m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00563				[1], [2], [3]
m⁶A modification DANCR DANCR IGF2BP2 : m⁶A sites Indirect Enhancement RNA modification SOX2 SOX2 METTL1 Methylation : modification sites
m6A Regulator	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)			READER	Regulator Info
m6A Target	Differentiation antagonizing non-protein coding RNA (DANCR)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> N7-methylguanosine (m7G)
Epigenetic Regulator	Methyltransferase-like protein 1 (METTL1)			WRITER	View Details
Regulated Target	Transcription factor SOX-2 (SOX2)				View Details
Crosstalk Relationship	m6A → m7G			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	IGF2BP2 interacts with Differentiation antagonizing non-protein coding RNA (DANCR), increasing its m6A level and promoting its physical interaction with Transcription factor SOX-2 (SOX2), which was regulated by METTL1-mediated m7G modification.
In-vitro Model	iPSC (Mouse induced pluripotent stem cells (iPSCs))
	BxPC-3	Pancreatic ductal adenocarcinoma	Homo sapiens		CVCL_0186
	SW1990	Pancreatic adenocarcinoma	Homo sapiens		CVCL_1723

References

Ref 1	METTL1-mediated m(7)G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development. Stem Cell Res Ther. 2020 Jul 22;11(1):306. doi: 10.1186/s13287-020-01814-4.
Ref 2	IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader. Cell Death Differ. 2020 Jun;27(6):1782-1794. doi: 10.1038/s41418-019-0461-z. Epub 2019 Dec 5.
Ref 3	Long Noncoding RNA DANCR Regulates Cell Proliferation by Stabilizing SOX2 mRNA in Nasopharyngeal Carcinoma. Am J Pathol. 2020 Dec;190(12):2343-2354. doi: 10.1016/j.ajpath.2020.09.005. Epub 2020 Sep 22.