	RMBase: m6A_site_351354
mod ID: M6ASITE030878		Click to Show/Hide the Full List
mod site	chr17:18208250-18208251:+		[3]
Sequence	GGAGATGGACAAGGAAGAGAACCGGCGCTCGGTGCTGCTGC
Motif Score	2.930744048
Cell/Tissue List	HeLa; CD34; HepG2; HEK293T; A549; Jurkat; peripheral-blood; GSC-11; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5; ENST00000490106.1
External Link	RMBase: m6A_site_351355
mod ID: M6ASITE030879		Click to Show/Hide the Full List
mod site	chr17:18208273-18208274:+		[5]
Sequence	GGCGCTCGGTGCTGCTGCCCACACACCGGCGGAGGGGTAGC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000490106.1; ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351356
mod ID: M6ASITE030880		Click to Show/Hide the Full List
mod site	chr17:18208307-18208308:+		[3]
Sequence	GGGTAGCTTCAGCTCTGAGAACTACTGGCGCAAGTCATACG
Motif Score	3.373380952
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; MM6; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; endometrial; HEC-1-A; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000490106.1; ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351357
mod ID: M6ASITE030881		Click to Show/Hide the Full List
mod site	chr17:18208340-18208341:+		[3]
Sequence	GTCATACGAGTCCTCAGAGGACTGCTCTGAGGCAGCAGGCA
Motif Score	4.065041667
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TREX; endometrial; HEC-1-A
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5; ENST00000490106.1
External Link	RMBase: m6A_site_351358
mod ID: M6ASITE030882		Click to Show/Hide the Full List
mod site	chr17:18208419-18208420:+		[3]
Sequence	TACCCGCCGCCCTCCTGGGAACTCTGGCTCATCCTTACGTA
Motif Score	3.373380952
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; fibroblasts; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; MSC; TREX; endometrial; HEC-1-A; AML
Seq Type List	m6A-seq; MeRIP-seq; miCLIP
Transcript ID List	ENST00000399138.5; ENST00000541285.1; ENST00000490106.1
External Link	RMBase: m6A_site_351359
mod ID: M6ASITE030883		Click to Show/Hide the Full List
mod site	chr17:18208435-18208436:+		[4]
Sequence	GGGAACTCTGGCTCATCCTTACGTAGTTGCCCCTCCTTTTG
Motif Score	2.046785714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000399138.5; ENST00000490106.1; ENST00000541285.1
External Link	RMBase: m6A_site_351360
mod ID: M6ASITE030884		Click to Show/Hide the Full List
mod site	chr17:18208578-18208579:+		[3]
Sequence	GAAGAATAGAATTGGCCAGGACCTAGGTTCTCATATTCTTG
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq; DART-seq
Transcript ID List	ENST00000490106.1; ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351361
mod ID: M6ASITE030885		Click to Show/Hide the Full List
mod site	chr17:18208640-18208641:+		[3]
Sequence	GCTGTTGGCATCAATAGGGGACAGAGGCTGATGCTGGAGTG
Motif Score	3.643047619
Cell/Tissue List	HeLa; liver; HEK293T
Seq Type List	m6A-seq; m6A-REF-seq; DART-seq
Transcript ID List	ENST00000399138.5; ENST00000490106.1; ENST00000541285.1
External Link	RMBase: m6A_site_351362
mod ID: M6ASITE030886		Click to Show/Hide the Full List
mod site	chr17:18208734-18208735:+		[4]
Sequence	GCTGGGTTTATTTAAAAGCAACAAAATGTTTTGGTTAAGAA
Motif Score	2.173910714
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5; ENST00000490106.1
External Link	RMBase: m6A_site_351363
mod ID: M6ASITE030887		Click to Show/Hide the Full List
mod site	chr17:18208795-18208796:+		[7]
Sequence	AAATCTTCGCAGTGTTCTAAACAAAGTTCAGTCTTCTGCTC
Motif Score	2.20572619
Cell/Tissue List	CD34; HEK293T; hESC-HEK293T
Seq Type List	m6A-seq; DART-seq; MAZTER-seq
Transcript ID List	ENST00000399138.5; ENST00000490106.1; ENST00000541285.1
External Link	RMBase: m6A_site_351364
mod ID: M6ASITE030888		Click to Show/Hide the Full List
mod site	chr17:18208867-18208868:+		[6]
Sequence	TTGAGGTCTCCTGGAGCCTCACAGGCTCTGCTGTTCTCCAC
Motif Score	2.047297619
Cell/Tissue List	brain; liver
Seq Type List	m6A-REF-seq
Transcript ID List	ENST00000490106.1; ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m6A_site_351365
mod ID: M6ASITE030889		Click to Show/Hide the Full List
mod site	chr17:18208925-18208926:+		[7]
Sequence	CGCCCTGCAAGCTCATGCAAACACCCTTTCTTCCTCCTGCG
Motif Score	2.20572619
Cell/Tissue List	CD34; hESC-HEK293T; Huh7
Seq Type List	m6A-seq; MAZTER-seq; MeRIP-seq
Transcript ID List	ENST00000490106.1; ENST00000399138.5; ENST00000541285.1
External Link	RMBase: m6A_site_351366
mod ID: M6ASITE030890		Click to Show/Hide the Full List
mod site	chr17:18208981-18208982:+		[7]
Sequence	TTGCCTGGGCAGGGGCTTAAACAGTGCCAGCCCCTGCCATC
Motif Score	2.20572619
Cell/Tissue List	CD34; HEK293T; Huh7
Seq Type List	m6A-seq; DART-seq; MeRIP-seq
Transcript ID List	ENST00000399138.5; ENST00000490106.1; ENST00000541285.1
External Link	RMBase: m6A_site_351367
mod ID: M6ASITE030891		Click to Show/Hide the Full List
mod site	chr17:18209122-18209123:+		[5]
Sequence	TGACCTCTCTTATCAAGAGCACACTTCTTTGCTGGTTGCTC
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000541285.1; ENST00000490106.1; ENST00000399138.5
External Link	RMBase: m6A_site_351368
mod ID: M6ASITE030892		Click to Show/Hide the Full List
mod site	chr17:18209173-18209174:+		[4]
Sequence	TATGCGTGTGATTATTTGGAACAGTTAGACTTGCCACGTTG
Motif Score	2.951386905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000399138.5; ENST00000490106.1; ENST00000541285.1
External Link	RMBase: m6A_site_351369
mod ID: M6ASITE030893		Click to Show/Hide the Full List
mod site	chr17:18209639-18209640:+		[8]
Sequence	TTCTTGTCAGCCAGGCCAGGACCCGGGCTTGCCAAGAGCAG
Motif Score	3.622404762
Cell/Tissue List	Huh7
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000399138.5; ENST00000490106.1
External Link	RMBase: m6A_site_351370
mod ID: M6ASITE030894		Click to Show/Hide the Full List
mod site	chr17:18209725-18209726:+		[7]
Sequence	TACAGAGGTCCGGGTCTGAGACCTCATAGGCTGCAGAAATC
Motif Score	2.876744048
Cell/Tissue List	CD34; HEK293T; HeLa; A549; Huh7
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000490106.1; ENST00000399138.5
External Link	RMBase: m6A_site_351371
mod ID: M6ASITE030895		Click to Show/Hide the Full List
mod site	chr17:18209786-18209787:+		[9]
Sequence	AGCCCCTCTCAGGGGCCAGAACTCCTTTGCCAGCGTGGATT
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HeLa; A549; LCLs; Huh7; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000490106.1; ENST00000399138.5
External Link	RMBase: m6A_site_351372
mod ID: M6ASITE030896		Click to Show/Hide the Full List
mod site	chr17:18209819-18209820:+		[3]
Sequence	CGTGGATTTCTCAAGTCGGGACTGCATAATTAAAGCAGTTG
Motif Score	4.065041667
Cell/Tissue List	HeLa; HEK293T; A549; HepG2; hESCs; LCLs; Huh7; HEK293A-TOA
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000399138.5; ENST00000490106.1
External Link	RMBase: m6A_site_351373
mod ID: M6ASITE030897		Click to Show/Hide the Full List
mod site	chr17:18209922-18209923:+		[4]
Sequence	CGCCCTGATATGTGTGCTCTACAATAAAAACCAAATCTAAT
Motif Score	2.078666667
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000490106.1; ENST00000399138.5
External Link	RMBase: m6A_site_351374
mod ID: M6ASITE030898		Click to Show/Hide the Full List
mod site	chr17:18209931-18209932:+		[3]
Sequence	ATGTGTGCTCTACAATAAAAACCAAATCTAATATATTTTGA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000490106.1; ENST00000399138.5
External Link	RMBase: m6A_site_351375

N7-methylguanosine (m7G)

In total 2 m6A sequence/site(s) in this target gene
mod ID: m7GSITE000040		Click to Show/Hide the Full List
mod site	chr17:18184234-18184235:+		[10]
Sequence	GAGGACCCTAGAGCAGCGTCGTGGGGGCCATGGCGGCCGCC
Cell/Tissue List	A549; HeLa; HepG2
Seq Type List	BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List	ENST00000541285.1; ENST00000399138.5
External Link	RMBase: m7G_site_356
mod ID: m7GSITE000041		Click to Show/Hide the Full List
mod site	chr17:18208507-18208508:+		[10]
Sequence	GTTTTTGTTTTTTGTTTTTTGTTTTTTTTGATTCTATATAT
Cell/Tissue List	A549; HeLa; HepG2
Seq Type List	BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List	ENST00000541285.1; ENST00000490106.1; rmsk_4650910; ENST00000399138.5
External Link	RMBase: m7G_site_357

Ref 1	RADAR: a rigorously annotated database of A-to-I RNA editing. Nucleic Acids Res. 2014 Jan;42(Database issue):D109-13. doi: 10.1093/nar/gkt996. Epub 2013 Oct 25.
Ref 2	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 5	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 6	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 7	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 8	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 9	Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus. Nat Commun. 2019 Oct 9;10(1):4595. doi: 10.1038/s41467-019-12504-y.
Ref 10	METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

Visitor Map