m6A-centered Disease Response Information
General Information of the Disease (ID: M6ADIS0162)
| Name |
Pre-eclampsia
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|---|---|---|---|---|---|
| ICD |
ICD-11: JA24
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Full List of Target Gene(s) of This m6A-centered Disease Response
Forkhead box protein O3 (FOXO3)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [2] | |||
| Response Summary | Global RNA m6A methylation and METTL14 expression were significantly increased in placental tissues obtained from patients with preeclampsia. Forkhead box protein O3 (FOXO3) inhibition effectively prevented the impairment of trophoblast proliferation and invasion, and diminished the induction of trophoblast autophagy and apoptosis in METTL14-overexpressing HTR-8/SVneo cells. | |||
| Responsed Disease | Pre-eclampsia [ICD-11: JA24] | |||
| Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
| Target Regulation | Up regulation | |||
| Cell Process | Cell autophagy | |||
| In-vitro Model | HTR-8/SVneo | Normal | Homo sapiens | CVCL_7162 |
| HTR-8 | Normal | Homo sapiens | CVCL_D728 | |
Heat shock 70 kDa protein 1A (HSPA1A)
| In total 2 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Disease Response by This Target Gene | [3] | |||
| Response Summary | Findings show that METTL3 and METTL14 were up-regulated in preeclampsia(PE). Heat shock 70 kDa protein 1A (HSPA1A) is involved in the pathophysiology of PE as its mRNA and protein expression is regulated by m6A modification. | |||
| Responsed Disease | Pre-eclampsia [ICD-11: JA24] | |||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Wnt signaling pathway | hsa04310 | ||
| mTOR signaling pathway | hsa04150 | |||
| Experiment 2 Reporting the m6A-centered Disease Response by This Target Gene | [3] | |||
| Response Summary | Findings show that METTL3 and METTL14 were up-regulated in preeclampsia(PE). Heat shock 70 kDa protein 1A (HSPA1A) is involved in the pathophysiology of PE as its mRNA and protein expression is regulated by m6A modification. | |||
| Responsed Disease | Pre-eclampsia [ICD-11: JA24] | |||
| Target Regulator | Methyltransferase-like 14 (METTL14) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Wnt signaling pathway | hsa04310 | ||
| mTOR signaling pathway | hsa04150 | |||
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
| In total 3 item(s) under this disease | ||
| Crosstalk ID: M6ACROT05657 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Circ_SETD2 | |
| Epigenetic Regulator | Circ_SETD2 | |
| Regulated Target | hsa-miR-181a-5p | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT05658 | ||
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | |
| m6A Target | Circ_SETD2 | |
| Epigenetic Regulator | Circ_SETD2 | |
| Regulated Target | hsa-miR-181a-5p | |
| Crosstalk relationship | m6A → ncRNA | |
| Crosstalk ID: M6ACROT05738 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | HOXD antisense growth-associated long non-coding RNA (HAGLR) | |
| Epigenetic Regulator | HOXD antisense growth-associated long non-coding RNA (HAGLR) | |
| Regulated Target | MicroRNA 135a-1 (MIR135A1) | |
| Crosstalk relationship | m6A → ncRNA | |
References