m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00558				[1], [2], [3]
m⁶A modification DANCR DANCR LRPPRC : m⁶A sites Indirect Enhancement RNA modification SOX2 SOX2 ADAR Methylation : modification sites
m6A Regulator	Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC)			READER	Regulator Info
m6A Target	Differentiation antagonizing non-protein coding RNA (DANCR)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)			WRITER	View Details
Regulated Target	Transcription factor SOX-2 (SOX2)				View Details
Crosstalk Relationship	m6A → A-to-I			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	LRPPRC interacts with Differentiation antagonizing non-protein coding RNA (DANCR), increasing its m6A level and promoting its physical interaction with Transcription factor SOX-2 (SOX2), which was regulated by ADAR1-mediated A-to-I modification.
In-vitro Model	HN4	Clear cell renal cell carcinoma	Homo sapiens		CVCL_IS30
	CAL-27	Tongue squamous cell carcinoma	Homo sapiens		CVCL_1107
	UM-UC-3	Bladder carcinoma	Homo sapiens		CVCL_1783
	T24	Bladder carcinoma	Homo sapiens		CVCL_0554

References

Ref 1	ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation. J Exp Clin Cancer Res. 2019 Jul 17;38(1):315. doi: 10.1186/s13046-019-1300-2.
Ref 2	DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression. Mol Ther. 2019 Feb 6;27(2):326-341. doi: 10.1016/j.ymthe.2018.12.015. Epub 2019 Jan 9.
Ref 3	Long Noncoding RNA DANCR Regulates Cell Proliferation by Stabilizing SOX2 mRNA in Nasopharyngeal Carcinoma. Am J Pathol. 2020 Dec;190(12):2343-2354. doi: 10.1016/j.ajpath.2020.09.005. Epub 2020 Sep 22.