m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00562
 [1], [2], [3]
m6A modification DANCR DANCR LRPPRC : m6A sites Indirect Enhancement RNA modification SOX2 SOX2 METTL1 Methylation : modification sites
m6A Modification:
m6A Regulator Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) READER
 Regulator Info 
m6A Target Differentiation antagonizing non-protein coding RNA (DANCR)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> N7-methylguanosine (m7G)
Epigenetic Regulator Methyltransferase-like protein 1 (METTL1) WRITER View Details
Regulated Target Transcription factor SOX-2 (SOX2) View Details
Crosstalk Relationship m6A  →  m7G Enhancement
Crosstalk Mechanism m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary LRPPRC interacts with Differentiation antagonizing non-protein coding RNA (DANCR), increasing its m6A level and promoting its physical interaction with Transcription factor SOX-2 (SOX2), which was regulated by METTL1-mediated m7G modification.
In-vitro Model
 iPSC (Mouse induced pluripotent stem cells (iPSCs))
UM-UC-3 Bladder carcinoma Homo sapiens CVCL_1783
T24 Bladder carcinoma Homo sapiens CVCL_0554
References
Ref 1 METTL1-mediated m(7)G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development. Stem Cell Res Ther. 2020 Jul 22;11(1):306. doi: 10.1186/s13287-020-01814-4.
Ref 2 DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression. Mol Ther. 2019 Feb 6;27(2):326-341. doi: 10.1016/j.ymthe.2018.12.015. Epub 2019 Jan 9.
Ref 3 Long Noncoding RNA DANCR Regulates Cell Proliferation by Stabilizing SOX2 mRNA in Nasopharyngeal Carcinoma. Am J Pathol. 2020 Dec;190(12):2343-2354. doi: 10.1016/j.ajpath.2020.09.005. Epub 2020 Sep 22.