m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05958
 [1]
m6A modification DANCR DANCR LRPPRC : m6A sites Direct Enhancement Non-coding RNA DANCR IL11  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) READER
 Regulator Info 
m6A Target Differentiation antagonizing non-protein coding RNA (DANCR)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Differentiation antagonizing non-protein coding RNA (DANCR) LncRNA View Details
Regulated Target Interleukin-11 (IL11) View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary Differentiation antagonizing non-protein coding RNA (DANCR) activated Interleukin-11 (IL11)-STAT3 signaling and increased CCND1 and PLAU expression via guiding leucine-rich pentatricopeptide repeat containing (LRPPRC) to stabilize mRNA.
Responsed Disease Bladder cancer ICD-11: 2C94
 Disease Info 
Responsed Drug BP-1-102
 Drug Info 
Pathway Response JAK-STAT signaling pathway hsa04630
Cell Process Cell migration
Cell invasion
Cell proliferation
mRNA stability
In-vitro Model
 UM-UC-3 Bladder carcinoma Homo sapiens CVCL_1783
T24 Bladder carcinoma Homo sapiens CVCL_0554
HEK293T Normal Homo sapiens CVCL_0063
In-vivo Model Ten mice were included in each group, and lentivirus-transduced UM-UC-3 cells (3 × 106 cells) that stably expressed firefly luciferase were inoculated into the mice's footpads.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Interleukin-11 (IL11) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name VM-501 Phase 3 [2]
Synonyms
IL-11 agonist (thrombocytopenia, small molecule therapeutic/iv/sc), Viromed
    Click to Show/Hide
MOA Agonist
External Link
TTD: D05XKW
2C94: Bladder cancer 83 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Enfortumab vedotin Phase 3 [3]
Synonyms
Padcev
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External Link
TTD: DAG87H
 Compound Name Atezolizumab Approved [4]
External Link
TTD: D0YM2K
 Compound Name Halaven Phase 1/2 [4]
Synonyms
Eribulin mesylate; Eribulin (mesylate); Eribulin mesilate; UNII-AV9U0660CW; Eribulin mesylate [USAN]; 441045-17-6; AV9U0660CW; CHEBI:70710; E 7389; E7389; Eribulin mesylate (USAN); B-1939; NSC-707389; Eribulin mesilate (JAN); CHEMBL1683544; QAMYWGZHLCQOOJ-WRNBYXCMSA-N; HY-13442A; AKOS030238218; CS-2803; D08914; 2-(3-amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopent
    Click to Show/Hide
External Link
CID: 17755248
TTD: D0XQ5X
 Compound Name RG-7446 Approved [5]
External Link
TTD: D0OZ4J
 Compound Name Pemigatinib Approved [4]
Synonyms
Unii-Y6BX7BL23K; Y6BX7BL23K; GTPL9767; SCHEMBL15556271; HCDMJFOHIXMBOV-UHFFFAOYSA-N; example 126 [WO2014007951]; 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-4,7-dihydropyrrolo[4,5]pyrido[1,2-d]pyrimidin-2-one; 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one; INCB54828
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External Link
CID: 86705695
TTD: D0O6UY
DrugBank: DB15102
 Compound Name Erdafitinib Approved [6]
Synonyms
1346242-81-6; UNII-890E37NHMV; 890E37NHMV; Erdafitinib [USAN:INN]; Erdafitinib (USAN/INN); GTPL9039; SCHEMBL2583760; CHEMBL3545376; MolPort-044-560-398; JNJ-42756493 (Erdafitinib); s8401; compound 4 [WO2011135376]; ZINC168520308; AKOS030526429; CS-4988; DB12147; AC-30222; 1,2-Ethanediamine, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-(3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl)-; HY-18708; AS-35040; KB-333716; D10927; N'-(3,5-dimethoxyphenyl)-N'-[3-(1-methylpyrazol-4-yl)quino
    Click to Show/Hide
External Link
CID: 67462786
TTD: D0NW0T
DrugBank: DB12147
 Compound Name Hexyl aminolevulinate Approved [7]
Synonyms
Hexvix (TN)
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External Link
CID: 6433082
TTD: D0AY9Q
 Compound Name BCG vaccine Approved [7]
Synonyms
OncoTice; TiceBCG; BCG vaccine, Organon
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External Link
TTD: D0A8LZ
 Compound Name Valrubicin Approved [8]
Synonyms
Valstar; Valrubicin [USAN]; Valstar Preservative Free; AD 32; Antibiotic AD 32; Valstar (TN); N-Trifluoroacetyladriamycin 14-valerate; N-Trifluoroacetyldoxorubicin 14-valerate; Trifluoroacetyladriamycin-14-valerate; Valrubicin (USP/INN); N-Trifluoroacetyladriamycin-14-valerate; Adriamycin, trifluoroacetyl-, 14-valerate; [2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-4-[5-hydroxy-6-methyl-4-[(2,2,2-trifluoroacetyl)amino]oxan-2-yl]oxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethyl] pentanoate; (2S-cis)-2-(1,2,3,4,6,11-Hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-3-((trifluoroacetyl)amino)-alpha-L-lyxo-hexopyranosyl)oxy)-2-naphthacenyl)-2-oxoethyl pentanoate; (2S-cis)-Pentanoic acid, 2-(1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-3-((trifluoroacetyl)amino)-alpha-L-lyxo-hexopyranosyl)oxy)-2-naphth acenyl)-2-oxoethyl ester; (8S,10S)-8-Glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-((2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-alpha-L-lyxo-hexopyranosyl)oxy)-5,12-naphthacenedione 8(sup 2)-valerate; Pentanoic acid, 2-((2S,4S)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-3-((trifluoroacetylamino)-, alpha-L-lysohexopyranoxyl)oxy)-2-naphthacenyl)-2-oxoethyl ester
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External Link
CID: 454216
TTD: D07IPB
DrugBank: DB00385
 Compound Name Vicineum Phase 3 [9]
Synonyms
Oportuzumab monatox
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External Link
TTD: DRP4Q9
 Compound Name Sasanlimab Phase 3 [10]
Synonyms
PF-06801591
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External Link
TTD: DP2Z0X
 Compound Name CG0070 Phase 3 [11]
Synonyms
CG-5757; Oncolytic virus therapy, Cell Genesys; Oncolytic virus therapy, Cold Genesys
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External Link
TTD: D7EZ0H
 Compound Name Nadofaragene firadenovec Phase 3 [4]
External Link
TTD: D0X4TK
 Compound Name Oportuzumab monatox Phase 3 [11]
External Link
TTD: D0OF1R
 Compound Name Apaziquone Phase 3 [12]
Synonyms
EOquin; 114560-48-4; Apaziquonum; NOR-701; EO 9 (pharmaceutical); EO-9; Apaziquone [USAN:INN]; NSC-382459; Apaziquonum [INN-Latin]; E 09; NSC 382459; UNII-H464ZO600O; E-85/053; E-09; EO9; NSC 382456; H464ZO600O; 5-(Azridin-1-yl)-3-(hydroxymethyl)-2-((1E)-3-hydroxyprop-1-enyl)-methyl-1H-indole-4,7-dione; (E)-5-(1-Azirinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-indole-4,7-dione; E09; 1H-Indole-4,7-dione, 5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-, (E)-; Neoquin; Qapzola; EO 9; Eoquin (TN); Apaziquone (USAN/INN); E-85/050; 3-hydroxymethyl-5-aziridinyl-1-methyl-2-(1H-indole-4,7-dione)prop-beta-en-alpha-ol; 5-(aziridin-1-yl)-3-(hydroxymethyl)-2-[(E)-3-hydroxyprop-1-enyl]-1-methylindole-4,7-dione; Apaziquone/EOquin
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External Link
CID: 5813717
TTD: D0FP0R
DrugBank: DB12593
 Compound Name Tesetaxel Phase 2 [13]
Synonyms
DJ-927; 333754-36-2; UNII-UG97LO5M8Y; UG97LO5M8Y; Tesetaxel [INN]; DJ927; DJ 927; CHEMBL2107787; SCHEMBL12060837; DB12019; Z-3104; (2AS,2BR,3S,4S,6S,8AR,10R,11AS,11BR,13AR)-2A-ACETOXY-6-(((2R,3S)-3-((TERT-BUTOXYCARBONYL)AMINO)-3-(3-FLUOROPYRIDIN-2-YL)-2-HYDROXYPROPANOYL)OXY)-10-((DIMETHYLAMINO)METHYL)-4-HYDROXY-7,11B,14,14-TETRAMETHYL-2A,2B,3,4,5,6,8A,11A,11B,12,13,13A-DODECAHYDRO-2H-4,8-METHANOOXETO[3'',2'':3',4']BENZO[1',2':3,4]CYCLODECA[1,2-D][1,3]DIOXOL-3-YL BENZOATE
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External Link
CID: 6918574
TTD: D0F9VH
DrugBank: DB12019
 Compound Name EN3488 Phase 3 [14]
External Link
TTD: D09KHE
 Compound Name NKTR 214 Phase 3 [11]
External Link
TTD: D02QQE
 Compound Name Ramucirumab Phase 3 [4]
External Link
TTD: D01QWT
 Compound Name Vicinium Phase 3 [4]
External Link
TTD: D00RTC
 Compound Name ICP-192 Phase 2 [15]
External Link
TTD: DZM65T
 Compound Name Inodiftagene vixteplasmid Phase 2 [16]
Synonyms
BC-819
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External Link
TTD: DE2V3Y
 Compound Name CPX-POM Phase 2 [17]
External Link
TTD: D7K3FB
 Compound Name LY3012212 Phase 2 [18]
Synonyms
Icrucumab
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External Link
TTD: D0X2RL
 Compound Name CV-301 Phase 2 [4]
External Link
TTD: D0W8FE
 Compound Name ABI-009 Phase 2 [4]
External Link
TTD: D0W3UV
 Compound Name ALT-801 Phase 2 [11]
Synonyms
ALT-801 (donor lymphocyte infusion, cancer); ALT-801 (donor lymphocyte infusion, cancer), Altor; STAR IL-2 conjugate (donor lymphocyte infusion, cancer), Altor; STAR-Ck (donor lymphocyte infusion, cancer), Altor; Soluble T-cell Antigen Receptor IL-2 conjugate (donor lymphocyte infusion, cancer), Altor
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External Link
TTD: D0V5JH
 Compound Name INO-5401 Phase 2 [4]
External Link
TTD: D0P2ME
 Compound Name RX-3117 Phase 2 [4]
Synonyms
Antimetabolite (cancer), Rexahn; Antimetabolite (cancer), Rexahn/ Teva
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External Link
CID: 11242315
TTD: D0L7WS
 Compound Name BC-819 Phase 2 [19]
External Link
TTD: D0K0KQ
 Compound Name IPI-549 Phase 2 [20]
Synonyms
XUMALORDVCFWKV-IBGZPJMESA-N; IPI549; 1693758-51-8; CHEMBL3984425; GTPL9563; SCHEMBL16629991; IPI 549; MolPort-044-756-207; EX-A1057; s8330; BDBM50192880; ZINC584906867; AKOS030627132; CS-6106; compound 26 [PMID: 27660692]; AC-29898; HY-100716; Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]-; 2-amino-N-[(1S)-1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide; (S)-2-amino-N-(1-(8-((
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External Link
CID: 91933883
TTD: D0I3LO
 Compound Name B-701 Phase 2 [4]
Synonyms
VKRFJPYJBOIVPD-UHFFFAOYSA-N; B 701; NSC 46406; 78218-88-9; Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, (3-chloropropyl) ester; AC1L3VIX; AC1Q6T2K; NSC46406; NSC-46406; 3-chloropropyl n,n-bis(2-chloroethyl)-n'-(3-hydroxypropyl)phosphorodiamidate; LS-107974; 3-[[bis(2-chloroethyl)amino-(3-chloropropoxy)phosphoryl]amin; 3-[[bis(2-chloroethyl)amino-(3-chloropropoxy)phosphoryl]amino]propan-1-ol; Phosphorodiamidic acid,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, 3-chloropropyl ester
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External Link
CID: 95987
TTD: D0G6CF
 Compound Name NC-6004 Phase 2 [4]
External Link
TTD: D0FG2Z
 Compound Name ALT-803 Phase 2 [4]
Synonyms
IL-15 agonist/ IL-15R alpha-Fc fusion complex (cancer), Altor BioScience
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External Link
TTD: D0FD7H
 Compound Name Vesigenurtacel-L Phase 2 [21]
External Link
TTD: D0E8QE
 Compound Name BAY1163877 Phase 2 [22]
Synonyms
Rogaratinib
    Click to Show/Hide
External Link
CID: 71611869
TTD: D0E8PR
DrugBank: DB15078
 Compound Name Coxsackievirus A21 Phase 1/2 [11]
Synonyms
Cavatak (TN)
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External Link
TTD: D0C4BL
 Compound Name OGX-427 Phase 2 [23]
External Link
CID: 71710946
TTD: D0AX1N
 Compound Name PIRITREXIM Phase 2 [24]
Synonyms
72732-56-0; Piritrexim [INN]; Piritreximum [Latin]; Piritrexime [French]; 6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine; Piritrexima [Spanish]; BW 301U; UNII-MK2A783ZUT; BW-301U; TCMDC-137235; BRN 5768301; MK2A783ZUT; CHEMBL7492; 2,4-Diamino-5-methyl-6-(2,5-dimethoxybenzyl)pyrido(2,3-d)pyrimidine; 6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE; 6-((2,5-Dimethoxyphenyl)methyl)-5-methylpyrido(2,3-d)pyrimidine-2,4-diamine
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External Link
CID: 54369
TTD: D09AYQ
DrugBank: DB03695
 Compound Name VesiGel Phase 2 [4]
External Link
TTD: D08LYZ
 Compound Name Instiladrin Phase 2 [25]
External Link
TTD: D07CNY
 Compound Name CDX-1307 Phase 2 [26]
Synonyms
BHCG-VAC; BetaHCG-VAC; MDX-1307; Dendritic cell targeted hCG-beta vaccine, Medarex; B11-hCG-beta, Medarex; Antigen-presenting cell-targeted vaccine (injectable, cancer), Celldex Therapeutics; Antigen-presenting cell-targeted vaccine (intradermal, cancer), Celldex Therapeutics; Antigen-presenting cell-targeted vaccine (iv, cancer), Celldex Therapeutics
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External Link
TTD: D04REV
 Compound Name APR-246 Phase 2 [27]
Synonyms
Eprenetapopt
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External Link
CID: 52918385
TTD: D03XTY
DrugBank: DB11684
 Compound Name MV-NIS Phase 1 [4]
Synonyms
MV-NIS (intratumoral, SCCHN); Measles virus encoding thyroidal sodium iodide symporter (intratumoral, Head and neck tumor), Nisco International Inc; MV-NIS (intratumoral, SCCHN), Nisco International Inc
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External Link
TTD: D01IJJ
 Compound Name 4SCAR-PSMA Phase 1/2 [28]
External Link
TTD: D0VI8T
 Compound Name MAGE-A10 TCR Phase 1/2 [4]
External Link
TTD: D0L1CO
 Compound Name Lx-TB-PstS1 Phase 1/2 [29]
Synonyms
Lx-Bladder
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External Link
TTD: D0H7LN
 Compound Name 4SCAR-FRa Phase 1/2 [28]
External Link
TTD: D09NUH
 Compound Name ABY-025 Phase 1/2 [30]
External Link
TTD: D08KCJ
 Compound Name ADP-A2M10 Phase 1 [31]
External Link
TTD: DM38KC
 Compound Name TAR-200 Phase 1 [4]
External Link
TTD: D0WM3D
 Compound Name ASG-15ME Phase 1 [32]
External Link
TTD: D0UM4S
 Compound Name Vesimune Phase 2 [33]
External Link
TTD: D0S0ZQ
 Compound Name NEO-PV-01 Phase 1 [4]
External Link
TTD: D0Q6AU
 Compound Name Neo-Urinary Conduit Phase 1 [34]
External Link
TTD: D0B6LP
 Compound Name FPA144 Phase 1 [11]
External Link
TTD: D06NND
 Compound Name Ad-IFN-alpha Phase 1 [35]
Synonyms
Ad-IFN-alpha (cancer); Ad-IFN-alpha (cancer), MD Anderson Cancer Center/NCI; Adenoviral-mediated IFN-alpha (gene therapy, cancer), MD Anderson Cancer Center/NCI
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External Link
TTD: D03QWG
 Compound Name LNK-754 Phase 1 [36]
Synonyms
LNK 754; 439153-64-7; OSI 754; CP 609754; CP-609,754; DTXSID60195986; 2(1H)-Quinolinone, 6-((4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methyl-
    Click to Show/Hide
External Link
CID: 46208720
TTD: D03BXU
DrugBank: DB12640
 Compound Name example 7 [US8664233] Clinical trial [37]
Synonyms
SCHEMBL977927; GTPL8283; HFGHRUCCKVYFKL-UHFFFAOYSA-N; SB19793; 4-ethoxy-2-(piperazin-1-yl)-7-(pyridin-4-yl)-5H-pyrimido[5,4-b]indole; 4-ethoxy-2-piperazin-1-yl-7-pyridin-4-yl-5H-pyrimido[5,4-b]indole
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External Link
CID: 24990553
TTD: D0Y9FX
 Compound Name (S)-DRF-1042 Clinical trial [38]
Synonyms
5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin; 5(S)-(2'-hydroxyethoxy)-20(S)-CPT
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External Link
CID: 91623363
TTD: D0M8KY
 Compound Name Larotaxel Discontinued in Phase 3 [39]
Synonyms
Benzenepropanoic acid; PNU 100940; XRP 9881; XRP9881
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External Link
CID: 6918260
TTD: D0J0RV
DrugBank: DB12984
 Compound Name Keyhole limpet hemocyanin Discontinued in Phase 3 [40]
External Link
TTD: D07UQR
 Compound Name IDM-2 Discontinued in Phase 2/3 [41]
Synonyms
Bexidem; MAK anticancer agents (2), Immuno-Designed Molecules/IDM Pharma
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External Link
TTD: D0YW4R
 Compound Name NKS-01 Discontinued in Phase 2 [42]
Synonyms
14alpha-Hydroxy-4-androstene-3,6,17-trione
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External Link
CID: 6918079
TTD: D0U9LL
 Compound Name S-288310 Discontinued in Phase 1/2 [43]
Synonyms
Peptide vaccine (bladder cancer), OncoTherapy Science; Peptide vaccine (bladder cancer), Shionogi
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External Link
TTD: D0Z2KU
 Compound Name Capzola Application submitted [4]
External Link
TTD: D0VO7K
 Compound Name MINAMESTANE Terminated [44]
Synonyms
FCE-24928; 4-Aminoandrosta-1,4,6-triene-3,17-dione
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External Link
CID: 65886
TTD: D0FS9K
 Compound Name CG-8840 Terminated [45]
Synonyms
CV-884
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External Link
TTD: D02GJE
 Compound Name ET-009 Investigative [46]
External Link
TTD: D0XT3G
 Compound Name TD-6989 Investigative [46]
External Link
TTD: D0V9BX
 Compound Name SL-601 Investigative [46]
External Link
TTD: D0QI1O
 Compound Name ASC-JMZ1 Investigative [46]
External Link
TTD: D0O0II
 Compound Name TD-3633 Investigative [46]
External Link
TTD: D0A5KO
 Compound Name CEL-011 Investigative [46]
External Link
TTD: D09TSX
 Compound Name Debio-1141 Investigative [46]
Synonyms
PLK-1 targeting UsiRNA (liposomal, cancer), Marina; PLK1-targeting UsiRNA (liposomal, cancer), MDRNA; PLK-1 targeting UsiRNA (liposomal, bladder cancer), Marina/Debiopharm
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External Link
TTD: D09OLR
 Compound Name TD-1770 Investigative [46]
External Link
TTD: D08VWJ
 Compound Name Chitosan/IL-12 Investigative [46]
Synonyms
Chitosan/IL-12 immunotherapy (intravesical, cancer), National Cancer Institute
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External Link
TTD: D08UZA
 Compound Name BAMLET Investigative [46]
Synonyms
BAMLET (liquid formulation, bladder cancer); BAMLET instillation (bladder cancer), NatImmune; BAMLET (liquid formulation, bladder cancer), NatImmune; Bovine alpha-lactalbumin-lipid complex (liquid formulation, bladder cancer), NatImmune
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External Link
TTD: D07FCA
 Compound Name TMX-202 Investigative [47]
Synonyms
TMX-20X
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TTD: D05TCC
 Compound Name SX-MTR1 Investigative [48]
Synonyms
MTOR modulators (small peptide mimetics, bladder cancer), Serometrix
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External Link
TTD: D05SOW
 Compound Name AP-300 Investigative [46]
External Link
TTD: D03KIK
 Compound Name BC-821 Investigative [46]
Synonyms
IGF2-DTA; Diphtheria toxin A conjugated insulin-like growth factor 2 (cancer), BioCancell
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External Link
TTD: D03IQK
 Compound Name OGX-427 + Paclitaxel Investigative [49]
External Link
CID: 91866823
TTD: D00ZBZ
References
Ref 1 DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression. Mol Ther. 2019 Feb 6;27(2):326-341. doi: 10.1016/j.ymthe.2018.12.015. Epub 2019 Jan 9.
Ref 2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033052)
Ref 3 ClinicalTrials.gov (NCT03474107) An Open-Label, Randomized Phase 3 Study to Evaluate Enfortumab Vedotin vs Chemotherapy in Subjects With Previously Treated Locally Advanced or Metastatic Urothelial Cancer (EV-301). U.S.National Institutes of Health.
Ref 4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034572)
Ref 6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
Ref 7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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