m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR00833)
Target Name Cyclic AMP-responsive element-binding protein 1 (CREB1)
Synonyms
CREB-1; cAMP-responsive element-binding protein 1
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Gene Name Creb1
Chromosomal Location 2q33.3
Family BZIP family
Function
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity).
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Gene ID 1385
Uniprot ID
CREB1_HUMAN
HGNC ID
HGNC:2345
KEGG ID
hsa:1385
Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator
DNA modification
m6A Regulator: Fat mass and obesity-associated protein (FTO)
 Regulator Info 
In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02079
 Crosstalk Info 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Disease Major depressive disorder
 Disease Info 
Crosstalk ID: M6ACROT02083
 Crosstalk Info 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Disease Major depressive disorder
 Disease Info 
m6A Regulator: Methyltransferase-like 3 (METTL3)
 Regulator Info 
In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02087
 Crosstalk Info 
Epigenetic Regulator DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Disease Major depressive disorder
 Disease Info 
Crosstalk ID: M6ACROT02091
 Crosstalk Info 
Epigenetic Regulator Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO)
Crosstalk relationship DNA modification → m6A
Disease Major depressive disorder
 Disease Info 
Non-coding RNA
m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
 Regulator Info 
In total 3 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05198
 Crosstalk Info 
Epigenetic Regulator hsa_circ_0006357 (Circ_EZH2)
Regulated Target Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Crosstalk relationship ncRNA → m6A
Disease Colorectal cancer
 Disease Info 
Crosstalk ID: M6ACROT05199
 Crosstalk Info 
Epigenetic Regulator hsa-miR-133b
Regulated Target Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)
Crosstalk relationship ncRNA → m6A
Disease Colorectal cancer
 Disease Info 
Crosstalk ID: M6ACROT05200
 Crosstalk Info 
Epigenetic Regulator hsa_circ_0006357 (Circ_EZH2)
Regulated Target hsa-miR-133b
Crosstalk relationship ncRNA → m6A
Disease Colorectal cancer
 Disease Info 
References
Ref 1 CN patent application no. 1882326, Ppar agonists for the treatment of hcv infection.
Ref 2 Clinical pipeline report, company report or official report of Innovent Biologics.
Ref 3 Deubiquitinases (DUBs) and DUB inhibitors: a patent review. Expert Opin Ther Pat. 2015;25(10):1191-1208. doi: 10.1517/13543776.2015.1056737. Epub 2015 Jun 16.