m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00224)

Target Name	Differentiation antagonizing non-protein coding RNA (DANCR)
Synonyms	Anti-differentiation ncRNA protein; Putative uncharacterized protein DANCR; Small nucleolar RNA host gene protein 13; ANCR; KIAA0114; SNHG13 Click to Show/Hide
Gene Name	DANCR
Chromosomal Location	4q12
Gene ID	57291
Uniprot ID	DANCR_HUMAN
HGNC ID	HGNC:28964

Full List of m6A Methylation Regulator of This Target Gene and Corresponding Disease/Drug Response(s)

DANCR can be regulated by the following regulator(s), and cause disease/drug response(s). You can browse detail information of regulator(s) or disease/drug response(s).

Browse Regulator

Browse Disease

Methyltransferase-like 3 (METTL3) [WRITER]

Regulator Info

*Representative RIP-seq result supporting the interaction between DANCR and the regulator*
Cell Line	MDA-MB-231	Homo sapiens
Regulation	logFC: 9.97E+00	GSE60213

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[1]
Response Summary	METTL3 contributes to OS progression by increasing Putative uncharacterized protein DANCR (DANCR) mRNA stability via m6A modification, meaning that METTL3 is a promising therapeutic target for OS treatment.
Target Regulation	Up regulation
Responsed Disease	Osteosarcoma		ICD-11: 2B51	Disease Info
Cell Process	Cell proliferation
	Cell migration
	Cell invasion
In-vitro Model	U2OS	Osteosarcoma	Homo sapiens	CVCL_0042
	SJSA-1	Osteosarcoma	Homo sapiens	CVCL_1697
	SaOS-2	Osteosarcoma	Homo sapiens	CVCL_0548
	MG-63	Osteosarcoma	Homo sapiens	CVCL_0426
	HOS	Osteosarcoma	Homo sapiens	CVCL_0312
	hFOB 1.19	Normal	Homo sapiens	CVCL_3708

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) [READER]

Regulator Info

In total 1 item(s) under this regulator
Experiment 1 Reporting the m6A Methylation Regulator of This Target Gene				[2]
Response Summary	IGF2BP2 functions in partnerships with Putative uncharacterized protein DANCR (DANCR) to regulate its stability. In tumor cells, IGF2BP2 is upregulated, which increases the chance of IGF2PB2 to interact with and stabilize DANCR.DANCR is a novel target for IGF2BP2 through m6A modification, and IGF2BP2 and DANCR work together to promote cancer stemness-like properties and pancreatic cancer pathogenesis.
Target Regulation	Up regulation
Responsed Disease	Pancreatic cancer		ICD-11: 2C10	Disease Info
Cell Process	Cell proliferation
In-vitro Model	BxPC-3	Pancreatic ductal adenocarcinoma	Homo sapiens	CVCL_0186
In-vitro Model	SW1990	Pancreatic adenocarcinoma	Homo sapiens	CVCL_1723
In-vivo Model	DANCR KO or empty vector control were harvested and then mixed with matrigel (1:1) (BD Biosciences). Three different numbers of cells (1 × 10⁴, 1 × 10⁵, and 5 × 10⁵ cells) were subcutaneously injected into nude mice, five animals per group.

Osteosarcoma [ICD-11: 2B51]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[1]
Response Summary	METTL3 contributes to OS progression by increasing Putative uncharacterized protein DANCR (DANCR) mRNA stability via m6A modification, meaning that METTL3 is a promising therapeutic target for OS treatment.
Responsed Disease	Osteosarcoma [ICD-11: 2B51]
Target Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
Target Regulation	Up regulation
Cell Process	Cell proliferation
	Cell migration
	Cell invasion
In-vitro Model	U2OS	Osteosarcoma	Homo sapiens	CVCL_0042
	SJSA-1	Osteosarcoma	Homo sapiens	CVCL_1697
	SaOS-2	Osteosarcoma	Homo sapiens	CVCL_0548
	MG-63	Osteosarcoma	Homo sapiens	CVCL_0426
	HOS	Osteosarcoma	Homo sapiens	CVCL_0312
	hFOB 1.19	Normal	Homo sapiens	CVCL_3708

Pancreatic cancer [ICD-11: 2C10]

Disease Info

In total 1 item(s) under this disease
Experiment 1 Reporting the m6A-centered Disease Response				[2]
Response Summary	IGF2BP2 functions in partnerships with Putative uncharacterized protein DANCR (DANCR) to regulate its stability. In tumor cells, IGF2BP2 is upregulated, which increases the chance of IGF2PB2 to interact with and stabilize DANCR.DANCR is a novel target for IGF2BP2 through m6A modification, and IGF2BP2 and DANCR work together to promote cancer stemness-like properties and pancreatic cancer pathogenesis.
Responsed Disease	Pancreatic cancer [ICD-11: 2C10]
Target Regulator	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)		READER	Regulator Info
Target Regulation	Up regulation
Cell Process	Cell proliferation
In-vitro Model	BxPC-3	Pancreatic ductal adenocarcinoma	Homo sapiens	CVCL_0186
In-vitro Model	SW1990	Pancreatic adenocarcinoma	Homo sapiens	CVCL_1723
In-vivo Model	DANCR KO or empty vector control were harvested and then mixed with matrigel (1:1) (BD Biosciences). Three different numbers of cells (1 × 10⁴, 1 × 10⁵, and 5 × 10⁵ cells) were subcutaneously injected into nude mice, five animals per group.

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

RNA modification

m6A Regulator: Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC)

Regulator Info

In total 3 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00558		Crosstalk Info
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)
Regulated Target	Transcription factor SOX-2 (SOX2)
Crosstalk relationship	m6A → A-to-I
Crosstalk ID: M6ACROT00560		Crosstalk Info
Epigenetic Regulator	Fat mass and obesity-associated protein (FTO)
Regulated Target	Transcription factor SOX-2 (SOX2)
Crosstalk relationship	m6A → m6Am
Crosstalk ID: M6ACROT00562		Crosstalk Info
Epigenetic Regulator	Methyltransferase-like protein 1 (METTL1)
Regulated Target	Transcription factor SOX-2 (SOX2)
Crosstalk relationship	m6A → m7G

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

Regulator Info

In total 3 item(s) under this m6A regulator
Crosstalk ID: M6ACROT00559		Crosstalk Info
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)
Regulated Target	Transcription factor SOX-2 (SOX2)
Crosstalk relationship	m6A → A-to-I
Crosstalk ID: M6ACROT00561		Crosstalk Info
Epigenetic Regulator	Fat mass and obesity-associated protein (FTO)
Regulated Target	Transcription factor SOX-2 (SOX2)
Crosstalk relationship	m6A → m6Am
Crosstalk ID: M6ACROT00563		Crosstalk Info
Epigenetic Regulator	Methyltransferase-like protein 1 (METTL1)
Regulated Target	Transcription factor SOX-2 (SOX2)
Crosstalk relationship	m6A → m7G

Histone modification

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03473		Crosstalk Info
Epigenetic Regulator	Histone acetyltransferase p300 (P300)
Regulated Target	Histone H3 lysine 18 lactylation (H3K18la)
Crosstalk relationship	Histone modification → m6A
Disease	Pancreatic cancer	Disease Info

Non-coding RNA

m6A Regulator: Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC)

Regulator Info

In total 3 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05958		Crosstalk Info
Epigenetic Regulator	Differentiation antagonizing non-protein coding RNA (DANCR)
Regulated Target	Interleukin-11 (IL11)
Crosstalk relationship	m6A → ncRNA
Disease	Bladder cancer	Disease Info
Drug	BP-1-102	Drug Info
Crosstalk ID: M6ACROT05959		Crosstalk Info
Epigenetic Regulator	Differentiation antagonizing non-protein coding RNA (DANCR)
Regulated Target	G1/S-specific cyclin-D1 (CCND1)
Crosstalk relationship	m6A → ncRNA
Disease	Bladder cancer	Disease Info
Drug	BP-1-102	Drug Info
Crosstalk ID: M6ACROT05960		Crosstalk Info
Epigenetic Regulator	Differentiation antagonizing non-protein coding RNA (DANCR)
Regulated Target	Urokinase-type plasminogen activator (PLAU)
Crosstalk relationship	m6A → ncRNA
Disease	Bladder cancer	Disease Info
Drug	BP-1-102	Drug Info

RNA Modification Sequencing Data Associated with the Target (ID: M6ATAR00224)

Differentiation antagonizing non-protein coding RNA (DANCR)

5-methylcytidine (m5C)

In total 11 m6A sequence/site(s) in this target gene
mod ID: M5CSITE003306		Click to Show/Hide the Full List
mod site	chr4:52712696-52712697:+		[4]
Sequence	GGTAGAGCAGCCCTCGGCGGCCCGGGGGGCGGGCGGCGGTG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000441504.1; ENST00000650700.1; ENST00000578365.1; ENST00000411630.6
External Link	RMBase: m5C_site_34046
mod ID: M5CSITE003307		Click to Show/Hide the Full List
mod site	chr4:52712697-52712698:+		[4]
Sequence	GTAGAGCAGCCCTCGGCGGCCCGGGGGGCGGGCGGCGGTGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000650700.1; ENST00000411630.6; ENST00000578365.1; ENST00000441504.1
External Link	RMBase: m5C_site_34047
mod ID: M5CSITE003308		Click to Show/Hide the Full List
mod site	chr4:52712698-52712699:+		[4]
Sequence	TAGAGCAGCCCTCGGCGGCCCGGGGGGCGGGCGGCGGTGCC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000578365.1; ENST00000650700.1; ENST00000441504.1; ENST00000411630.6
External Link	RMBase: m5C_site_34048
mod ID: M5CSITE003309		Click to Show/Hide the Full List
mod site	chr4:52712705-52712706:+		[4]
Sequence	GCCCTCGGCGGCCCGGGGGGCGGGCGGCGGTGCCCGTCCCG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000578365.1; ENST00000411630.6; ENST00000650700.1; ENST00000441504.1
External Link	RMBase: m5C_site_34049
mod ID: M5CSITE003310		Click to Show/Hide the Full List
mod site	chr4:52712709-52712710:+		[4]
Sequence	TCGGCGGCCCGGGGGGCGGGCGGCGGTGCCCGTCCCGGGGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000578365.1; ENST00000411630.6; ENST00000650700.1; ENST00000441504.1
External Link	RMBase: m5C_site_34050
mod ID: M5CSITE003311		Click to Show/Hide the Full List
mod site	chr4:52712717-52712718:+		[4]
Sequence	CCGGGGGGCGGGCGGCGGTGCCCGTCCCGGGGCTGCGCGAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000578365.1; ENST00000650700.1; ENST00000411630.6; ENST00000441504.1
External Link	RMBase: m5C_site_34051
mod ID: M5CSITE003312		Click to Show/Hide the Full List
mod site	chr4:52712718-52712719:+		[4]
Sequence	CGGGGGGCGGGCGGCGGTGCCCGTCCCGGGGCTGCGCGAGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000441504.1; ENST00000650700.1; ENST00000578365.1; ENST00000411630.6
External Link	RMBase: m5C_site_34052
mod ID: M5CSITE003313		Click to Show/Hide the Full List
mod site	chr4:52712719-52712720:+		[4]
Sequence	GGGGGGCGGGCGGCGGTGCCCGTCCCGGGGCTGCGCGAGGC
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000578365.1; ENST00000441504.1; ENST00000650700.1; ENST00000411630.6
External Link	RMBase: m5C_site_34053
mod ID: M5CSITE003314		Click to Show/Hide the Full List
mod site	chr4:52712722-52712723:+		[4]
Sequence	GGGCGGGCGGCGGTGCCCGTCCCGGGGCTGCGCGAGGCACA
Seq Type List	Bisulfite-seq
Transcript ID List	MIMAT0018968; ENST00000441504.1; ENST00000650700.1; ENST00000411630.6; ENST00000578365.1
External Link	RMBase: m5C_site_34054
mod ID: M5CSITE003315		Click to Show/Hide the Full List
mod site	chr4:52712723-52712724:+		[4]
Sequence	GGCGGGCGGCGGTGCCCGTCCCGGGGCTGCGCGAGGCACAG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000411630.6; MIMAT0018968; ENST00000650700.1; ENST00000578365.1; ENST00000441504.1
External Link	RMBase: m5C_site_34055
mod ID: M5CSITE003316		Click to Show/Hide the Full List
mod site	chr4:52712724-52712725:+		[4]
Sequence	GCGGGCGGCGGTGCCCGTCCCGGGGCTGCGCGAGGCACAGG
Seq Type List	Bisulfite-seq
Transcript ID List	ENST00000578365.1; ENST00000441504.1; MIMAT0018968; ENST00000650700.1; ENST00000411630.6
External Link	RMBase: m5C_site_34056

N6-methyladenosine (m6A)

In total 31 m6A sequence/site(s) in this target gene
mod ID: M6ASITE065695		Click to Show/Hide the Full List
mod site	chr4:52713316-52713317:+		[5]
Sequence	GTAAAGTAAGTCTCCATAAAACCCAGAGAAGAGACTGGAAA
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000444958.1; ENST00000391286.1; ENST00000411630.6; ENST00000425653.1; ENST00000650700.1
External Link	RMBase: m6A_site_637590
mod ID: M6ASITE065696		Click to Show/Hide the Full List
mod site	chr4:52713329-52713330:+		[5]
Sequence	CCATAAAACCCAGAGAAGAGACTGGAAAGCTCCTCTTTGGA
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000650700.1; ENST00000411630.6; ENST00000444958.1; ENST00000391286.1; ENST00000425653.1
External Link	RMBase: m6A_site_637591
mod ID: M6ASITE065697		Click to Show/Hide the Full List
mod site	chr4:52713497-52713498:+		[6]
Sequence	ACTTTTCTTTCTATAGGTTGACAACTACAGGCACAAGCCAT
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000425653.1; ENST00000444958.1; ENST00000411630.6; ENST00000650700.1
External Link	RMBase: m6A_site_637592
mod ID: M6ASITE065698		Click to Show/Hide the Full List
mod site	chr4:52713509-52713510:+		[6]
Sequence	ATAGGTTGACAACTACAGGCACAAGCCATTGAAGCTGGAAT
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000650700.1; ENST00000411630.6; ENST00000444958.1; ENST00000425653.1
External Link	RMBase: m6A_site_637593
mod ID: M6ASITE065699		Click to Show/Hide the Full List
mod site	chr4:52713554-52713555:+		[7]
Sequence	TGTTGCTGGTATTTCAATTGACTTAAGCCAACTATCCCTTC
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000425653.1; ENST00000444958.1; ENST00000411630.6; ENST00000650700.1
External Link	RMBase: m6A_site_637594
mod ID: M6ASITE065700		Click to Show/Hide the Full List
mod site	chr4:52713564-52713565:+		[7]
Sequence	ATTTCAATTGACTTAAGCCAACTATCCCTTCAGTTACAATA
Motif Score	2.595904762
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000650700.1; ENST00000425653.1; ENST00000411630.6; ENST00000444958.1
External Link	RMBase: m6A_site_637595
mod ID: M6ASITE065701		Click to Show/Hide the Full List
mod site	chr4:52713579-52713580:+		[7]
Sequence	AGCCAACTATCCCTTCAGTTACAATAGGAAAGTGCCTCTAA
Motif Score	2.07285119
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000444958.1; ENST00000425653.1; ENST00000650700.1; ENST00000411630.6
External Link	RMBase: m6A_site_637596
mod ID: M6ASITE065702		Click to Show/Hide the Full List
mod site	chr4:52713617-52713618:+		[7]
Sequence	TAATAAGGCCAAATATGCGTACTAACTTGTAGCAACCACGT
Motif Score	3.278136905
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000411630.6; ENST00000425653.1; ENST00000650700.1; ENST00000444958.1
External Link	RMBase: m6A_site_637597
mod ID: M6ASITE065703		Click to Show/Hide the Full List
mod site	chr4:52713621-52713622:+		[7]
Sequence	AAGGCCAAATATGCGTACTAACTTGTAGCAACCACGTGTCC
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000444958.1; ENST00000425653.1; ENST00000411630.6; ENST00000650700.1
External Link	RMBase: m6A_site_637598
mod ID: M6ASITE065704		Click to Show/Hide the Full List
mod site	chr4:52713670-52713671:+		[7]
Sequence	CCACAGGAGCTAGAGCAGTGACAATGCTGGTGGCAACAGGG
Motif Score	2.859755952
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000623036.1; ENST00000425653.1; ENST00000411630.6; ENST00000650700.1; ENST00000444958.1
External Link	RMBase: m6A_site_637599
mod ID: M6ASITE065705		Click to Show/Hide the Full List
mod site	chr4:52713743-52713744:+		[6]
Sequence	AACCTTTTCATTTAATTGTCACAACTCGGAGGTGGATTCTG
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000650700.1; ENST00000623036.1; ENST00000444958.1; ENST00000425653.1; ENST00000411630.6
External Link	RMBase: m6A_site_637600
mod ID: M6ASITE065706		Click to Show/Hide the Full List
mod site	chr4:52713770-52713771:+		[5]
Sequence	GGAGGTGGATTCTGTTAGGGACAGGCTGCCCCAGGACCACT
Motif Score	3.643047619
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	rmsk_1311503; ENST00000411630.6; ENST00000650700.1; ENST00000444958.1; ENST00000425653.1; ENST00000623036.1
External Link	RMBase: m6A_site_637601
mod ID: M6ASITE065707		Click to Show/Hide the Full List
mod site	chr4:52713785-52713786:+		[5]
Sequence	TAGGGACAGGCTGCCCCAGGACCACTCCGCCCCCGCTAACT
Motif Score	3.622404762
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000623036.1; ENST00000650700.1; rmsk_1311503; ENST00000411630.6; ENST00000425653.1; ENST00000444958.1
External Link	RMBase: m6A_site_637602
mod ID: M6ASITE065708		Click to Show/Hide the Full List
mod site	chr4:52713803-52713804:+		[7]
Sequence	GGACCACTCCGCCCCCGCTAACTCAATGCAGCTGACCCTTA
Motif Score	2.590089286
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000650700.1; ENST00000411630.6; ENST00000623036.1; ENST00000425653.1; rmsk_1311503; ENST00000444958.1
External Link	RMBase: m6A_site_637603
mod ID: M6ASITE065709		Click to Show/Hide the Full List
mod site	chr4:52713832-52713833:+		[7]
Sequence	AGCTGACCCTTACCCTGAATACTCTGCAGCTGCATTCCTGA
Motif Score	2.53247619
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000444958.1; ENST00000425653.1; ENST00000623036.1; ENST00000411630.6; rmsk_1311503; ENST00000650700.1
External Link	RMBase: m6A_site_637604
mod ID: M6ASITE065710		Click to Show/Hide the Full List
mod site	chr4:52713853-52713854:+		[5]
Sequence	CTCTGCAGCTGCATTCCTGAACCGTTATCTAGGCGCTATAG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293T; HepG2
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000650700.1; rmsk_1311503; ENST00000444958.1; ENST00000425653.1; ENST00000623036.1; ENST00000411630.6
External Link	RMBase: m6A_site_637605
mod ID: M6ASITE065711		Click to Show/Hide the Full List
mod site	chr4:52713886-52713887:+		[5]
Sequence	CGCTATAGCAAGGTCACCAGACTTGCTACACCGAAGCCCTC
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	rmsk_1311503; ENST00000411630.6; ENST00000623036.1; ENST00000650700.1; ENST00000425653.1; ENST00000444958.1
External Link	RMBase: m6A_site_637606
mod ID: M6ASITE065712		Click to Show/Hide the Full List
mod site	chr4:52713893-52713894:+		[6]
Sequence	GCAAGGTCACCAGACTTGCTACACCGAAGCCCTCTGGGTGG
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000425653.1; ENST00000411630.6; ENST00000444958.1; ENST00000650700.1; ENST00000623036.1; rmsk_1311503
External Link	RMBase: m6A_site_637607
mod ID: M6ASITE065713		Click to Show/Hide the Full List
mod site	chr4:52713934-52713935:+		[7]
Sequence	CACGGGGGAGGTCATGAGAAACGTGGATTACACCCCCTTGT
Motif Score	2.179660714
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000650700.1; ENST00000425653.1; ENST00000623036.1; rmsk_1311503; ENST00000444958.1; ENST00000411630.6
External Link	RMBase: m6A_site_637608
mod ID: M6ASITE065714		Click to Show/Hide the Full List
mod site	chr4:52713943-52713944:+		[7]
Sequence	GGTCATGAGAAACGTGGATTACACCCCCTTGTAAATTCCTA
Motif Score	2.07285119
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000425653.1; rmsk_1311503; ENST00000444958.1; ENST00000623036.1; ENST00000650700.1; ENST00000411630.6
External Link	RMBase: m6A_site_637609
mod ID: M6ASITE065715		Click to Show/Hide the Full List
mod site	chr4:52713969-52713970:+		[6]
Sequence	CCTTGTAAATTCCTATTTTCACAAGATAATATATTGTAAGC
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000650700.1; ENST00000444958.1; ENST00000411630.6; ENST00000623036.1; ENST00000425653.1; rmsk_1311503
External Link	RMBase: m6A_site_637610
mod ID: M6ASITE065716		Click to Show/Hide the Full List
mod site	chr4:52714023-52714024:+		[7]
Sequence	ATATGTGGTAAAGTTAATTGACTAACAACCCCAGGGTCTCT
Motif Score	3.28175
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	rmsk_1311503; ENST00000650700.1; ENST00000411630.6; ENST00000623036.1; ENST00000425653.1; ENST00000444958.1
External Link	RMBase: m6A_site_637611
mod ID: M6ASITE065717		Click to Show/Hide the Full List
mod site	chr4:52714027-52714028:+		[7]
Sequence	GTGGTAAAGTTAATTGACTAACAACCCCAGGGTCTCTCTCC
Motif Score	2.168095238
Cell/Tissue List	HEK293T; hESC-HEK293T
Seq Type List	DART-seq; MAZTER-seq
Transcript ID List	ENST00000650700.1; ENST00000623036.1; ENST00000411630.6; rmsk_1311503; ENST00000444958.1; ENST00000425653.1
External Link	RMBase: m6A_site_637612
mod ID: M6ASITE065718		Click to Show/Hide the Full List
mod site	chr4:52714057-52714058:+		[5]
Sequence	GGTCTCTCTCCCCCATATAAACCCCTCATTTTGTAAGCTCA
Motif Score	2.185083333
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000444958.1; ENST00000650700.1; rmsk_1311503; ENST00000623036.1; ENST00000411630.6; ENST00000425653.1
External Link	RMBase: m6A_site_637613
mod ID: M6ASITE065719		Click to Show/Hide the Full List
mod site	chr4:52714093-52714094:+		[7]
Sequence	GCTCAGGGCTGCCACCTCCGACTGGTGGAGAAGCCTGGCAG
Motif Score	3.287565476
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000623036.1; ENST00000425653.1; rmsk_1311503; ENST00000411630.6; ENST00000444958.1; ENST00000650700.1
External Link	RMBase: m6A_site_637614
mod ID: M6ASITE065720		Click to Show/Hide the Full List
mod site	chr4:52714122-52714123:+		[5]
Sequence	GAAGCCTGGCAGGTTAATAAACTTACTTGGCCTGACCTTGG
Motif Score	2.627720238
Cell/Tissue List	HeLa; HEK293T
Seq Type List	m6A-seq; DART-seq
Transcript ID List	ENST00000411630.6; rmsk_1311503; ENST00000650700.1; ENST00000444958.1; ENST00000425653.1; ENST00000623036.1
External Link	RMBase: m6A_site_637615
mod ID: M6ASITE065721		Click to Show/Hide the Full List
mod site	chr4:52714126-52714127:+		[7]
Sequence	CCTGGCAGGTTAATAAACTTACTTGGCCTGACCTTGGGTCT
Motif Score	2.494845238
Cell/Tissue List	HEK293T
Seq Type List	DART-seq
Transcript ID List	ENST00000623036.1; ENST00000425653.1; ENST00000444958.1; ENST00000411630.6; rmsk_1311503; ENST00000650700.1
External Link	RMBase: m6A_site_637616
mod ID: M6ASITE065722		Click to Show/Hide the Full List
mod site	chr4:52720128-52720129:+
Sequence	AAGTTTTCTTACAGAATGAAACTTTTCTGCTATTTTTCTCA
Motif Score	2.627720238
Cell/Tissue List	HEK293T
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000444958.1; ENST00000650700.1
External Link	RMBase: m6A_site_637617
mod ID: M6ASITE065723		Click to Show/Hide the Full List
mod site	chr4:52720172-52720173:+		[8]
Sequence	TTAATTGGCTATTTGAGAAAACCGAATTTCTGGCTCTCAGC
Motif Score	2.185083333
Cell/Tissue List	HEK293T; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000444958.1; ENST00000650700.1
External Link	RMBase: m6A_site_637618
mod ID: M6ASITE065724		Click to Show/Hide the Full List
mod site	chr4:52720267-52720268:+		[9]
Sequence	ATCATCCTTACCTTCTTTAAACCTTTTGTGCCAGTCAAAAA
Motif Score	2.185083333
Cell/Tissue List	Huh7; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000444958.1; ENST00000650700.1
External Link	RMBase: m6A_site_637619
mod ID: M6ASITE065725		Click to Show/Hide the Full List
mod site	chr4:52720317-52720318:+		[9]
Sequence	TTGATATGTCATCACCGGAAACTACTTTTTTTTTTTGTTTC
Motif Score	2.627720238
Cell/Tissue List	Huh7; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000650700.1; ENST00000444958.1
External Link	RMBase: m6A_site_637620

Ref 1	METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification. Front Cell Dev Biol. 2022 Jan 12;9:784719. doi: 10.3389/fcell.2021.784719. eCollection 2021.
Ref 2	IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader. Cell Death Differ. 2020 Jun;27(6):1782-1794. doi: 10.1038/s41418-019-0461-z. Epub 2019 Dec 5.
Ref 3	Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1. Br J Cancer. 2007 Oct 22;97(8):1077-83. doi: 10.1038/sj.bjc.6604010. Epub 2007 Oct 16.
Ref 4	Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6784-6789. doi: 10.1073/pnas.1817334116. Epub 2019 Mar 14.
Ref 5	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	DART-seq: an antibody-free method for global m(6)A detection. Nat Methods. 2019 Dec;16(12):1275-1280. doi: 10.1038/s41592-019-0570-0. Epub 2019 Sep 23.
Ref 8	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 9	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.

m6A Target Gene Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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