m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00555				[1], [2], [3], [4]
RNA modification GAS5 GAS5 YBX1 : modification sites Indirect Enhancement m⁶A modification FOXO3 FOXO3 YTHDF2 : m⁶A sites
m6A Regulator	YTH domain-containing family protein 2 (YTHDF2)			READER	Regulator Info
m6A Target	Forkhead box protein O3 (FOXO3)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> 5-methylcytidine (m5C)
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)			READER	View Details
Regulated Target	Growth arrest specific 5 (GAS5)				View Details
Crosstalk Relationship	m5C → m6A			Enhancement
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with Forkhead box protein O3 (FOXO3), which was regulated by YTHDF2-mediated m6A modification.
In-vitro Model	HSC (Hematopoietic stem cell)
In-vitro Model	HGC-27	Gastric carcinoma	Homo sapiens		CVCL_1279

References

Ref 1	Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31.
Ref 2	lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer. Sci Rep. 2015 May 11;5:10159. doi: 10.1038/srep10159.
Ref 3	Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis. Theranostics. 2019 Jul 28;9(19):5558-5576. doi: 10.7150/thno.34463. eCollection 2019.
Ref 4	Knockdown of long noncoding RNA growth arrest-specific transcript 5 regulates forkhead box O3 to inhibit lipopolysaccharide-induced human bronchial epithelial cell pyroptosis. Kaohsiung J Med Sci. 2022 Feb;38(2):87-96. doi: 10.1002/kjm2.12452. Epub 2021 Sep 16.