m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00559
|
[1], [2], [3] | |||
.png)
.png)
 : m6A sites
Indirect
Enhancement
RNA modification
SOX2
SOX2
ADAR
Methylation
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | READER | |||
| m6A Target | Differentiation antagonizing non-protein coding RNA (DANCR) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | Transcription factor SOX-2 (SOX2) | View Details | |||
| Crosstalk Relationship | m6A → A-to-I | Enhancement | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | IGF2BP2 interacts with Differentiation antagonizing non-protein coding RNA (DANCR), increasing its m6A level and promoting its physical interaction with Transcription factor SOX-2 (SOX2), which was regulated by ADAR1-mediated A-to-I modification. | ||||
In-vitro Model |
HN4 | Clear cell renal cell carcinoma | Homo sapiens | CVCL_IS30 | |
| CAL-27 | Tongue squamous cell carcinoma | Homo sapiens | CVCL_1107 | ||
| BxPC-3 | Pancreatic ductal adenocarcinoma | Homo sapiens | CVCL_0186 | ||
| SW1990 | Pancreatic adenocarcinoma | Homo sapiens | CVCL_1723 | ||
References