m6A Target Gene Information

General Information of the m6A Target Gene (ID: M6ATAR01491)

Target Name	Cysteine methyltransferase DNMT3A (DNMT3A)
Synonyms	cytosine-5; Dnmt3a; EC 2.1.1.37; Cysteine methyltransferase DNMT3A; EC 2.1.1.-; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA Click to Show/Hide
Gene Name	Dnmt3a
Chromosomal Location	2p23.3
Family	Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
Function	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). Click to Show/Hide
Gene ID	1788
Uniprot ID	DNM3A_HUMAN
HGNC ID	HGNC:2978
KEGG ID	hsa:1788

Full List of Crosstalk(s) between m6A Modification and Epigenetic Regulation Related to This Regulator

DNA modification

m6A Regulator: ELAV-like protein 1 (ELAVL1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02070		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Dachshund family transcription factor 1 (DACH1)
Crosstalk relationship	m6A → DNA modification
Disease	Chronic obstructive pulmonary disease	Disease Info

m6A Regulator: YTH domain-containing family protein 2 (YTHDF2)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02071		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Dachshund family transcription factor 1 (DACH1)
Crosstalk relationship	m6A → DNA modification
Disease	Chronic obstructive pulmonary disease	Disease Info

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02076		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Alpha tubulin acetyltransferase 1 (ATAT1)
Crosstalk relationship	m6A → DNA modification
Disease	Alzheimer disease	Disease Info
Crosstalk ID: M6ACROT02106		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Crosstalk relationship	m6A → DNA modification
Disease	Gastric cancer	Disease Info
Drug	Decitabine	Drug Info

m6A Regulator: YTH domain-containing family protein 1 (YTHDF1)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02077		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Regulated Target	Alpha tubulin acetyltransferase 1 (ATAT1)
Crosstalk relationship	m6A → DNA modification
Disease	Alzheimer disease	Disease Info

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT02107		Crosstalk Info
Epigenetic Regulator	Cysteine methyltransferase DNMT3A (DNMT3A)
Crosstalk relationship	m6A → DNA modification
Disease	Gastric cancer	Disease Info
Drug	Decitabine	Drug Info

Histone modification

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT03531		Crosstalk Info
Epigenetic Regulator	Lysine-specific histone demethylase 1A (KDM1A)
Regulated Target	Histone H3 lysine 9 trimethylation (H3K9me3)
Crosstalk relationship	Histone modification → m6A
Disease	Alzheimer disease	Disease Info

Non-coding RNA

m6A Regulator: Methyltransferase-like 3 (METTL3)

Regulator Info

In total 2 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05035		Crosstalk Info
Epigenetic Regulator	hsa-miR-33a
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	ncRNA → m6A
Disease	Non-small cell lung cancer	Disease Info
Crosstalk ID: M6ACROT05961		Crosstalk Info
Epigenetic Regulator	Long intergenic non-protein coding RNA 942 (LINC00942)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	ncRNA → m6A
Disease	Gastric cancer	Disease Info
Drug	Decitabine	Drug Info

m6A Regulator: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Regulator Info

In total 1 item(s) under this m6A regulator
Crosstalk ID: M6ACROT05962		Crosstalk Info
Epigenetic Regulator	Long intergenic non-protein coding RNA 942 (LINC00942)
Regulated Target	Methyltransferase-like protein 3 (METTL3)
Crosstalk relationship	ncRNA → m6A
Disease	Gastric cancer	Disease Info
Drug	Decitabine	Drug Info

References

Ref 1	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics. 2005 Aug;86(2):127-41. doi: 10.1016/j.ygeno.2005.04.008.
Ref 2	Comparative evaluation of CC chemokine-induced migration of murine CD8alpha+ and CD8alpha- dendritic cells and their in vivo trafficking. J Leukoc Biol. 2004 Feb;75(2):275-85. doi: 10.1189/jlb.1202613. Epub 2003 Nov 3.
Ref 3	Investigation of the effects of the CFTR potentiator ivacaftor on human P-glycoprotein (ABCB1). Sci Rep. 2017 Dec 13;7(1):17481. doi: 10.1038/s41598-017-17773-5.
Ref 4	MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA. Biochem Biophys Res Commun. 2017 Jan 22;482(4):582-589. doi: 10.1016/j.bbrc.2016.11.077. Epub 2016 Nov 14.
Ref 5	A peroxisome proliferator-activated receptor alpha/gamma dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent models of type 2 diabetes and dyslipidemia. Mol Endocrinol. 2005 Jun;19(6):1593-605. doi: 10.1210/me.2005-0015. Epub 2005 Apr 14.