m6A-centered Disease Response Information

General Information of the Disease (ID: M6ADIS0370)
Name
Single episode depressive disorder, severe, without psychotic symptoms
ICD
ICD-11: 6A70
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Disease
In total 17 item(s) under this disease
Crosstalk ID: M6ACROT02078
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target Glucocorticoid receptor (NR3C1)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02079
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target Cyclic AMP-responsive element-binding protein 1 (CREB1)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02080
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target BDNF/NT-3 growth factors receptor (NTRK2)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02081
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target Neurotrophic factor BDNF precursor form (BDNF)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02082
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target Glucocorticoid receptor (NR3C1)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02083
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target Cyclic AMP-responsive element-binding protein 1 (CREB1)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02084
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target BDNF/NT-3 growth factors receptor (NTRK2)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02085
 Crosstalk Info 
m6A Regulator Fat mass and obesity-associated protein (FTO)
 Regulator Info 
m6A Target Neurotrophic factor BDNF precursor form (BDNF)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02086
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Glucocorticoid receptor (NR3C1)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02087
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Cyclic AMP-responsive element-binding protein 1 (CREB1)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02088
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target BDNF/NT-3 growth factors receptor (NTRK2)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02089
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Neurotrophic factor BDNF precursor form (BDNF)
 Target Gene 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02090
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Glucocorticoid receptor (NR3C1)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02091
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Cyclic AMP-responsive element-binding protein 1 (CREB1)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02092
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target BDNF/NT-3 growth factors receptor (NTRK2)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT02093
 Crosstalk Info 
m6A Regulator Methyltransferase-like 3 (METTL3)
 Regulator Info 
m6A Target Neurotrophic factor BDNF precursor form (BDNF)
 Target Gene 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Crosstalk ID: M6ACROT05059
 Crosstalk Info 
m6A Regulator RNA demethylase ALKBH5 (ALKBH5)
 Regulator Info 
m6A Target Fatty-acid amide hydrolase 1 (FAAH)
 Target Gene 
Epigenetic Regulator Circ_STAG1
Regulated Target RNA demethylase ALKBH5 (ALKBH5)
Crosstalk relationship ncRNA → m6A
References
Ref 1 CN patent application no. 1882326, Ppar agonists for the treatment of hcv infection.
Ref 2 A primary adrenal steroid, 11beta-hydroxyandrostenedione, has an osteotropic effect and little androgenic activity. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):203-11. doi: 10.1016/s0960-0760(00)00124-2.