m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05738
|
[1] | |||
m6A modification
HAGLR
HAGLR
METTL3
Methylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
HOXD-AS1
MIR135A1
lncRNA miRNA circRNA
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | HOXD antisense growth-associated long non-coding RNA (HAGLR) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | HOXD antisense growth-associated long non-coding RNA (HAGLR) | LncRNA | View Details | ||
| Regulated Target | MicroRNA 135a-1 (MIR135A1) | View Details | |||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | Preeclampsia (PE) is a serious pregnancy-specific syndrome. METTL3-mediated lncRNA HOXD antisense growth-associated long non-coding RNA (HAGLR) stability regulates inflammation, and the migration and invasion of trophoblast cells via the MicroRNA 135a-1 (MIR135A1)/ beta-TRCP axis. | ||||
| Responsed Disease | Pre-eclampsia | ICD-11: JA24 | |||
| Cell Process | Cell migration | ||||
| Cell invasion | |||||
In-vitro Model |
HTR-8/SVneo | Normal | Homo sapiens | CVCL_7162 | |
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| JA24: Pre-eclampsia | 1 Compound(s) Regulating the Disease | Click to Show/Hide the Full List | ||
 Compound Name |
Digibind | Phase 2 | [2] | |
|---|---|---|---|---|
| Synonyms |
Digoxin Immune Fab (ovine); Ovine antidigoxin polyclonal antibody fragments (pre-eclampsia), BTG; Ovine antidigoxin polyclonal antibody fragments (pre-eclampsia), GlaxoSmithKline/Glenveigh
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| External Link | ||||
References