m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00521
|
[1], [2], [3] | |||
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.png)
 : modification sites
Indirect
Inhibition
m6A modification
FOXO3
FOXO3
METTL3
Methylation
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Forkhead box protein O3 (FOXO3) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Double-stranded RNA-specific editase 1 (ADARB1) | WRITER | View Details | ||
| Regulated Target | MicroRNA 221 (MIR221) | View Details | |||
| Crosstalk Relationship | A-to-I → m6A | Inhibition | |||
| Crosstalk Mechanism | RNA modification indirectly impacts m6A modification through downstream signaling pathways | ||||
| Crosstalk Summary | ADARB1 interacts with MicroRNA 221 (MIR221), increasing it's A-to-I level and inhibiting its physical interaction with Forkhead box protein O3 (FOXO3), which was regulated by METTL3-mediated m6A modification. | ||||
In-vitro Model |
Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | |
| U-118MG | Astrocytoma | Homo sapiens | CVCL_0633 | ||
References