m6A-centered Drug Response Information
General Information of the Drug (ID: M6ADRUG0034)
| Name |
Adriamycin
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| Synonyms |
25316-40-9; Doxorubicin HCl; Adriacin; ADRIAMYCIN HYDROCHLORIDE; Hydroxydaunorubicin hydrochloride; Doxorubicin (Adriamycin) HCl; UNII-82F2G7BL4E; ADRIAMYCIN, HYDROCHLORIDE; KW-125; Lipodox; MLS001401460; 82F2G7BL4E; SMR000058570; CPD000058570; DSSTox_RID_78854; DSSTox_RID_80678; DSSTox_CID_10636; DSSTox_GSID_30636; DSSTox_GSID_45111; CCRIS 740; CAS-NOCAS_45111
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| Status | Phase 3 | [1] | |||
| Structure |
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3D MOL
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| Formula |
C27H30ClNO11
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| InChI |
InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
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| InChIKey |
MWWSFMDVAYGXBV-RUELKSSGSA-N
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Full List of m6A Targets Related to This Drug
Rho GTPase activating protein 5 (ARHGAP5)
| In total 1 item(s) under this target gene | ||||
| Experiment 1 Reporting the m6A-centered Drug Response by This Target Gene | [3] | |||
| Response Summary | ARHGAP5-AS1 also stabilized ARHGAP5 mRNA in the cytoplasm by recruiting METTL3 to stimulate m6A modification of Rho GTPase activating protein 5 (ARHGAP5) mRNA. As a result, ARHGAP5 was upregulated to promote chemoresistance and its upregulation was also associated with poor prognosis in gastric cancer. downregulation of ARHGAP5-AS1 in resistant cells evidently reversed the resistance to chemotherapeutic drugs including cisplatin (DDP), ADM, and 5-FU. | |||
| Responsed Disease | Gastric cancer | ICD-11: 2B72 | ||
| Target Regulator | Methyltransferase-like 3 (METTL3) | WRITER | ||
| Target Regulation | Up regulation | |||
| Pathway Response | Autophagy | hsa04140 | ||
| Cell Process | Cellular processes | |||
| Cellular transport | ||||
| Cellular catabolism | ||||
| In-vitro Model | BGC-823 | Gastric carcinoma | Homo sapiens | CVCL_3360 |
| SGC-7901 | Gastric carcinoma | Homo sapiens | CVCL_0520 | |
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Drug
| In total 10 item(s) under this drug | ||
| Crosstalk ID: M6ACROT02217 | ||
| m6A Regulator | Methyltransferase-like 14 (METTL14) | |
| m6A Target | Transcription factor E2F8 (E2F8) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 3B (DNMT3B) | |
| Regulated Target | Methyltransferase-like protein 14 (METTL14) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT02241 | ||
| m6A Regulator | Methyltransferase-like 14 (METTL14) | |
| m6A Target | Transcription factor E2F8 (E2F8) | |
| Epigenetic Regulator | Cysteine methyltransferase DNMT3A (DNMT3A) | |
| Regulated Target | Methyltransferase-like protein 14 (METTL14) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT02265 | ||
| m6A Regulator | Methyltransferase-like 14 (METTL14) | |
| m6A Target | Transcription factor E2F8 (E2F8) | |
| Epigenetic Regulator | DNA (cytosine-5)-methyltransferase 1 (DNMT1) | |
| Regulated Target | Methyltransferase-like protein 14 (METTL14) | |
| Crosstalk relationship | DNA modification → m6A | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT05138 | ||
| m6A Regulator | Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) | |
| m6A Target | microRNA 222 (MIR222) | |
| Epigenetic Regulator | Prostate cancer associated transcript 6 (PCAT6) | |
| Regulated Target | Heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT05284 | ||
| m6A Regulator | Wilms tumor 1-associating protein (WTAP) | |
| m6A Target | DLGAP1 antisense RNA 1 (DLGAP1-AS1) | |
| Epigenetic Regulator | DLGAP1 antisense RNA 1 (DLGAP1-AS1) | |
| Regulated Target | hsa-miR-299-3p | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT05285 | ||
| m6A Regulator | Wilms tumor 1-associating protein (WTAP) | |
| m6A Target | DLGAP1 antisense RNA 1 (DLGAP1-AS1) | |
| Epigenetic Regulator | hsa-miR-299-3p | |
| Regulated Target | Pre-mRNA-splicing regulator WTAP (WTAP) | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT05286 | ||
| m6A Regulator | Wilms tumor 1-associating protein (WTAP) | |
| m6A Target | DLGAP1 antisense RNA 1 (DLGAP1-AS1) | |
| Epigenetic Regulator | DLGAP1 antisense RNA 1 (DLGAP1-AS1) | |
| Regulated Target | hsa-miR-299-3p | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT05307 | ||
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | |
| m6A Target | ATP-dependent translocase ABCB1 (ABCB1) | |
| Epigenetic Regulator | A1BG antisense RNA 1 (A1BG-AS1) | |
| Regulated Target | Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT05613 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Epigenetic Regulator | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | |
| Regulated Target | Transcription factor E2F1 (E2F1) | |
| Crosstalk relationship | m6A → ncRNA | |
| Disease | Breast cancer | |
| Crosstalk ID: M6ACROT05982 | ||
| m6A Regulator | Methyltransferase-like 3 (METTL3) | |
| m6A Target | Rho GTPase activating protein 5 (ARHGAP5) | |
| Epigenetic Regulator | ARHGAP5 antisense RNA 1 (head to head) (ARHGAP5-AS1) | |
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | |
| Crosstalk relationship | ncRNA → m6A | |
| Disease | Gastric cancer | |
References